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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>AURA BIOSCIENCES INC</name>
        <lei>N/A</lei>
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        <cusip>05153U107</cusip>
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          <isin value="US05153U1079"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>METSERA INC</name>
        <lei>N/A</lei>
        <title>METSERA INC SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KSI543000"/>
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        <balance>1686508.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
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          <isin value="US90184D1000"/>
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        <balance>166525.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>DIANTHUS THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>DIANTHUS THERAPEUTICS INC</title>
        <cusip>252828108</cusip>
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          <isin value="US2528281080"/>
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        <balance>153693.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BIOCRYST PHARMACEUTICALS INC</title>
        <cusip>09058V103</cusip>
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          <isin value="US09058V1035"/>
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        <balance>1084881.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NEUROGENE INC</name>
        <lei>529900A7VIY892SZVW73</lei>
        <title>NEUROGENE INC</title>
        <cusip>64135M105</cusip>
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          <isin value="US64135M1053"/>
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        <balance>99857.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
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          <isin value="US91307C1027"/>
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        <balance>157893.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
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          <isin value="US0311621009"/>
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        <balance>1483750.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>419708362.50000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
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          <isin value="US78667J1088"/>
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        <balance>138987.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PRAXIS PRECISION MEDICINES INC.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC</title>
        <cusip>74006W207</cusip>
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          <isin value="US74006W2070"/>
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        <balance>231510.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC</title>
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          <isin value="US05464T1043"/>
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        <balance>71003.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
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          <isin value="US00287Y1091"/>
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        <balance>2974704.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ENTRADA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC</title>
        <cusip>29384C108</cusip>
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          <isin value="US29384C1080"/>
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        <balance>309169.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>NOVO-NORDISK AS</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO-NORDISK AS CL B ADR</title>
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        <assetCat>EC</assetCat>
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        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Q32 BIO INC</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>Q32 BIO INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
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      <invstOrSec>
        <name>TRIVENI BIO INC</name>
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        <title>TRIVENI BIO INC SERIES B PC PP</title>
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        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
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        <name>ADVERUM BIOTECHNOLOGIES INC</name>
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        <title>ADVERUM BIOTECHNOLOGIES INC</title>
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        <name>ORUKA THERAPEUTICS INC</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ORUKA THERAPEUTICS INC PIPE</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC</title>
        <cusip>344174107</cusip>
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        <balance>601441.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
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        <balance>17689.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2358651.26000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
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        <balance>947720.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32980656.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="24540994.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
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        <balance>964650.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>55177980.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABSCI CORP</name>
        <lei>N/A</lei>
        <title>ABSCI CORP</title>
        <cusip>00091E109</cusip>
        <identifiers>
          <isin value="US00091E1091"/>
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        <balance>39900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>121695.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASTRIA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ASTRIA THERAPEUTICS INC</title>
        <cusip>04635X102</cusip>
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          <isin value="US04635X1028"/>
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        <balance>596256.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6195099.84000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TENAYA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TENAYA THERAPEUTICS INC</title>
        <cusip>87990A106</cusip>
        <identifiers>
          <isin value="US87990A1060"/>
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        <balance>1746113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6233623.41000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="5975823.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>INTRA-CELLULAR THERAPIES INC</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>INTRA-CELLULAR THERAPIES INC</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
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        <balance>49599.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4248154.35000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BICARA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC</title>
        <cusip>055477103</cusip>
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          <isin value="US0554771032"/>
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        <balance>243100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5054049.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP WT 07/02/2024</title>
        <cusip>374163129</cusip>
        <identifiers>
          <isin value="US3741631291"/>
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        <balance>2100000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3192000.00000000</valUSD>
        <pctVal>0.067182649302</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB2 HOLDINGS LLC ADI</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="71E99L226"/>
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        <balance>1954526.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS LTD ADR</title>
        <cusip>45258D105</cusip>
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          <isin value="US45258D1054"/>
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        <balance>191705.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6276421.70000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="AIA874000"/>
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        <balance>8274568.00000000</balance>
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        <curCd>USD</curCd>
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        <pctVal>0.000001741655</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JVX197000"/>
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        <balance>32866.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
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          <isin value="US45826J1051"/>
