Segment Reporting [Abstract]
Schedule of Revenue by Major Customers, by Reporting Segments [Table]
Schedule of Revenue by Major Customers, by Reporting Segments [Table]
Concentration Risk Type [Axis]
Concentration Risk Type [Axis]
Concentration Risk Type [Domain]
Concentration Risk Type [Domain]
Customer Concentration Risk [Member]
Customer Concentration Risk [Member]
Credit Concentration Risk [Member]
Credit Concentration Risk [Member]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark [Domain]
Sales [Member]
Sales [Member]
Accounts Receivable [Member]
Accounts Receivable [Member]
Geographical [Axis]
Geographical [Axis]
Geographical [Domain]
Geographical [Domain]
Non-U.S. Customers [Member]
Non Us Customers [Member]
Non U.S. customers.
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Minimum [Member]
Minimum [Member]
Revenue, Major Customer [Line Items]
Revenue, Major Customer [Line Items]
Number of reportable segments
Number of Reportable Segments
Percentage of risk concentration by major customer
Concentration Risk, Percentage
Accounts receivable
Accounts Receivable, Net
Earnings Per Share [Abstract]
Excluded from computation of earnings per share, amount
Excluded from Computation of Earnings Per Share, Amount
Excluded from Computation of Earnings Per Share, Amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Debt Disclosure [Abstract]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-term Debt Instruments [Table]
Scenario [Axis]
Scenario [Axis]
Scenario, Unspecified [Domain]
Scenario, Unspecified [Domain]
Debt Instrument [Axis]
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
3.25% Convertible Senior Notes due 2020 [Member]
Senior 3 Point 25 Percent Convertible Notes Due 2020 [Member]
Senior 3 Point 25 Percent Convertible Notes Due 2020 [Member]
Balance Sheet Location [Axis]
Balance Sheet Location [Axis]
Balance Sheet Location [Domain]
Balance Sheet Location [Domain]
Other Current Assets [Member]
Other Current Assets [Member]
Other non-current assets [Member]
Other Noncurrent Assets [Member]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Convertible Debt [Member]
Convertible Debt [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Convertible Senior Notes, face amount
Debt Instrument, Face Amount
Convertible Senior Notes, interest rate, stated percentage
Debt Instrument, Interest Rate, Stated Percentage
Debt issuance cost
Debt Issuance Costs, Gross
Deferred financing costs
Debt Issuance Costs, Net
Remaining amortization period of discount on the liability component
Debt Instrument, Term
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Debt Instrument, Unamortized Discount
Debt Instrument, Unamortized Discount
Convertible Senior Notes, conversion ratio
Debt Instrument, Convertible, Conversion Ratio
Convertible Senior Notes, conversion price (in dollars per share)
Debt Instrument, Convertible, Conversion Price
Convertible Senior Notes, threshold trading days
Debt Instrument, Convertible, Threshold Trading Days
Convertible Senior Notes, threshold consecutive trading days
Debt Instrument, Convertible, Threshold Consecutive Trading Days
Convertible Senior Notes, threshold percentage of stock price trigger
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger
Convertible Senior Notes, threshold consecutive business days
Debt Instrument, Convertible, Threshold Consecutive Business Days
Debt Instrument, Convertible, Threshold Consecutive Business Days
Debt Instrument, Convertible, Threshold Consecutive Trading Days, Following Consecutive Business Days
Debt Instrument, Convertible, Threshold Consecutive Trading Days, Following Consecutive Business Days
Debt Instrument, Convertible, Threshold Consecutive Trading Days, Following Consecutive Business Days
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger, Following Consecutive Business Days
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger, Following Consecutive Business Days
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger, Following Consecutive Business Days
Convertible Senior Notes, observation period
Debt instrument, Convertible, Observation Period
Debt instrument, Convertible, Observation Period
Carrying value of equity component, net of issuance costs
Debt Instrument, Convertible, Carrying Amount of Equity Component
Interest expense, Convertible Senior Notes, Amortization
Amortization of Debt Discount (Premium)
Interest expense, Convertible Senior Notes
Interest Expense, Debt, Excluding Amortization
Debt Conversion, Converted Instrument, Rate
Debt Conversion, Converted Instrument, Rate
Debt Instrument, Interest Rate, Effective Percentage
Debt Instrument, Interest Rate, Effective Percentage
Interest Expense, Debt
Interest Expense, Debt
Convertible Senior Notes, fair value disclosures
Convertible Debt, Fair Value Disclosures
Proceeds from issuance of Convertible Senior Notes
Proceeds from Convertible Debt
Fair value of outstanding Convertible Senior Notes
Notes Payable, Fair Value Disclosure
Repurchase of Convertible Debt
Repurchase of Convertible Debt
Repurchase of Convertible Debt
Repayments of Convertible Debt
Repayments of Convertible Debt
Repayments of Debt
Repayments of Debt
Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt, Subsequent Adjustments
Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt, Subsequent Adjustments
Gain on extinguishment of Convertible Senior Notes
Gain (Loss) on Extinguishment of Debt
Finite-Lived Intangible Assets, Net, Amortization Expense, Fiscal Year Maturity [Abstract]
2017
Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months
2018
Finite-Lived Intangible Assets, Amortization Expense, Year Two
2019
Finite-Lived Intangible Assets, Amortization Expense, Year Three
2020
Finite-Lived Intangible Assets, Amortization Expense, Year Four
2021
Finite-Lived Intangible Assets, Amortization Expense, Year Five
Thereafter
Finite-Lived Intangible Assets, Amortization Expense, after Year Five
Total
Finite-Lived Intangible Assets, Net
Statement of Comprehensive Income [Abstract]
Net loss
Net Income (Loss) Attributable to Parent
Other comprehensive loss, net of tax
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Changes in cumulative translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Quarterly Financial Information Disclosure [Abstract]
Selected Quarterly Financial Data (unaudited)
Quarterly Financial Information [Text Block]
Variable Rate [Axis]
Variable Rate [Axis]
Variable Rate [Domain]
