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      <invstOrSec>
        <name>SUTRO BIOPHARMA INC</name>
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      <invstOrSec>
        <name>AURA BIOSCIENCES INC</name>
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        <name>TWIST BIOSCIENCE CORP</name>
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        <name>AMGEN INC</name>
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        <name>HOMOLOGY MEDICINES INC</name>
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      </invstOrSec>
      <invstOrSec>
        <name>ADVERUM BIOTECHNOLOGIES INC</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
        <title>ADVERUM BIOTECHNOLOGIES INC</title>
        <cusip>00773U108</cusip>
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          <isin value="US00773U1088"/>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>GRAPHITE BIO INC</name>
        <lei>N/A</lei>
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        <cusip>38870X104</cusip>
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          <isin value="US38870X1046"/>
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        <balance>1312653.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
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          <isin value="US1523091007"/>
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        <curCd>USD</curCd>
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        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US3441741077"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ADC THERAPEUTICS SA</name>
        <lei>N/A</lei>
        <title>ADC THERAPEUTICS SA</title>
        <cusip>N/A</cusip>
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          <isin value="CH0499880968"/>
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        <curCd>USD</curCd>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>23ANDME HOLDING CO</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal" value="IFA467000"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FUSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KINNATE BIOPHARMA INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>XENCOR INC</name>
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        <title>XENCOR INC</title>
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          <isin value="US98401F1057"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KEZAR LIFE SCIENCES INC</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>TREVI THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>CRINETICS PHARMACEUTICALS INC</name>
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        <name>ABSCI CORP</name>
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        <name>TENAYA THERAPEUTICS INC</name>
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        <name>ENANTA PHARMACEUTICALS INC</name>
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        <name>IVERIC BIO INC</name>
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        <name>THESEUS PHARMACEUTICALS INC</name>
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        </securityLending>
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        <name>INTRA-CELLULAR THERAPIES INC</name>
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        <name>GERON CORP</name>
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        <name>ITEOS THERAPEUTICS INC</name>
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        <name>BIO AB HOLDINGS LLC</name>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS LTD ADR</title>
        <cusip>45258D105</cusip>
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          <isin value="US45258D1054"/>
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        <balance>324318.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ACLARIS THERAPEUTICS INC</name>
        <lei>5493000B2LQ9QTW1DF52</lei>
        <title>ACLARIS THERAPEUTICS INC</title>
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          <isin value="US00461U1051"/>
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        <balance>435589.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="AIA874000"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PLIANT THERAPEUTICS INC</name>
        <lei>5493002Q5LITR7VHZH02</lei>
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          <isin value="US7291391057"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VALENZABIO INC</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal" value="HDH471000"/>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
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        <title>INTELLIA THERAPEUTICS INC</title>
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          <isin value="US45826J1051"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
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          <isin value="US75886F1075"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RALLYBIO CORP</name>
        <lei>N/A</lei>
        <title>RALLYBIO CORP</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALTIMMUNE INC</name>
        <lei>549300EOYCQ8SW3NVE64</lei>
        <title>ALTIMMUNE INC</title>
        <cusip>02155H200</cusip>
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          <isin value="US02155H2004"/>
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        <balance>40469.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SALIOGEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SALIOGEN THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="IEH140000"/>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>ROIVANT SCIENCES LTD</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>ROIVANT SCIENCES LTD PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HFC838000"/>
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        <balance>2500000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8900000.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>BM</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SURFACE ONCOLOGY INC</name>
        <lei>549300FCSG6MNIMFH738</lei>
        <title>SURFACE ONCOLOGY INC</title>
        <cusip>86877M209</cusip>
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          <isin value="US86877M2098"/>
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        <balance>144645.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
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        <identifiers>
          <other otherDesc="Internal" value="IFC137000"/>
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        <balance>116649.00000000</balance>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>OMEGA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>OMEGA THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AKOUOS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>BIOMARIN PHARMACEUTICAL INC</name>
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        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
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        <name>ZENTALIS PHARMACEUTICALS INC</name>
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        <name>VERVE THERAPEUTICS INC</name>
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        <name>ALDEYRA THERAPEUTICS INC</name>
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        <name>PROTHENA CORP PLC</name>
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        <title>PROTHENA CORP PLC</title>
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        <invCountry>IE</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>AMYLYX PHARMACEUTICALS INC</name>
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        <name>KALEIDO BIOSCIENCES INC</name>
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        <title>KALEIDO BIOSCIENCES INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