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        <balance>879921.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
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          <isin value="US75886F1075"/>
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        <balance>206183.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SALIOGEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SALIOGEN THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IEH140000"/>
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        <balance>94461.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CARGO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CARGO THERAPEUTICS INC</title>
        <cusip>14179K101</cusip>
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          <isin value="US14179K1016"/>
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        <balance>213400.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GLYCOMIMETICS INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Bloomberg" value="EQ0000000096770470"/>
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        <balance>12099897.00000000</balance>
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        <assetCat>EC</assetCat>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC</title>
        <cusip>254604101</cusip>
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          <isin value="US2546041011"/>
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        <balance>775288.00000000</balance>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>THIRD HARMONICS BIO INC</name>
        <lei>N/A</lei>
        <title>THIRD HARMONICS BIO INC</title>
        <cusip>88427A107</cusip>
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          <isin value="US88427A1079"/>
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        <balance>219600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2802096.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
        <cusip>N/A</cusip>
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          <isin value="IE00B91XRN20"/>
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        <balance>738117.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11964876.57000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>AMYLYX PHARMACEUTICALS INC</title>
        <cusip>03237H101</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ARROWHEAD PHARMACEUTICALS INC</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC</title>
        <cusip>04280A100</cusip>
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        <balance>221115.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
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        <balance>1877722.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>370699877.24000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
        <title>ARVINAS INC</title>
        <cusip>04335A105</cusip>
        <identifiers>
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      <invstOrSec>
        <name>CARDURION PHARMACEUTICALS INC</name>
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      <invstOrSec>
        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
        <lei>N/A</lei>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
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          <other otherDesc="Internal" value="038505921"/>
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      <invstOrSec>
        <name>ORUKA THERAPEUTICS INC</name>
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      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
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          <isin value="US80706P1030"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>10X GENOMICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KEROS THERAPEUTICS INC</name>
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        <name>GRITSTONE BIO INC</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
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        <fairValLevel>3</fairValLevel>
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        <name>ARGENX SE</name>
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        <name>CAMP4 THERAPEUTICS CORP</name>
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        <name>REPLIMUNE GROUP INC</name>
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        <name>CYCLERION THERAPEUTICS INC</name>
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        <name>EDGEWISE THERAPEUTICS INC</name>
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        <name>DESIGN THERAPEUTICS INC</name>
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        <name>ROCKET PHARMACEUTICALS INC</name>
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        <name>SENSORION SA</name>
        <lei>969500P0W8XJ9CGZDP97</lei>
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        <name>CARTESIAN THERAPEUTICS INC</name>
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        <name>VTV THERAPEUTICS INC</name>
        <lei>549300WQE5EI9R35SE66</lei>
        <title>VTV THERAPEUTICS INC CL A</title>
        <cusip>918385204</cusip>
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          <isin value="US9183852048"/>
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        <balance>178200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2849418.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
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        <balance>211909.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8789985.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MEDAVAIL HOLDINGS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
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        <balance>55.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.01000000</valUSD>
        <pctVal>0.000000000210</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TYRA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC</title>
        <cusip>90240B106</cusip>
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          <isin value="US90240B1061"/>
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        <balance>363102.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5693439.36000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PERSPECTIVE THERAPEUTICS INC</name>
        <lei>5493005LRKM6BCABC605</lei>
        <title>PERSPECTIVE THERAPEUTICS INC</title>
        <cusip>46489V302</cusip>
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          <isin value="US46489V3024"/>
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        <balance>713700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3104595.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>INOZYME PHARMA INC</name>
        <lei>N/A</lei>
        <title>INOZYME PHARMA INC</title>
        <cusip>45790W108</cusip>
        <identifiers>
          <isin value="US45790W1080"/>
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        <balance>1902410.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5155531.10000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="881563.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOME INC</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC</title>
        <cusip>45257U108</cusip>
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          <isin value="US45257U1088"/>
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        <balance>352282.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4773421.10000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GDA208000"/>
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        <balance>11945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.12000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
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        <balance>11113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>222704.52000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
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          <isin value="NL0010696654"/>
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        <balance>275559.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1645087.23000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AVIDITY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES</title>
        <cusip>05370A108</cusip>
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          <isin value="US05370A1088"/>
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        <balance>805717.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>34670002.51000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
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          <isin value="US09075V1026"/>
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        <balance>175500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20777445.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
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          <isin value="US47103J1051"/>