Variable Rate [Domain]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Domain]
Debt Instrument, Redemption, Period [Domain]
Principal amount of Convertible Senior Notes outstanding
Long-term Debt, Gross
Unamortized deferred issuance costs
Unamortized deferred issuance costs
Net carrying amount of liability component
Long-term Debt
Less: current portion
Long-term Debt, Current Maturities
Long-term debt
Long-term Debt, Excluding Current Maturities
Remaining amortization period of discount on the liability component
Debt Instrument, Convertible, Remaining Discount Amortization Period
Statement of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets, Current [Abstract]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Accounts receivable, net
Accounts Receivable, Net, Current
Inventories
Inventory, Net
Restricted cash
Restricted Cash and Cash Equivalents, Current
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total current assets
Assets, Current
Property, plant and equipment, net
Property, Plant and Equipment, Net
Goodwill
Goodwill
Intangible assets, net
Intangible Assets, Net (Excluding Goodwill)
Other non-current assets
Other Assets, Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities and Equity [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Accounts payable
Accounts Payable, Current
Accrued payroll and related expenses
Employee-related Liabilities, Current
Current portion of lease obligation
Current Portion Of Lease Obligation
Current portion of lease obligation.
Current portion of contingent consideration
Business Combination, Contingent Consideration, Liability, Current
Deferred grant revenue
Deferred Revenue, Current
Other current liabilities
Other Liabilities, Current
Total current liabilities
Liabilities, Current
Long-term debt
Lease obligation, net of current portion
Capital Lease Obligations, Noncurrent
Contingent consideration—non-current
Business Combination, Contingent Consideration, Liability, Noncurrent
Deferred tax liability—non-current
Deferred Tax Liabilities, Net, Noncurrent
Income taxes payable
Accrued Income Taxes, Noncurrent
Deferred rent
Deferred Rent Credit, Noncurrent
Other non-current liabilities
Other Liabilities, Noncurrent
Commitments and contingencies (Note 6)
Commitments and Contingencies
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Preferred stock, $.001 par value per share; 5,000 shares authorized; none issued or outstanding at December 31, 2016 and 2015
Preferred Stock, Value, Issued
Common stock, $.001 par value per share; 97,500 shares authorized; 32,897 and 33,323 shares issued and outstanding at December 31, 2016 and 2015, respectively
Common Stock, Value, Issued
Additional paid-in capital
Additional Paid in Capital
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
(Accumulated deficit) retained earnings
Retained Earnings (Accumulated Deficit)
Total stockholders’ equity
Stockholders' Equity Attributable to Parent
Total liabilities and stockholders’ equity
Liabilities and Equity
Fair Value Disclosures [Abstract]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, Hierarchy [Axis]
Fair Value, Hierarchy [Axis]
Fair Value Hierarchy [Domain]
Fair Value Hierarchy [Domain]
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Eligible Item or Group for Fair Value Option [Axis]
Financial Instrument [Axis]
Fair Value, Option, Eligible Item or Group [Domain]
Financial Instruments [Domain]
Cash equivalents [Member]
Cash Equivalents [Member]
Contingent consideration [Member]
Commitments [Member]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets:
Assets, Fair Value Disclosure [Abstract]
Total assets measured at fair value
Assets, Fair Value Disclosure, Recurring
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Total liabilities measured at fair value
Liabilities, Fair Value Disclosure, Recurring
Income Statement [Abstract]
Total revenues
Sales Revenue, Goods, Net
Costs and expenses
Costs and Expenses [Abstract]
Cost of sales (excludes amortization of intangible assets of $6,485, $6,341, and $6,283, respectively)
Cost of Goods Sold
Research and development
Research and Development Expense
Sales and marketing
Selling and Marketing Expense
General and administrative
General and Administrative Expense
Amortization of intangible assets from acquired businesses and technology
Amortization Of Acquired Intangibles
Amortization Of Acquired Intangibles
Impairment loss
Impairment of Intangible Assets, Finite-lived
Total costs and expenses
Costs and Expenses
Operating (loss) income
Operating Income (Loss)
Interest expense, net
Interest Income (Expense), Nonoperating, Net
Loss before benefit for income taxes
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest
Benefit for income taxes
Income Tax Expense (Benefit)
Net loss
Basic and diluted loss per share
Earnings Per Share, Basic and Diluted
Shares used in basic and diluted per share calculation
Weighted Average Number of Shares Outstanding, Basic and Diluted
Income Tax Disclosure [Abstract]
Components of (Benefit) Provision for Income Taxes
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Income before (Benefit) Provision for Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Reconciliation of Income Tax Computed at Federal Statutory Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Summary of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Beginning balance, (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Granted, number of shares (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Cancelled (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Ending balance, (in shares)
Vested and expected to vest, (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Exercisable, (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Available for future grant, (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Rollforward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Beginning balance, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Granted, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Exercised, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Cancelled, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Ending balance, weighted average exercise price per share (in dollars per share)
