<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000320351</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000007486</seriesId>
        <classId>C000020460</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>Fidelity Select Portfolios</regName>
      <regFileNumber>811-03114</regFileNumber>
      <regCik>0000320351</regCik>
      <regLei>Z57125JG1LHEQKDYS630</regLei>
      <regStreet1>245 Summer Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02210</regZipOrPostalCode>
      <regPhone>1-800-FIDELITY</regPhone>
      <seriesName>Select Biotechnology Portfolio</seriesName>
      <seriesId>S000007486</seriesId>
      <seriesLei>FQDPG178WXRZSXLIRG32</seriesLei>
      <repPdEnd>2022-02-28</repPdEnd>
      <repPdDate>2021-11-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>7463817554.09</totAssets>
      <totLiabs>511148098.00</totLiabs>
      <netAssets>6952669456.09</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>218.28000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="42855285.00000000" lei="FOR8UP27PHTHYVLBNG30" name="GOLDMAN SACHS and CO LLC (GOV REPO)"/>
        <borrower aggrVal="112108815.29000000" lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY and CO LLC"/>
        <borrower aggrVal="1243380.00000000" lei="VYVVCKR63DVZZN70PB21" name="WELLS FARGO SECURITIES, LLC"/>
        <borrower aggrVal="34331730.45000000" lei="571474TGEMMWANRLN572" name="STATE STREET BANK AND TRUST COMPANY"/>
        <borrower aggrVal="32705.00000000" lei="1V8Y6QCX6YMJ2OELII46" name="CREDIT SUISSE SECURITIES(USA)LLC"/>
        <borrower aggrVal="75366822.16000000" lei="549300HN4UKV1E2R3U73" name="BOFA SECURITIES INC"/>
        <borrower aggrVal="205176.00000000" lei="549300K66TF1ST7A3V76" name="NATIONAL BANK OF CANADA FINANCIAL INC"/>
        <borrower aggrVal="4911248.32000000" lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL INC."/>
        <borrower aggrVal="4936082.38000000" lei="58PU97L1C0WSRCWADL48" name="JEFFERIES LLC"/>
        <borrower aggrVal="67240608.29000000" lei="MBNUM2BPBDO7JBLYG310" name="CITIGROUP GLOBAL MARKETS INC."/>
        <borrower aggrVal="8120776.00000000" lei="OXTKY6Q8X53C9ILVV871" name="NOMURA SECURITIES INTERNATIONAL INC"/>
        <borrower aggrVal="20863.00000000" lei="KBVRJ5K57JZ3E2AVWX40" name="ING FINANCIAL MARKETS LLC"/>
        <borrower aggrVal="18154506.00000000" lei="RCNB6OTYUAMMP879YW96" name="BNP PARIBAS SECURITIES CORP."/>
        <borrower aggrVal="746356.00000000" lei="9J6MBOOO7BECTDTUZW19" name="DEUTSCHE BANK SECURITIES INC."/>
        <borrower aggrVal="75159034.66000000" lei="ZBUT11V806EZRVTWT807" name="JPMORGAN SECURITIES LLC"/>
        <borrower aggrVal="3031002.00000000" lei="T6FIZBDPKLYJKFCRVK44" name="UBS SECURITIES LLC."/>
        <borrower aggrVal="970600.00000000" lei="RUC0QBLBRPRCU4W1NE59" name="BMO CAPITAL MARKETS CORP"/>
        <borrower aggrVal="18969861.00000000" lei="549300JRHF1MHHWUAW04" name="NATIONAL FINANCIAL SERVICES, LLC"/>
        <borrower aggrVal="3159077.02000000" lei="549300BLWPABP1VNME36" name="SCOTIA CAPITAL (USA) INC."/>
      </borrowers>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000020460" rtn1="-5.11000000" rtn2="-1.30000000" rtn3="-6.05000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <commodityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </commodityContracts>
          <creditContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </creditContracts>
          <equityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </equityContracts>
          <foreignExchgContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </foreignExchgContracts>
          <interestRtContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </interestRtContracts>
          <otherContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </otherContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="86904686.52000000" netUnrealizedAppr="-499618066.89000000"/>
        <othMon2 netRealizedGain="128234119.63000000" netUnrealizedAppr="-227958900.22000000"/>
        <othMon3 netRealizedGain="36413531.21000000" netUnrealizedAppr="-481073106.63000000"/>
      </returnInfo>
      <mon1Flow redemption="95294979.57000000" reinvestment="0.00000000" sales="27950941.42000000"/>
      <mon2Flow redemption="109574317.68000000" reinvestment="0.00000000" sales="27012682.16000000"/>
      <mon3Flow redemption="150340632.37000000" reinvestment="0.00000000" sales="33430667.40000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>EYEPOINT PHARMACEUTICALS INC</name>
        <lei>549300QE1RU34T50MR69</lei>
        <title>EYEPOINT PHARMACEUTICALS INC</title>
        <cusip>30233G209</cusip>
        <identifiers>
          <isin value="US30233G2093"/>
        </identifiers>
        <balance>400000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6320000.00000000</valUSD>
        <pctVal>0.090900337487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>CHINOOK THERAPEUTICS INC CVR RT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GGJ521000"/>
        </identifiers>
        <balance>115821.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5791.05000000</valUSD>
        <pctVal>0.000083292468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEKTAR THERAPEUTICS</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>NEKTAR THERAPEUTICS</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
        </identifiers>
        <balance>232631.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2619425.06000000</valUSD>
        <pctVal>0.037675098414</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TERNS PHARMACEUTICALS INC</name>
        <lei>254900S1ZDQMF4MYP709</lei>
        <title>TERNS PHARMACEUTICALS INC</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
        </identifiers>
        <balance>689509.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5205792.95000000</valUSD>
        <pctVal>0.074874736716</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA BIOSCIENCES</name>
        <lei>549300ULW08F62IJML11</lei>
        <title>IDEAYA BIOSCIENCES</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
        </identifiers>
        <balance>1318874.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29015228.00000000</valUSD>
        <pctVal>0.417325002766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4400.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC</title>
        <cusip>87184Q107</cusip>
        <identifiers>
          <isin value="US87184Q1076"/>
        </identifiers>
        <balance>2306295.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9132928.20000000</valUSD>
        <pctVal>0.131358584751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXELIXIS INC</name>
        <lei>254900PJQB59O2O95R37</lei>
        <title>EXELIXIS INC</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>3546234.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59541268.86000000</valUSD>
        <pctVal>0.856379973707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMBRX BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>AMBRX BIOPHARMA INC ADR(180 LOCK UP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHC087000"/>
        </identifiers>
        <balance>1302291.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11567599.81000000</valUSD>
        <pctVal>0.166376380799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADAGIO THERAPUTICS INC</name>
        <lei>N/A</lei>
        <title>ADAGIO THERAPUTICS INC (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HJG157000"/>
        </identifiers>
        <balance>95500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4267704.00000000</valUSD>
        <pctVal>0.061382236376</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>MORPHIC HOLDING INC</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
        </identifiers>
        <balance>805337.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38414574.90000000</valUSD>
        <pctVal>0.552515478300</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SUTRO BIOPHARMA INC</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>SUTRO BIOPHARMA INC</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
        </identifiers>
        <balance>737300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12593084.00000000</valUSD>
        <pctVal>0.181125883799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLAKOS INC</name>
        <lei>549300S6ZD1W6BPMDY37</lei>
        <title>ALLAKOS INC</title>
        <cusip>01671P100</cusip>
        <identifiers>
          <isin value="US01671P1003"/>
        </identifiers>
        <balance>739307.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57924703.45000000</valUSD>
        <pctVal>0.833128970330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQUILLIUM INC</name>
        <lei>549300OC7SSPSNNGHE64</lei>
        <title>EQUILLIUM INC</title>
        <cusip>29446K106</cusip>
        <identifiers>
          <isin value="US29446K1060"/>
        </identifiers>
        <balance>184263.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>954482.34000000</valUSD>
        <pctVal>0.013728285891</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AURA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
        </identifiers>
        <balance>471300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8219472.00000000</valUSD>
        <pctVal>0.118220376387</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="272064.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMICUS THERAPEUTICS INC</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>1304101.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13966921.71000000</valUSD>
        <pctVal>0.200885743212</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SANGAMO THERAPEUTICS INC</name>
        <lei>2549006WMRKRC4G32Z67</lei>
        <title>SANGAMO THERAPEUTICS INC</title>
        <cusip>800677106</cusip>
        <identifiers>
          <isin value="US8006771062"/>
        </identifiers>
        <balance>154227.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1278541.83000000</valUSD>
        <pctVal>0.018389222126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
        </identifiers>
        <balance>543332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51888206.00000000</valUSD>
        <pctVal>0.746306240037</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNIC INC</name>
        <lei>549300R5T12FW5MEQB20</lei>
        <title>IMMUNIC INC</title>
        <cusip>4525EP101</cusip>
        <identifiers>
          <isin value="US4525EP1011"/>
        </identifiers>
        <balance>509372.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4344943.16000000</valUSD>
        <pctVal>0.062493164495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAGENTA THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>MAGENTA THERAPEUTICS INC</title>
        <cusip>55910K108</cusip>
        <identifiers>
          <isin value="US55910K1088"/>
        </identifiers>
        <balance>72800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>409864.00000000</valUSD>
        <pctVal>0.005895059481</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUCANA PLC</name>
        <lei>213800K5NF92PPHPA304</lei>
        <title>NUCANA PLC SPONSORED ADR</title>
        <cusip>67022C106</cusip>
        <identifiers>
          <isin value="US67022C1062"/>
        </identifiers>
        <balance>624329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1704418.17000000</valUSD>
        <pctVal>0.024514586530</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="758394.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KRONOS BIO INC</name>
        <lei>N/A</lei>
        <title>KRONOS BIO INC</title>
        <cusip>50107A104</cusip>
        <identifiers>
          <isin value="US50107A1043"/>
        </identifiers>
        <balance>579460.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6843422.60000000</valUSD>
        <pctVal>0.098428706315</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3739046.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERASTEM INC</name>
        <lei>549300IY0EFBIU8NQC81</lei>
        <title>VERASTEM INC</title>