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        <balance>681036.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC</title>
        <cusip>04280A100</cusip>
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          <isin value="US04280A1007"/>
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        <balance>2336532.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
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          <isin value="US5011471027"/>
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        <balance>2105960.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
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        <cusip>04335A105</cusip>
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          <isin value="US04335A1051"/>
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        <balance>742119.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GH RESEARCH PLC</name>
        <lei>875500HKJS7QQG6EWH62</lei>
        <title>GH RESEARCH PLC</title>
        <cusip>N/A</cusip>
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          <isin value="IE000GID8VI0"/>
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        <balance>1388224.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OLINK HOLDING AB</name>
        <lei>8945004Z7ZHV3LML4J27</lei>
        <title>OLINK HOLDING AB ADR</title>
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          <isin value="US6807101000"/>
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        <balance>57100.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>SE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC CL A WT 04/16/2024</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="038505921"/>
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        <balance>148009.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SANA BIOTECHNOLOGY INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
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        <title>MINERVA NEUROSCIENCES INC</title>
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        <balance>28272.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>EVOTEC SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>EVOTEC SE</title>
        <cusip>N/A</cusip>
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          <isin value="DE0005664809"/>
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        <balance>153400.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LONGBOARD PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>10X GENOMICS INC</name>
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        <title>10X GENOMICS INC</title>
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        <balance>15719.00000000</balance>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SILVERBACK THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SILVERBACK THERAPEUTICS INC</title>
        <cusip>82835W108</cusip>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MARINUS PHARMACEUTICALS INC</name>
        <lei>549300NCT4OJF7JV1084</lei>
        <title>MARINUS PHARMACEUTICALS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KEROS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KEROS THERAPEUTICS</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>ROYALTY PHARMA PLC</title>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>GENERATION BIO CO</name>
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        <title>GENERATION BIO</title>
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        <fairValLevel>1</fairValLevel>
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        <name>CEREVEL THERAPEUTICS HOLDINGS INC</name>
        <lei>254900RJNIRS9COSQR41</lei>
        <title>CEREVEL THERAPEUTICS HOLDINGS INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>INSTIL BIO INC</name>
        <lei>N/A</lei>
        <title>INSTIL BIO INC</title>
        <cusip>45783C101</cusip>
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        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7514384.80000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CENTURY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CENTURY THERAPEUTICS INC</title>
        <cusip>15673T100</cusip>
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          <isin value="US15673T1007"/>
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        <balance>834618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8780181.36000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="999400.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TRICIDA INC</name>
        <lei>549300QVPFFJC8SZXG25</lei>
        <title>TRICIDA INC</title>
        <cusip>89610F101</cusip>
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          <isin value="US89610F1012"/>
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        <balance>178300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2232316.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="485776.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>REPLIMUNE GROUP INC</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>REPLIMUNE GROUP INC</title>
        <cusip>76029N106</cusip>
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          <isin value="US76029N1063"/>
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        <balance>1080217.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="224298.08000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>SEAGEN INC</name>
        <lei>N/A</lei>
        <title>SEAGEN INC</title>
        <cusip>81181C104</cusip>
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          <isin value="US81181C1045"/>
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        <balance>828539.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS LTD</name>
        <lei>N/A</lei>
        <title>KINIKSA PHARMACEUTICALS LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG5269C1010"/>
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        <balance>192666.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="255496.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC PP PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="EDE963000"/>
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        <balance>94809.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DICE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DICE MOLECULES HOLDING LLC</title>
        <cusip>23345J104</cusip>
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          <isin value="US23345J1043"/>
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        <balance>294700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
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          <isin value="US28036F1057"/>
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        <balance>724054.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DESIGN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DESIGN THERAPEUTICS INC</title>
        <cusip>25056L103</cusip>
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          <isin value="US25056L1035"/>
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        <balance>1024935.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="6225898.00000000"/>
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      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMA INC</title>
        <cusip>90400D108</cusip>
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          <isin value="US90400D1081"/>
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        <balance>978351.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46657559.19000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ALKERMES PLC</name>
        <lei>N/A</lei>
        <title>ALKERMES PLC</title>
        <cusip>N/A</cusip>
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          <isin value="IE00B56GVS15"/>
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        <balance>893536.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>21149997.12000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ROCKET PHARMACEUTICALS INC</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC</title>