Vested and expected to vest, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Exercisable, weighted average exercise price per share (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Weighted- average remaining contractual term, outstanding (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted- average remaining contractual term, vested and expected to vest (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted- average remaining contractual term, exercisable (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Aggregate intrinsic value, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate intrinsic value, vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate intrinsic value, available for future grant
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Preferred stock, par value per share
Preferred Stock, Par or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Common stock, par value per share
Common Stock, Par or Stated Value Per Share
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, shares issued
Common Stock, Shares, Issued
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Beginning balance
Unrecognized Tax Benefits
Decreases related to prior year tax positions
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Increases related to current year tax positions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Decreases due to settlements
Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities
Expiration of the statute of limitations for the assessment of taxes
Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations
Other
Unrecognized Tax Benefits, Period Increase (Decrease)
Ending balance
Assets and Liabilities Measured at Fair Value on Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Changes in Estimated Fair Value of Contingent Consideration Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Other Liabilities Disclosure [Abstract]
Customer incentives
Payables to Customers
Accrued interest
Other Accrued Liabilities, Current
Other
Other Sundry Liabilities, Current
Total other current liabilities
Business Combinations [Abstract]
Acquisition
Business Combination Disclosure [Text Block]
Income Tax Examination [Table]
Income Tax Examination [Table]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name [Domain]
Federal research credits [Member]
Research Tax Credit Carryforward [Member]
Gross State Research Credits [Member]
State and Local Jurisdiction [Member]
Federal [Member]
Domestic Tax Authority [Member]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Unrecognized Tax Benefits
Deferred tax benefits
Deferred Tax Assets, Deferred Income
Federal Net Operating Loss carryforwards
Operating Loss Carryforwards
State Net Operating Loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Federal research credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Federal research credits, expiration date
Tax Credit Carryforward, Expiration Date
Federal alternative minimum tax credit
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Gross research credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Investment, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Investment, Amount
Deferred Tax Liabilities, Undistributed Foreign Earnings
Deferred Tax Liabilities, Undistributed Foreign Earnings
Cumulative changes in ownership percentage
Cumulative Change In Ownership Percentage
Cumulative Change In Ownership Percentage
Cumulative changes in ownership period
Cumulative Change In Ownership Period
Cumulative Change In Ownership Period
Realized upon settlement
Percentage Of Likelihood Of Amount Realized Upon Settlement
Percentage of likelihood of amount realized upon settlement.
Unrecognized tax benefits that would impact effective tax rate
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Accrued interest and penalties associated with uncertain tax positions
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Interest expense, net of accrued interest reversed
Unrecognized Tax Benefits, Interest on Income Taxes Expense
Income tax reserves and related interest
Income Tax Reconciliation Tax Reserves And Interest
Income Tax Reconciliation Tax Reserves And Interest
Statement of Cash Flows [Abstract]
OPERATING ACTIVITIES
Net Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash provided by operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation, amortization and other
Depreciation, Depletion and Amortization
Stock-based compensation expense
Share-based Compensation
Impairment loss
Impairment of Intangible Assets (Excluding Goodwill)
Amortization of debt discount and deferred issuance costs
Amortization of Debt Issuance Costs and Discounts
Change in fair value of acquisition contingencies
Change In Fair Value Of Acquisition Contingencies
Change In Fair Value Of Acquisition Contingencies
Change in fair value of acquisition contingencies
Deferred Income Tax Expense (Benefit)
Excess tax benefit from share-based compensation
Excess Tax Benefit from Share-based Compensation, Operating Activities
Excess tax benefit from share-based compensation
Increase (Decrease) in Operating Capital [Abstract]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Inventories
Increase (Decrease) in Inventories
Prepaid expenses and other current and non-current assets
Increase (Decrease) in Prepaid Expenses, Other
Restricted cash
Increase (Decrease) in Restricted Cash
Accounts payable
Increase (Decrease) in Accounts Payable
Accrued payroll and related expenses
Increase (Decrease) in Employee Related Liabilities
Income taxes payable
Increase (Decrease) in Income Taxes Payable
Deferred grant revenue
Increase (Decrease) in Deferred Revenue
Other current and non-current liabilities
Increase (Decrease) in Other Operating Liabilities
Net cash provided by operating activities
Net Cash Provided by (Used in) Operating Activities
INVESTING ACTIVITIES
Net Cash Provided by (Used in) Investing Activities [Abstract]
Acquisitions of property, equipment and intangibles
Payments to Acquire Property, Plant, and Equipment
Acquisition of Immutopics, net of cash acquired
Payments to Acquire Businesses, Net of Cash Acquired
Net cash used for investing activities
Net Cash Provided by (Used in) Investing Activities
FINANCING ACTIVITIES
Net Cash Provided by (Used in) Financing Activities [Abstract]
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Payments of debt issuance costs
Payments of Debt Issuance Costs
Excess tax benefit from share-based compensation
Excess Tax Benefit from Share-based Compensation, Financing Activities
Payments on lease obligation
Payments On Lease Obligation
Payments on lease obligation.
