<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0304</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-11-07</periodOfReport>

    <issuer>
        <issuerCik>0000350698</issuerCik>
        <issuerName>AUTONATION, INC.</issuerName>
        <issuerTradingSymbol>AN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001166559</rptOwnerCik>
            <rptOwnerName>BILL &amp; MELINDA GATES FOUNDATION TRUST</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>500 FIFTH AVENUE N</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SEATTLE</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98119</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>1</isOther>
            <otherText>(See Footnote 2)</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2011-11-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>250000.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>36.0241</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9013691.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This transaction was executed in multiple trades at prices ranging from $35.85 to $36.62.  The price reported above reflects the weighted-average sale price.  The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.</footnote>
        <footnote id="F2">For purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended (the &quot;Act&quot;), the reporting person may be deemed to be a member of a &quot;group&quot; that beneficially owns more than 10% of the common stock of the issuer.  Neither the filing of this Form 4 nor any of its contents shall be deemed an admission that the reporting person and any other person or persons constitute a &quot;group&quot; under Section 13(d) or is otherwise subject to Section 16 of the Act, and the reporting person expressly disclaims membership in a group.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Bill &amp; Melinda Gates Foundation Trust By: /s/ Alan Heuberger, Attorney-in-fact for each of the Co-Trustees, William H. Gates III and Melinda French Gates</signatureName>
        <signatureDate>2011-11-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
