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Represents the number of directors of reporting entity.

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Number of Collaboration Agreements

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Shareholder Ownership Percentage

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Shareholder Ownership Percentage of Related Party in Affiliate

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

Face (par) amount of debt instrument at time of issuance.

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Carrying amount as of the balance sheet date of obligations due all related parties. For classified balance sheets, represents the current portion of such liabilities (due within one year or within the normal operating cycle if longer).

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Total number of nonredeemable preferred shares (or preferred stock redeemable solely at the option of the issuer) issued to shareholders (includes related preferred shares that were issued, repurchased, and remain in the treasury). May be all or portion of the number of preferred shares authorized. Excludes preferred shares that are classified as debt.

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Amount of transactions with related party during the financial reporting period.

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Expenses recognized resulting from transactions (excluding transactions that are eliminated in consolidated or combined financial statements) with related party.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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The number of shares issued or sold by the subsidiary or equity method investee per stock transaction.

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Related Party Transactions (Details)		3 Months Ended			6 Months Ended
Related Party Transactions (Details)	Jan. 06, 2018 shares	Jun. 30, 2018 USD ($) agreement shares	Mar. 31, 2018 USD ($)	Jun. 30, 2017 USD ($)	Jun. 30, 2018 USD ($) director agreement shares	Jun. 30, 2017 USD ($)	Dec. 31, 2017 USD ($)	Sep. 30, 2016 USD ($) shares
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of exclusive channel collaboration agreements (agreement) \| agreement		2			2
Royalty and milestone payments incurred					$ 0
Related party payable		$ 276,000			276,000		$ 2,303,000
Research and development expense		1,415,000		$ 1,679,000	3,060,000	$ 3,143,000
Common stock issued (shares) \| shares	409,091
Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares								1,205,840
Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal								$ 18,087,500
Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed		100,000		1,700,000	300,000	3,200,000
Related party payable		300,000			300,000		2,300,000
Research and development expense		$ 106,000		1,678,000	$ (197,000)	3,187,000
Shareholder ownership percentage of related party in affiliate, more than		50.00%			50.00%
Shareholder ownership percentage		18.00%			18.00%
Affiliated Entity \| 2017 Private Placement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares		545,456			545,456			259,176
Preferred stock, shares issued (shares) \| shares								3,016
Common stock issued (shares) \| shares					545,456
Affiliated Entity \| Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares								450,835
Affiliated Entity \| Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal								$ 6,762,500
Director
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of directors (director) \| director					2
2012 ECC Dispute \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Related party payable		$ 200,000			$ 200,000		$ 700,000
Research and development expense			$ 1,400,000	1,100,000
Due to Related Parties, Reduction From Prior Period		500,000			500,000
Direct Expenses for Work Performed \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed		40,000		300,000	100,000	600,000
Pass-through Costs \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed		$ 60,000		$ 1,400,000	200,000	$ 2,600,000
Reduction to Pass-Through Costs \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed					$ 500,000