Commitments and Contingencies (Details) $ in Thousands	Dec. 31, 2015 USD ($)
Other Commitments [Line Items]
Total	$ 20,208
2016	11,464
2017	1,262
2018	1,262
2019	1,424
2020	1,479
2021 and thereafter	3,317
License fee obligations
Other Commitments [Line Items]
Total	48
2016	8
2017	8
2018	8
2019	8
2020	8
2021 and thereafter	8
Research obligations
Other Commitments [Line Items]
Total	202
2016	202
2017	0
2018	0
2019	0
2020	0
2021 and thereafter	0
Operating lease obligations
Other Commitments [Line Items]
Total	9,958
2016	1,254
2017	1,254
2018	1,254
2019	1,416
2020	1,471
2021 and thereafter	3,309
Collaboration with related party
Other Commitments [Line Items]
Total	10,000
2016	10,000
2017	0
2018	0
2019	0
2020	0
2021 and thereafter	$ 0