X0508 4 2025-11-17 0 0000034956 TENAX THERAPEUTICS, INC. TENX 0001492647 Almenoff June Sherie 101 GLEN LENNOX DRIVE SUITE 300 CHAPEL HILL NC 27517 1 0 0 0 0 Common Stock 2025-11-17 4 P 0 93 7.15 A 93 D Common Stock 2025-11-18 4 P 0 1900 7.5157 A 1993 D Stock Option (right to buy) 3200 2022-06-10 2031-06-10 Common Stock 4 4 D Stock Option (right to buy) 992 2023-06-09 2032-06-09 Common Stock 4 4 D Stock Option (right to buy) 5.94 2025-12-10 2034-12-10 Common Stock 100000 100000 D Stock Option (right to buy) 5.75 2026-07-01 2035-07-01 Common Stock 80000 80000 D This transaction was executed in multiple trades at prices ranging from $7.45 to $7.70. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected. /s/ S. Halle Vakani, as Attorney-in-Fact 2025-11-19