Repurchases of common stock
Payments for Repurchase of Common Stock
Repayments of Convertible Debt
Payments on acquisition contingencies
Payment On Acquisition Contingency
Payment On Acquisition Contingency
Payment for acquisition holdback
Proceeds from (Payments for) Other Financing Activities
Net cash (used for) provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash and Cash Equivalents
Net (decrease) increase in cash and cash equivalents
Cash and Cash Equivalents, Period Increase (Decrease)
Cash and cash equivalents, beginning of period
Cash and cash equivalents, at end of period
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION
Supplemental Cash Flow Information [Abstract]
Cash paid during the period for interest
Interest Paid
Cash paid during the period for income taxes
Income Taxes Paid
NON-CASH INVESTING ACTIVITIES
Noncash Investing Activities [Abstract]
Non Cash Investing Activities [Abstract]
Purchase of property, equipment and intangibles by incurring current liabilities
Noncash or Part Noncash Acquisition, Fixed Assets Acquired
NON-CASH FINANCING ACTIVITIES
Non Cash Financing Activities [Abstract]
Non Cash Financing Activities [Abstract]
Decrease of accrued payroll and related expenses upon issuance of common stock
Stock Issued
Receivable for stock option exercises
Receivable For Stock Option Exercises
Receivable For Stock Option Exercises
Debt issuance costs by incurring current liabilities
Debt Issuance Costs Incurred During Noncash or Partial Noncash Transaction
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Commitments and Contingencies Disclosure [Abstract]
Commitments for Minimum Rentals under Non-cancelable Leases
Commitments For Minimum Rentals Under Noncancelable Leases Table [Text Block]
Commitments for minimum rentals under non-cancelable leases.
Income Taxes
Income Tax Disclosure [Text Block]
Sales to Individual Customers in Excess of 10% of Total Revenue
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
Long-Lived Assets (Excluding Intangible Assets) and Total Net Revenue
Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block]
Consolidated Net Product Revenues by Disease State
Revenue from External Customers by Products and Services [Table Text Block]
Accounting Policies [Abstract]
Company Operations and Summary of Significant Accounting Policies
Basis of Presentation and Significant Accounting Policies [Text Block]
Valuation and Qualifying Accounts [Abstract]
Consolidated Valuation and Qualifying Accounts
Schedule of Valuation and Qualifying Accounts Disclosure [Text Block]
Cost of sales (excludes amortization of intangible assets)
Gross profit
Gross Profit
Total costs and expenses
Net income (loss)
Basic and diluted loss per share
Earnings Per Share, Basic
Diluted net earnings (loss) per share
Earnings Per Share, Diluted
Leases [Abstract]
Sale Leaseback Transaction [Table]
Sale Leaseback Transaction [Table]
Business Acquisition [Axis]
Business Acquisition [Axis]
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree [Domain]
Bio Helix [Member]
Bio Helix [Member]
Bio Helix [Member]
Andiatec Acquisition [Member]
Andiatec Acquisition [Member]
Andiatec Acquisition [Member]
Category of Item Purchased [Axis]
Category of Item Purchased [Axis]
Long-term Purchase Commitment, Category of Item Purchased [Domain]
Long-term Purchase Commitment, Category of Item Purchased [Domain]
Research and Development Arrangement [Member]
Research and Development Arrangement [Member]
Loss Contingency Nature [Axis]
Loss Contingency Nature [Axis]
Loss Contingency, Nature [Domain]
Loss Contingency, Nature [Domain]
Research and Development Collaboration Agreements [Member]
Research And Development Collaboration Agreements [Member]
Research and development collaboration agreements.
Claims and litigation [Member]
Claims And Litigation [Member]
Claims and litigation.
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name [Domain]
Finite-Lived Intangible Assets, Major Class Name [Domain]
Patented technology [Member]
Patented Technology [Member]
License agreements [Member]
Licensing Agreements [Member]
Property Subject to or Available for Operating Lease [Axis]
Property Subject to or Available for Operating Lease [Axis]
Property Subject to or Available for Operating Lease [Domain]
Property Subject to or Available for Operating Lease [Domain]
Property Subject to Operating Lease [Member]
Property Subject to Operating Lease [Member]
San Diego [Member]
San Diego [Member]
San Diego.
Sale Leaseback Transaction [Line Items]
Sale Leaseback Transaction [Line Items]
Payments for Royalties
Payments for Royalties
Change in amount of contingent consideration, liability
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability
Milestone Payments Made Under Agreement
Milestone Payments Made Under Agreement
Milestone payments made under agreement.
Rent expense under operating leases
Operating Leases, Rent Expense
Area under new operating lease
Area of Real Estate Property
Lease term period
Lease Expiration Date
Lease expiration year
Lease Expiration Year
Lease expiration year.
Number of extension
Number Of Extension
Number of extension.
Extend the lease options
Lessor Leasing Arrangements, Operating Leases, Renewal Term
Lease incentives for tenant improvements
Incentive from Lessor
Facility sold
Sale Leaseback Transaction, Gross Proceeds, Financing Activities
Capital contributed
Capital Contributed By Company Sale And Lease Back Transaction
Capital contributed by company sale and lease back transaction.