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        <balance>366399.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>16564898.79000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
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          <isin value="US0197701065"/>
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        <balance>2359877.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC</title>
        <cusip>29337E102</cusip>
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          <isin value="US29337E1029"/>
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        <balance>479038.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CARTESIAN THERAPEUTICS INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>CARTESIAN THERAPEUTICS INC CVR RT</title>
        <cusip>816212112</cusip>
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        <balance>5385728.00000000</balance>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC</title>
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      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
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        <name>SCHRODINGER INC</name>
        <lei>984500044BAE4791E559</lei>
        <title>SCHRODINGER INC</title>
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        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>VIRIDIAN THERAPEUTICS INC</name>
        <lei>549300C775BNYF550E70</lei>
        <title>VIRIDIAN THERAPEUTICS INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SPYRE THERAPEUTICS INC</name>
        <lei>52990017AIJPRH3HQH40</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US92337R1014"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VERONA PHARMA PLC</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>VERONA PHARMA PLC ADR</title>
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          <isin value="US9250501064"/>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
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          <isin value="CH0363463438"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>STRUCTURE THERAPEUTICS INC</name>
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          <isin value="US86366E1064"/>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
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          <isin value="US86627T1088"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ATEA PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ANNEXON INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ROIVANT SCIENCES LTD</name>
        <lei>549300DL466NY5J6U724</lei>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
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          <isin value="US74366E1029"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VENTYX BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CYTOKINETICS INC</name>
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        <name>ATYR PHARMA INC</name>
        <lei>529900ENQUXMC5EBKO36</lei>
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        <name>NATIONAL RESILIENCE INC</name>
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        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <name>ALECTOR INC</name>
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        <name>BRIDGEBIO PHARMA INC</name>
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        <name>GALDERMA GROUP AG</name>
        <lei>89450001OK6O8ELQ4584</lei>
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        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
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        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
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        <name>ASCENDIS PHARMA A/S</name>
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        <title>ASCENDIS PHARMA AS SPON ADR</title>
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        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RECURSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>RECURSION PHARMACEUTICALS INC</title>
        <cusip>75629V104</cusip>
        <identifiers>
          <isin value="US75629V1044"/>
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        <balance>149900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1059793.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>BOUNDLESS BIO INC</name>
        <lei>N/A</lei>
        <title>BOUNDLESS BIO INC</title>
        <cusip>10170A100</cusip>
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          <isin value="US10170A1007"/>
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        <balance>23700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64701.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
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        <balance>473209.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221523329.17000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASTRIA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ASTRIA THERAPEUTICS INC WT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KAD591000"/>
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        <balance>115136.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GLAUKOS CORP</name>
        <lei>5299004JA1LHE21M6T14</lei>
        <title>GLAUKOS CORP</title>
        <cusip>377322102</cusip>
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          <isin value="US3773221029"/>
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        <balance>5700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HAD933000"/>
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        <balance>3099905.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7501770.10000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIOHAVEN LTD</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
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        <balance>1664912.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76602601.12000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="276060.00000000"/>
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      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
        <cusip>05454B204</cusip>
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          <isin value="US05454B2043"/>
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        <balance>66454.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.66000000</valUSD>
        <pctVal>0.000000013891</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
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        <balance>349532.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58644478.96000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC WT 11/23/27</title>
        <cusip>68404V118</cusip>
        <identifiers>
          <isin value="US68404V1180"/>
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        <balance>91712.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1244.47000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PHARVARIS BV</name>
        <lei>9845003BE146D3B75D32</lei>
        <title>PHARVARIS BV</title>
        <cusip>N/A</cusip>
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          <isin value="NL00150005Y4"/>
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        <balance>112407.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CANDID THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>CANDID THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KPC029000"/>
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        <balance>1666667.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
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          <isin value="US5588681057"/>
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        <balance>135295.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
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          <isin value="US30063P1057"/>
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        <balance>56900.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>352911.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC</title>
        <cusip>192010106</cusip>
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          <isin value="US1920101060"/>
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        <balance>448539.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
        <title>ARCELLX INC</title>
        <cusip>03940C100</cusip>
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          <isin value="US03940C1009"/>
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        <balance>1043991.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>STOKE THERAPEUTICS INC</title>
        <cusip>86150R107</cusip>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DAY ONE BIOPHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC</title>
        <cusip>23954D109</cusip>
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        <fairValLevel>1</fairValLevel>
