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Warrants - Narrative (Details) - USD ($)
$ / shares in Units, $ in Millions
1 Months Ended 12 Months Ended
May 31, 2018
May 29, 2018
Dec. 11, 2017
Dec. 08, 2017
Jul. 31, 2018
May 31, 2018
Dec. 31, 2017
Mar. 31, 2017
Sep. 30, 2016
Dec. 31, 2018
Dec. 31, 2017
Jan. 06, 2018
Dec. 07, 2017
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             5,452,923     7,392,966 5,452,923    
Warrants exercise price (usd per share)             $ 11.32     $ 7.36 $ 11.32    
Warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             1,385,556     1,205,840 1,385,556    
Level 3 | Warrants                          
Class of Warrant or Right [Line Items]                          
Non-cash expense (income) resulting from change in estimated fair value                   $ 0.9 $ 4.9    
Issued in 2017 Common Stock Offering - pre-funded warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             1,184,422       1,184,422   1,184,422
Issued in 2017 Common Stock Offering - common warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)       82,118     82,118       82,118 409,091 2,809,404
Issued in 2017 Series A Preferred Stock Offering                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)               687,468          
Warrants exercise price (usd per share)               $ 12.69          
Warrant exercise period               5 years          
Period of time after issuance for warrants to become exercisable               6 months          
Issued with September 2016 Convertible Notes                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             1,205,840   1,205,840 1,205,840 1,205,840    
Warrants exercise price (usd per share)                 $ 22.50 $ 22.50      
Warrant exercise period                 5 years        
Period of time after issuance for warrants to become exercisable                 6 months        
Warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             4,067,367     6,187,126 4,067,367    
Warrants | Issued in July 2018 Private Placement - common warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)         958,152   0     958,152 0    
Warrants exercise price (usd per share)         $ 2.70         $ 2.70      
Warrant exercise period         5 years 6 months                
Warrants | Issued in July 2018 Registered Direct Offering - underwriter warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)         103,186   0     103,186 0    
Warrants exercise price (usd per share)         $ 3.464         $ 3.464      
Warrants | Warrants Issued in 2018 Private Placement - Common Warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares) 1,528,668         1,528,668              
Warrants exercise price (usd per share) $ 2.86         $ 2.86              
Warrant exercise period   5 years 6 months       5 years 6 months              
Warrants | Issued in May 2018 Registered Direct Offering - underwriter warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares) 142,676         142,676 0     142,676 0    
Warrants exercise price (usd per share) $ 3.679         $ 3.679       $ 3.679      
Warrant exercise period 5 years                        
Warrants | Issued in 2017 Common Stock Offering - pre-funded warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             483,221     0 483,221    
Warrants exercise price (usd per share)     $ 0.05             $ 0.05      
Warrants | Issued in 2017 Common Stock Offering - common warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             2,809,404     2,679,702 2,809,404    
Warrants exercise price (usd per share)     $ 3.85       $ 3.85     $ 3.85 $ 3.85 $ 3.85 $ 3.85
Warrant exercise period     5 years       5 years            
Warrants | Issued in 2017 Common Stock Offering - underwriter warrants                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)       87,274     87,274     87,274 87,274    
Warrants exercise price (usd per share)     $ 4.8125 $ 4.8125     $ 4.8125     $ 4.8125 $ 4.8125    
Warrant exercise period     5 years 5 years     5 years            
Warrants | Issued in 2017 Series A Preferred Stock Offering                          
Class of Warrant or Right [Line Items]                          
Number of warrants (shares)             687,468     687,468 687,468    
Warrants exercise price (usd per share)                   $ 12.69      
Common Stock | Issued in 2017 Common Stock Offering - common warrants                          
Class of Warrant or Right [Line Items]                          
Number of shares per warrant (shares)                         1
Common Stock | Warrants | Issued in 2017 Common Stock Offering - common warrants                          
Class of Warrant or Right [Line Items]                          
Number of shares per warrant (shares)             1       1