<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000320351</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000007486</seriesId>
        <classId>C000020460</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>Fidelity Select Portfolios</regName>
      <regFileNumber>811-03114</regFileNumber>
      <regCik>0000320351</regCik>
      <regLei>Z57125JG1LHEQKDYS630</regLei>
      <regStreet1>245 Summer Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02210</regZipOrPostalCode>
      <regPhone>1-800-FIDELITY</regPhone>
      <seriesName>Select Biotechnology Portfolio</seriesName>
      <seriesId>S000007486</seriesId>
      <seriesLei>FQDPG178WXRZSXLIRG32</seriesLei>
      <repPdEnd>2024-02-28</repPdEnd>
      <repPdDate>2023-08-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>4918268263.22</totAssets>
      <totLiabs>324209687.18</totLiabs>
      <netAssets>4594058576.04</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>9790817.71000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>3262.25000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="9632658.68000000" lei="FOR8UP27PHTHYVLBNG30" name="GOLDMAN SACHS and CO LLC (GOV REPO)"/>
        <borrower aggrVal="14497840.09000000" lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY and CO LLC"/>
        <borrower aggrVal="17763097.00000000" lei="549300H8L46OOZOFHU82" name="CANADIAN IMPRL BK COMM NY BRH"/>
        <borrower aggrVal="13287398.00000000" lei="VYVVCKR63DVZZN70PB21" name="WELLS FARGO SECURITIES, LLC(GOV REPO)"/>
        <borrower aggrVal="16027664.93000000" lei="571474TGEMMWANRLN572" name="STATE STREET BANK AND TRUST COMPANY"/>
        <borrower aggrVal="82585095.13000000" lei="549300HN4UKV1E2R3U73" name="BOFA SECURITIES INC"/>
        <borrower aggrVal="76736.00000000" lei="549300K66TF1ST7A3V76" name="NATIONAL BANK OF CANADA FINANCIAL INC"/>
        <borrower aggrVal="14713485.06000000" lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL INC."/>
        <borrower aggrVal="3277427.00000000" lei="58PU97L1C0WSRCWADL48" name="JEFFERIES LLC"/>
        <borrower aggrVal="21291223.56000000" lei="MBNUM2BPBDO7JBLYG310" name="CITIGROUP GLOBAL MARKETS INC."/>
        <borrower aggrVal="3292462.00000000" lei="OXTKY6Q8X53C9ILVV871" name="NOMURA SECURITIES INTERNATIONAL INC"/>
        <borrower aggrVal="34347724.00000000" lei="549300ZBQI1JB1844X09" name="TD PRIME SERVICES LLC"/>
        <borrower aggrVal="42971062.00000000" lei="RCNB6OTYUAMMP879YW96" name="BNP PARIBAS SECURITIES CORP (GOV REPO)"/>
        <borrower aggrVal="21872256.80000000" lei="ZBUT11V806EZRVTWT807" name="JPMORGAN SECURITIES LLC"/>
        <borrower aggrVal="71.68000000" lei="RUC0QBLBRPRCU4W1NE59" name="BMO CAPITAL MARKETS CORP"/>
        <borrower aggrVal="2372632.00000000" lei="549300JRHF1MHHWUAW04" name="NATIONAL FINANCIAL SERVICES, LLC"/>
        <borrower aggrVal="786466.00000000" lei="549300BLWPABP1VNME36" name="SCOTIA CAPITAL (USA) INC."/>
      </borrowers>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000020460" rtn1="0.30000000" rtn2="2.17000000" rtn3="-3.30000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <commodityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </commodityContracts>
          <creditContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </creditContracts>
          <equityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </equityContracts>
          <foreignExchgContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </foreignExchgContracts>
          <interestRtContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </interestRtContracts>
          <otherContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </otherContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="22701114.18000000" netUnrealizedAppr="-4736631.12000000"/>
        <othMon2 netRealizedGain="-44892305.08000000" netUnrealizedAppr="141330771.20000000"/>
        <othMon3 netRealizedGain="-37622545.79000000" netUnrealizedAppr="-117334851.31000000"/>
      </returnInfo>
      <mon1Flow redemption="70424090.17000000" reinvestment="0.00000000" sales="27285286.44000000"/>
      <mon2Flow redemption="85704474.81000000" reinvestment="0.00000000" sales="13889409.78000000"/>
      <mon3Flow redemption="71474825.21000000" reinvestment="0.00000000" sales="10094917.20000000"/>



    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>CHINOOK THERAPEUTICS INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GGJ521000"/>
        </identifiers>
        <balance>115821.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1.16000000</valUSD>
        <pctVal>0.000000025250</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TERNS PHARMACEUTICALS INC</name>
        <lei>254900S1ZDQMF4MYP709</lei>
        <title>TERNS PHARMACEUTICALS INC</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
        </identifiers>
        <balance>658996.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3472908.92000000</valUSD>
        <pctVal>0.075595660406</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA BIOSCIENCES INC</name>
        <lei>549300ULW08F62IJML11</lei>
        <title>IDEAYA BIOSCIENCES</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
        </identifiers>
        <balance>1094957.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32147937.52000000</valUSD>
        <pctVal>0.699772042256</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3860840.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXELIXIS INC</name>
        <lei>254900PJQB59O2O95R37</lei>
        <title>EXELIXIS INC</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>754172.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16885911.08000000</valUSD>
        <pctVal>0.367559768786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>MORPHIC HOLDING INC</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
        </identifiers>
        <balance>857637.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47238645.96000000</valUSD>
        <pctVal>1.028255194793</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAGENTA THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>DIANTHUS THERAPEUTICS INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JTL095000"/>
        </identifiers>
        <balance>448100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1882020.00000000</valUSD>
        <pctVal>0.040966391021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AURA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
        </identifiers>
        <balance>356492.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3700386.96000000</valUSD>
        <pctVal>0.080547230705</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMICUS THERAPEUTICS INC</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>2439801.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31278248.82000000</valUSD>
        <pctVal>0.680841314978</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
        </identifiers>
        <balance>298525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6564564.75000000</valUSD>
        <pctVal>0.142892491276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2651994.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BIOCRYST PHARMACEUTICALS INC</title>
        <cusip>09058V103</cusip>
        <identifiers>
          <isin value="US09058V1035"/>
        </identifiers>
        <balance>2806881.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19956923.91000000</valUSD>
        <pctVal>0.434407258411</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16739073.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>274069.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61490120.84000000</valUSD>
        <pctVal>1.338470544557</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>412244.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>105674626.96000000</valUSD>
        <pctVal>2.300245528238</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HALOZYME THERAPEUTICS INC</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>HALOZYME THERAPEUTICS INC</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
        </identifiers>
        <balance>73200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3115392.00000000</valUSD>
        <pctVal>0.067813501905</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOGEN INC</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>IMMUNOGEN INC</title>
        <cusip>45253H101</cusip>
        <identifiers>
          <isin value="US45253H1014"/>
        </identifiers>
        <balance>1516023.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24013804.32000000</valUSD>
        <pctVal>0.522714369495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>827452.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16549040.00000000</valUSD>
        <pctVal>0.360227013349</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
        </identifiers>
        <balance>266603.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21541522.40000000</valUSD>
        <pctVal>0.468899602463</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21088800.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>4472438.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>657269488.48000000</valUSD>
