Rule 497(e)

File Nos. 002-75503

811-03364

MAXIM SERIES FUND, INC.

Maxim Conservative Profile II Portfolio

Maxim Moderately Conservative Profile II Portfolio

Maxim Moderate Profile II Portfolio

Maxim Moderately Aggressive Profile II Portfolio

Maxim Aggressive Profile II Portfolio

(the “Profile II Portfolios”)

Supplement dated June 23, 2010 to the Prospectus for the Profile II Portfolios and the Statement of Additional Information, both dated May 1, 2010

Effective immediately, the cover page of the Prospectus for the Profile II Portfolios and the cover page of the Statement of Additional Information are revised to include the ticker symbols for the Profile II Portfolios.  As a result, please note the addition of the ticker symbols to the cover pages of the Prospectus and Statement of Additional Information as follows:

Maxim Conservative Profile II Portfolio

Ticker:  MXCPX

Maxim Moderately Conservative Profile II Portfolio

Ticker:  MXDPX

Maxim Moderate Profile II Portfolio

Ticker:  MXMPX

Maxim Moderately Aggressive Profile II Portfolio

Ticker:  MXBPX

Maxim Aggressive Profile II Portfolio

Ticker:  MXAPX

This Supplement must be accompanied by or read in conjunction with the current Prospectus and Statement of Additional Information, each dated May 1, 2010, and should be retained for future reference.