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Gross-to-Net (Tables)
 12 Months Ended
Dec. 31, 2017
Revenue Recognition [Abstract]  
Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block]
The Company's gross-to-net adjustments for the three years ended December 31, 2017, 2016 and 2015 are as follows (in thousands):
 
 
Years ended December 31,
 
 
2017
 
2016
 
2015
Gross product sales
 
$
215,883

 
$
217,633

 
$
99,721

 
 
 
 
 
 
 
Reduction to gross product sales:
 
 

 
 

 
 
Chargebacks and billbacks
 
125,159

 
141,343

 
50,127

Sales discounts and other allowances
 
32,720

 
27,419

 
17,974

Total reduction to gross product sales
 
$
157,879

 
$
168,762

 
$
68,101

 
 
 
 
 
 
 
Product sales, net
 
$
58,004

 
$
48,871

 
$
31,620

 
 
 
 
 
 
 
Contract manufacturing product sales
 
$
8,995

 
$
17,033

 
$
11,877

 
 
 
 
 
 
 
Total product sales, net
 
$
66,999

 
$
65,904

 
$
43,497
Schedule Of Annual Activity Allowance For Customer Deductions Disclosure [Table Text Block]
The annual activity in the Company's allowance for customer deductions and doubtful accounts for the three years ended December 31, 2017, 2016 and 2015 is as follows (in thousands):

 
 
Returns
 
Chargebacks & Rebates
 
Discounts
 
Doubtful Accounts
 
TOTAL
Balance at December 31, 2014
 
$
674

 
$
4,552

 
$
345

 
$
16

 
$
5,587

Provision
 
1,724

 
65,713

 
2,201

 
74

 
69,712

Charges processed
 
(1,464
)
 
(57,815
)
 
(1,754
)
 
—

 
(61,033
)
Balance at December 31, 2015
 
$
934

 
$
12,450

 
$
792

 
$
90

 
$
14,266

Provision
 
3,568

 
160,556

 
4,667

 
347

 
169,138

Charges processed
 
(2,192
)
 
(137,125
)
 
(2,156
)
 
(20
)
 
(141,493
)
Balance at December 31, 2016
 
$
2,310

 
$
35,881

 
$
3,303

 
$
417

 
$
41,911

Provision
 
6,034

 
148,000

 
4,398

 
1,768

 
160,200

Charges processed
 
(7,023
)
 
(159,809
)
 
(6,737
)
 
—

 
(173,569
)
Balance at December 31, 2017
 
$
1,321

 
$
24,072

 
$
964

 
$
2,185

 
$
28,542