        <pctVal>14.30694619149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="382096.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
        <cusip>09075P105</cusip>
        <identifiers>
          <isin value="US09075P1057"/>
        </identifiers>
        <balance>274527.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1037712.06000000</valUSD>
        <pctVal>0.022588132972</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="816423.30000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENTRADA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
        </identifiers>
        <balance>581805.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8564169.60000000</valUSD>
        <pctVal>0.186418380572</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6107328.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
        </identifiers>
        <balance>938308.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46784036.88000000</valUSD>
        <pctVal>1.018359607428</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVO-NORDISK AS</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO-NORDISK AS CL B ADR</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="US6701002056"/>
        </identifiers>
        <balance>24500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4547690.00000000</valUSD>
        <pctVal>0.098990683830</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIGIL NEUROSCIENCE INC</name>
        <lei>N/A</lei>
        <title>VIGIL NEUROSCIENCE INC</title>
        <cusip>92673K108</cusip>
        <identifiers>
          <isin value="US92673K1088"/>
        </identifiers>
        <balance>140325.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>846159.75000000</valUSD>
        <pctVal>0.018418566850</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>6449301.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29731277.61000000</valUSD>
        <pctVal>0.647168013160</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8617473.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="74W995233"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82.75000000</valUSD>
        <pctVal>0.000001801239</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADVERUM BIOTECHNOLOGIES INC</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
        <title>ADVERUM BIOTECHNOLOGIES INC</title>
        <cusip>00773U108</cusip>
        <identifiers>
          <isin value="US00773U1088"/>
        </identifiers>
        <balance>6902392.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12010162.08000000</valUSD>
        <pctVal>0.261428144226</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="223938.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
        </identifiers>
        <balance>2787194.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21015442.76000000</valUSD>
        <pctVal>0.457448297886</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="747214.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC</title>
        <cusip>344174107</cusip>
        <identifiers>
          <isin value="US3441741077"/>
        </identifiers>
        <balance>178719.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1352902.83000000</valUSD>
        <pctVal>0.029448967783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="457985.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FUSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>FUSION PHARMACEUTICALS INC</title>
        <cusip>36118A100</cusip>
        <identifiers>
          <isin value="CA36118A1003"/>
        </identifiers>
        <balance>830309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2474320.82000000</valUSD>
        <pctVal>0.053859148268</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KINNATE BIOPHARMA INC</name>
        <lei>549300YVIWV7HJ5WHI66</lei>
        <title>KINNATE BIOPHARMA INC</title>
        <cusip>49705R105</cusip>
        <identifiers>
          <isin value="US49705R1059"/>
        </identifiers>
        <balance>351780.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>784469.40000000</valUSD>
        <pctVal>0.017075737869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>APPLIED THERAPEUTICS INC</title>
        <cusip>03828A101</cusip>
        <identifiers>
          <isin value="US03828A1016"/>
        </identifiers>
        <balance>2639536.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3510582.88000000</valUSD>
        <pctVal>0.076415718735</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="156674.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>20943.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>460327.14000000</valUSD>
        <pctVal>0.010020053779</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>228299.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27626461.99000000</valUSD>
        <pctVal>0.601351975224</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
        </identifiers>
        <balance>1444265.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15121454.55000000</valUSD>
        <pctVal>0.329152410656</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
        </identifiers>
        <balance>1002783.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17368201.56000000</valUSD>
        <pctVal>0.378057903975</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABSCI CORP</name>
        <lei>N/A</lei>
        <title>ABSCI CORP</title>
        <cusip>00091E109</cusip>
        <identifiers>
          <isin value="US00091E1091"/>
        </identifiers>
        <balance>992700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1776933.00000000</valUSD>
        <pctVal>0.038678936513</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="303584.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASTRIA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ASTRIA THERAPEUTICS INC</title>
        <cusip>04635X102</cusip>
        <identifiers>
          <isin value="US04635X1028"/>
        </identifiers>
        <balance>269898.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2402092.20000000</valUSD>
        <pctVal>0.052286930178</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TENAYA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TENAYA THERAPEUTICS INC</title>
        <cusip>87990A106</cusip>
        <identifiers>
          <isin value="US87990A1060"/>
        </identifiers>
        <balance>1477379.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5717456.73000000</valUSD>
        <pctVal>0.124453283199</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTRA-CELLULAR THERAPIES INC</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>INTRA-CELLULAR THERAPIES INC</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
        </identifiers>
        <balance>95002.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5274511.04000000</valUSD>
        <pctVal>0.114811575705</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP WT 07/02/2024</title>
        <cusip>374163129</cusip>
        <identifiers>
          <isin value="US3741631291"/>
        </identifiers>
        <balance>2100000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1440232.67000000</valUSD>
        <pctVal>0.031349897833</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ITEOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ITEOS THERAPEUTICS INC</title>
        <cusip>46565G104</cusip>
        <identifiers>
          <isin value="US46565G1040"/>
        </identifiers>
        <balance>139700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1685480.50000000</valUSD>
        <pctVal>0.036688267511</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB HOLDINGS LLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="71E99L226"/>
        </identifiers>
        <balance>1954526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>71574742.12000000</valUSD>
        <pctVal>1.557984969832</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS LTD ADR</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
        </identifiers>
        <balance>234318.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13185073.86000000</valUSD>
        <pctVal>0.287002737160</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AIA874000"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9102024.80000000</valUSD>
        <pctVal>0.198126006652</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PLIANT THERAPEUTICS INC</name>
        <lei>5493002Q5LITR7VHZH02</lei>
        <title>PLIANT THERAPEUTICS INC</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
        </identifiers>
        <balance>199831.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3373147.28000000</valUSD>
        <pctVal>0.073424124315</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FREQUENCY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JVX197000"/>
        </identifiers>
        <balance>1798561.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4478416.89000000</valUSD>
        <pctVal>0.097482799051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
        </identifiers>
        <balance>823501.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30864817.48000000</valUSD>
        <pctVal>0.671842053581</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>286648.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>236911705.52000000</valUSD>