        <cusip>77313F106</cusip>
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          <isin value="US77313F1066"/>
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        <balance>223736.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SENSORION SA</name>
        <lei>969500P0W8XJ9CGZDP97</lei>
        <title>SENSORION SA</title>
        <cusip>N/A</cusip>
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          <isin value="FR0012596468"/>
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        <balance>2378022.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>FR</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SELECTA BIOSCIENCES INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>SELECTA BIOSCIENCES INC</title>
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        <balance>1032715.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ATARA BIOTHERAPEUTICS INC</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>ATARA BIOTHERAPEUTICS INC</title>
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        <balance>82240.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <balance>443611.00000000</balance>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MYOS CORP PIPE</title>
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        <fairValLevel>1</fairValLevel>
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        <name>GUARDANT HEALTH INC</name>
        <lei>254900M8C3E5VC8BR186</lei>
        <title>GUARDANT HEALTH INC</title>
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        <balance>82500.00000000</balance>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>POSEIDA THERAPEUTICS INC</name>
        <lei>549300USKSDMNGMN8V04</lei>
        <title>POSEIDA THERAPEUTICS INC</title>
        <cusip>73730P108</cusip>
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        <balance>570083.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TYRA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC</title>
        <cusip>90240B106</cusip>
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        <balance>472301.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NEXIMMUNE INC</name>
        <lei>5493005RDYAV26LAQ930</lei>
        <title>NEXIMMUNE INC</title>
        <cusip>65344D109</cusip>
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        <balance>525000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>INOZYME PHARMA INC</name>
        <lei>N/A</lei>
        <title>INOZYME PHARMA INC</title>
        <cusip>45790W108</cusip>
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        <balance>609380.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1828140.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>CHINOOK THERAPEUTICS INC</title>
        <cusip>16961L106</cusip>
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        <balance>352081.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7323284.80000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GDA208000"/>
        </identifiers>
        <balance>11945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>549.47000000</valUSD>
        <pctVal>0.000010522293</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
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        <balance>11113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>912710.69000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>255608.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4994580.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SHATTUCK LABS INC</name>
        <lei>N/A</lei>
        <title>SHATTUCK LABS INC</title>
        <cusip>82024L103</cusip>
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          <isin value="US82024L1035"/>
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        <balance>110936.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>360542.00000000</valUSD>
        <pctVal>0.006904341789</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVIDITY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
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        <balance>279484.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5483476.08000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2505650.58000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
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        <balance>195228.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28237777.92000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
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        <balance>948574.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>25564069.30000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Y-MABS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>Y-MABS THERAPEUTICS INC</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
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        <balance>1740751.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>27991276.08000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LYELL IMMUNOPHARMA INC</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC</title>
        <cusip>55083R104</cusip>
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          <isin value="US55083R1041"/>
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        <balance>362253.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INHIBRX INC</name>
        <lei>549300VBKG2LTV1TLY22</lei>
        <title>INHIBRX INC</title>
        <cusip>45720L107</cusip>
        <identifiers>
          <isin value="US45720L1070"/>
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        <balance>188726.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3347999.24000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="2747926.00000000"/>
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      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
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        <balance>742948.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8038697.36000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
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        <balance>1318870.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>18081707.70000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PMV PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>PMV PHARMACEUTICALS INC</title>
        <cusip>69353Y103</cusip>
        <identifiers>
          <isin value="US69353Y1038"/>
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        <balance>772700.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>10755984.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>FATE THERAPEUTICS INC</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
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        <balance>690487.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>18049330.18000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RELAY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
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        <balance>928789.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>21334283.33000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PRELUDE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC</title>
        <cusip>74065P101</cusip>
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        <balance>359156.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
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        <balance>579072.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>CINCOR PHARMA INC</name>
        <lei>N/A</lei>
        <title>CINCOR PHARMA INC</title>
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        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>SCHRODINGER INC</name>
        <lei>N/A</lei>
        <title>SCHRODINGER INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC WT</title>
