-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 GkgOpemBGPWrYOusuF1lRA==

<SEC-DOCUMENT>0000352747-10-000003.txt : 20100329
<SEC-HEADER>0000352747-10-000003.hdr.sgml : 20100329
<ACCEPTANCE-DATETIME>20100329150729
ACCESSION NUMBER:		0000352747-10-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100329
DATE AS OF CHANGE:		20100329
EFFECTIVENESS DATE:		20100329

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			UNIGENE LABORATORIES INC
		CENTRAL INDEX KEY:			0000352747
		STANDARD INDUSTRIAL CLASSIFICATION:	MEDICINAL CHEMICALS & BOTANICAL PRODUCTS [2833]
		IRS NUMBER:				222328609
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-35274-7N
		FILM NUMBER:		10710464

	BUSINESS ADDRESS:	
		STREET 1:		81 FULTON STREET
		CITY:			BOONTON
		STATE:			NJ
		ZIP:			07005
		BUSINESS PHONE:		973-265-1100

	MAIL ADDRESS:	
		STREET 1:		81 FULTON STREET
		CITY:			BOONTON
		STATE:			NJ
		ZIP:			07005
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <submissionType>D</submissionType>

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        <cik>0000352747</cik>
        <entityName>UNIGENE LABORATORIES INC</entityName>
        <issuerAddress>
            <street1>81 FULTON STREET</street1>
            <city>BOONTON</city>
            <stateOrCountry>NJ</stateOrCountry>
            <zipCode>07005</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>973-265-1100</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
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        <edgarPreviousNameList>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Zvi</firstName>
                <lastName>Eiref</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marvin</firstName>
                <lastName>Miller</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bruce</firstName>
                <lastName>Morra</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Slusser</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ronald</firstName>
                <middleName>S.</middleName>
                <lastName>Levy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <lastName>Levy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chairman of the Board.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J.</firstName>
                <middleName>Thomas</middleName>
                <lastName>August</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Allen</firstName>
                <lastName>Bloom</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>P.</middleName>
                <lastName>Gilligan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nozer</firstName>
                <middleName>M.</middleName>
                <lastName>Mehta</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <middleName>P.</middleName>
                <lastName>Shields</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Steinhauer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>81 Fulton Street</street1>
                <city>Boonton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07005</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$5,000,001 - $25,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-17</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Issuance of senior secured convertible notes convertible into shares of Unigene's common stock, under certain circumstances. Full conversion is subject to Unigene amending its charter to increase the number of shares which Unigene is authorized to issue.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>RBC Capital Markets Corporation</recipientName>
                <recipientCRDNumber>31194</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Three World Financial Center</street1>
                    <street2>200 Vesey Street</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10281-8098</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>IL</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>36000000</totalOfferingAmount>
            <totalAmountSold>33000000</totalAmountSold>
            <totalRemaining>3000000</totalRemaining>
            <clarificationOfResponse>Consideration for issuance of the senior secured convertible notes on March 17, 2010 consisted of surrender of existing senior secured non-convertible term notes in the principal amount of $19,357,528 and the balance in cash.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>464274</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Sales commissions includes $55,000 of out-of-pocket and legal expenses.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>UNIGENE LABORATORIES INC</issuerName>
                <signatureName>/s/ Warren P. Levy</signatureName>
                <nameOfSigner>Warren P. Levy</nameOfSigner>
                <signatureTitle>President and Chief Executive Officer</signatureTitle>
                <signatureDate>2010-03-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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