        <cusip>92337C104</cusip>
        <identifiers>
          <isin value="US92337C1045"/>
        </identifiers>
        <balance>204500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>546015.00000000</valUSD>
        <pctVal>0.007853314521</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BIOCRYST PHARMACEUTICALS INC</title>
        <cusip>09058V103</cusip>
        <identifiers>
          <isin value="US09058V1035"/>
        </identifiers>
        <balance>1465285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17671337.10000000</valUSD>
        <pctVal>0.254166219343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12792042.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>400793.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75950273.50000000</valUSD>
        <pctVal>1.092390109722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>17090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3398859.20000000</valUSD>
        <pctVal>0.048885672207</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HALOZYME THERAPEUTICS INC</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>HALOZYME THERAPEUTICS INC</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
        </identifiers>
        <balance>280308.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9216527.04000000</valUSD>
        <pctVal>0.132560983924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOGEN INC</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>IMMUNOGEN INC</title>
        <cusip>45253H101</cusip>
        <identifiers>
          <isin value="US45253H1014"/>
        </identifiers>
        <balance>1191123.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7349228.91000000</valUSD>
        <pctVal>0.105703700663</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>475835.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18514739.85000000</valUSD>
        <pctVal>0.266296851402</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRAXIS PRECISION MEDICINES INC.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC</title>
        <cusip>74006W108</cusip>
        <identifiers>
          <isin value="US74006W1080"/>
        </identifiers>
        <balance>381129.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6521117.19000000</valUSD>
        <pctVal>0.093792998950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
        </identifiers>
        <balance>274009.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9464270.86000000</valUSD>
        <pctVal>0.136124274564</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6611577.72000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>1887454.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>217585697.12000000</valUSD>
        <pctVal>3.129527421002</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC</title>
        <cusip>98420X103</cusip>
        <identifiers>
          <isin value="US98420X1037"/>
        </identifiers>
        <balance>100731.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>448252.95000000</valUSD>
        <pctVal>0.006447206397</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
        <cusip>09075P105</cusip>
        <identifiers>
          <isin value="US09075P1057"/>
        </identifiers>
        <balance>351727.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8065100.11000000</valUSD>
        <pctVal>0.116000050929</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8064481.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PACIFIC BIOSCIENCES OF CALIFORNIA INC</name>
        <lei>529900F1BWRE1M0KZN89</lei>
        <title>PACIFIC BIOSCIENES OF CALI INC</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
        </identifiers>
        <balance>354274.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8222699.54000000</valUSD>
        <pctVal>0.118266797982</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENTRADA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
        </identifiers>
        <balance>285800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8511124.00000000</valUSD>
        <pctVal>0.122415196835</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
        </identifiers>
        <balance>991362.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>95369024.40000000</valUSD>
        <pctVal>1.371689320228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EPIZYME INC</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>EPIZYME INC</title>
        <cusip>29428V104</cusip>
        <identifiers>
          <isin value="US29428V1044"/>
        </identifiers>
        <balance>865135.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2828991.45000000</valUSD>
        <pctVal>0.040689284423</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="991208.94000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HOMOLOGY MEDICINES INC</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>HOMOLOGY MEDICINES INC</title>
        <cusip>438083107</cusip>
        <identifiers>
          <isin value="US4380831077"/>
        </identifiers>
        <balance>1253091.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6328109.55000000</valUSD>
        <pctVal>0.091016976859</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1052925.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SEER INC</name>
        <lei>N/A</lei>
        <title>SEER INC CL A PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GJD267000"/>
        </identifiers>
        <balance>263158.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5871054.98000000</valUSD>
        <pctVal>0.084443177071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>5300401.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24540856.63000000</valUSD>
        <pctVal>0.352970276884</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18405472.32000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="74W995233"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82.75000000</valUSD>
        <pctVal>0.000001190190</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRAPHITE BIO INC</name>
        <lei>N/A</lei>
        <title>GRAPHITE BIO INC</title>
        <cusip>38870X104</cusip>
        <identifiers>
          <isin value="US38870X1046"/>
        </identifiers>
        <balance>108200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>975964.00000000</valUSD>
        <pctVal>0.014037255850</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
        </identifiers>
        <balance>178800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2118780.00000000</valUSD>
        <pctVal>0.030474338142</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1341420.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC</title>
        <cusip>344174107</cusip>
        <identifiers>
          <isin value="US3441741077"/>
        </identifiers>
        <balance>587199.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6793892.43000000</valUSD>
        <pctVal>0.097716315623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="344786.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADC THERAPEUTICS SA</name>
        <lei>N/A</lei>
        <title>ADC THERAPEUTICS SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0499880968"/>
        </identifiers>
        <balance>755238.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16811597.88000000</valUSD>
        <pctVal>0.241800620411</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16723938.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FUSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>FUSION PHARMACEUTICALS INC</title>
        <cusip>36118A100</cusip>
        <identifiers>
          <isin value="CA36118A1003"/>
        </identifiers>
        <balance>1740302.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10093751.60000000</valUSD>
        <pctVal>0.145178073885</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KINNATE BIOPHARMA INC</name>
        <lei>549300YVIWV7HJ5WHI66</lei>
        <title>KINNATE BIOPHARMA INC</title>
        <cusip>49705R105</cusip>
        <identifiers>
          <isin value="US49705R1059"/>
        </identifiers>
        <balance>639303.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12773273.94000000</valUSD>
        <pctVal>0.183717549362</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3172824.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>APPLIED THERAPEUTICS INC</title>
        <cusip>03828A101</cusip>
        <identifiers>
          <isin value="US03828A1016"/>
        </identifiers>
        <balance>569640.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6539467.20000000</valUSD>
        <pctVal>0.094056926498</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>860043.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31150757.46000000</valUSD>
        <pctVal>0.448040247803</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABSCI CORP</name>
        <lei>N/A</lei>
        <title>ABSCI CORP (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIF651000"/>
        </identifiers>
        <balance>210224.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2106970.04000000</valUSD>
        <pctVal>0.030304475903</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>651004.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52607633.24000000</valUSD>
        <pctVal>0.756653736701</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALBIREO PHARMA INC</name>
        <lei>549300835H8LC7O8VC29</lei>
        <title>ALBIREO PHARMA INC</title>
        <cusip>01345P106</cusip>
        <identifiers>
          <isin value="US01345P1066"/>
        </identifiers>
        <balance>8750.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>209912.50000000</valUSD>
        <pctVal>0.003019164096</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
        </identifiers>
        <balance>2842420.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43204784.00000000</valUSD>
        <pctVal>0.621412887134</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
        </identifiers>
        <balance>2123187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58005468.84000000</valUSD>
        <pctVal>0.834290616091</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COHERUS BIOSCIENCES INC</name>
        <lei>5493007IL8W5MV932D26</lei>
        <title>COHERUS BIOSCIENCES INC</title>
        <cusip>19249H103</cusip>
        <identifiers>
          <isin value="US19249H1032"/>
        </identifiers>
        <balance>11587.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>215170.59000000</valUSD>
        <pctVal>0.003094791020</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABSCI CORP</name>
        <lei>N/A</lei>
        <title>ABSCI CORP</title>
        <cusip>00091E109</cusip>
        <identifiers>
          <isin value="US00091E1091"/>
        </identifiers>
        <balance>919976.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9705746.80000000</valUSD>
        <pctVal>0.139597414508</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5195875.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EDITAS MEDICINE INC</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>EDITAS MEDICINE INC</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
        </identifiers>
        <balance>157223.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5134903.18000000</valUSD>
        <pctVal>0.073855131650</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="512762.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TENAYA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TENAYA THERAPEUTICS INC</title>
        <cusip>87990A106</cusip>
        <identifiers>
          <isin value="US87990A1060"/>
        </identifiers>
        <balance>258300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5075595.00000000</valUSD>
        <pctVal>0.073002104185</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OMEGA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>OMEGA THERAPEUTICS INC (180-DAY LOCK-UP LINE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HII552000"/>
        </identifiers>
        <balance>1102941.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18954592.56000000</valUSD>
