May 3, 2006

VIA EDGAR

The United States Securities

and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Subject:  Multi-Flex Variable Account of

Nationwide Life Insurance Company

SEC File No. 33-23905

CIK No. 0000356723

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933 and on behalf of the Multi-Flex Variable Account (the “Variable Account”) and Nationwide Life Insurance Company (“the Company”), we certify that the form of the prospectus which would have been filed under paragraphs (b) and (c) under Rule 497 does not differ from the form of the Prospectus contained in Post Effective Amendment No. 21 to the Registration Statement for the Company and the Variable Account which became effective May 1, 2006.

Please contact the undersigned at (614) 249-3398 with any questions regarding this filing.

Very truly yours,

NATIONWIDE LIFE INSURANCE COMPANY

/s/ TIMOTHY D. CRAWFORD

Timothy D. Crawford

Variable Products Securities Counsel