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Business and Organization (Details)
$ / shares in Units, $ in Thousands
3 Months Ended
Apr. 12, 2019
USD ($)
May 24, 2018
$ / shares
Mar. 31, 2019
USD ($)
$ / shares
Mar. 31, 2018
USD ($)
Dec. 31, 2018
USD ($)
$ / shares
Jul. 02, 2018
$ / shares
Dec. 31, 2017
USD ($)
Subsequent Event [Line Items]              
Net loss     $ 3,666 $ 2,901      
Cash used in operating activities     3,077 4,761      
Cash and cash equivalents     11,322   $ 14,430    
Working capital     9,100        
Accumulated deficit     $ 192,746   $ 189,080    
Stock split, conversion ratio   0.2          
Common stock, par value (in dollars per share) | $ / shares   $ 0.001 $ 0.001   $ 0.001 $ 0.001  
Stockholders equity     $ 6,003 $ 6,259 $ 9,557   $ 9,007
Castle Creek Pharmaceuticals, LLC Co-Development And License Agreement | Subsequent Event              
Subsequent Event [Line Items]              
Upfront payment received $ 7,500            
First milestone payment receivable $ 2,500