        <pctVal>5.156915211216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PEPGEN INC</name>
        <lei>N/A</lei>
        <title>PEPGEN INC</title>
        <cusip>713317105</cusip>
        <identifiers>
          <isin value="US7133171055"/>
        </identifiers>
        <balance>281834.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1775554.20000000</valUSD>
        <pctVal>0.038648923835</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RALLYBIO CORP</name>
        <lei>N/A</lei>
        <title>RALLYBIO CORP</title>
        <cusip>75120L100</cusip>
        <identifiers>
          <isin value="US75120L1008"/>
        </identifiers>
        <balance>1550692.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8249681.44000000</valUSD>
        <pctVal>0.179572839646</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2120802.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SALIOGEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SALIOGEN THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IEH140000"/>
        </identifiers>
        <balance>94461.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6312828.63000000</valUSD>
        <pctVal>0.137412889398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
        <title>EQRX INC 1 YR EARNOUT (CVR) RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IFC137000"/>
        </identifiers>
        <balance>116649.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30328.74000000</valUSD>
        <pctVal>0.000660173123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OMEGA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>OMEGA THERAPEUTICS INC</title>
        <cusip>68217N105</cusip>
        <identifiers>
          <isin value="US68217N1054"/>
        </identifiers>
        <balance>492903.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1808954.01000000</valUSD>
        <pctVal>0.039375945692</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="980991.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC SER B-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IFB621000"/>
        </identifiers>
        <balance>899280.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2239207.20000000</valUSD>
        <pctVal>0.048741372425</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZENTALIS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS LLC</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>745133.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19790732.48000000</valUSD>
        <pctVal>0.430789728786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
        </identifiers>
        <balance>314190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16636360.50000000</valUSD>
        <pctVal>0.362127740093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1413765.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN INC</name>
        <lei>N/A</lei>
        <title>ACELYRIN INC 180-DAY LOCK-UP LINE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JTL152000"/>
        </identifiers>
        <balance>1206226.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29026019.35000000</valUSD>
        <pctVal>0.631816483607</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERVE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERVE THERAPEUTICS INC</title>
        <cusip>92539P101</cusip>
        <identifiers>
          <isin value="US92539P1012"/>
        </identifiers>
        <balance>291593.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3752801.91000000</valUSD>
        <pctVal>0.081688159780</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3736161.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
        </identifiers>
        <balance>999717.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52805051.94000000</valUSD>
        <pctVal>1.149420519263</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7421210.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>AMYLYX PHARMACEUTICALS INC</title>
        <cusip>03237H101</cusip>
        <identifiers>
          <isin value="US03237H1014"/>
        </identifiers>
        <balance>136000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2932160.00000000</valUSD>
        <pctVal>0.063825046012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>627436.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>167751288.96000000</valUSD>
        <pctVal>3.651483458110</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>1070432.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29586740.48000000</valUSD>
        <pctVal>0.644021837995</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
        </identifiers>
        <balance>1985122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>247107986.56000000</valUSD>
        <pctVal>5.378860161878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
        <title>ARVINAS INC</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
        </identifiers>
        <balance>244716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6903438.36000000</valUSD>
        <pctVal>0.150268836274</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GH RESEARCH PLC</name>
        <lei>875500HKJS7QQG6EWH62</lei>
        <title>GH RESEARCH PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE000GID8VI0"/>
        </identifiers>
        <balance>539924.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5739392.12000000</valUSD>
        <pctVal>0.124930756214</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3389864.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FUSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>FUSION PHARMACEUTICALS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JQW154000"/>
        </identifiers>
        <balance>1483000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4419340.00000000</valUSD>
        <pctVal>0.096196857894</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS</title>
        <cusip>61559X104</cusip>
        <identifiers>
          <isin value="KY61559X1045"/>
        </identifiers>
        <balance>381585.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21967848.45000000</valUSD>
        <pctVal>0.478179546176</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10489254.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC CL A WT 04/16/2024</title>
        <cusip>98420X111</cusip>
        <identifiers>
          <isin value="US98420X1110"/>
        </identifiers>
        <balance>450000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4.50000000</valUSD>
        <pctVal>0.000000097952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="038505921"/>
        </identifiers>
        <balance>148009.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6808.41000000</valUSD>
        <pctVal>0.000148200330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>1693925.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10587031.25000000</valUSD>
        <pctVal>0.230450506339</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="200625.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SANA BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
        </identifiers>
        <balance>1024494.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5481042.90000000</valUSD>
        <pctVal>0.119307205367</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5480540.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC</title>
        <cusip>603380205</cusip>
        <identifiers>
          <isin value="US6033802058"/>
        </identifiers>
        <balance>491746.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4115914.02000000</valUSD>
        <pctVal>0.089592110154</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="50220.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LONGBOARD PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LONGBOARD PHARMACEUTICALS INC</title>
        <cusip>54300N103</cusip>
        <identifiers>
          <isin value="US54300N1037"/>
        </identifiers>
        <balance>680289.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3938873.31000000</valUSD>
        <pctVal>0.085738421589</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10X GENOMICS INC</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X GENOMICS INC</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
        </identifiers>
        <balance>324600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16830510.00000000</valUSD>
        <pctVal>0.366353839887</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
        </identifiers>
        <balance>366646.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3116491.00000000</valUSD>
        <pctVal>0.067837424108</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="132370.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ARS PHARMACEUTICALS INC</title>
        <cusip>82835W108</cusip>
        <identifiers>
          <isin value="US82835W1080"/>
        </identifiers>
        <balance>1131518.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8022462.62000000</valUSD>
        <pctVal>0.174626911851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6368947.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KEROS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KEROS THERAPEUTICS</title>
