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        <title>NOVO-NORDISK AS CL B ADR</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
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          <other otherDesc="Internal" value="JAB709000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MERCK KGAA</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BRISTOL-MYERS SQUIBB CO</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
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          <isin value="US45826J1051"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
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          <other otherDesc="Internal" value="FEC032000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
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          <other otherDesc="Internal" value="JMF122000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>DISC MEDICINE INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
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        <invCountry>IE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MERCK and CO INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARVINAS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>LEAP THERAPEUTICS INC</name>
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        <title>LEAP THERAPEUTICS INC WT</title>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
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        <name>ROYALTY PHARMA PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>GENERATION BIO CO</name>
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        <title>GENERATION BIO</title>
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        <name>EDGEWISE THERAPEUTICS INC</name>
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        <name>AGOMAB THERAPEUTICS SA</name>
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        <title>AGOMAB THERAPEUTICS SA ANTI-DILUTION WT PP 11/04/2034</title>
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        <name>AGOMAB THERAPEUTICS SA</name>
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        <name>AVIDITY BIOSCIENCES INC</name>
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        <title>AVIDITY BIOSCIENCES</title>
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        <name>BIONTECH SE</name>
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        <title>BIONTECH SE ADR</title>
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        <name>CATALENT INC</name>
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        <title>CATALENT INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC SER B PC PP</title>
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        <fairValLevel>3</fairValLevel>
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      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
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        <balance>303500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13068710.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASTRAZENECA PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC SPONS ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
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        <balance>1942000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>131318040.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KPV179000"/>
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        <balance>264317.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4879291.82000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ION BEAM APPLICATIONS SA</name>
        <lei>5493002RVRZ1S3CPUI26</lei>
        <title>ION BEAM APPLICATIONS SA REG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003766806"/>
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        <balance>422400.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.94629761"/>
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        <pctVal>0.437325400532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SPYRE THERAPEUTICS INC</name>
        <lei>52990017AIJPRH3HQH40</lei>
        <title>SPYRE THERAPEUTICS INC</title>
        <cusip>00773J202</cusip>
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          <isin value="US00773J2024"/>
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        <balance>106942.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3040361.06000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ELI LILLY and CO</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
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        <balance>448561.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>356762991.35000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GALAPAGOS NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS GENOMICS NV SPON AR</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
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        <balance>36900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1019916.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ELANCO ANIMAL HEALTH INC</name>
        <lei>549300SHPNDCE059M934</lei>
        <title>ELANCO ANIMAL HEALTH INC</title>
        <cusip>28414H103</cusip>
        <identifiers>
          <isin value="US28414H1032"/>
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        <balance>2275600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30060676.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK BIOSCIENCES INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JAC126000"/>
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        <balance>85.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16847.85000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ZOETIS INC</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>ZOETIS INC CL A</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
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        <balance>104400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18296100.00000000</valUSD>
        <pctVal>1.284049136130</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>GALDERMA GROUP AG</name>
        <lei>89450001OK6O8ELQ4584</lei>
        <title>GALDERMA GROUP AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH1335392721"/>
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        <balance>92240.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.88095000"/>
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        <pctVal>0.663190600854</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PULMONX CORP</name>
        <lei>549300WZMFR0ZK7RJY40</lei>
        <title>PULMONX CORP</title>
        <cusip>745848101</cusip>
        <identifiers>
          <isin value="US7458481014"/>
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        <balance>1482029.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9559087.05000000</valUSD>
        <pctVal>0.670871796106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
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        <balance>30339690.87000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30345758.81000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
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        <balance>36100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4912488.00000000</valUSD>
        <pctVal>0.344766150854</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
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        <balance>1193000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50189510.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA SER D PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KRS502000"/>
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        <balance>7649.00000000</balance>
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        <assetCat>EP</assetCat>
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        <invCountry>BE</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NYXOAH SA</name>
        <lei>5493002O1ESKZ18OXR80</lei>
        <title>NYXOAH SA</title>
        <cusip>N/A</cusip>
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          <isin value="BE0974358906"/>
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        <balance>257880.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>242800.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
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          <isin value="BE0003739530"/>
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        <balance>361600.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC</title>
        <cusip>26818M108</cusip>
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          <isin value="US26818M1080"/>
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        <balance>515400.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARRIVENT BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ARRIVENT BIOPHARMA INC</title>
        <cusip>04272N102</cusip>
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          <isin value="US04272N1028"/>
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        <balance>128700.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GSK PLC</name>
        <lei>5493000HZTVUYLO1D793</lei>
        <title>GSK PLC SPONS ADR</title>
        <cusip>37733W204</cusip>
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          <isin value="US37733W2044"/>
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        <balance>2023560.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>69064102.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
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        <balance>130677.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4530571.59000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NYXOAH SA</name>
        <lei>5493002O1ESKZ18OXR80</lei>
        <title>NYXOAH SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0974358906"/>
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        <balance>298200.00000000</balance>
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        <valUSD>2420143.49000000</valUSD>
        <pctVal>0.169849484734</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>FINANCIERE DE TUBIZE SA</name>
        <lei>549300I1MGC0OK6W8828</lei>
        <title>FINANCIERE DE TUBIZE SA</title>
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          <isin value="BE0003823409"/>
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        <balance>79300.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="178384.68000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
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        <balance>15770473.83100000</balance>
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        <curCd>USD</curCd>
        <valUSD>15772050.88000000</valUSD>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="15772050.88000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HED067000"/>
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        <balance>5900.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>98058.00000000</valUSD>
        <pctVal>0.006881864998</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
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        <balance>148200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4056234.00000000</valUSD>
        <pctVal>0.284672895515</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
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        <balance>270200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11518626.00000000</valUSD>
        <pctVal>0.808395328223</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA ANTI-DILUTION WT PP 10/10/2033</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JYV555000"/>
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        <balance>10.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.94629761"/>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
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        <balance>427500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4227975.00000000</valUSD>
        <pctVal>0.296725949592</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3465456.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
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        <balance>628900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58223562.00000000</valUSD>
        <pctVal>4.086221352559</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-1 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JMF025000"/>
        </identifiers>
        <balance>14400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>180000.00000000</valUSD>
        <pctVal>0.012632683714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
        </identifiers>
        <balance>117400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5264216.00000000</valUSD>
        <pctVal>0.369450976284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>760000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11734400.00000000</valUSD>
        <pctVal>0.823538687644</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="294904.00000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2024-12-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