Cash transaction, netting
Sale Leaseback Transaction, Net Proceeds, Financing Activities
Partnership that acquired the facility
Limited Liability Company (LLC) or Limited Partnership (LP), Managing Member or General Partner, Ownership Interest
Amended terms
Lessor Leasing Arrangements, Operating Leases, Term of Contract
Lease payments
Sale Leaseback Transaction, Monthly Rental Payments
Purchase Commitment, Remaining Minimum Amount Committed
Purchase Commitment, Remaining Minimum Amount Committed
Accrued in other current liabilities
Agreement for payments totaling
Royalty Guarantees, Commitments, Amount
Initial cash payments
Initial Cash Payments
Initial cash payments.
Fixed cash payment
Contract Termination Charges
Contract termination charges.
Contract value Discount
Contract Value Discount
Contract value discount.
Assigned licensed technology
Finite-lived Intangible Assets, Fair Value Disclosure
One-time charge to cost of sales
Fair Value To Cost Of Sales
Fair value to cost of sales.
Amortization expense
Amortization of Intangible Assets
Company had royalty and license expenses relating to those agreements
Royalty And License Expense
Royalty and license expense.
Current commitments
Contractual Obligation
Operating Leases, 2017
Operating Leases, Future Minimum Payments Due, Next Twelve Months
Operating Leases, 2018
Operating Leases, Future Minimum Payments, Due in Two Years
Operating Leases, 2019
Operating Leases, Future Minimum Payments, Due in Three Years
Operating Leases, 2020
Operating Leases, Future Minimum Payments, Due in Four Years
Operating Leases, 2021
Operating Leases, Future Minimum Payments, Due in Five Years
Operating Leases, Thereafter
Operating Leases, Future Minimum Payments, Due Thereafter
Operating Leases, Minimum Payments, Total
Operating Leases, Future Minimum Payments Due
Lease Obligation, 2017
Lease Obligation Future Minimum Payments Due Current
Lease obligation future minimum payments due current.
Lease Obligation, 2018
Leases Obligation Future Minimum Payments Due In Two Years
Leases obligation future minimum payments due in two years.
Lease Obligation, 2019
Leases Obligation Future Minimum Payments Due In Three Years
Leases obligation future minimum payments due in three years.
Lease Obligation, 2020
Leases Obligation Future Minimum Payments Due In Four Years
Leases obligation future minimum payments due in four years.
Lease Obligation, 2021
Leases Obligation Future Minimum Payments Due In Five Years
Leases obligation future minimum payments due in five years.
Lease Obligation, Thereafter
Leases Obligation Future Minimum Payments Due Thereafter
Leases obligation future minimum payments due thereafter.
Lease Obligation, Minimum Payments, Total
Leases Obligation Future Minimum Payments Due
Leases obligation future minimum payments due.
Schedule of Revenues from External Customers and Long-Lived Assets [Table]
Schedule of Revenues from External Customers and Long-Lived Assets [Table]
Foreign [Member]
Foreign Tax Authority [Member]
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-lived assets, Total
Long-Lived Assets
Equity [Abstract]
Stockholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Compensation Related Costs [Abstract]
Pay contributed by employer
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Pay contributed by employee
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Contribution to 401 (K) Plan
Defined Benefit Plan, Contributions by Employer
Industry and Geographic Information
Industry And Geographic Information [Text Block]
Industry and geographic information.
Statement of Stockholders' Equity [Abstract]
Statement [Table]
Statement [Table]
Maximum [Member]
Maximum [Member]
Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional paid-in capital [Member]
Common Stock Including Additional Paid in Capital [Member]
Accumulated other comprehensive income (loss) [Member]
AOCI Attributable to Parent [Member]
Retained earnings [Member]
Retained Earnings [Member]
Statement [Line Items]
Statement [Line Items]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Beginning Balance
Beginning Balance, shares
Shares, Issued
Issuance of common stock under equity compensation plans
Adjustment To Additional Paid In Capital Stock Issued Equity Compensation Plans
Adjustment to additional paid in capital stock issued equity compensation plans.
Issuance of common stock under equity compensation plans, shares
Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures
Issuance of common stock under equity compensation plans
Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt
Tax impact from the issuance of convertible senior notes
Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature
Tax impact from the issuance of convertible senior notes
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Convertible senior notes, equity portion, net of tax and issuance costs
Adjustments to Additional Paid in Capital, Income Tax Benefit from Share-based Compensation
Stock-based compensation expense
Stock Repurchased During Period, Value
Repurchase of Convertible Senior Notes
Repurchase of common stock, shares
Stock Repurchased During Period, Shares
Repurchases of common stock
Ending Balance
Ending Balance, shares
Compensation Expense Related to Stock-Based Compensation Plans
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Estimated Fair Value of Each Stock Option Award
Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Summary of Status of Stock Option Activity
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Summary of Status of Stock Awards Activity
Schedule of Nonvested Share Activity [Table Text Block]
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Intangible assets
Deferred Tax Assets, Goodwill and Intangible Assets
Sale-leaseback, net
Deferred Tax Assets, Deferred Gain on Sale Leaseback Transaction
Allowance for returns and discounts
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Returns and Allowances
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Other, net
Deferred Tax Assets, Other
Total deferred tax assets
Deferred Tax Assets, Gross
Valuation allowance for deferred tax assets
Total deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax liabilities:
Components of Deferred Tax Liabilities [Abstract]
Convertible Senior Notes
Deferred Tax Liabilities, Convertible Senior Notes
Deferred Tax Liabilities, Convertible Senior Notes
Intangible assets
Deferred Tax Liabilities, Intangible Assets
Property, plant and equipment
Deferred Tax Liabilities, Property, Plant and Equipment
Deferred Tax Liabilities, Gross
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Liabilities, Net
Amortization of intangible assets
Cost of Goods Sold, Amortization
Goodwill And Intangible Assets [Table]
Goodwill And Intangible Assets [Table]
Goodwill And Intangible Assets [Table]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Software and Software Development Costs [Member]
Software and Software Development Costs [Member]
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Cost of sales [Member]
Cost of Sales [Member]
Purchased technology [Member]
Purchased Technology [Member]
Purchased Technology [Member]
Customer relationships [Member]
Customer Relationships [Member]
Patent and trademark costs [Member]
Patents And Trademarks [Member]
Patents and trademarks.