        <cusip>492327101</cusip>
        <identifiers>
          <isin value="US4923271013"/>
        </identifiers>
        <balance>305329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10720101.19000000</valUSD>
        <pctVal>0.233347072366</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>1223079.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51626164.59000000</valUSD>
        <pctVal>1.123759389121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21054348.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
        </identifiers>
        <balance>292447.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146951693.03000000</valUSD>
        <pctVal>3.198733551122</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CEREVEL THERAPEUTICS HOLDINGS INC</name>
        <lei>254900RJNIRS9COSQR41</lei>
        <title>CEREVEL THERAPEUTICS HOLDINGS INC</title>
        <cusip>15678U128</cusip>
        <identifiers>
          <isin value="US15678U1280"/>
        </identifiers>
        <balance>947780.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22462386.00000000</valUSD>
        <pctVal>0.488944266343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTURY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CENTURY THERAPEUTICS INC</title>
        <cusip>15673T100</cusip>
        <identifiers>
          <isin value="US15673T1007"/>
        </identifiers>
        <balance>178881.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>443624.88000000</valUSD>
        <pctVal>0.009656491589</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REPLIMUNE GROUP INC</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>REPLIMUNE GROUP INC</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
        </identifiers>
        <balance>1164814.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23785501.88000000</valUSD>
        <pctVal>0.517744854278</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAGIMET BIOSCIENCES INC</name>
        <lei>2549002OT2F8BV0VPD02</lei>
        <title>SAGIMET BIOSCIENCES INC</title>
        <cusip>786700104</cusip>
        <identifiers>
          <isin value="US7867001049"/>
        </identifiers>
        <balance>145860.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1761988.80000000</valUSD>
        <pctVal>0.038353642445</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC PP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EDE963000"/>
        </identifiers>
        <balance>4740.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16827.00000000</valUSD>
        <pctVal>0.000366277436</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
        </identifiers>
        <balance>308185.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1926156.25000000</valUSD>
        <pctVal>0.041927115602</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHIMMUNE INC</name>
        <lei>N/A</lei>
        <title>MORPHIMMUNE INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Bloomberg" value="EQ0000000093235146"/>
        </identifiers>
        <balance>434782.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2383692.32000000</valUSD>
        <pctVal>0.051886415476</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMA INC</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>941151.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34624945.29000000</valUSD>
        <pctVal>0.753689678024</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALKERMES PLC</name>
        <lei>N/A</lei>
        <title>ALKERMES PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>568636.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16598484.84000000</valUSD>
        <pctVal>0.361303291311</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROCKET PHARMACEUTICALS INC</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>223736.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3501468.40000000</valUSD>
        <pctVal>0.076217321613</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SENSORION SA</name>
        <lei>969500P0W8XJ9CGZDP97</lei>
        <title>SENSORION SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
        </identifiers>
        <balance>1560440.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.92221146"/>
        <valUSD>1184444.18000000</valUSD>
        <pctVal>0.025782087023</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25582.09000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SELECTA BIOSCIENCES INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>SELECTA BIOSCIENCES INC</title>
        <cusip>816212104</cusip>
        <identifiers>
          <isin value="US8162121045"/>
        </identifiers>
        <balance>2421075.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2977922.25000000</valUSD>
        <pctVal>0.064821164134</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>373611.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10528357.98000000</valUSD>
        <pctVal>0.229173350877</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10526695.36000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MEDAVAIL HOLDINGS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
        </identifiers>
        <balance>2777.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>446.54000000</valUSD>
        <pctVal>0.000009719945</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>POSEIDA THERAPEUTICS INC</name>
        <lei>549300USKSDMNGMN8V04</lei>
        <title>POSEIDA THERAPEUTICS INC</title>
        <cusip>73730P108</cusip>
        <identifiers>
          <isin value="US73730P1084"/>
        </identifiers>
        <balance>570083.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1191473.47000000</valUSD>
        <pctVal>0.025935095303</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TYRA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC</title>
        <cusip>90240B106</cusip>
        <identifiers>
          <isin value="US90240B1061"/>
        </identifiers>
        <balance>309400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4712162.00000000</valUSD>
        <pctVal>0.102570786201</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INOZYME PHARMA INC</name>
        <lei>N/A</lei>
        <title>INOZYME PHARMA INC</title>
        <cusip>45790W108</cusip>
        <identifiers>
          <isin value="US45790W1080"/>
        </identifiers>
        <balance>2465187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12079416.30000000</valUSD>
        <pctVal>0.262935617821</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GDA208000"/>
        </identifiers>
        <balance>11945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>549.47000000</valUSD>
        <pctVal>0.000011960448</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
        </identifiers>
        <balance>11113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>245152.78000000</valUSD>
        <pctVal>0.005336300701</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>43708.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>380696.68000000</valUSD>
        <pctVal>0.008286718022</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SHATTUCK LABS INC</name>
        <lei>N/A</lei>
        <title>SHATTUCK LABS INC</title>
        <cusip>82024L103</cusip>
        <identifiers>
          <isin value="US82024L1035"/>
        </identifiers>
        <balance>110936.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>239621.76000000</valUSD>
        <pctVal>0.005215905631</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVIDITY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
        </identifiers>
        <balance>374450.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2830842.00000000</valUSD>
        <pctVal>0.061619632252</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
        </identifiers>
        <balance>493674.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4215975.96000000</valUSD>
        <pctVal>0.091770182948</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INHIBRX INC</name>
        <lei>549300VBKG2LTV1TLY22</lei>
        <title>INHIBRX INC</title>
        <cusip>45720L107</cusip>
        <identifiers>
          <isin value="US45720L1070"/>
        </identifiers>
        <balance>210609.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4507032.60000000</valUSD>
        <pctVal>0.098105684231</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1301120.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
        </identifiers>
        <balance>425448.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4679928.00000000</valUSD>
        <pctVal>0.101869140816</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>2277888.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8860984.32000000</valUSD>
        <pctVal>0.192879219394</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2344892.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TURNSTONE BIOLOGICS CORP</name>
        <lei>N/A</lei>
        <title>TURNSTONE BIOLOGICS CORP</title>
        <cusip>90042W100</cusip>
        <identifiers>
          <isin value="US90042W1009"/>
        </identifiers>
        <balance>185500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2001545.00000000</valUSD>
