X0201 4 2003-11-11 0 0000353569 QUIDEL CORP /DE/ QDEL 0001219494 DE BRUIN ANDRE 7359 FAY AVENUE LA JOLLA CA 92037 1 0 0 0 Common Stock 2003-11-11 4 M 0 100 3.25 A 23400 D Common Stock 2003-11-11 4 S 0 100 7.251 D 23300 D Common Stock 2003-11-11 4 M 0 100 3.25 A 23400 D Common Stock 2003-11-11 4 S 0 100 7.30 D 23300 D Common Stock 2003-11-11 4 M 0 100 3.25 A 23400 D Common Stock 2003-11-11 4 S 0 100 7.321 D 23300 D Common Stock 2003-11-11 4 M 0 600 3.25 A 23900 D Common Stock 2003-11-11 4 S 0 600 7.26 D 23300 D Common Stock 2003-11-11 4 M 0 11948 3.25 A 35248 D Common Stock 2003-11-11 4 S 0 11948 7.25 D 23300 D Common Stock 2003-11-12 4 M 0 3500 3.25 A 26800 D Common Stock 2003-11-12 4 S 0 3500 7.25 D 23300 D Common Stock 2003-11-12 4 M 0 1000 3.25 A 24300 D Common Stock 2003-11-12 4 S 0 1000 7.26 D 23300 D Common Stock 2003-11-12 4 M 0 1000 3.25 A 24300 D Common Stock 2003-11-12 4 S 0 1000 7.27 D 23300 D Common Stock 2003-11-12 4 M 0 1000 3.25 A 24300 D Common Stock 2003-11-12 4 S 0 1000 7.33 D 23300 D Common Stock 2003-11-12 4 M 0 1000 3.25 A 24300 D Common Stock 2003-11-12 4 S 0 1000 7.36 D 23300 D Common Stock 2003-11-12 4 M 0 6115 3.25 A 29415 D Common Stock 2003-11-12 4 S 0 6115 7.40 D 23300 D Common Stock 2003-11-12 4 M 0 4493 3.25 A 27793 D Common Stock 2003-11-12 4 S 0 4493 7.41 D 23300 D Common Stock 2003-11-12 4 M 0 500 3.25 A 23800 D Common Stock 2003-11-12 4 S 0 500 7.42 D 23300 D Common Stock 2003-11-12 4 M 0 2200 3.25 A 25500 D Common Stock 2003-11-12 4 S 0 2200 7.62 D 23300 D Incentive Stock Option 3.25 2003-11-11 4 M 0 12848 0.00 D 2008-06-09 Common Stock 12848 114653 D Incentive Stock Option 3.25 2003-11-12 4 M 0 20808 0.00 D 2008-06-09 Common Stock 20808 93845 D This amount includes 21,800 shares of Common Stock owned directly by the Reporting Person's spouse for which she has sole voting and dispositive power. Although when initially granted the options vested at different times, as of March 9, 2002 all options issued pursuant to this grant were vested. /s/ Paul E. Landers, Attorney-in-Fact for Andre de Bruin 2003-11-13