Software development costs [Member]
Computer Software, Intangible Asset [Member]
Indefinite-lived Intangible Assets [Axis]
Indefinite-lived Intangible Assets [Axis]
Indefinite-lived Intangible Assets, Major Class Name [Domain]
Indefinite-lived Intangible Assets, Major Class Name [Domain]
In Process Research and Development [Member]
In Process Research and Development [Member]
Goodwill And Intangible Assets [Line Items]
Goodwill And Intangible Assets [Line Items]
Goodwill And Intangible Assets [Line Items]
Goodwill Gross
Goodwill, Gross
Accumulated Amortization on Goodwill
Goodwill, Impaired, Accumulated Impairment Loss
Goodwill Net
Finite-Lived intangible asset, useful life
Finite-Lived Intangible Asset, Useful Life
Gross Assets
Finite-Lived Intangible Assets, Gross
Accumulated Amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Gross intangible asset including Goodwill
Intangible Assets Including Goodwill Gross
Intangible Assets Including Goodwill Gross
Net intangible asset including Goodwill
Intangible Assets, Net (Including Goodwill)
Document And Entity Information [Abstract]
Document and Entity Information [Abstract]
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Document Type
Document Type
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Amendment Flag
Amendment Flag
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Current Reporting Status
Entity Current Reporting Status
Entity Public Float
Entity Public Float
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Goodwill and Intangible Assets Disclosure [Abstract]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Other Intangible Assets [Member]
Other Intangible Assets [Member]
Project Stella [Member]
Project Stella [Member]
Project Stella [Member]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Loss on contract termination
Loss on Contract Termination
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Research and development [Member]
Research and Development Expense [Member]
Sales and marketing [Member]
Selling and Marketing Expense [Member]
General and administrative [Member]
General and Administrative Expense [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Stock-based compensation expense
Allocated Share-based Compensation Expense
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Segments [Axis]
Segments [Axis]
Segments [Domain]
Segments [Domain]
Infectious Disease [Member]
Immunoassays [Member]
Immunoassays
Women's Health [Member]
Molecular [Member]
Molecular
Gastrointestinal Disease [Member]
Virology [Member]
Virology
Royalty, License Fees and Grant Revenue [Member]
Specialty products [Member]
Specialty products
Other Disease [Member]
Royalties, grants and other [Member]
Royalties, grants and other
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
Revenues
Revenues
Amortization of intangible assets included in gross profit
Amortization Of Intangible Asset Included In Gross Profit
Amortization of intangible assets included in gross profit.
Debt
Debt Disclosure [Text Block]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Share Repurchase Program [Axis]
Share Repurchase Program [Axis]
Share Repurchase Program [Domain]
Share Repurchase Program [Domain]
Share Repurchase Program, Amendment [Member]
Share Repurchase Program, Amendment [Member]
Share Repurchase Program, Amendment [Member]
Title of Individual [Axis]
Title of Individual [Axis]
Relationship to Entity [Domain]
Relationship to Entity [Domain]
Non-employee director [Member]
Non Employee Director [Member]
Non employee director.
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
Employee Deferred Bonus Compensation Program [Member]
Employee Deferred Bonus Compensation Program [Member]
Employee deferred bonus compensation program.
2010 Plan [Member]
Two Thousand Ten Plan [Member]
Two thousand ten plan.
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Restricted stock [Member]
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Deferred Bonus Liability
Deferred Bonus Liability
Deferred bonus liability.
Restricted stock granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Performance-based vesting period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Additional stock-based compensation expense
Additional Stock Based Compensation Expense
Additional Stock Based Compensation Expense
Share-based compensation expense recognized
Exercise price of stock (in dollars per share)
Percentage of deferred 2011 cash bonus
Percentage Of Cash Value Of Cash Bonus Officers Could Elect To Receive In Form Of Restricted Stock
Percentage of cash value of cash bonus officers could elect to receive in form of restricted stock.
Deferred period of grants (Condition 1)
Length Of Time Of Deferral Period Under Condition One
Length of time of deferral period under condition one.
Percentage of premium on amount deferred (Condition 1)
Percentage Of Premium On Amount Deferred Based On Length Of Time For One Year Under Condition One
Percentage of premium on amount deferred based on length of time for one year under condition one.
Deferred period of grants (Condition 2)
Length Of Time Of Deferral Period Under Condition Two
Length of time of deferral period under condition two.
Percentage of premium on amount deferred (Condition 2)
Percentage Of Premium On Amount Deferred Based On Length Of Time For One Year Under Condition Two
Percentage of premium on amount deferred based on length of time for one year under condition two
Deferred period of grants (Condition 3)
Length Of Time Of Deferral Period Under Condition Three
Length of time of deferral period under condition three.