        <pctVal>0.043568121016</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC</title>
        <cusip>29337E102</cusip>
        <identifiers>
          <isin value="US29337E1029"/>
        </identifiers>
        <balance>197700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3088074.00000000</valUSD>
        <pctVal>0.067218864298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>FATE THERAPEUTICS INC</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>115887.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>290876.37000000</valUSD>
        <pctVal>0.006331577301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="290658.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRELUDE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
        </identifiers>
        <balance>748056.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2790248.88000000</valUSD>
        <pctVal>0.060736031851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
        </identifiers>
        <balance>542835.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18440104.95000000</valUSD>
        <pctVal>0.401390288016</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6918669.90000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
        </identifiers>
        <balance>1255346.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37547398.86000000</valUSD>
        <pctVal>0.817303441793</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5676918.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
        </identifiers>
        <balance>2927126.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4800486.64000000</valUSD>
        <pctVal>0.104493370307</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHRODINGER INC</name>
        <lei>N/A</lei>
        <title>SCHRODINGER INC</title>
        <cusip>80810D103</cusip>
        <identifiers>
          <isin value="US80810D1037"/>
        </identifiers>
        <balance>539101.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19887435.89000000</valUSD>
        <pctVal>0.432894695634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INCYTE CORP</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>123300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7956549.00000000</valUSD>
        <pctVal>0.173192153915</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
        </identifiers>
        <balance>1137580.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59063153.60000000</valUSD>
        <pctVal>1.285642153281</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JVT552000"/>
        </identifiers>
        <balance>432900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2861469.00000000</valUSD>
        <pctVal>0.062286297674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>648775.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73356989.25000000</valUSD>
        <pctVal>1.596779580316</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIRIDIAN THERAPEUTICS INC</name>
        <lei>549300C775BNYF550E70</lei>
        <title>VIRIDIAN THERAPEUTICS INC</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
        </identifiers>
        <balance>260700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4736919.00000000</valUSD>
        <pctVal>0.103109677893</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1996883.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TANGO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
        </identifiers>
        <balance>613088.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3978941.12000000</valUSD>
        <pctVal>0.086610587438</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REZOLUTE INC</name>
        <lei>549300T05L48T72P2G08</lei>
        <title>REZOLUTE INC</title>
        <cusip>76200L309</cusip>
        <identifiers>
          <isin value="US76200L3096"/>
        </identifiers>
        <balance>26700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38448.00000000</valUSD>
        <pctVal>0.000836907047</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="432.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CANDEL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CANDEL THERAPEUTICS INC</title>
        <cusip>137404109</cusip>
        <identifiers>
          <isin value="US1374041093"/>
        </identifiers>
        <balance>452557.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>552119.54000000</valUSD>
        <pctVal>0.012018121468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="80032.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>23ANDME HOLDING CO</name>
        <lei>N/A</lei>
        <title>23ANDME HOLDING CO CL A</title>
        <cusip>90138Q108</cusip>
        <identifiers>
          <isin value="US90138Q1085"/>
        </identifiers>
        <balance>298674.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>328541.40000000</valUSD>
        <pctVal>0.007151441248</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="277750.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MINERALYS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MINERALYS THERAPEUTICS INC</title>
        <cusip>603170101</cusip>
        <identifiers>
          <isin value="US6031701013"/>
        </identifiers>
        <balance>32500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>417300.00000000</valUSD>
        <pctVal>0.009083471468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
        </identifiers>
        <balance>584590.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10341397.10000000</valUSD>
        <pctVal>0.225103727539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERONA PHARMA PLC</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>VERONA PHARMA PLC ADR</title>
        <cusip>925050106</cusip>
        <identifiers>
          <isin value="US9250501064"/>
        </identifiers>
        <balance>1430301.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27790748.43000000</valUSD>
        <pctVal>0.604928038465</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0363463438"/>
        </identifiers>
        <balance>534309.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.88335000"/>
        <valUSD>2931184.03000000</valUSD>
        <pctVal>0.063803801834</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2429171.59000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC</title>
        <cusip>299734202</cusip>
        <identifiers>
          <isin value="US2997342025"/>
        </identifiers>
        <balance>13449.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>88897.89000000</valUSD>
        <pctVal>0.001935062179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="88574.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STRUCTURE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
        </identifiers>
        <balance>275597.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7769079.43000000</valUSD>
        <pctVal>0.169111457797</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1479975.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATEA PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ATEA PHARMACEUTICALS INC</title>
        <cusip>04683R106</cusip>
        <identifiers>
          <isin value="US04683R1068"/>
        </identifiers>
        <balance>66800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>224448.00000000</valUSD>
        <pctVal>0.004885614675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLOVIR INC</name>
        <lei>N/A</lei>
        <title>ALLOVIR INC</title>
        <cusip>019818103</cusip>
        <identifiers>
          <isin value="US0198181036"/>
        </identifiers>
        <balance>942101.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2948776.13000000</valUSD>
        <pctVal>0.064186733390</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="860750.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JXB346000"/>
        </identifiers>
        <balance>15715577.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47775354.08000000</valUSD>
        <pctVal>1.039937852102</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC SER B-1 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IFB620000"/>
        </identifiers>
        <balance>957854.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2385056.46000000</valUSD>
        <pctVal>0.051916109046</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANNEXON INC</name>
        <lei>N/A</lei>
        <title>ANNEXON INC</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
        </identifiers>
        <balance>106806.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>293716.50000000</valUSD>
        <pctVal>0.006393399107</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN INC</name>
        <lei>N/A</lei>
        <title>ACELYRIN INC</title>
        <cusip>00445A100</cusip>
        <identifiers>
          <isin value="US00445A1007"/>
        </identifiers>
        <balance>8700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>220371.00000000</valUSD>
        <pctVal>0.004796869616</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERRICA PHARMACEUTICALS INC</name>
        <lei>5493002L68H6THU5GW50</lei>
        <title>VERRICA PHARMACEUTICALS INC</title>
        <cusip>92511W108</cusip>
        <identifiers>
