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        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
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        <balance>97000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11737970.00000000</valUSD>
        <pctVal>1.369862749740</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MERCK KGAA</name>
        <lei>529900OAREIS0MOPTW25</lei>
        <title>MERCK KGAA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE0006599905"/>
        </identifiers>
        <balance>128900.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.92221146"/>
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        <pctVal>2.707787329259</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRISTOL-MYERS SQUIBB CO</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>BRISTOL-MYERS SQUIBB CO</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
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        <balance>143980.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8876367.00000000</valUSD>
        <pctVal>1.035903525594</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
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        <balance>133200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4992336.00000000</valUSD>
        <pctVal>0.582623325889</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SANOFI</name>
        <lei>549300E9PC51EN656011</lei>
        <title>SANOFI SPON ADR</title>
        <cusip>80105N105</cusip>
        <identifiers>
          <isin value="US80105N1054"/>
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        <balance>1133122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>60259427.96000000</valUSD>
        <pctVal>7.032489066089</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CASTLE CREEK PHARMACEUTICAL HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK PHARMACEUTICAL HOLDINGS INC SER C PC PERP PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="FEC032000"/>
        </identifiers>
        <balance>200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42284.00000000</valUSD>
        <pctVal>0.004934692839</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JMF122000"/>
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        <balance>22477.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>230164.48000000</valUSD>
        <pctVal>0.026861011526</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN INC</name>
        <lei>N/A</lei>
        <title>ACELYRIN INC 180-DAY LOCK-UP LINE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JTL152000"/>
        </identifiers>
        <balance>160830.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3870132.71000000</valUSD>
        <pctVal>0.451658219946</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
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        <balance>83800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4426316.00000000</valUSD>
        <pctVal>0.516566783437</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ROCHE HOLDING AG</name>
        <lei>549300U41AUUVOAAOB37</lei>
        <title>ROCHE HOLDINGS AG (GENUSSCHEINE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
        </identifiers>
        <balance>79746.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.88335000"/>
        <valUSD>23404527.49000000</valUSD>
        <pctVal>2.731391406166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>68800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18394368.00000000</valUSD>
        <pctVal>2.146688015749</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MERCK and CO INC</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC NEW</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
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        <balance>720836.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78556707.28000000</valUSD>
        <pctVal>9.167846488375</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
        <title>ARVINAS INC</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
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        <balance>26300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>741923.00000000</valUSD>
        <pctVal>0.086585046722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AEGLEA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>AEGLEA BIOTHERAPEUTICS INC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JVB495000"/>
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        <balance>304.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>166060.00000000</valUSD>
        <pctVal>0.019379791243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEAP THERAPEUTICS INC</name>
        <lei>549300T31SMMJ2DDLI13</lei>
        <title>LEAP THERAPEUTICS INC WT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EBC951000"/>
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        <balance>60600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>357.54000000</valUSD>
        <pctVal>0.000041726186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HCE668000"/>
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        <balance>158879.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1714304.41000000</valUSD>
        <pctVal>0.200065407645</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>ROYALTY PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
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        <balance>912300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27204786.00000000</valUSD>
        <pctVal>3.174895059032</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GENERATION BIO CO</name>
        <lei>N/A</lei>
        <title>GENERATION BIO</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
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        <balance>394176.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1884161.28000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
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        <balance>436300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2726875.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MEDAVAIL HOLDINGS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
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        <balance>3333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>535.95000000</valUSD>
        <pctVal>0.000062547266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>150300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1309113.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NOVARTIS AG</name>
        <lei>5493007HIVTX6SY6XD66</lei>
        <title>NOVARTIS AG SPON ADR</title>
        <cusip>66987V109</cusip>
        <identifiers>
          <isin value="US66987V1098"/>
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        <balance>24896.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2501550.08000000</valUSD>
        <pctVal>0.291939770778</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AVIDITY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
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        <balance>507400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3835944.00000000</valUSD>
        <pctVal>0.447668276174</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CATALENT INC</name>
        <lei>N/A</lei>
        <title>CATALENT INC</title>
        <cusip>148806102</cusip>
        <identifiers>
          <isin value="US1488061029"/>
        </identifiers>
        <balance>77600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3877672.00000000</valUSD>
        <pctVal>0.452538081841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LANTHEUS HOLDINGS INC</name>
        <lei>5299005HUB5IOJGO7S39</lei>
        <title>LANTHEUS HLDGS INC</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
        </identifiers>
        <balance>119700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8192268.00000000</valUSD>
        <pctVal>0.956066744853</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASTRAZENECA PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC SPONS ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
        </identifiers>
        <balance>1199200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>81329744.00000000</valUSD>
        <pctVal>9.491469713379</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELI LILLY and CO</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
        </identifiers>
        <balance>328761.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>182199346.20000000</valUSD>
        <pctVal>21.26331021347</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GALAPAGOS NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS GENOMICS NV SPON AR</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
