<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000355379</cik>
        <entityName>MIDWEST HOLDING INC.</entityName>
        <issuerAddress>
            <street1>2900 SOUTH 70TH STREET</street1>
            <street2>SUITE 400</street2>
            <city>LINCOLN</city>
            <stateOrCountry>NE</stateOrCountry>
            <stateOrCountryDescription>NEBRASKA</stateOrCountryDescription>
            <zipCode>68506</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>402-489-8266</issuerPhoneNumber>
        <jurisdictionOfInc>NEBRASKA</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>MIDWEST HOLDING INC</previousName>
            <previousName>MIDWEST NATIONAL CORP</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>A.</firstName>
                <middleName>Michael</middleName>
                <lastName>Salem</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1075 Old Post Road</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10506</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Minnich</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7 East 20th Street, Apartment 12F</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10003</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Sachin</firstName>
                <lastName>Goel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>622 30th Street</street1>
                <city>Peru</city>
                <stateOrCountry>IL</stateOrCountry>
                <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
                <zipCode>61354</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName>A.</middleName>
                <lastName>Oliver</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>9601 Hollow Tree Drive</street1>
                <city>Lincoln</city>
                <stateOrCountry>NE</stateOrCountry>
                <stateOrCountryDescription>NEBRASKA</stateOrCountryDescription>
                <zipCode>68512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Scott</firstName>
                <lastName>Morrison</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5524 Bee Caves Road</street1>
                <street2>Suite K-1</street2>
                <city>Austin</city>
                <stateOrCountry>TX</stateOrCountry>
                <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                <zipCode>78746</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jack</firstName>
                <lastName>Theeler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>41416 251st Street</street1>
                <city>Mitchell</city>
                <stateOrCountry>SD</stateOrCountry>
                <stateOrCountryDescription>SOUTH DAKOTA</stateOrCountryDescription>
                <zipCode>57301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Hompe</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12 Rosebrook Road</street1>
                <city>New Canaan</city>
                <stateOrCountry>CT</stateOrCountry>
                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                <zipCode>06840</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dana</firstName>
                <lastName>Stapleton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>45696 116th Street</street1>
                <city>Sisseton</city>
                <stateOrCountry>SD</stateOrCountry>
                <stateOrCountryDescription>SOUTH DAKOTA</stateOrCountryDescription>
                <zipCode>57262</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Firman</firstName>
                <lastName>Leung</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>241 Central Park West</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Insurance</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2020-04-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>10000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5177000</totalOfferingAmount>
            <totalAmountSold>5177000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>37</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>A portion of the proceeds of the offering may be used for general working capital purposes. Thus, proceeds may be used for payments to officers and directors in the ordinary course, but are not specifically earmarked for such payments.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>MIDWEST HOLDING INC.</issuerName>
                <signatureName>/s/ Mark A. Oliver</signatureName>
                <nameOfSigner>Mark A. Oliver</nameOfSigner>
                <signatureTitle>President</signatureTitle>
                <signatureDate>2020-05-07</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