          <isin value="US92511W1080"/>
        </identifiers>
        <balance>1504676.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6846275.80000000</valUSD>
        <pctVal>0.149024564808</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2572046.75000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
        <title>EQRX INC 2 YR EARNOUT (CVR) RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IFC139000"/>
        </identifiers>
        <balance>49993.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7498.95000000</valUSD>
        <pctVal>0.000163231484</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROIVANT SCIENCES LTD</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>ROIVANT SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
        </identifiers>
        <balance>4662519.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53945344.83000000</valUSD>
        <pctVal>1.174241554327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="22099857.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IKENA ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>IKENA ONCOLOGY INC</title>
        <cusip>45175G108</cusip>
        <identifiers>
          <isin value="US45175G1085"/>
        </identifiers>
        <balance>539627.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2503869.28000000</valUSD>
        <pctVal>0.054502336845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN INC</name>
        <lei>N/A</lei>
        <title>ACELYRIN INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JPJ013000"/>
        </identifiers>
        <balance>146574.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3350730.01000000</valUSD>
        <pctVal>0.072936162100</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARUNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
        </identifiers>
        <balance>327042.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61405405.92000000</valUSD>
        <pctVal>1.336626534112</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AEROVATE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>AEROVATE THERAPEUTICS INC</title>
        <cusip>008064107</cusip>
        <identifiers>
          <isin value="US0080641071"/>
        </identifiers>
        <balance>345151.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5484449.39000000</valUSD>
        <pctVal>0.119381355270</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1317281.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
        </identifiers>
        <balance>459213.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9101601.66000000</valUSD>
        <pctVal>0.198116796060</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VENTYX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>VENTYX BIOSCIENCES INC</title>
        <cusip>92332V107</cusip>
        <identifiers>
          <isin value="US92332V1070"/>
        </identifiers>
        <balance>573852.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19224042.00000000</valUSD>
        <pctVal>0.418454438092</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
        </identifiers>
        <balance>869471.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30379316.74000000</valUSD>
        <pctVal>0.661274039874</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9475728.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATYR PHARMA INC</name>
        <lei>529900ENQUXMC5EBKO36</lei>
        <title>ATYR PHARMA INC</title>
        <cusip>002120202</cusip>
        <identifiers>
          <isin value="US0021202025"/>
        </identifiers>
        <balance>2258063.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3838707.10000000</valUSD>
        <pctVal>0.083558079124</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATIONAL RESILIENCE INC</name>
        <lei>N/A</lei>
        <title>NATIONAL RESILIENCE INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GII424000"/>
        </identifiers>
        <balance>732064.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44458246.72000000</valUSD>
        <pctVal>0.967733562472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP WT 12/31/2025 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JJW836000"/>
        </identifiers>
        <balance>17850.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31019.13000000</valUSD>
        <pctVal>0.000675201012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALECTOR INC</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>ALECTOR INC</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
        </identifiers>
        <balance>1962455.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10695379.75000000</valUSD>
        <pctVal>0.232808954717</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARISTEA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARISTEA THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GGH900000"/>
        </identifiers>
        <balance>836400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4608564.00000000</valUSD>
        <pctVal>0.100315743121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMBRX BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>AMBRX BIOPHARMA INC ADR</title>
        <cusip>02290A102</cusip>
        <identifiers>
          <isin value="US02290A1025"/>
        </identifiers>
        <balance>1297308.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18317988.96000000</valUSD>
        <pctVal>0.398732159305</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="216036.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORAGENICS INC</name>
        <lei>549300639MGD19K4ZW90</lei>
        <title>ORAGENICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="684023922"/>
        </identifiers>
        <balance>2597.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9349.20000000</valUSD>
        <pctVal>0.000203506329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
        </identifiers>
        <balance>6599395.75700000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6600715.64000000</valUSD>
        <pctVal>0.143679396567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
        </identifiers>
        <balance>585633.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2547503.55000000</valUSD>
        <pctVal>0.055452134704</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="137460.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
        </identifiers>
        <balance>659409.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64635270.18000000</valUSD>
        <pctVal>1.406931781782</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
        </identifiers>
        <balance>826116.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57299405.76000000</valUSD>
        <pctVal>1.247250221380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
        </identifiers>
        <balance>3436606.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8350952.58000000</valUSD>
        <pctVal>0.181777233393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RECURSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>RECURSION PHARMACEUTICALS INC</title>
        <cusip>75629V104</cusip>
        <identifiers>
          <isin value="US75629V1044"/>
        </identifiers>
        <balance>149900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1304130.00000000</valUSD>
        <pctVal>0.028387317628</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1025730.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VOR BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>VOR BIOPHARMA INC</title>
        <cusip>929033108</cusip>
        <identifiers>
          <isin value="US9290331084"/>
        </identifiers>
        <balance>1114702.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2786755.00000000</valUSD>
        <pctVal>0.060659979708</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1943000.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALPINE IMMUNE SCIENCES INC</name>
        <lei>5493000845S6RLSDWJ40</lei>
        <title>ALPINE IMMUNE SCIENCES INC</title>
        <cusip>02083G100</cusip>
        <identifiers>
          <isin value="US02083G1004"/>
        </identifiers>
        <balance>163100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2014285.00000000</valUSD>
        <pctVal>0.043845435722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COMPASS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>COMPASS THERAPEUTICS INC</title>
        <cusip>20454B104</cusip>
        <identifiers>
          <isin value="US20454B1044"/>
        </identifiers>
        <balance>563400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1312722.00000000</valUSD>
        <pctVal>0.028574341799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1119099.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGULUS THERAPEUTICS INC</name>
        <lei>529900ZYH2KYFH6Z7098</lei>
        <title>REGULUS THERAPEUTICS INC</title>
        <cusip>75915K309</cusip>
        <identifiers>
          <isin value="US75915K3095"/>
        </identifiers>
        <balance>2206600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3442296.00000000</valUSD>
        <pctVal>0.074929301466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25272.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>584109.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>203468529.06000000</valUSD>
