Consolidated Statements of Cash Flows - USD ($)	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
OPERATING ACTIVITIES:
Net loss	$ (11,286,000)	$ (4,940,000)
Adjustments to reconcile net loss to net cash (used for) provided by operating activities:
Depreciation, amortization and other	12,410,000	11,820,000
Stock-based compensation expense	4,086,000	3,994,000
Amortization of debt discount and deferred issuance costs	2,854,000	2,810,000
Change in deferred tax assets and liabilities	(7,218,000)	(2,431,000)
Change in fair value of acquisition contingencies	0	0
Gain on extinguishment of Convertible Senior Notes	(421,000)
Changes in assets and liabilities:
Accounts receivable	2,494,000	18,766,000
Inventories	3,818,000	1,072,000
Income taxes receivable	63,000	(398,000)
Prepaid expenses and other current and non-current assets	(915,000)	(365,000)
Restricted cash	63,000	(1,734,000)
Accounts payable	(1,942,000)	(3,727,000)
Accrued payroll and related expenses	(1,526,000)	(631,000)
Income taxes payable	(2,000)	(211,000)
Deferred grant revenue	(2,697,000)	(36,000)
Other current and non-current liabilities	(2,237,000)	(727,000)
Net cash (used for) provided by operating activities:	(2,456,000)	23,262,000
INVESTING ACTIVITIES:
Acquisitions of property, equipment and intangibles	(5,424,000)	(7,348,000)
Acquisition of Immutopics, net of cash acquired	(5,094,000)	0
Net cash used for investing activities:	(10,518,000)	(7,348,000)
FINANCING ACTIVITIES:
Payments on lease obligation	(285,000)	(246,000)
Repurchases of common stock	(20,079,000)	(12,133,000)
Repurchases of Convertible Senior Notes	(4,459,000)	0
Proceeds from issuance of common stock	2,098,000	820,000
Payments of debt issuance costs	0	(365,000)
Payments on acquisition contingencies	(195,000)	(129,000)
Net cash used for financing activities:	(22,920,000)	(12,053,000)
Effect of exchange rates on cash	(10,000)	(21,000)
Net (decrease) increase in cash and cash equivalents	(35,904,000)	3,840,000
Cash and cash equivalents, beginning of period	191,471,000	200,895,000
Cash and cash equivalents, end of period	155,567,000	204,735,000
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:
Cash paid for interest	3,243,000	3,458,000
Cash paid for income taxes	409,000	638,000
NON-CASH INVESTING ACTIVITIES:
Purchase of property, equipment, and intangibles by incurring current liabilities	953,000	1,122,000
NON-CASH FINANCING ACTIVITIES:
Reduction of other current liabilities upon issuance of restricted share units	539,000	408,000
Increase of other current liabilities for purchase of common stock		$ 2,660,000
Senior 3 Point 25 Percent Convertible Notes Due 2020 [Member] | Convertible Debt [Member]
FINANCING ACTIVITIES:
Repurchases of Convertible Senior Notes	$ (4,500,000)