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Related Party Transactions (Details)	3 Months Ended			9 Months Ended
Related Party Transactions (Details)	Sep. 30, 2017 USD ($) agreement	Jun. 30, 2017 USD ($)	Sep. 30, 2016 USD ($) shares	Sep. 30, 2017 USD ($) director agreement	Sep. 30, 2016 USD ($) shares	Mar. 07, 2017 shares	Dec. 31, 2016 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of exclusive channel collaboration agreements (agreement) \| agreement	2			2
Royalty and milestone payments incurred				$ 0
Research and development expense	$ 1,657,000		$ 1,645,000	4,800,000	$ 6,599,000
Related party payable	1,731,000			1,731,000			$ 942,000
Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares			6,029,174		6,029,174
Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal			$ 18,087,500		$ 18,087,500
Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	1,000,000		500,000
Research and development expense	981,000		$ 534,000	4,168,000	$ 2,783,000
Related party payable	$ 1,700,000			$ 1,700,000			$ 900,000
Shareholder ownership percentage of related party in affiliate, more than	50.00%			50.00%
Shareholder ownership percentage	38.00%			38.00%
Affiliated Entity \| Private Placement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares						1,295,875
Preferred stock, shares issued (shares) \| shares						3,016
Affiliated Entity \| Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares			2,254,168		2,254,168
Affiliated Entity \| Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal			$ 6,762,500		$ 6,762,500
Director
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of directors (director) \| director				2
2012 ECC \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed				$ 4,200,000	2,800,000
2012 ECC Dispute \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development expense		$ 1,100,000
Related party payable	$ 800,000			800,000
2015 ECC \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	0		0	0	0
Direct Expenses for Work Performed \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	300,000		200,000	900,000	1,000,000
Pass-through Costs \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	$ 700,000		$ 300,000	$ 3,300,000	$ 1,800,000