        <pctVal>4.428949385216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HAD933000"/>
        </identifiers>
        <balance>3099905.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4804852.75000000</valUSD>
        <pctVal>0.104588408494</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOHAVEN LTD</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
        </identifiers>
        <balance>2300704.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42079876.16000000</valUSD>
        <pctVal>0.915962987051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15575837.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
        <cusip>05454B105</cusip>
        <identifiers>
          <isin value="US05454B1052"/>
        </identifiers>
        <balance>1661354.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>383772.77000000</valUSD>
        <pctVal>0.008353676028</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="112381.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
        </identifiers>
        <balance>426932.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25073716.36000000</valUSD>
        <pctVal>0.545785734878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC WT 11/23/27</title>
        <cusip>68404V118</cusip>
        <identifiers>
          <isin value="US68404V1180"/>
        </identifiers>
        <balance>91712.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24584.01000000</valUSD>
        <pctVal>0.000535126176</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PHARVARIS BV</name>
        <lei>9845003BE146D3B75D32</lei>
        <title>PHARVARIS BV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
        </identifiers>
        <balance>353507.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7246893.50000000</valUSD>
        <pctVal>0.157744908560</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>189208.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34057440.00000000</valUSD>
        <pctVal>0.741336651161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>60900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5095503.00000000</valUSD>
        <pctVal>0.110915063786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ICOSAVAX INC</name>
        <lei>N/A</lei>
        <title>ICOSAVAX INC</title>
        <cusip>45114M109</cusip>
        <identifiers>
          <isin value="US45114M1099"/>
        </identifiers>
        <balance>403331.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3121781.94000000</valUSD>
        <pctVal>0.067952593296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TANGO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JWW429000"/>
        </identifiers>
        <balance>466637.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2725626.72000000</valUSD>
        <pctVal>0.059329385441</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>1141944.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45106788.00000000</valUSD>
        <pctVal>0.981850519609</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC</title>
        <cusip>192010106</cusip>
        <identifiers>
          <isin value="US1920101060"/>
        </identifiers>
        <balance>448539.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4.49000000</valUSD>
        <pctVal>0.000000097734</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="0.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WEREWOLF THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>WEREWOLF THERAPEUTICS INC</title>
        <cusip>95075A107</cusip>
        <identifiers>
          <isin value="US95075A1079"/>
        </identifiers>
        <balance>2100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5754.00000000</valUSD>
        <pctVal>0.000125248729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BICYCLE THERAPEUTICS PLC</name>
        <lei>213800XKUI6R7GKC3E43</lei>
        <title>BICYCLE THERAPEUTICS LTD ADR</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
        </identifiers>
        <balance>266347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5790383.78000000</valUSD>
        <pctVal>0.126040704186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="789162.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEERING CORP</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
        </identifiers>
        <balance>611885.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5513083.85000000</valUSD>
        <pctVal>0.120004648585</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2296649.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
        <title>ARCELLX INC</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
        </identifiers>
        <balance>1359901.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48738851.84000000</valUSD>
        <pctVal>1.060910544201</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="71.68000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DAY ONE BIOPHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC</title>
        <cusip>23954D109</cusip>
        <identifiers>
          <isin value="US23954D1090"/>
        </identifiers>
        <balance>446133.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6018334.17000000</valUSD>
        <pctVal>0.131002556244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
        </identifiers>
        <balance>474277.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.92221146"/>
        <valUSD>42582571.68000000</valUSD>
        <pctVal>0.926905283752</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BEIGENE LTD</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD SP ADR</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
        </identifiers>
        <balance>37198.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7720444.90000000</valUSD>
        <pctVal>0.168052818052</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
        </identifiers>
        <balance>808003.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21016158.03000000</valUSD>
        <pctVal>0.457463867343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9353196.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
        </identifiers>
        <balance>196013.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2234548.20000000</valUSD>
        <pctVal>0.048639958829</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SERES THERAPEUTICS INC</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>SERES THERAPEUTICS INC</title>
        <cusip>81750R102</cusip>
        <identifiers>
          <isin value="US81750R1023"/>
        </identifiers>
        <balance>854347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2947497.15000000</valUSD>
        <pctVal>0.064158893518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17250.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JLJ198000"/>
        </identifiers>
        <balance>54800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1389837.60000000</valUSD>
        <pctVal>0.030252935982</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM BIOSCIENCES INC</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
        </identifiers>
        <balance>2134682.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15262976.30000000</valUSD>
        <pctVal>0.332232949305</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7908615.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>799548.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>158166585.36000000</valUSD>
        <pctVal>3.442850863611</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
        </identifiers>
        <balance>110925.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4021031.25000000</valUSD>
        <pctVal>0.087526773623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DK0060257814"/>
        </identifiers>
        <balance>718902.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.87310000"/>
        <valUSD>26860373.57000000</valUSD>
        <pctVal>0.584676340656</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LEXICON PHARMACEUTICALS INC</title>
        <cusip>528872302</cusip>
        <identifiers>
          <isin value="US5288723027"/>
        </identifiers>
        <balance>1087400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1870328.00000000</valUSD>
        <pctVal>0.040711888388</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1870156.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>CORCEPT THERAPEUTICS INC</title>
        <cusip>218352102</cusip>
        <identifiers>
          <isin value="US2183521028"/>
        </identifiers>
        <balance>516336.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16899677.28000000</valUSD>
        <pctVal>0.367859421038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
        </identifiers>
        <balance>310422924.83300000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>310453967.13000000</valUSD>
        <pctVal>6.757727660442</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="310453967.13000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC WT 09/15/2027</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JLL163000"/>