        <pctVal>0.272623237444</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>THESEUS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>THESEUS PHARMACEUTICALS INC</title>
        <cusip>88369M101</cusip>
        <identifiers>
          <isin value="US88369M1018"/>
        </identifiers>
        <balance>1592300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22785813.00000000</valUSD>
        <pctVal>0.327727546144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5769792.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTRA-CELLULAR THERAPIES INC</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>INTRA-CELLULAR THERAPIES INC</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
        </identifiers>
        <balance>903976.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36592948.48000000</valUSD>
        <pctVal>0.526315089637</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP WT 07/02/2024</title>
        <cusip>374163129</cusip>
        <identifiers>
          <isin value="US3741631291"/>
        </identifiers>
        <balance>2100000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>687168.34000000</valUSD>
        <pctVal>0.009883518040</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ITEOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ITEOS THERAPEUTICS INC</title>
        <cusip>46565G104</cusip>
        <identifiers>
          <isin value="US46565G1040"/>
        </identifiers>
        <balance>303681.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10719939.30000000</valUSD>
        <pctVal>0.154184509528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB HOLDINGS LLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="71E99L226"/>
        </identifiers>
        <balance>1954526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>110638680.57000000</valUSD>
        <pctVal>1.591312247313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS LTD ADR</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
        </identifiers>
        <balance>400875.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14427491.25000000</valUSD>
        <pctVal>0.207510098691</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACLARIS THERAPEUTICS INC</name>
        <lei>5493000B2LQ9QTW1DF52</lei>
        <title>ACLARIS THERAPEUTICS INC</title>
        <cusip>00461U105</cusip>
        <identifiers>
          <isin value="US00461U1051"/>
        </identifiers>
        <balance>791489.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10131059.20000000</valUSD>
        <pctVal>0.145714667783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AIA874000"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14397748.32000000</valUSD>
        <pctVal>0.207082307176</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PLIANT THERAPEUTICS INC</name>
        <lei>5493002Q5LITR7VHZH02</lei>
        <title>PLIANT THERAPEUTICS INC</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
        </identifiers>
        <balance>971031.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13769219.58000000</valUSD>
        <pctVal>0.198042200437</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VALENZABIO INC</name>
        <lei>N/A</lei>
        <title>VALENZABIO INC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HDH471000"/>
        </identifiers>
        <balance>1685311.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14999990.90000000</valUSD>
        <pctVal>0.215744341000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
        </identifiers>
        <balance>1140113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>127966283.12000000</valUSD>
        <pctVal>1.840534544726</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>YUMANITY THERAPEUTICS INC</name>
        <lei>549300GNQLMQP5WNHC81</lei>
        <title>YUMANITY THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GJJ217000"/>
        </identifiers>
        <balance>173913.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>732173.73000000</valUSD>
        <pctVal>0.010530828980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FIBROGEN INC</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
        </identifiers>
        <balance>6531.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>81702.81000000</valUSD>
        <pctVal>0.001175128639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
        </identifiers>
        <balance>839801.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96585513.01000000</valUSD>
        <pctVal>1.389186033076</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>259154.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>164959295.62000000</valUSD>
        <pctVal>2.372603741078</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVAVAX INC</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>NOVAVAX INC</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
        </identifiers>
        <balance>251576.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52486300.88000000</valUSD>
        <pctVal>0.754908617639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="43791437.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RALLYBIO CORP</name>
        <lei>N/A</lei>
        <title>RALLYBIO CORP</title>
        <cusip>75120L100</cusip>
        <identifiers>
          <isin value="US75120L1008"/>
        </identifiers>
        <balance>1196785.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15402622.95000000</valUSD>
        <pctVal>0.221535383600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1033461.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARIX BIOSCIENCE PLC</name>
        <lei>213800OVT3AHQCXNIX43</lei>
        <title>ARIX BIOSCIENCE PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BD045071"/>
        </identifiers>
        <balance>1411100.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.75190797"/>
        <valUSD>2458467.09000000</valUSD>
        <pctVal>0.035360045598</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROIVANT SCIENCES LTD</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>ROIVANT SCIENCES LTD PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HFC838000"/>
        </identifiers>
        <balance>2500000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16575000.00000000</valUSD>
        <pctVal>0.238397641433</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RENEO PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>RENEO PHARMACEUTICALS INC</title>
        <cusip>75974E103</cusip>
        <identifiers>
          <isin value="US75974E1038"/>
        </identifiers>
        <balance>150258.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1033775.04000000</valUSD>
        <pctVal>0.014868750003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="104576.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SURFACE ONCOLOGY INC</name>
        <lei>549300FCSG6MNIMFH738</lei>
        <title>SURFACE ONCOLOGY INC</title>
        <cusip>86877M209</cusip>
        <identifiers>
          <isin value="US86877M2098"/>
        </identifiers>
        <balance>885265.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5107979.05000000</valUSD>
        <pctVal>0.073467882836</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2136054.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROQR THERAPEUTICS NV</name>
        <lei>549300NGS2FJGGDBGS06</lei>
        <title>PROQR THERAPEUTICS NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010872495"/>
        </identifiers>
        <balance>555016.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3918412.96000000</valUSD>
        <pctVal>0.056358395645</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OMEGA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>OMEGA THERAPEUTICS INC</title>
        <cusip>68217N105</cusip>
        <identifiers>
          <isin value="US68217N1054"/>
        </identifiers>
        <balance>79800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1443582.00000000</valUSD>
        <pctVal>0.020762989080</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AKOUOS INC</name>
        <lei>N/A</lei>
        <title>AKOUOS INC</title>
        <cusip>00973J101</cusip>
        <identifiers>
          <isin value="US00973J1016"/>
        </identifiers>
        <balance>716626.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5510853.94000000</valUSD>
        <pctVal>0.079262418194</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3101707.67000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOMARIN PHARMACEUTICAL INC</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
        </identifiers>
        <balance>48000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4141920.00000000</valUSD>
        <pctVal>0.059573089532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZENTALIS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS LLC</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>638433.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52383427.65000000</valUSD>
        <pctVal>0.753428995594</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERVE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERVE THERAPEUTICS INC</title>
        <cusip>92539P101</cusip>
        <identifiers>
          <isin value="US92539P1012"/>
        </identifiers>
        <balance>156456.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5332020.48000000</valUSD>
        <pctVal>0.076690262836</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALDEYRA THERAPEUTICS INC</name>
        <lei>529900HGKY864E4Y9014</lei>
        <title>ALDEYRA THERAPEUTICS INC</title>
        <cusip>01438T106</cusip>
        <identifiers>
          <isin value="US01438T1060"/>
        </identifiers>
        <balance>1201911.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9218657.37000000</valUSD>
        <pctVal>0.132591624385</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
        </identifiers>
        <balance>868489.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43554723.35000000</valUSD>
        <pctVal>0.626446052484</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KALEIDO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>KALEIDO BIOSCIENCES INC</title>
        <cusip>483347100</cusip>
        <identifiers>
          <isin value="US4833471000"/>
        </identifiers>
        <balance>249460.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>895561.40000000</valUSD>
        <pctVal>0.012880828085</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="640097.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>17990.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4240962.60000000</valUSD>
        <pctVal>0.060997615761</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>1142001.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>79997170.05000000</valUSD>
        <pctVal>1.150596480319</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
        </identifiers>
        <balance>1412797.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>113800798.35000000</valUSD>
        <pctVal>1.636792876012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
        <title>ARVINAS INC</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
        </identifiers>
        <balance>1456729.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>110143279.69000000</valUSD>
        <pctVal>1.584186913898</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GH RESEARCH PLC</name>
        <lei>875500HKJS7QQG6EWH62</lei>
        <title>GH RESEARCH PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE000GID8VI0"/>
        </identifiers>
        <balance>1359736.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35992211.92000000</valUSD>
        <pctVal>0.517674716845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5177532.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OLINK HOLDING AB</name>
        <lei>8945004Z7ZHV3LML4J27</lei>
        <title>OLINK HOLDING AB ADR</title>
        <cusip>680710100</cusip>
        <identifiers>
          <isin value="US6807101000"/>
        </identifiers>
