Note 5 - Property, Plant and Equipment

12 Months Ended

Dec. 31, 2011

Property, Plant and Equipment Disclosure [Text Block]

5. Property, Plant and Equipment

Property, plant and equipment consisted of the following at December 31, 2011 and 2010:

	2011			2010			Estimated Useful Lives (years)
Building and improvements	$	--		$	1,497,425		25
Leasehold improvements		10,470,946			10,470,946		Lesser of lease term or useful life
Manufacturing equipment		6,386,070			5,759,643		10
Laboratory equipment		3,618,143			3,603,600		5
Other equipment		48,618			724,580		10
Office equipment and furniture		1,417,906			1,395,019		5
Equipment formerly under capital leases		1,093,424			1,093,424		Lesser of lease term or useful life
		23,035,107			24,544,637
Less accumulated depreciation and amortization		(20,058,049	)		(21,475,687	)
		2,977,058			3,068,950
Land		--			121,167
Property, plant and equipment, net	$	2,977,058		$	3,190,117

Depreciation and amortization expense on property, plant and equipment was approximately $611,000, $637,000, and $641,000 in 2011, 2010, and 2009, respectively. Our fully depreciated assets included above at December 31, 2011 and December 31, 2010, respectively, were approximately $17,000,000 and $19,000,000.