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Related Party Transactions (Details)	3 Months Ended		6 Months Ended
Related Party Transactions (Details)	Jun. 30, 2017 USD ($) agreement	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($) director agreement	Jun. 30, 2016 USD ($)	Mar. 07, 2017 shares	Dec. 31, 2016 USD ($)	Sep. 30, 2016 USD ($) shares
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of exclusive channel collaboration agreements (agreement) \| agreement	2		2
Royalty and milestone payments incurred			$ 0
Research and development expense	$ 1,679,000	$ 2,352,000	3,143,000	$ 4,954,000
Related party payable	1,678,000		1,678,000			$ 942,000
Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares							6,029,174
Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal							$ 18,087,500
Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	1,700,000	900,000
Research and development expense	1,678,000	925,000	3,187,000	2,249,000
Related party payable	$ 1,700,000		$ 1,700,000			$ 900,000
Shareholder ownership percentage of related party in affiliate, more than	50.00%		50.00%
Shareholder ownership percentage	38.00%		38.00%
Affiliated Entity \| Private Placement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares					1,295,875
Preferred stock, shares issued (shares) \| shares					3,016
Affiliated Entity \| Warrants Issued With September 2016 Convertible Notes
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Warrants issued to purchase common stock (in shares) \| shares							2,254,168
Affiliated Entity \| Convertible Debt
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Convertible debt principal							$ 6,762,500
Director
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of directors (director) \| director			2
2012 ECC \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed			$ 3,200,000	2,200,000
2012 ECC Dispute \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development expense	$ 1,100,000		800,000
Related party payable	800,000		800,000
2015 ECC \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	0	0	0	0
Direct Expenses for Work Performed \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	300,000	300,000	600,000	800,000
Pass-through Costs \| Affiliated Entity
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expenses for work performed	$ 1,400,000	$ 600,000	$ 2,600,000	$ 1,400,000