Consolidated Statements of Shareholders' Equity (Deficit) (USD $) In Thousands, except Share data	Total	Common Stock	Subscription Receivable	Additional paid-in capital	Deficit accumulated	Noncontrolling Interest
Beginning balance at Dec. 31, 2010	$ (15,073)	$ 20		$ 2,438	$ (17,981)	$ 450
Beginning balance, shares at Dec. 31, 2010		20,375,498
Proceeds from equity financing, net	22,169	44	(550)	22,675
Proceeds from equity financing, net, shares		43,318,350
Preferred stock warrants exercised	7,259	8		7,251
Preferred stock warrants exercised, shares		8,410,266
Preferred stock converted	8,494	24		8,470
Preferred stock converted, shares		23,328,000
Stock-based compensation expense	2,900			2,900
Stock options exercised, shares	600,000	246,141
Net loss	(31,350)				(31,368)	18
Ending balance at Dec. 31, 2011	(5,601)	96	(550)	43,734	(49,349)	468
Ending balance, shares at Dec. 31, 2011		95,678,255
Proceeds from equity financing, net	40,185	455	(2,004)	41,734
Proceeds from equity financing, net, shares		455,075,000
Preferred stock converted	1,350	50		1,300
Preferred stock converted, shares		50,528,000
Reclass and exercise of warrants to equity	15,065			15,065
Reclass and exercise of warrants to equity, shares		62,406
Conversion of note payable	2,385	23		2,362
Conversion of note payable, shares		22,465,947
Issuance of common stock for exclusive collaboration channel agreement	6,917	33		6,884
Issuance of common stock for exclusive collaboration channel agreement, shares		32,938,000
Cancellation of certificate		(1)	550	(549)
Cancellation of certificate, shares		(1,000,000)
Stock-based compensation expense	1,224			1,224
Net loss	(23,170)				(22,726)	(468)
Ending balance at Dec. 31, 2012	$ 38,331	$ 656	$ (2,004)	$ 111,754	$ (72,075)
Ending balance, shares at Dec. 31, 2012		655,747,608