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Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions
The fair market value of these stock options at the date of grant was estimated using the Black-Scholes option-pricing model with the following weighted average assumptions for the nine months ended:
 
September 30, 2017
 
September 30, 2016
Expected term
6 years, 0 months

 
6 years, 2 months

Interest rate
1.95
%
 
1.37
%
Dividend rate

 

Volatility
88.7
%
 
92.5
%

Summary of Stock Option Activity
The following table summarizes stock option activity for the nine months ended September 30, 2017:
 
Number of
shares
 
Weighted-
average
exercise
price
 
Weighted- average
remaining
contractual
term
 
Aggregate
intrinsic
value
Outstanding at December 31, 2016
1,279,379

 
$
15.16

 
7 years, 2 months
 
$

Granted
295,000

 
2.88

 
 
 
 

Exercised

 

 
 
 
 

Forfeited
(268,256
)
 
9.62

 
 
 
 

Expired
(189,773
)
 
14.43

 
 
 
 

Outstanding at September 30, 2017(1)
1,116,350

 
$
13.38

 
7 years, 4 months
 
$
236,576

Exercisable at September 30, 2017
660,625

 
$
20.20

 
6 years
 
$
29,959


(1)
Includes both vested stock options as well as unvested stock options for which the requisite service period has not been rendered but that are expected to vest based on achievement of a service condition.