        <cusip>N/A</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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        <name>INCYTE CORP</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP</title>
        <cusip>45337C102</cusip>
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        <balance>327400.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
        </identifiers>
        <balance>580989.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15198672.24000000</valUSD>
        <pctVal>0.291052992141</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>292793.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38727730.11000000</valUSD>
        <pctVal>0.741632002413</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC PHARMACEUTICALS INC</name>
        <lei>54930033FJRNEYBW0L25</lei>
        <title>ORIC PHARMACEUTICALS INC</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
        </identifiers>
        <balance>318846.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1103207.16000000</valUSD>
        <pctVal>0.021126302337</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HORIZON THERAPEUTICS PLC</name>
        <lei>N/A</lei>
        <title>HORIZON THERAPEUTICS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
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        <balance>1387953.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82180697.13000000</valUSD>
        <pctVal>1.573751800044</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>YUMANITY THERAPEUTICS INC</name>
        <lei>549300GNQLMQP5WNHC81</lei>
        <title>YUMANITY THERAPEUTICS INC</title>
        <cusip>98872L102</cusip>
        <identifiers>
          <isin value="US98872L1026"/>
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        <balance>260182.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>444911.22000000</valUSD>
        <pctVal>0.008520003574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIOINVENT INTERNATIONAL AB</name>
        <lei>549300E7QRHEF2IJUY10</lei>
        <title>BIOINVENT AB</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SE0015244520"/>
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        <balance>929048.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="SEK" exchangeRt="10.66000000"/>
        <valUSD>4043886.23000000</valUSD>
        <pctVal>0.077440000582</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TANGO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
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        <balance>927488.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3802700.80000000</valUSD>
        <pctVal>0.072821324690</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROMETHEUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>PROMETHEUS BIOSCIENCES INC</title>
        <cusip>74349U108</cusip>
        <identifiers>
          <isin value="US74349U1088"/>
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        <balance>391755.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20492704.05000000</valUSD>
        <pctVal>0.392433150517</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10498617.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>ALPHA TAU MEDICAL LTD</name>
        <lei>N/A</lei>
        <title>ALPHA TAU MEDICAL LTD CL A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0011839383"/>
        </identifiers>
        <balance>308578.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2428508.86000000</valUSD>
        <pctVal>0.046505692009</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1762093.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>JOUNCE THERAPEUTICS INC</name>
        <lei>5493004MZJQIV2K8ZT61</lei>
        <title>JOUNCE THERAPEUTICS INC</title>
        <cusip>481116101</cusip>
        <identifiers>
          <isin value="US4811161011"/>
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        <balance>769979.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2818123.14000000</valUSD>
        <pctVal>0.053966764936</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CANDEL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CANDEL THERAPEUTICS INC</title>
        <cusip>137404109</cusip>
        <identifiers>
          <isin value="US1374041093"/>
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        <balance>899399.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3120914.53000000</valUSD>
        <pctVal>0.059765188552</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="32965.00000000"/>
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      <invstOrSec>
        <name>GALAPAGOS NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS GENOMICS NV SPON AR</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
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        <balance>53743.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2690374.58000000</valUSD>
        <pctVal>0.051520393303</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
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        <balance>779768.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16944358.64000000</valUSD>
        <pctVal>0.324482705082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>VERONA PHARMA PLC</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>VERONA PHARMA PLC ADR</title>
        <cusip>925050106</cusip>
        <identifiers>
          <isin value="US9250501064"/>
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        <balance>413400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4307628.00000000</valUSD>
        <pctVal>0.082490628038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="812760.00000000"/>
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      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0363463438"/>
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        <balance>1371271.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.97750000"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="20814975.96000000"/>
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      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC</title>
        <cusip>299734103</cusip>
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          <isin value="US2997341035"/>
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        <balance>1098999.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2406807.81000000</valUSD>
        <pctVal>0.046090119159</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INHIBIKASE THERAPEUTICS INC</name>
        <lei>549300066CFEWOA17F12</lei>
        <title>INHIBIKASE THERAPEUTICS INC</title>
        <cusip>45719W106</cusip>
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          <isin value="US45719W1062"/>
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        <balance>433300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>415794.68000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CYTEIR THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYTEIR THERAPEUTICS INC</title>
        <cusip>23284P103</cusip>
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          <isin value="US23284P1030"/>
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        <balance>484023.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ATEA PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ATEA PHARMACEUTICALS INC</title>
        <cusip>04683R106</cusip>
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          <isin value="US04683R1068"/>
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        <balance>66800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>501000.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ALLOVIR INC</name>
        <lei>N/A</lei>
        <title>ALLOVIR INC</title>
        <cusip>019818103</cusip>
        <identifiers>
          <isin value="US0198181036"/>
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        <balance>1067983.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8020552.33000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC SER B-1 PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="IFB620000"/>