Percentage of premium on amount deferred (Condition 3)
Percentage Of Premium On Amount Deferred Based On Length Of Time For One Year Under Condition Three
Percentage of premium on amount deferred based on length of time for one year under condition three
Minimum percentage of common stock under payroll deductions
Percentage Of Employee Compensation For Purchase Of Common Stock Under Espp
Percentage of employee compensation for purchase of common stock under ESPP.
Fair value of payroll deductions
Share-based Compensation Arrangement by Share-based Payment Award, Discount from Market Price, Purchase Date
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Period
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Period
hare-based Compensation Arrangement by Share-based Payment Award, Purchase Period
Stock sold under the plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Capital shares reserved for future issuance (In shares)
Preferred Stock, Capital Shares Reserved for Future Issuance
Payments for repurchase of common stock
Repurchase of available shares under share repurchase program (in shares)
Stock Repurchase Program, Remaining Number of Shares Authorized to be Repurchased
Stock-based compensation expense
Stock Repurchase Program, Remaining Authorized Repurchase Amount
Stock Repurchase Program, Remaining Authorized Repurchase Amount
Exercise of stock options
Common stock reserve under equity incentive plans (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for purchase under ESPP (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Beginning Balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Granted (in shares)
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Ending Balance (in shares)
Beginning Balance, Weighted Average Grant Date Fair Value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Granted, Weighted Average Grant Date Fair Value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Vested, Weighted Average Grant Date Fair Value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Forfeited, Weighted Average Grant Date Fair Value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Ending Balance, Weighted Average Grant Date Fair Value (in dollars per share)
Schedule of Long-term Debt Instruments
Schedule of Long-term Debt Instruments [Table Text Block]
Schedule of Acquired Finite-Lived Intangible Asset by Major Class [Table]
Schedule of Acquired Finite-Lived Intangible Asset by Major Class [Table]
Adjustments for New Accounting Pronouncements [Axis]
Adjustments for New Accounting Pronouncements [Axis]
Type of Adoption [Domain]
Type of Adoption [Domain]
Capitalized Software Costs [Member]
Capitalized Software Cost [Member]
Capitalized Software Cost [Member]
Other Noncurrent Liabilities [Member]
Other Noncurrent Liabilities [Member]
Acquired Finite-Lived Intangible Assets [Line Items]
Acquired Finite-Lived Intangible Assets [Line Items]
Number of business segment
Number of Operating Segments
Cash and cash equivalents maximum maturity period
Cash And Cash Equivalents Maximum Maturity Period
Cash and cash equivalents maximum maturity period.
Product shipment costs
Shipping, Handling and Transportation Costs
Account receivable, reserves
Allowance for Doubtful Accounts Receivable, Current
Advertising cost expensed
Advertising Expense
Revenue recognition milestone method payment received
Revenue Recognition Milestone Method Payment Received
Revenue Recognition Milestone Method Payment Received
Maximum amount of milestone based grant related to research and commercialization activities
Maximum Amount Of Milestone Based Grant Related To Research And Commercialization Activities
Maximum amount of milestone based grant related to research and commercialization activities.
Net of reserves, inventories
Inventory Adjustments
Estimated useful lives of the assets
Property, Plant and Equipment, Useful Life
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Fund received for research and development activities
Amount Of Fund Received For Subsequent Research And Commercialization Activities
Amount of fund received for subsequent research and commercialization activities.
Company's grant revenue
Revenue from Grants
Prior period reclassification adjustment
Prior Period Reclassification Adjustment
Property, Plant and Equipment [Abstract]
Equipment, furniture and fixtures [Member]
Equipment [Member]
Building and building improvements [Member]
Building and Building Improvements [Member]
Instruments available for lease [Member]
Instruments Available For Lease [Member]
Instruments available for lease.
Land [Member]
Land [Member]
Property, plant and equipment, gross
Property, Plant and Equipment, Gross
Less: accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Total property, plant and equipment, net
Impairment Loss
Asset Impairment Charges [Text Block]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance
Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value
Cash payments
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Net gain recorded for fair value adjustments
Unrealized gain on foreign currency translation
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Other Comprehensive Income (Loss)
Balance
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Valuation and Qualifying Accounts Disclosure [Table]
Valuation and Qualifying Accounts Disclosure [Table]
Valuation Allowances and Reserves Type [Axis]
Valuation Allowances and Reserves Type [Axis]
Valuation Allowances and Reserves [Domain]
Valuation Allowances and Reserves [Domain]
Allowance for Doubtful Accounts [Member]
Allowance for Doubtful Accounts [Member]
Valuation and Qualifying Accounts Disclosure [Line Items]
Valuation and Qualifying Accounts Disclosure [Line Items]
Movement in Valuation Allowances and Reserves [Roll Forward]
Movement in Valuation Allowances and Reserves [Roll Forward]
Beginning Balance
Valuation Allowances and Reserves, Balance
Additions charged to expense or as reductions to revenue
Valuation Allowances and Reserves, Additions for Charges to Cost and Expense
Deductions
Valuation Allowances and Reserves, Deductions
Ending Balance
Compensation and Retirement Disclosure [Abstract]
Employee Benefit Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Customer [Axis]
Customer [Axis]
Customer [Domain]
Customer [Domain]
Customer A [Member]
Customer One [Member]
Customer one.