        </identifiers>
        <balance>36900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1398141.00000000</valUSD>
        <pctVal>0.163168015831</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STRUCTURE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
        </identifiers>
        <balance>98000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2762620.00000000</valUSD>
        <pctVal>0.322407556816</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLOVIR INC</name>
        <lei>N/A</lei>
        <title>ALLOVIR INC</title>
        <cusip>019818103</cusip>
        <identifiers>
          <isin value="US0198181036"/>
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        <balance>661100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2069243.00000000</valUSD>
        <pctVal>0.241488000553</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="307679.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN INC</name>
        <lei>N/A</lei>
        <title>ACELYRIN INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JPJ013000"/>
        </identifiers>
        <balance>19543.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>446759.43000000</valUSD>
        <pctVal>0.052138410751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARUNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
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        <balance>2100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>394296.00000000</valUSD>
        <pctVal>0.046015742310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VENTYX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>VENTYX BIOSCIENCES INC</title>
        <cusip>92332V107</cusip>
        <identifiers>
          <isin value="US92332V1070"/>
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        <balance>141000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4723500.00000000</valUSD>
        <pctVal>0.551249210757</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK BIOSCIENCES INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JAC126000"/>
        </identifiers>
        <balance>85.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14596.20000000</valUSD>
        <pctVal>0.001703428332</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
        </identifiers>
        <balance>85900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3001346.00000000</valUSD>
        <pctVal>0.350267728106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PULMONX CORP</name>
        <lei>549300WZMFR0ZK7RJY40</lei>
        <title>PULMONX CORP</title>
        <cusip>745848101</cusip>
        <identifiers>
          <isin value="US7458481014"/>
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        <balance>288700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3019802.00000000</valUSD>
        <pctVal>0.352421608795</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
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        <balance>2494532.57100000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2495031.48000000</valUSD>
        <pctVal>0.291179027027</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
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        <balance>36100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3538522.00000000</valUSD>
        <pctVal>0.412958073409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
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        <balance>237400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16466064.00000000</valUSD>
        <pctVal>1.921648096599</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
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        <balance>30000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5070000.00000000</valUSD>
        <pctVal>0.591686990270</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>295600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11676200.00000000</valUSD>
        <pctVal>1.362653971557</pctVal>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
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        <balance>309000.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
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        <balance>478500.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5454900.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GSK PLC</name>
        <lei>5493000HZTVUYLO1D793</lei>
        <title>GSK PLC SPONS ADR</title>
        <cusip>37733W204</cusip>
        <identifiers>
          <isin value="US37733W2044"/>
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        <balance>1020860.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35862811.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GERRESHEIMER AG</name>
        <lei>5299006GD4UWSYZOKC28</lei>
        <title>GERRESHEIMER AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE000A0LD6E6"/>
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        <balance>167800.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.92221146"/>
        <valUSD>21816276.28000000</valUSD>
        <pctVal>2.546036854245</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
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        <balance>14671.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2902217.22000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
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        <balance>144577.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5240916.25000000</valUSD>
        <pctVal>0.611633523120</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
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        <balance>9600798.03600000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9601758.12000000</valUSD>
        <pctVal>1.120559243260</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="9601758.12000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVOZYNE LLC</name>
        <lei>N/A</lei>
        <title>EVOZYNE LLC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HED067000"/>
        </identifiers>
        <balance>5900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>80004.00000000</valUSD>
        <pctVal>0.009336750684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
        </identifiers>
        <balance>134700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3122346.00000000</valUSD>
        <pctVal>0.364388857460</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2109380.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
        </identifiers>
        <balance>175900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6856582.00000000</valUSD>
        <pctVal>0.800187449136</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSPIRE MEDICAL SYSTEMS INC</name>
        <lei>549300XQQCQ7HCJKTW25</lei>
        <title>INSPIRE MEDICAL SYSTEMS INC</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
        </identifiers>
        <balance>21800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4945984.00000000</valUSD>
        <pctVal>0.577213883015</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>353200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27012736.00000000</valUSD>
        <pctVal>3.152482142566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-1 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JMF025000"/>
        </identifiers>
        <balance>14400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>155808.00000000</valUSD>
        <pctVal>0.018183346465</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
        </identifiers>
        <balance>367700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2158399.00000000</valUSD>
        <pctVal>0.251892822113</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="930395.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>244400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5010200.00000000</valUSD>
        <pctVal>0.584708118077</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INDIVIOR PLC</name>
        <lei>213800V3NCQTY7IED471</lei>
        <title>INDIVIOR PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BN4HT335"/>
        </identifiers>
        <balance>303000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.78939059"/>
        <valUSD>6985895.28000000</valUSD>
        <pctVal>0.815278767764</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FULCRUM THERAPEUTICS INC</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>762000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4213860.00000000</valUSD>
        <pctVal>0.491772414363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2023-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
