X0202 SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value per share 03/31/2026 0000034956 Tenax Therapeutics, Inc. 88032L605 101 Glen Lennox Drive Suite 300 Chapel Hill NC 27517 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 1447782 0 1447782 1447782 N 5.5 IA Joseph Edelman b X1 0 1447782 0 1447782 1447782 N 5.5 IN Perceptive Life Sciences Master Fund, Ltd. b E9 0 1447782 0 1447782 1447782 N 5.5 CO Tenax Therapeutics, Inc. 101 Glen Lennox Drive, Suite 300, Chapel Hill, NC 27517 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, $0.0001 par value per share (the "Common Stock") of Tenax Therapeutics, Inc. (the "Issuer") are: Perceptive Advisors LLC ("Perceptive Advisors") Joseph Edelman ("Mr. Edelman") Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor New York, NY 10003 Perceptive Advisors is a Delaware limited liability company Mr. Edelman is a United States citizen The Master Fund is a Cayman Islands corporation Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 26,525,159 outstanding shares of Common Stock as of May 8, 2026, as reported in the the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 12, 2026. The Master Fund directly holds 1,447,782 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own the securities directly held by the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own the securities directly held by the Master Fund. Perceptive Advisors: 5.5% Mr. Edelman: 5.5% Master Fund: 5.5% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,447,782 Mr. Edelman: 1,447,782 Master Fund: 1,447,782 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,447,782 Mr. Edelman: 1,447,782 Master Fund: 1,447,782 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2026 Joseph Edelman /s/ Joseph Edelman 05/15/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/15/2026