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        <balance>957854.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1829501.14000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>VERRICA PHARMACEUTICALS INC</name>
        <lei>5493002L68H6THU5GW50</lei>
        <title>VERRICA PHARMACEUTICALS INC</title>
        <cusip>92511W108</cusip>
        <identifiers>
          <isin value="US92511W1080"/>
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        <balance>1597876.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6263673.92000000</valUSD>
        <pctVal>0.119948703901</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="322616.00000000"/>
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      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
        <title>EQRX INC 2 YR EARNOUT (CVR) RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IFC139000"/>
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        <balance>49993.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>132981.38000000</valUSD>
        <pctVal>0.002546579591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PRECIPIO INC</name>
        <lei>54930079ULTBRXUQNR89</lei>
        <title>PRECIPIO INC</title>
        <cusip>74019L503</cusip>
        <identifiers>
          <isin value="US74019L5030"/>
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        <balance>525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>619.50000000</valUSD>
        <pctVal>0.000011863360</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

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      <invstOrSec>
        <name>HOOKIPA PHARMA INC</name>
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      <invstOrSec>
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        <name>WAVE LIFE SCIENCES LTD</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
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          <isin value="US52490G1022"/>
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        <balance>1207675.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>56144810.75000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>4D MOLECULAR THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>4D MOLECULAR THERAPEUTICS INC</title>
        <cusip>35104E100</cusip>
        <identifiers>
          <isin value="US35104E1001"/>
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        <balance>197868.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1555242.48000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="984072.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>ANTENGENE CORP LTD</name>
        <lei>655600N0NSGOMS4CVH68</lei>
        <title>ANTENGENE CORP LTD</title>
        <cusip>N/A</cusip>
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          <isin value="KYG039571008"/>
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        <balance>318671.00000000</balance>
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        <currencyConditional curCd="HKD" exchangeRt="7.84870000"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
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          <isin value="US3741631036"/>
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        <balance>189606.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>500559.84000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RECURSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>RECURSION PHARMACEUTICALS INC</title>
        <cusip>75629V104</cusip>
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          <isin value="US75629V1044"/>
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        <balance>89200.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>937492.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="436165.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>VOR BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>VOR BIOPHARMA INC</title>
        <cusip>929033108</cusip>
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          <isin value="US9290331084"/>
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        <balance>696659.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="1879119.00000000"/>
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      <invstOrSec>
        <name>ADICET BIO INC</name>
        <lei>549300VRD2QO80WBOP18</lei>
        <title>ADICET BIO INC</title>
        <cusip>007002108</cusip>
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          <isin value="US0070021086"/>
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        <balance>807861.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11439311.76000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>COMPASS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>COMPASS THERAPEUTICS INC</title>
        <cusip>20454B104</cusip>
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          <isin value="US20454B1044"/>
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        <balance>2750000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7562500.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RAIN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RAIN THERAPEUTICS INC</title>
        <cusip>75082Q105</cusip>
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          <isin value="US75082Q1058"/>
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        <balance>341004.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="106740.00000000"/>
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      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
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          <isin value="US92532F1003"/>
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        <balance>1063775.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
        <cusip>75615P103</cusip>
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          <isin value="US75615P1030"/>
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        <balance>699412.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC SER B PC PP</title>
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        <balance>3099905.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RUBIUS THERAPEUTICS</name>
        <lei>549300ER84PB0QV6HZ76</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>PHARVARIS BV</name>
        <lei>9845003BE146D3B75D32</lei>
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        <name>NKARTA INC</name>
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        <name>MADRIGAL PHARMACEUTICALS INC</name>
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        <name>BELLUS HEALTH INC NEW</name>
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        <name>ICOSAVAX INC</name>
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        <name>PTC THERAPEUTICS INC</name>
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        <title>PTC THERAPEUTICS INC</title>
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        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>WEREWOLF THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>BICYCLE THERAPEUTICS PLC</name>
        <lei>213800XKUI6R7GKC3E43</lei>
        <title>BICYCLE THERAPEUTICS LTD ADR</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MACROGENICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IMMUNEERING CORP</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DAY ONE BIOPHARMACEUTICALS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>UCB SA</name>
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          <isin value="BE0003739530"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>AGIOS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
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        <name>SERES THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ADAGIO THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ALNYLAM PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