        <balance>120900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2534064.00000000</valUSD>
        <pctVal>0.036447353293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC CL A WT 04/16/2024</title>
        <cusip>98420X111</cusip>
        <identifiers>
          <isin value="US98420X1110"/>
        </identifiers>
        <balance>450000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>94394.79000000</valUSD>
        <pctVal>0.001357676941</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>23ANDME HOLDING CO</name>
        <lei>N/A</lei>
        <title>23ANDME CL B (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHB508000"/>
        </identifiers>
        <balance>3206518.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25039699.06000000</valUSD>
        <pctVal>0.360145109991</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="038505921"/>
        </identifiers>
        <balance>148009.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6808.41000000</valUSD>
        <pctVal>0.000097925121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>1543247.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40973207.85000000</valUSD>
        <pctVal>0.589316205937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SANA BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
        </identifiers>
        <balance>15490.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>294464.90000000</valUSD>
        <pctVal>0.004235278289</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="292754.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC</title>
        <cusip>603380106</cusip>
        <identifiers>
          <isin value="US6033801068"/>
        </identifiers>
        <balance>317679.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>308466.31000000</valUSD>
        <pctVal>0.004436660076</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KODIAK SCIENCES INC</name>
        <lei>254900IXI5NI8C9OQE24</lei>
        <title>KODIAK SCIENCES INC</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
        </identifiers>
        <balance>234468.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21533541.12000000</valUSD>
        <pctVal>0.309716163784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10249344.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVOTEC SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>EVOTEC SE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE0005664809"/>
        </identifiers>
        <balance>318400.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.88175646"/>
        <valUSD>15093872.97000000</valUSD>
        <pctVal>0.217094643508</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LONGBOARD PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LONGBOARD PHARMACEUTICALS INC</title>
        <cusip>54300N103</cusip>
        <identifiers>
          <isin value="US54300N1037"/>
        </identifiers>
        <balance>371100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2115270.00000000</valUSD>
        <pctVal>0.030423853936</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10X GENOMICS INC</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X GENOMICS INC</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
        </identifiers>
        <balance>138819.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21212931.39000000</valUSD>
        <pctVal>0.305104845325</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
        </identifiers>
        <balance>1105871.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31871202.22000000</valUSD>
        <pctVal>0.458402379421</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1807014.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COMPASS PATHWAYS LTD</name>
        <lei>213800N7CUZIC6QSTZ31</lei>
        <title>COMPASS PATHWAYS LTD ADR</title>
        <cusip>20451W101</cusip>
        <identifiers>
          <isin value="US20451W1018"/>
        </identifiers>
        <balance>102838.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3414221.60000000</valUSD>
        <pctVal>0.049106629066</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="388440.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SILVERBACK THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SILVERBACK THERAPEUTICS INC</title>
        <cusip>82835W108</cusip>
        <identifiers>
          <isin value="US82835W1080"/>
        </identifiers>
        <balance>90166.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>633866.98000000</valUSD>
        <pctVal>0.009116886456</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MARINUS PHARMACEUTICALS INC</name>
        <lei>549300NCT4OJF7JV1084</lei>
        <title>MARINUS PHARMACEUTICALS INC</title>
        <cusip>56854Q200</cusip>
        <identifiers>
          <isin value="US56854Q2003"/>
        </identifiers>
        <balance>474765.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5274639.15000000</valUSD>
        <pctVal>0.075864949186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KEROS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KEROS THERAPEUTICS</title>
        <cusip>492327101</cusip>
        <identifiers>
          <isin value="US4923271013"/>
        </identifiers>
        <balance>294886.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16451689.94000000</valUSD>
        <pctVal>0.236624077182</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>1614859.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67953266.72000000</valUSD>
        <pctVal>0.977369442760</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SOLID BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>SOLID BIOSCIENCES INC</title>
        <cusip>83422E105</cusip>
        <identifiers>
          <isin value="US83422E1055"/>
        </identifiers>
        <balance>619600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1084300.00000000</valUSD>
        <pctVal>0.015595448724</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="604892.75000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
        </identifiers>
        <balance>456947.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>127584171.87000000</valUSD>
        <pctVal>1.835038652071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>ROYALTY PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
        </identifiers>
        <balance>470720.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18720534.40000000</valUSD>
        <pctVal>0.269256787169</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 THERAPEUTICS INC</title>
        <cusip>3621LQ109</cusip>
        <identifiers>
          <isin value="US3621LQ1099"/>
        </identifiers>
        <balance>110139.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1420793.10000000</valUSD>
        <pctVal>0.020435217134</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1126170.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COMPUGEN LTD</name>
        <lei>N/A</lei>
        <title>COMPUGEN LTD (NASDAQ)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0010852080"/>
        </identifiers>
        <balance>56288.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>248792.96000000</valUSD>
        <pctVal>0.003578380384</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="247962.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GENERATION BIO CO</name>
        <lei>N/A</lei>
        <title>GENERATION BIO</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
        </identifiers>
        <balance>137100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2354007.00000000</valUSD>
        <pctVal>0.033857599802</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHE032000"/>
        </identifiers>
        <balance>1433576.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26407186.71000000</valUSD>
        <pctVal>0.379813636715</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CEREVEL THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>CEREVEL THERAPEUTICS HOLDINGS INC</title>
        <cusip>15678U128</cusip>
        <identifiers>
          <isin value="US15678U1280"/>
        </identifiers>
        <balance>1064870.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33213295.30000000</valUSD>
        <pctVal>0.477705656938</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PASSAGE BIO INC</name>
        <lei>N/A</lei>
        <title>PASSAGE BIO INC</title>
        <cusip>702712100</cusip>
        <identifiers>
          <isin value="US7027121000"/>
        </identifiers>
        <balance>458848.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3345001.92000000</valUSD>
        <pctVal>0.048111044845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSTIL BIO INC</name>
        <lei>N/A</lei>
        <title>INSTIL BIO INC</title>
        <cusip>45783C101</cusip>
        <identifiers>
          <isin value="US45783C1018"/>
        </identifiers>
        <balance>13800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>303324.00000000</valUSD>
        <pctVal>0.004362698412</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ESSA PHARMA INC</name>
        <lei>N/A</lei>
        <title>ESSA PHARMA INC</title>
        <cusip>29668H708</cusip>
        <identifiers>
          <isin value="CA29668H7085"/>
        </identifiers>
        <balance>597650.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7984604.00000000</valUSD>
        <pctVal>0.114842278213</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTURY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CENTURY THERAPEUTICS INC</title>
        <cusip>15673T100</cusip>
        <identifiers>
          <isin value="US15673T1007"/>
        </identifiers>
        <balance>67000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1280370.00000000</valUSD>
        <pctVal>0.018415516631</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REPLIMUNE GROUP INC</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>REPLIMUNE GROUP INC</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
        </identifiers>
        <balance>1054117.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30031793.33000000</valUSD>
        <pctVal>0.431946226117</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SEAGEN INC</name>
        <lei>N/A</lei>
        <title>SEAGEN INC</title>
        <cusip>81181C104</cusip>
        <identifiers>
          <isin value="US81181C1045"/>
        </identifiers>
        <balance>938374.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>150139840.00000000</valUSD>
        <pctVal>2.159456032653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS LTD</name>
        <lei>N/A</lei>
        <title>KINIKSA PHARMACEUTICALS LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG5269C1010"/>
        </identifiers>
        <balance>182140.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2116466.80000000</valUSD>
        <pctVal>0.030441067468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="388108.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC PP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EDE963000"/>
        </identifiers>
        <balance>94809.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>206683.62000000</valUSD>
        <pctVal>0.002972723229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DICE MOLECULES HOLDING LLC</name>
        <lei>N/A</lei>
        <title>DICE MOLECULES HOLDING LLC</title>
        <cusip>23345J104</cusip>
        <identifiers>
          <isin value="US23345J1043"/>
        </identifiers>
        <balance>30000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>949200.00000000</valUSD>
        <pctVal>0.013652310180</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="597996.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
        </identifiers>
        <balance>713600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12430912.00000000</valUSD>
        <pctVal>0.178793369633</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="513890.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DESIGN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DESIGN THERAPEUTICS INC</title>
        <cusip>25056L103</cusip>
