Gross-to-Net (Details 1) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Accounts, Notes, Loans and Financing Receivable [Line Items]
Gross Company product sales	$ 215,883	$ 217,633	$ 99,721
Reduction to gross product sales:
Chargebacks and billbacks	125,159	141,343	50,127
Sales discounts and other allowances	32,720	27,419	17,974
Total reduction to gross product sales	157,879	168,762	68,101
Company product sales, net	66,999	65,904	43,497
Company Product
Reduction to gross product sales:
Company product sales, net	58,004	48,871	31,620
Contract Manufacturing Product
Reduction to gross product sales:
Company product sales, net	$ 8,995	$ 17,033	$ 11,877