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        <name>IMAGO BIOSCIENCES INC</name>
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        <name>ZEALAND PHARMA A/S</name>
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        <name>CORCEPT THERAPEUTICS INC</name>
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        <name>Fidelity Revere Street Trust</name>
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        <name>KYMERA THERAPEUTICS INC</name>
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        <name>OPTINOSE INC</name>
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        <name>MIRATI THERAPEUTICS INC</name>
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        <title>Mirati Therapeutics Inc</title>
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        <name>BEAM THERAPEUTICS INC</name>
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        <name>XENON PHARMACEUTICALS INC</name>
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        <name>TRAVERE THERAPEUTICS INC</name>
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        <title>TRAVERE THERAPEUTICS INC</title>
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        <name>ANAPTYSBIO INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CRISPR THERAPEUTICS AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
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          <isin value="CH0334081137"/>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GRITSTONE BIO INC</name>
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          <isin value="US39868T1051"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INSMED INC</name>
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          <isin value="US4576693075"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
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          <isin value="US26886C1071"/>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIOATLA INC</name>
        <lei>N/A</lei>
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          <isin value="US09077B1044"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SYNDAX PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
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          <isin value="US3755581036"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALX ONCOLOGY HOLDINGS INC</name>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>ALLENA PHARMACEUTICALS INC</name>
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        <name>MORPHOSYS AG</name>
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        <name>BIOMEA FUSION INC</name>
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        <name>MERUS NV</name>
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        <name>ERASCA INC</name>
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        <name>XILIO THERAPEUTICS INC</name>
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        <name>AURINIA PHARMACEUTICALS INC</name>
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        <name>CELLDEX THERAPEUTICS INC</name>
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        <name>QUANTERIX CORP</name>
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      <invstOrSec>
        <name>ELEVATEBIO, LLC</name>
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        <title>ELEVATEBIO LLC SER C PC PP</title>
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        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
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      <invstOrSec>
        <name>AUTOLUS THERAPEUTICS PLC</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
        </identifiers>
        <balance>380185.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1254610.50000000</valUSD>
        <pctVal>0.024025660546</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="970860.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZAI LAB LTD</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>ZAI LAB LTD UNSPNRD ADR</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
        </identifiers>
        <balance>35572.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1643782.12000000</valUSD>
        <pctVal>0.031478256580</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>204174.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3446457.12000000</valUSD>
        <pctVal>0.065999295282</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2981008.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SURROZEN INC</name>
        <lei>N/A</lei>
        <title>SURROZEN INC</title>
        <cusip>86889P109</cusip>
        <identifiers>
          <isin value="US86889P1093"/>
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        <balance>252900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>649953.00000000</valUSD>
        <pctVal>0.012446532329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="88151.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
        </identifiers>
        <balance>1257805.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9961815.60000000</valUSD>
        <pctVal>0.190767732323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1420056.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>2SEVENTY BIO INC</name>
        <lei>N/A</lei>
        <title>2SEVENTY BIO INC-W/I</title>
        <cusip>901384107</cusip>
        <identifiers>
          <isin value="US9013841070"/>
        </identifiers>
        <balance>103752.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1528266.96000000</valUSD>
        <pctVal>0.029266153284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NGM BIOPHARMACEUTICALS INC</name>
        <lei>5493008V5DSDZIGQOP17</lei>
        <title>NGM BIOPHARMACEUTICALS INC</title>
        <cusip>62921N105</cusip>
        <identifiers>
          <isin value="US62921N1054"/>
        </identifiers>
        <balance>183700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2592007.00000000</valUSD>
        <pctVal>0.049636664380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>3193396.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76896975.68000000</valUSD>
        <pctVal>1.472569083990</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13518512.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>920424.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12922752.96000000</valUSD>
        <pctVal>0.247469374714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5696435.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SEER INC</name>
        <lei>N/A</lei>
        <title>SEER INC</title>
        <cusip>81578P106</cusip>
        <identifiers>
          <isin value="US81578P1066"/>
        </identifiers>
        <balance>304058.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3070985.80000000</valUSD>
        <pctVal>0.058809058567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC WT 10/04/2022</title>
        <cusip>87184Q115</cusip>
        <identifiers>
          <isin value="US87184Q1159"/>
        </identifiers>
        <balance>21625.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.22000000</valUSD>
        <pctVal>0.000000004212</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT THERAPEUTICS INC</name>
        <lei>549300MB473BIU78ES48</lei>
        <title>RAPT THERAPEUTICS INC</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
        </identifiers>
        <balance>1024677.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27369122.67000000</valUSD>
        <pctVal>0.524115851675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="721170.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FULCRUM THERAPEUTICS INC</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>1784376.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13204382.40000000</valUSD>
        <pctVal>0.252862549189</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2022-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
