Commitments and Contingencies - Additional Information (Detail) $ in Thousands	3 Months Ended		9 Months Ended	12 Months Ended
	Dec. 31, 2013 USD ($) ft²	Sep. 30, 2011 USD ($)	Sep. 30, 2011 USD ($)	Dec. 31, 2015 USD ($) Lease	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($) ft²	Apr. 01, 2011 USD ($)
Sale Leaseback Transaction [Line Items]
Reimbursement Related To Research And Development Expense				$ 0	$ 400	$ 1,400
Rent expense under operating leases	$ 2,300			$ 2,300	3,300
Lease expiration year				2022
Number of extension | Lease				2
Extend the lease options				5 years
Lease incentives for tenant improvements				$ 1,700
Facility sold				15,000
Capital contributed				3,800
Cash transaction, netting				$ 7,000
Partnership that acquired the facility				25.00%
Lease payments	$ 1,100			$ 1,100	1,100
Purchase commitments				4,000
Accrued in other current liabilities				6,999	8,043
Agreement for payments totaling							$ 29,500
Initial cash payments		$ 13,800
Fixed cash payment		$ 15,700
Contract value Discount			$ 1,000
One-time charge to cost of sales				700
Amortization expense				10,200	17,400	16,600
Company had royalty and license expenses relating to those agreements				$ 500	900	$ 1,000
San Diego [Member]
Sale Leaseback Transaction [Line Items]
Lease term period				Dec. 01, 2019
Number of extension | Lease				3
Extend the lease options				5 years
Amended terms				10 years
Property Subject to Operating Lease [Member]
Sale Leaseback Transaction [Line Items]
Area under new operating lease | ft²	30,000					30,000
Patented technology [Member]
Sale Leaseback Transaction [Line Items]
Assigned licensed technology				$ 28,800
License agreements [Member]
Sale Leaseback Transaction [Line Items]
Amortization expense	$ 8,000			700	8,000
Research and Development Collaboration Agreements [Member]
Sale Leaseback Transaction [Line Items]
Current commitments				4,200
Claims and litigation [Member]
Sale Leaseback Transaction [Line Items]
Accrued in other current liabilities				200	300
Research and Development Arrangement [Member]
Sale Leaseback Transaction [Line Items]
Milestone Payments Made Under Agreement				1,700	900
Bio Helix [Member]
Sale Leaseback Transaction [Line Items]
Payments for Royalties				100	49
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability				0	$ 800
Andiatec Acquisition [Member]
Sale Leaseback Transaction [Line Items]
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability				$ 67