X0201 42004-01-080 0000356830 GENOME THERAPEUTICS CORP GENE 0001234374 HENNESSEY ROBERT J 100 BEAVER STREET WALTHAM 02453 1000Common Stock2004-01-084A090001.625A57460DCommon Stock2004-01-084S090003.8733D48460DCommon Stock2004-01-094A090001.625A57460DCommon Stock2004-01-094S090003.9933D48460DCommon Stock2004-01-124A090001.625A57460DCommon Stock2004-01-124S090004.16D48460DStock Options1.6252004-01-084M090001.625D1995-12-112004-03-31Common Shares9000701716DStock Options1.6252004-01-094M090001.625D1995-12-112004-03-31Common Shares9000692716DStock Options1.6252004-01-124M090001.625D1995-12-112004-03-31Common Shares9000683716DPlease note that this transaction occurred in accordance with the terms and conditions of a Rule 10b5-1 Trading Plan.Manny Bougoulas, Controller, by power of atty2004-01-12