        </identifiers>
        <balance>46000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.46000000</valUSD>
        <pctVal>0.000000010012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOVANT INC</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
        </identifiers>
        <balance>361241.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8203783.11000000</valUSD>
        <pctVal>0.178573759437</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
        </identifiers>
        <balance>869513.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16590308.04000000</valUSD>
        <pctVal>0.361125304899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5899536.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC</title>
        <cusip>68404V100</cusip>
        <identifiers>
          <isin value="US68404V1008"/>
        </identifiers>
        <balance>794031.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>944896.89000000</valUSD>
        <pctVal>0.020567802398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13090.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRATI THERAPEUTICS INC</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>213741.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7951165.20000000</valUSD>
        <pctVal>0.173074963420</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
        </identifiers>
        <balance>1112850.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25795863.00000000</valUSD>
        <pctVal>0.561504877942</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8873304.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
        </identifiers>
        <balance>961033.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37461066.34000000</valUSD>
        <pctVal>0.815424220652</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
        </identifiers>
        <balance>289228.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5692007.04000000</valUSD>
        <pctVal>0.123899313554</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="309684.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR THERAPEUTICS AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR THERAPEUTICS AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>242822.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12143528.22000000</valUSD>
        <pctVal>0.264331157711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12142428.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>COGENT BIOSCIENCES INC</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
        </identifiers>
        <balance>170618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2083245.78000000</valUSD>
        <pctVal>0.045346521937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
        </identifiers>
        <balance>314169.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7254162.21000000</valUSD>
        <pctVal>0.157903128354</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC</title>
        <cusip>23255M204</cusip>
        <identifiers>
          <isin value="US23255M2044"/>
        </identifiers>
        <balance>41864.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>148617.20000000</valUSD>
        <pctVal>0.003234987049</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4260.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRITSTONE BIO INC</name>
        <lei>5493003TER6KY3MUVY84</lei>
        <title>GRITSTONE BIO INC</title>
        <cusip>39868T105</cusip>
        <identifiers>
          <isin value="US39868T1051"/>
        </identifiers>
        <balance>669785.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1219008.70000000</valUSD>
        <pctVal>0.026534461409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="62244.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>407692.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8924377.88000000</valUSD>
        <pctVal>0.194259122566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
        <title>EQRX INC</title>
        <cusip>26886C107</cusip>
        <identifiers>
          <isin value="US26886C1071"/>
        </identifiers>
        <balance>507567.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1162328.43000000</valUSD>
        <pctVal>0.025300688068</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>303121.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23182694.08000000</valUSD>
        <pctVal>0.504623389020</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JPE358000"/>
        </identifiers>
        <balance>1555907.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15.56000000</valUSD>
        <pctVal>0.000000338698</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALX ONCOLOGY HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ALX ONCOLOGY HOLDINGS INC</title>
        <cusip>00166B105</cusip>
        <identifiers>
          <isin value="US00166B1052"/>
        </identifiers>
        <balance>1136549.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4841698.74000000</valUSD>
        <pctVal>0.105390444197</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
        </identifiers>
        <balance>811647.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2597270.40000000</valUSD>
        <pctVal>0.056535421937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="697280.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
        <lei>549300749HO5QS40BX97</lei>
        <title>ALLENA PHARMACEUTICALS INC</title>
        <cusip>018119107</cusip>
        <identifiers>
          <isin value="US0181191075"/>
        </identifiers>
        <balance>93683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9.37000000</valUSD>
        <pctVal>0.000000203959</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
        </identifiers>
        <balance>417052.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5759488.12000000</valUSD>
        <pctVal>0.125368190776</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
        </identifiers>
        <balance>265356.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6087266.64000000</valUSD>
        <pctVal>0.132503026229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOMEA FUSION INC</name>
        <lei>N/A</lei>
        <title>BIOMEA FUSION INC</title>
        <cusip>09077A106</cusip>
        <identifiers>
          <isin value="US09077A1060"/>
        </identifiers>
        <balance>392829.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6627025.23000000</valUSD>
        <pctVal>0.144252083866</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="393071.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
        </identifiers>
        <balance>609953.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13644648.61000000</valUSD>
        <pctVal>0.297006413482</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2424908.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
        </identifiers>
        <balance>755200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21070080.00000000</valUSD>
        <pctVal>0.458637600092</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELEVATEBIO, LLC</name>
        <lei>N/A</lei>
        <title>ELEVATEBIO LLC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HCJ459000"/>
        </identifiers>
        <balance>216600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>903222.00000000</valUSD>
        <pctVal>0.019660654844</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>987777.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39777779.79000000</valUSD>
        <pctVal>0.865852690635</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18673199.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>218574.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9960417.18000000</valUSD>
        <pctVal>0.216810844161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
        </identifiers>
        <balance>1257805.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7383315.35000000</valUSD>
        <pctVal>0.160714436435</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>3193396.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65464618.00000000</valUSD>
        <pctVal>1.424984399228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4067200.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>904630.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27455520.50000000</valUSD>
        <pctVal>0.597631049878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7836370.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT THERAPEUTICS INC</name>
        <lei>549300MB473BIU78ES48</lei>
        <title>RAPT THERAPEUTICS INC</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
        </identifiers>
        <balance>872800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16670480.00000000</valUSD>
        <pctVal>0.362870427620</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FULCRUM THERAPEUTICS INC</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>1777797.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9831217.41000000</valUSD>
        <pctVal>0.213998521074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="253274.00000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2023-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
