<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001499743</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000354950</issuerCik>
      <issuerName>HOME DEPOT, INC.</issuerName>
      <secFileNumber>001-08207</secFileNumber>
      <issuerAddress>
        <com:street1>2455 PACES FERRY ROAD</com:street1>
        <com:city>ATLANTA</com:city>
        <com:stateOrCountry>GA</com:stateOrCountry>
        <com:zipCode>30339-4024</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>770-433-8211</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Carey Matt</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 summer street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5769</noOfUnitsSold>
      <aggregateMarketValue>1979286.21</aggregateMarketValue>
      <noOfUnitsOutstanding>991030000</noOfUnitsOutstanding>
      <approxSaleDate>05/16/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/27/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>The Home Depot Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>961</amountOfSecuritiesAcquired>
      <paymentDate>03/27/2024</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/22/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>The Home Depot Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4080</amountOfSecuritiesAcquired>
      <paymentDate>02/22/2024</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Matthew Carey</name>
        <address>
          <com:street1>2455 Paces Ferry Road</com:street1>
          <com:city>Atlanta</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30339</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>The Home Depot INc</securitiesClassTitle>
      <saleDate>05/16/2024</saleDate>
      <amountOfSecuritiesSold>50239</amountOfSecuritiesSold>
      <grossProceeds>17000000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/16/2024</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Matthew Carey</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
