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Inventory (Details) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Inventory Disclosure [Abstract]      
Raw materials (LAVIV and product candidates) $ 338,000 $ 357,000  
Work-in-process (LAVIV) 144,000 214,000  
Total inventory 482,000 571,000  
Inventory reserve 0 0  
Inventory expiration/obsolescence expense $ 0 $ 0 $ 0