        <identifiers>
          <isin value="US25056L1035"/>
        </identifiers>
        <balance>1000000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16740000.00000000</valUSD>
        <pctVal>0.240770830624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9987084.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMA INC</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>1113318.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>83754913.14000000</valUSD>
        <pctVal>1.204643966881</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MARAVAI LIFESCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>MARAVAI LIFESCIENCES HOLDINGS INC</title>
        <cusip>56600D107</cusip>
        <identifiers>
          <isin value="US56600D1072"/>
        </identifiers>
        <balance>146700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6739398.00000000</valUSD>
        <pctVal>0.096932524155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROCKET PHARMACEUTICALS INC</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>333936.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8158056.48000000</valUSD>
        <pctVal>0.117337039126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7470694.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SENSORION SA</name>
        <lei>969500P0W8XJ9CGZDP97</lei>
        <title>SENSORION SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
        </identifiers>
        <balance>3270000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.88175646"/>
        <valUSD>6274793.84000000</valUSD>
        <pctVal>0.090250138880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SELECTA BIOSCIENCES INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>SELECTA BIOSCIENCES INC</title>
        <cusip>816212104</cusip>
        <identifiers>
          <isin value="US8162121045"/>
        </identifiers>
        <balance>1032715.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3098145.00000000</valUSD>
        <pctVal>0.044560510456</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATARA BIOTHERAPEUTICS INC</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>ATARA BIOTHERAPEUTICS INC</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
        </identifiers>
        <balance>641255.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11472051.95000000</valUSD>
        <pctVal>0.165002119293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IKENA ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>IKENA ONCOLOGY INC 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IBE064000"/>
        </identifiers>
        <balance>878347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12564753.84000000</valUSD>
        <pctVal>0.180718412105</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>530020.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38081937.00000000</valUSD>
        <pctVal>0.547731159096</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="19212690.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MYOS CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
        </identifiers>
        <balance>2777.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4804.21000000</valUSD>
        <pctVal>0.000069098783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GUARDANT HEALTH INC</name>
        <lei>254900M8C3E5VC8BR186</lei>
        <title>GUARDANT HEALTH INC</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
        </identifiers>
        <balance>48100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5056272.00000000</valUSD>
        <pctVal>0.072724182156</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>POSEIDA THERAPEUTICS INC</name>
        <lei>549300USKSDMNGMN8V04</lei>
        <title>POSEIDA THERAPEUTICS INC</title>
        <cusip>73730P108</cusip>
        <identifiers>
          <isin value="US73730P1084"/>
        </identifiers>
        <balance>615283.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4276216.85000000</valUSD>
        <pctVal>0.061504676398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TYRA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC</title>
        <cusip>90240B106</cusip>
        <identifiers>
          <isin value="US90240B1061"/>
        </identifiers>
        <balance>595475.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14940467.75000000</valUSD>
        <pctVal>0.214888221629</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEXIMMUNE INC</name>
        <lei>5493005RDYAV26LAQ930</lei>
        <title>NEXIMMUNE INC</title>
        <cusip>65344D109</cusip>
        <identifiers>
          <isin value="US65344D1090"/>
        </identifiers>
        <balance>525000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4147500.00000000</valUSD>
        <pctVal>0.059653346476</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INOZYME PHARMA INC</name>
        <lei>N/A</lei>
        <title>INOZYME PHARMA INC</title>
        <cusip>45790W108</cusip>
        <identifiers>
          <isin value="US45790W1080"/>
        </identifiers>
        <balance>609380.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4838477.20000000</valUSD>
        <pctVal>0.069591647216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANGION BIOMEDICA CORP</name>
        <lei>254900EE2QKYD5SGI956</lei>
        <title>ANGION BIOMEDICA CORP</title>
        <cusip>03476J107</cusip>
        <identifiers>
          <isin value="US03476J1079"/>
        </identifiers>
        <balance>251600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>905760.00000000</valUSD>
        <pctVal>0.013027514190</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6480.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LOGICBIO THERAPEUTICS</name>
        <lei>549300GHIQDMXT6NPC14</lei>
        <title>LOGICBIO THERAPEUTICS</title>
        <cusip>54142F102</cusip>
        <identifiers>
          <isin value="US54142F1021"/>
        </identifiers>
        <balance>315500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>946500.00000000</valUSD>
        <pctVal>0.013613476175</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHINOOK THERAPEUTICS INC</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>CHINOOK THERAPEUTICS INC</title>
        <cusip>16961L106</cusip>
        <identifiers>
          <isin value="US16961L1061"/>
        </identifiers>
        <balance>1015381.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16256249.81000000</valUSD>
        <pctVal>0.233813068673</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GDA208000"/>
        </identifiers>
        <balance>11945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>549.47000000</valUSD>
        <pctVal>0.000007903007</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
        </identifiers>
        <balance>20113.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1883381.32000000</valUSD>
        <pctVal>0.027088607216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSTIL BIO INC</name>
        <lei>N/A</lei>
        <title>INSTIL BIO 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IBA837000"/>
        </identifiers>
        <balance>1431274.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31459402.52000000</valUSD>
        <pctVal>0.452479478834</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>643408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17918912.80000000</valUSD>
        <pctVal>0.257727091920</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SHATTUCK LABS INC</name>
        <lei>N/A</lei>
        <title>SHATTUCK LABS INC</title>
        <cusip>82024L103</cusip>
        <identifiers>
          <isin value="US82024L1035"/>
        </identifiers>
        <balance>110936.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>940737.28000000</valUSD>
        <pctVal>0.013530591177</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVIDITY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
        </identifiers>
        <balance>442484.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9880667.72000000</valUSD>
        <pctVal>0.142113295941</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1056209.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
        </identifiers>
        <balance>55828.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19636940.72000000</valUSD>
        <pctVal>0.282437427005</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
        </identifiers>
        <balance>868174.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14385643.18000000</valUSD>
        <pctVal>0.206908199373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Y-MABS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>Y-MABS THERAPEUTICS INC</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
        </identifiers>
        <balance>1330984.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22733206.72000000</valUSD>
        <pctVal>0.326970911871</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPRUCE BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>SPRUCE BIOSCIENCES INC</title>
        <cusip>85209E109</cusip>
        <identifiers>
          <isin value="US85209E1091"/>
        </identifiers>
        <balance>438225.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1130620.50000000</valUSD>
        <pctVal>0.016261674845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LYELL IMMUNOPHARMA INC</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
        </identifiers>
        <balance>326647.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3119478.85000000</valUSD>
        <pctVal>0.044867354470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
        </identifiers>
        <balance>456912.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8123895.36000000</valUSD>
        <pctVal>0.116845700939</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6356350.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>1875470.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34677440.30000000</valUSD>
        <pctVal>0.498764402924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1475890.29000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PMV PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>PMV PHARMACEUTICALS INC</title>
        <cusip>69353Y103</cusip>
        <identifiers>
          <isin value="US69353Y1038"/>
        </identifiers>
        <balance>492700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10716225.00000000</valUSD>
        <pctVal>0.154131086882</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMARA INC</name>
        <lei>N/A</lei>
        <title>IMARA INC</title>
        <cusip>45249V107</cusip>
        <identifiers>
          <isin value="US45249V1070"/>
        </identifiers>
        <balance>413291.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1396923.58000000</valUSD>
        <pctVal>0.020091902668</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>FATE THERAPEUTICS INC</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>901787.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49607302.87000000</valUSD>
        <pctVal>0.713500090624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RELAY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
        </identifiers>
        <balance>1511389.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44465064.38000000</valUSD>
        <pctVal>0.639539455468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31566542.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRELUDE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
        </identifiers>
        <balance>561056.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8017490.24000000</valUSD>
        <pctVal>0.115315279845</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERACYTE INC</name>
        <lei>529900ESWZRHXOW27Z37</lei>
        <title>VERACYTE INC</title>
        <cusip>92337F107</cusip>
        <identifiers>
          <isin value="US92337F1075"/>
        </identifiers>
        <balance>141800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5881864.00000000</valUSD>
        <pctVal>0.084598642825</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
