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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Q3FzY/atsq9EGGYQTskbVxumHCp51/hCObu8GlySdRU91AyyO1bmbmYHE39q7fAQ
 oRjbrmT6lkB+Vf83KZuHYA==

<SEC-DOCUMENT>0001020488-10-000006.txt : 20100122
<SEC-HEADER>0001020488-10-000006.hdr.sgml : 20100122
<ACCEPTANCE-DATETIME>20100122120737
ACCESSION NUMBER:		0001020488-10-000006
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100115
FILED AS OF DATE:		20100122
DATE AS OF CHANGE:		20100122

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Eckert Rene
		CENTRAL INDEX KEY:			0001481587

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34600
		FILM NUMBER:		10540833

	MAIL ADDRESS:	
		STREET 1:		7001 BLACKSMITH COURT
		CITY:			SUMMERFIELD
		STATE:			NC
		ZIP:			27358

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXYGEN BIOTHERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0000034956
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				262593535
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1109

	BUSINESS ADDRESS:	
		STREET 1:		2530 MERIDIAN PARKWAY
		STREET 2:		SUITE 3084
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27713
		BUSINESS PHONE:		919-806-4414

	MAIL ADDRESS:	
		STREET 1:		2530 MERIDIAN PARKWAY
		STREET 2:		SUITE 3084
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27713

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNTHETIC BLOOD INTERNATIONAL INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SINEQUANON CORP
		DATE OF NAME CHANGE:	19901219

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED FRANCHISES INC
		DATE OF NAME CHANGE:	19760907
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-01-15</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000034956</issuerCik>
        <issuerName>OXYGEN BIOTHERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>OXBT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001481587</rptOwnerCik>
            <rptOwnerName>Eckert Rene</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7001 BLACKSMITH COURT</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SUMMERFIELD</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27358</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non-statutory Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>7.05</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2009-10-20</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-10-19</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>40000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <ownerSignature>
        <signatureName>/s/ Rene A. Eckert</signatureName>
        <signatureDate>2010-01-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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