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Stock-Based Compensation - Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2018
Dec. 31, 2017
Number of shares    
Outstanding at beginning of period (in shares) 217,926  
Granted (in shares) 84,800  
Exercised (shares) 0  
Forfeited (in shares) (11,113)  
Expired (in shares) (2,099)  
Outstanding at end of period (in shares) 289,514 217,926
Exercisable at end of period (in shares) 165,696  
Weighted- average exercise price    
Outstanding at beginning of period (in dollars per share) $ 60.31  
Granted (in dollars per share) 2.99  
Exercised (in dollars per share) 0.00  
Forfeited (in dollars per share) 6.12  
Expired (in dollars per share) 51.46  
Outstanding at end of period (in dollars per share) 45.67 $ 60.31
Exercisable at end of period (in dollars per share) $ 73.64  
Additional disclosures    
Weighted-average remaining contractual term (in years), outstanding 7 years 3 months 7 years 3 months
Weighted-average remaining contractual term (in years), granted 9 years 6 months  
Weighted-average remaining contractual term (in years), exercisable 5 years 11 months  
Aggregate intrinsic value, outstanding $ 0 $ 0
Aggregate intrinsic value, exercisable $ 0