        </identifiers>
        <balance>785492.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21726708.72000000</valUSD>
        <pctVal>0.312494486574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="20935854.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
        </identifiers>
        <balance>1179042.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47751201.00000000</valUSD>
        <pctVal>0.686803842776</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10457100.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
        </identifiers>
        <balance>483691.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4338708.27000000</valUSD>
        <pctVal>0.062403488291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2851563.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC WT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AAJ520000"/>
        </identifiers>
        <balance>382683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3.83000000</valUSD>
        <pctVal>0.000000055086</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
        </identifiers>
        <balance>559915.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11411067.70000000</valUSD>
        <pctVal>0.164124984972</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>1033193.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>364128208.99000000</valUSD>
        <pctVal>5.237243209815</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC PHARMACEUTICALS INC</name>
        <lei>54930033FJRNEYBW0L25</lei>
        <title>ORIC PHARMACEUTICALS INC</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
        </identifiers>
        <balance>724374.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10025336.16000000</valUSD>
        <pctVal>0.144194057021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2023408.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HORIZON THERAPEUTICS PLC</name>
        <lei>N/A</lei>
        <title>HORIZON THERAPEUTICS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>998991.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103655306.16000000</valUSD>
        <pctVal>1.490870619042</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HBH922000"/>
        </identifiers>
        <balance>1000000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8970000.00000000</valUSD>
        <pctVal>0.129015194187</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RIGEL PHARMACEUTICALS INC</name>
        <lei>529900KPTNUS5J8K9K66</lei>
        <title>RIGEL PHARMACEUTICALS INC</title>
        <cusip>766559603</cusip>
        <identifiers>
          <isin value="US7665596034"/>
        </identifiers>
        <balance>884000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2360280.00000000</valUSD>
        <pctVal>0.033947824140</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2390985.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>YUMANITY THERAPEUTICS INC</name>
        <lei>549300GNQLMQP5WNHC81</lei>
        <title>YUMANITY THERAPEUTICS INC</title>
        <cusip>98872L102</cusip>
        <identifiers>
          <isin value="US98872L1026"/>
        </identifiers>
        <balance>74369.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>313093.49000000</valUSD>
        <pctVal>0.004503212643</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33680.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
        </identifiers>
        <balance>267147.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22239987.75000000</valUSD>
        <pctVal>0.319876960791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TANGO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
        </identifiers>
        <balance>1578188.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16365809.56000000</valUSD>
        <pctVal>0.235388862700</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROMETHEUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>PROMETHEUS BIOSCIENCES INC</title>
        <cusip>74349U108</cusip>
        <identifiers>
          <isin value="US74349U1088"/>
        </identifiers>
        <balance>301200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8945640.00000000</valUSD>
        <pctVal>0.128664825165</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="356400.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZYMERGEN INC</name>
        <lei>254900B6L3GN956CY454</lei>
        <title>ZYMERGEN INC</title>
        <cusip>98985X100</cusip>
        <identifiers>
          <isin value="US98985X1000"/>
        </identifiers>
        <balance>888363.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8048568.78000000</valUSD>
        <pctVal>0.115762281391</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5128866.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JOUNCE THERAPEUTICS INC</name>
        <lei>5493004MZJQIV2K8ZT61</lei>
        <title>JOUNCE THERAPEUTICS INC</title>
        <cusip>481116101</cusip>
        <identifiers>
          <isin value="US4811161011"/>
        </identifiers>
        <balance>636734.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4883749.78000000</valUSD>
        <pctVal>0.070242801140</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CANDEL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CANDEL THERAPEUTICS INC</title>
        <cusip>137404109</cusip>
        <identifiers>
          <isin value="US1374041093"/>
        </identifiers>
        <balance>2451618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25398762.48000000</valUSD>
        <pctVal>0.365309506519</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
        </identifiers>
        <balance>50600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1811480.00000000</valUSD>
        <pctVal>0.026054453062</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0363463438"/>
        </identifiers>
        <balance>1218641.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.91805000"/>
        <valUSD>21490983.92000000</valUSD>
        <pctVal>0.309104065074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC</title>
        <cusip>299734103</cusip>
        <identifiers>
          <isin value="US2997341035"/>
        </identifiers>
        <balance>833899.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7188209.38000000</valUSD>
        <pctVal>0.103387762432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6722738.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HERON THERAPEUTICS INC</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>HERON THERAPEUTICS INC</title>
        <cusip>427746102</cusip>
        <identifiers>
          <isin value="US4277461020"/>
        </identifiers>
        <balance>225925.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2134991.25000000</valUSD>
        <pctVal>0.030707503980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2269890.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INHIBIKASE THERAPEUTICS INC</name>
        <lei>549300066CFEWOA17F12</lei>
        <title>INHIBIKASE THERAPEUTICS INC</title>
        <cusip>45719W106</cusip>
        <identifiers>
          <isin value="US45719W1062"/>
        </identifiers>
        <balance>433300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>866600.00000000</valUSD>
        <pctVal>0.012464277289</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="71200.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTEIR THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYTEIR THERAPEUTICS INC</title>
        <cusip>23284P103</cusip>
        <identifiers>
          <isin value="US23284P1030"/>
        </identifiers>
        <balance>1107031.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18387784.91000000</valUSD>
        <pctVal>0.264470862970</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GLOBAL BLOOD THERAPEUTICS INC</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>GLOBAL BLOOD THERAPEUTICS INC</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
        </identifiers>
        <balance>478016.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13508732.16000000</valUSD>
        <pctVal>0.194295619046</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATEA PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ATEA PHARMACEUTICALS INC</title>
        <cusip>04683R106</cusip>
        <identifiers>
          <isin value="US04683R1068"/>
        </identifiers>
        <balance>66800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>540412.00000000</valUSD>
        <pctVal>0.007772726769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLOVIR INC</name>
        <lei>N/A</lei>
        <title>ALLOVIR INC</title>
        <cusip>019818103</cusip>
        <identifiers>
          <isin value="US0198181036"/>
        </identifiers>
        <balance>730894.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12761409.24000000</valUSD>
        <pctVal>0.183546899800</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="799668.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CAREDX INC</name>
        <lei>549300NQOFKL9NON0U06</lei>
        <title>CAREDX INC</title>
        <cusip>14167L103</cusip>
        <identifiers>
          <isin value="US14167L1035"/>
        </identifiers>
        <balance>143800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6203532.00000000</valUSD>
        <pctVal>0.089225182344</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANNEXON INC</name>
        <lei>N/A</lei>
        <title>ANNEXON INC</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
        </identifiers>
        <balance>111236.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1812034.44000000</valUSD>
        <pctVal>0.026062427553</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERRICA PHARMACEUTICALS INC</name>
        <lei>5493002L68H6THU5GW50</lei>
        <title>VERRICA PHARMACEUTICALS INC</title>
        <cusip>92511W108</cusip>
        <identifiers>
          <isin value="US92511W1080"/>
        </identifiers>
        <balance>645496.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6680883.60000000</valUSD>
        <pctVal>0.096090913600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="332731.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REPARE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>REPARE THERAPEUTICS INC</title>
        <cusip>760273102</cusip>
        <identifiers>
          <isin value="US7602731025"/>
        </identifiers>
        <balance>705060.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16547758.20000000</valUSD>
        <pctVal>0.238005823583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12626860.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GENMAB AS</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>GENMAB AS SP ADR</title>
        <cusip>372303206</cusip>
        <identifiers>
          <isin value="US3723032062"/>
        </identifiers>
        <balance>21490.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>827794.80000000</valUSD>
        <pctVal>0.011906143463</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IKENA ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>IKENA ONCOLOGY INC</title>
        <cusip>45175G108</cusip>
        <identifiers>
          <isin value="US45175G1085"/>
        </identifiers>
        <balance>59211.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>847013.36000000</valUSD>
        <pctVal>0.012182563335</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HOOKIPA PHARMA INC</name>
        <lei>N/A</lei>
        <title>HOOKIPA PHARMA INC</title>
        <cusip>43906K100</cusip>
        <identifiers>
          <isin value="US43906K1007"/>
        </identifiers>
        <balance>1006500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3250995.00000000</valUSD>
        <pctVal>0.046758946625</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1440903.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CONTRAFECT CORP</name>
        <lei>549300JM7MIET5QG2X15</lei>
        <title>CONTRAFECT CORP</title>
        <cusip>212326300</cusip>
        <identifiers>
          <isin value="US2123263004"/>