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        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
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        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BEIGENE LTD</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD SP ADR</title>
        <cusip>07725L102</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
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        <balance>15603.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC</title>
        <cusip>26818M108</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARRIVENT BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ARRIVENT BIOPHARMA INC</title>
        <cusip>04272N102</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RAPPORT THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM BIOSCIENCES INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PHATHOM PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
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          <isin value="US71722W1071"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
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          <isin value="US02043Q1076"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
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          <isin value="US98937L1052"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
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          <isin value="US4131971040"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
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        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
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        <title>CORCEPT THERAPEUTICS INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Fidelity Revere Street Trust</name>
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        <assetCat>STIV</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
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        <title>CODIAK BIOSCIENCES INC WT 09/15/2027</title>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>IMMUNOVANT INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NEUMORA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>BEAM THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>XENON PHARMACEUTICALS INC</name>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
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        <name>CRISPR THERAPEUTICS AG</name>
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        <name>AEROVATE THERAPEUTICS INC</name>
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        <title>JADE BIOSCIENCES INC PIPE</title>
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        <name>COGENT BIOSCIENCES INC</name>
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        <name>CG ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>DENALI THERAPEUTICS INC</name>
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        <title>DENALI THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>INSMED INC</name>
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        <title>INSMED INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC SERIES C1 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KLT136000"/>
        </identifiers>
        <balance>2066543.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5001034.06000000</valUSD>
        <pctVal>0.105257743547</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JPE358000"/>
        </identifiers>
        <balance>1555907.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15.56000000</valUSD>
        <pctVal>0.000000327494</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
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        <balance>5570691.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18049038.84000000</valUSD>
        <pctVal>0.379881656213</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2773446.48000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
        <lei>549300749HO5QS40BX97</lei>
        <title>ALLENA PHARMACEUTICALS INC</title>
        <cusip>018119107</cusip>
        <identifiers>
          <isin value="US0181191075"/>
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        <balance>93683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.94000000</valUSD>
        <pctVal>0.000000019784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
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        <balance>445557.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23587787.58000000</valUSD>
        <pctVal>0.496456785967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
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        <balance>392132.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17704759.80000000</valUSD>
        <pctVal>0.372635547815</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TECTONIC THERAPEUTIC INC</name>
        <lei>N/A</lei>
        <title>TECTONIC THERAPEUTIC INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KEB735000"/>
        </identifiers>
        <balance>215508.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10727988.24000000</valUSD>
        <pctVal>0.225794070065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIOMEA FUSION INC</name>
        <lei>N/A</lei>
        <title>BIOMEA FUSION INC</title>
        <cusip>09077A106</cusip>
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          <isin value="US09077A1060"/>
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        <balance>392129.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2839013.96000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2505764.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
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        <balance>996054.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44663061.36000000</valUSD>
        <pctVal>0.940032201793</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
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        <balance>145464.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3991532.16000000</valUSD>
        <pctVal>0.084010559299</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELEVATEBIO, LLC</name>
        <lei>N/A</lei>
        <title>ELEVATEBIO LLC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HCJ459000"/>
        </identifiers>
        <balance>216600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>628140.00000000</valUSD>
        <pctVal>0.013220585630</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
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        <balance>442377.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15806130.21000000</valUSD>
        <pctVal>0.332674718899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AUTOLUS THERAPEUTICS PLC</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
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        <balance>1120733.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3720833.56000000</valUSD>
        <pctVal>0.078313112836</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
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        <balance>268899.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25997155.32000000</valUSD>
        <pctVal>0.547167220778</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
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        <balance>540520.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5599787.20000000</valUSD>
        <pctVal>0.117859818178</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1618232.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
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        <balance>1879062.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29012717.28000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="174472.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CONTINEUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CONTINEUM THERAPEUTICS INC CL A</title>
        <cusip>21217B100</cusip>
        <identifiers>
          <isin value="US21217B1008"/>
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        <balance>58800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>876708.00000000</valUSD>
        <pctVal>0.018452245020</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
        <cusip>03969T109</cusip>
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        <balance>399330.00000000</balance>
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        <valUSD>7323712.20000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>RAPT THERAPEUTICS INC</name>
        <lei>549300MB473BIU78ES48</lei>
        <title>RAPT THERAPEUTICS INC</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
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        <balance>802700.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1011402.00000000</valUSD>
        <pctVal>0.021287176024</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2024-12-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