Customer B [Member]
Customer Two [Member]
Customer two.
Customer C [Member]
Customer C [Member]
Customer C [Member]
Sales percentage
Consolidation
Consolidation, Policy [Policy Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Accounts Receivable
Trade and Other Accounts Receivable, Policy [Policy Text Block]
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Inventories
Inventory, Policy [Policy Text Block]
Property, Plant and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Intangible Assets
Goodwill and Intangible Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Convertible Debt
Debt, Policy [Policy Text Block]
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Product Shipment Costs
Shipping and Handling Cost, Policy [Policy Text Block]
Advertising Costs
Advertising Costs, Policy [Policy Text Block]
Deferred Rent
Deferred Rent Policy [Text Block]
Deferred rent.
Income Taxes
Income Tax, Policy [Policy Text Block]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Product Warranty
Standard Product Warranty, Policy [Policy Text Block]
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Earnings Per Share
Earnings Per Share, Policy [Policy Text Block]
Comprehensive (Loss) Income
Comprehensive Income, Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Accounting Periods
Accounting Period Policy [Text Block]
Accounting period.
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Fair Value Measurements and Disclosures
Fair Value Measurement, Policy [Policy Text Block]
Line of Credit Facility [Table]
Line of Credit Facility [Table]
Credit Facility [Axis]
Credit Facility [Axis]
Credit Facility [Domain]
Credit Facility [Domain]
Senior Credit Facility [Member]
Senior Credit Facility [Member]
Senior credit facility.
Line of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Senior Credit Facility
Line of Credit Facility, Maximum Borrowing Capacity
Write off of Deferred Debt Issuance Cost
Write off of Deferred Debt Issuance Cost
Senior Credit Facility, maturity date
Line of Credit Facility, Expiration Date
Senior Credit Facility, applicable margin
Fair Value Measurement
Fair Value Disclosures [Text Block]
Cash consideration
Payments to Acquire Businesses, Gross
Other payments to acquire businesses
Other Payments to Acquire Businesses
Summary of Inventories
Schedule of Inventory, Current [Table Text Block]
Property, Plant and Equipment
Property, Plant and Equipment [Table Text Block]
Summary of Intangible Assets
Schedule of Intangible Assets and Goodwill [Table Text Block]
Summary of Expected Future Annual Amortization Expense
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Schedule of Other Current Liabilities
Other Current Liabilities [Table Text Block]
Inventory Disclosure [Abstract]
Raw materials
Inventory, Raw Materials, Net of Reserves
Work-in-process (materials, labor and overhead)
Inventory, Work in Process, Net of Reserves
Finished goods (materials, labor and overhead)
Inventory, Finished Goods, Net of Reserves
Total inventories
United States
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Quarterly Financial Data
Quarterly Financial Information [Table Text Block]
Current:
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Federal
Current Federal Tax Expense (Benefit)
State
Current State and Local Tax Expense (Benefit)
Foreign
Current Foreign Tax Expense (Benefit)
Total current provision (benefit)
Current Income Tax Expense (Benefit)
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Federal
Deferred Federal Income Tax Expense (Benefit)
State
Deferred State and Local Income Tax Expense (Benefit)
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Total deferred benefit
Deferred Other Tax Expense (Benefit)
Benefit for income taxes
Tax benefit at statutory tax rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
State tax benefit, net of federal tax benefit
State and Local Income Tax Expense (Benefit), Continuing Operations
Permanent differences
Income Tax Reconciliation Permanent Difference
Income tax reconciliation permanent difference.
Federal and state research credits—current year
Federal research credits - prior year
Accrual (release) of uncertain tax positions
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount
Expiration of statutes for uncertain tax positions
Effective Income Tax Rate Reconciliation, Tax Contingency, Other, Amount
Impact of change in federal and state tax rate on revaluing deferred tax assets
Income Tax Reconciliation Impact Of Change In Federal And State Tax Rate On Revaluing Deferred Tax Assets
Income tax reconciliation impact of change in federal and state tax rate on revaluing deferred tax assets.
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Acquisition related adjustments
Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Amount
Other
Other Income Tax Expense (Benefit), Continuing Operations
Stock options [Member]
Employee Stock Option [Member]
Deferred bonus compensation program [Member]
Recorded as a component of accrued payroll and related expenses
Stock Based Compensation Expenses Included In Accrued Payroll And Related Expenses
Stock based compensation expenses included in accrued payroll and related expenses.
Weighted-average grant date fair value of stock options granted (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Total intrinsic value for options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Total unrecognized compensation expense related to non-vested stock options
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Expected weighted-average period of recognition for unrecognized compensation expense
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Maximum contractual term
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Remaining Contractual Term Two Maximum
Share based compensation arrangement by share based payment award options outstanding weighted average remaining contractual term two maximum.
Number of restricted share units issued (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Total unrecognized compensation expense related to non-vested stock awards
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Expected option life (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Volatility rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Dividend rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table]
Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table]
Fair Value, Inputs, Level 3 [Member]
Business Acquisition, Contingent Consideration [Line Items]
Business Acquisition, Contingent Consideration [Line Items]
Contingent consideration
Business Combination, Contingent Consideration, Liability
Current portion of contingent consideration
Contingent consideration non-current portion