        </identifiers>
        <balance>456309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1556013.69000000</valUSD>
        <pctVal>0.022380090119</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="791461.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARUNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
        </identifiers>
        <balance>229311.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29328876.90000000</valUSD>
        <pctVal>0.421836203852</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AEROVATE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>AEROVATE THERAPEUTICS INC</title>
        <cusip>008064107</cusip>
        <identifiers>
          <isin value="US0080641071"/>
        </identifiers>
        <balance>286251.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3924501.21000000</valUSD>
        <pctVal>0.056445962731</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IOVANCE BIOTHERAPEUTICS INC</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
        </identifiers>
        <balance>968579.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18131798.88000000</valUSD>
        <pctVal>0.260789024913</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
        </identifiers>
        <balance>1226378.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41230828.36000000</valUSD>
        <pctVal>0.593021552662</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VENTYX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>VENTYX BIOSCIENCES INC</title>
        <cusip>92332V107</cusip>
        <identifiers>
          <isin value="US92332V1070"/>
        </identifiers>
        <balance>421600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8284440.00000000</valUSD>
        <pctVal>0.119154808844</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
        </identifiers>
        <balance>2338471.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>91995449.14000000</valUSD>
        <pctVal>1.323167306039</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12773698.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATYR PHARMA INC</name>
        <lei>529900ENQUXMC5EBKO36</lei>
        <title>ATYR PHARMA INC</title>
        <cusip>002120202</cusip>
        <identifiers>
          <isin value="US0021202025"/>
        </identifiers>
        <balance>1146952.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9565579.68000000</valUSD>
        <pctVal>0.137581395756</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="76728.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATIONAL RESILIENCE INC</name>
        <lei>N/A</lei>
        <title>NATIONAL RESILIENCE INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GII424000"/>
        </identifiers>
        <balance>732064.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32510962.24000000</valUSD>
        <pctVal>0.467604025264</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FORMA THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>FORMA THERAPEUTICS HOLDINGS</title>
        <cusip>34633R104</cusip>
        <identifiers>
          <isin value="US34633R1041"/>
        </identifiers>
        <balance>702960.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10185890.40000000</valUSD>
        <pctVal>0.146503303002</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALECTOR INC</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>ALECTOR INC</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
        </identifiers>
        <balance>1020618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21075761.70000000</valUSD>
        <pctVal>0.303131938503</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TENAYA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TENAYA THERAPEUTICS INC (180-DAY LOCK-UP LINE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HII548000"/>
        </identifiers>
        <balance>1206563.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22523514.80000000</valUSD>
        <pctVal>0.323954920369</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELEDON PHARMACEUTICALS INC</name>
        <lei>549300S17CAM13O43606</lei>
        <title>ELEDON PHARMACEUTICALS INC</title>
        <cusip>28617K101</cusip>
        <identifiers>
          <isin value="US28617K1016"/>
        </identifiers>
        <balance>778742.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3808048.38000000</valUSD>
        <pctVal>0.054771025777</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARISTEA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARISTEA THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GGH900000"/>
        </identifiers>
        <balance>836400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7728336.00000000</valUSD>
        <pctVal>0.111156384591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMBRX BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>AMBRX BIOPHARMA INC ADR</title>
        <cusip>02290A102</cusip>
        <identifiers>
          <isin value="US02290A1025"/>
        </identifiers>
        <balance>87104.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>814422.40000000</valUSD>
        <pctVal>0.011713808705</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PULMONX CORP</name>
        <lei>549300WZMFR0ZK7RJY40</lei>
        <title>PULMONX CORP</title>
        <cusip>745848101</cusip>
        <identifiers>
          <isin value="US7458481014"/>
        </identifiers>
        <balance>8300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>268090.00000000</valUSD>
        <pctVal>0.003855929031</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORAGENICS INC</name>
        <lei>549300639MGD19K4ZW90</lei>
        <title>ORAGENICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="684023922"/>
        </identifiers>
        <balance>155806.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89604.03000000</valUSD>
        <pctVal>0.001288771608</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
        </identifiers>
        <balance>36056107.35500000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36063318.58000000</valUSD>
        <pctVal>0.518697441432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
        </identifiers>
        <balance>659409.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90352221.18000000</valUSD>
        <pctVal>1.299532816145</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CULLINAN ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>CULLINAN ONCOLOGY INC</title>
        <cusip>230031106</cusip>
        <identifiers>
          <isin value="US2300311063"/>
        </identifiers>
        <balance>428940.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7720920.00000000</valUSD>
        <pctVal>0.111049720524</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
        </identifiers>
        <balance>699908.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36052261.08000000</valUSD>
        <pctVal>0.518538401799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>4D MOLECULAR THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>4D MOLECULAR THERAPEUTICS INC</title>
        <cusip>35104E100</cusip>
        <identifiers>
          <isin value="US35104E1001"/>
        </identifiers>
        <balance>371568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8546064.00000000</valUSD>
        <pctVal>0.122917737625</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2865800.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GAMIDA CELL LTD</name>
        <lei>N/A</lei>
        <title>GAMIDA CELL LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0011552663"/>
        </identifiers>
        <balance>71867.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>183979.52000000</valUSD>
        <pctVal>0.002646170958</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANTENGENE CORP LTD</name>
        <lei>655600N0NSGOMS4CVH68</lei>
        <title>ANTENGENE CORP LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG039571008"/>
        </identifiers>
        <balance>2066800.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.79800000"/>
        <valUSD>3116897.67000000</valUSD>
        <pctVal>0.044830229449</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>HK</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
        </identifiers>
        <balance>3308806.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4897032.88000000</valUSD>
        <pctVal>0.070433851500</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="144448.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RECURSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>RECURSION PHARMACEUTICALS INC</title>
        <cusip>75629V104</cusip>
        <identifiers>
          <isin value="US75629V1044"/>
        </identifiers>
        <balance>250300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4785736.00000000</valUSD>
        <pctVal>0.068833072393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2682536.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VOR BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>VOR BIOPHARMA INC</title>
        <cusip>929033108</cusip>
        <identifiers>
          <isin value="US9290331084"/>
        </identifiers>
        <balance>696659.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8039444.86000000</valUSD>
        <pctVal>0.115631052371</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4757942.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRECIPIO INC</name>
        <lei>54930079ULTBRXUQNR89</lei>
        <title>PRECIPIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="BIG915000"/>
        </identifiers>
        <balance>525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1018.50000000</valUSD>
        <pctVal>0.000014649049</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RADIUS HEALTH INC</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>RADIUS HEALTH INC</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
        </identifiers>
        <balance>32349.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>532464.54000000</valUSD>
        <pctVal>0.007658418732</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COMPASS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>COMPASS THERAPEUTICS INC</title>
        <cusip>20454B104</cusip>
        <identifiers>
          <isin value="US20454B1044"/>
        </identifiers>
        <balance>2750000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8717500.00000000</valUSD>
        <pctVal>0.125383495577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="47867.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAIN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RAIN THERAPEUTICS INC</title>
        <cusip>75082Q105</cusip>
        <identifiers>
          <isin value="US75082Q1058"/>
        </identifiers>
        <balance>800000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10352000.00000000</valUSD>
        <pctVal>0.148892451530</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="449018.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IDG550000"/>
        </identifiers>
        <balance>729168.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26104214.40000000</valUSD>
        <pctVal>0.375455996647</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KURA ONCOLOGY INC</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>KURA ONCOLOGY INC</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
        </identifiers>
        <balance>926609.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12935461.64000000</valUSD>
        <pctVal>0.186050289341</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>943206.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>176322929.64000000</valUSD>
        <pctVal>2.536046489101</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
        </identifiers>
        <balance>114332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9786819.20000000</valUSD>
        <pctVal>0.140763475982</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HAD933000"/>
        </identifiers>
        <balance>3099905.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5858820.45000000</valUSD>
        <pctVal>0.084267208257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACUMEN PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>ACUMEN PHARMACEUTICALS INC</title>
        <cusip>00509G209</cusip>
        <identifiers>
          <isin value="US00509G2093"/>
        </identifiers>
        <balance>69042.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>545431.80000000</valUSD>
        <pctVal>0.007844926376</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
        <cusip>05454B105</cusip>
        <identifiers>
          <isin value="US05454B1052"/>
        </identifiers>
        <balance>397149.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1159675.08000000</valUSD>
        <pctVal>0.016679565846</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RUBIUS THERAPEUTICS</name>
        <lei>549300ER84PB0QV6HZ76</lei>
        <title>RUBIUS THERAPEUTICS INC</title>
        <cusip>78116T103</cusip>
        <identifiers>
          <isin value="US78116T1034"/>
        </identifiers>
        <balance>636329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7865026.44000000</valUSD>
        <pctVal>0.113122398377</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7864668.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
        </identifiers>
        <balance>580733.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53113840.18000000</valUSD>
        <pctVal>0.763934493297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
        <identifiers>
          <isin value="US23284F1057"/>
        </identifiers>
        <balance>409885.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2709339.85000000</valUSD>
        <pctVal>0.038968339673</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PHARVARIS BV</name>
        <lei>9845003BE146D3B75D32</lei>
        <title>PHARVARIS BV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
        </identifiers>
        <balance>551507.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8112667.97000000</valUSD>
        <pctVal>0.116684217784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NKARTA INC</name>
        <lei>N/A</lei>
        <title>NKARTA INC</title>
        <cusip>65487U108</cusip>
        <identifiers>
          <isin value="US65487U1088"/>
        </identifiers>
        <balance>47200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>750008.00000000</valUSD>
        <pctVal>0.010787338658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DECIBEL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DECIBEL THERAPEUTICS</title>
        <cusip>24343R106</cusip>
        <identifiers>
          <isin value="US24343R1068"/>
        </identifiers>
        <balance>158186.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1091483.40000000</valUSD>
        <pctVal>0.015698767313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>166540.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13774523.40000000</valUSD>
        <pctVal>0.198118485094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6294231.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>325212.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27763348.44000000</valUSD>
        <pctVal>0.399319263131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ICOSAVAX INC</name>
        <lei>N/A</lei>
        <title>ICOSAVAX INC</title>
        <cusip>45114M109</cusip>
        <identifiers>
          <isin value="US45114M1099"/>
        </identifiers>
        <balance>45100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>954316.00000000</valUSD>
        <pctVal>0.013725893428</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>2268744.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84306527.04000000</valUSD>
        <pctVal>1.212577810184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC</title>
        <cusip>192010106</cusip>
        <identifiers>
          <isin value="US1920101060"/>
        </identifiers>
        <balance>402539.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5132372.25000000</valUSD>
        <pctVal>0.073818729373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WEREWOLF THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>WEREWOLF THERAPEUTICS INC</title>
        <cusip>95075A107</cusip>
        <identifiers>
          <isin value="US95075A1079"/>
        </identifiers>
        <balance>370734.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5371935.66000000</valUSD>
        <pctVal>0.077264361464</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="128961.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BICYCLE THERAPEUTICS PLC</name>
        <lei>213800XKUI6R7GKC3E43</lei>
        <title>BICYCLE THERAPEUTICS LTD ADR</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
        </identifiers>
        <balance>1133499.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>60925571.25000000</valUSD>
        <pctVal>0.876290346244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MACROGENICS INC</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MACROGENICS INC</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
        </identifiers>
        <balance>576016.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10137881.60000000</valUSD>
        <pctVal>0.145812794122</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARENA PHARMACEUTICALS INC</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>ARENA PHARMACEUTICALS INC</title>
        <cusip>040047607</cusip>
        <identifiers>
          <isin value="US0400476075"/>
        </identifiers>
        <balance>298473.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16263793.77000000</valUSD>
        <pctVal>0.233921573184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEERING CORP</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
        </identifiers>
        <balance>225419.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5101231.97000000</valUSD>
        <pctVal>0.073370839822</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1099818.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>STOKE THERAPEUTICS INC</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
        </identifiers>
        <balance>270036.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6723896.40000000</valUSD>
        <pctVal>0.096709565188</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DAY ONE BIOPHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC</title>
        <cusip>23954D109</cusip>
        <identifiers>
          <isin value="US23954D1090"/>
        </identifiers>
        <balance>736607.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13531470.59000000</valUSD>
        <pctVal>0.194622665085</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10968727.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
        </identifiers>
        <balance>510877.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.88175646"/>
        <valUSD>55702132.06000000</valUSD>
        <pctVal>0.801161804279</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
        </identifiers>
        <balance>546320.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4889564.00000000</valUSD>
        <pctVal>0.070326426862</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AGIOS PHARMACEUTICALS INC</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>AGIOS PHARMACEUTICALS INC</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
        </identifiers>
        <balance>623189.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22197992.18000000</valUSD>
        <pctVal>0.319272939986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SERES THERAPEUTICS INC</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>SERES THERAPEUTICS INC</title>
        <cusip>81750R102</cusip>
        <identifiers>
          <isin value="US81750R1023"/>
        </identifiers>
        <balance>687847.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7401233.72000000</valUSD>
        <pctVal>0.106451684014</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="634840.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM BIOSCIENCES INC</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
        </identifiers>
        <balance>17768.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>886978.56000000</valUSD>
        <pctVal>0.012757381400</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="663936.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADAGIO THERAPUTICS INC</name>
        <lei>N/A</lei>
        <title>ADAGIO THERAPUTICS INC</title>
        <cusip>00534A102</cusip>
        <identifiers>
          <isin value="US00534A1025"/>
        </identifiers>
        <balance>230716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10852880.64000000</valUSD>
        <pctVal>0.156096600141</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2987040.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>1432939.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>263374188.20000000</valUSD>
        <pctVal>3.788101676102</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRAPHITE BIO INC</name>
        <lei>N/A</lei>
        <title>GRAPHITE BIO INC(180 DAY LOCK UP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHE872000"/>
        </identifiers>
        <balance>1204453.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10320957.76000000</valUSD>
        <pctVal>0.148445972085</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
        </identifiers>
        <balance>30600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1043154.00000000</valUSD>
        <pctVal>0.015003647255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMAGO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>IMAGO BIOSCIENCES INC</title>
        <cusip>45250K107</cusip>
        <identifiers>
          <isin value="US45250K1079"/>
        </identifiers>
        <balance>272800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6102536.00000000</valUSD>
        <pctVal>0.087772560432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DK0060257814"/>
        </identifiers>
        <balance>379717.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.55780000"/>
        <valUSD>7892193.59000000</valUSD>
        <pctVal>0.113513142539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LEXICON PHARMACEUTICALS INC</title>
        <cusip>528872302</cusip>
        <identifiers>
          <isin value="US5288723027"/>
        </identifiers>
        <balance>713268.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3266767.44000000</valUSD>
        <pctVal>0.046985801074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1172938.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>CORCEPT THERAPEUTICS INC</title>
        <cusip>218352102</cusip>
        <identifiers>
          <isin value="US2183521028"/>
        </identifiers>
        <balance>14159.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>297339.00000000</valUSD>
        <pctVal>0.004276616368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
        </identifiers>
        <balance>490499695.05100000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>490548745.02000000</valUSD>
        <pctVal>7.055545328568</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="490548745.02000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
        </identifiers>
        <balance>781871.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43409477.92000000</valUSD>
        <pctVal>0.624356992578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC</title>
        <cusip>68404V100</cusip>
        <identifiers>
          <isin value="US68404V1008"/>
        </identifiers>
        <balance>686019.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1090770.21000000</valUSD>
        <pctVal>0.015688509527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="362679.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TURNING POINT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
        </identifiers>
        <balance>451601.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17187934.06000000</valUSD>
        <pctVal>0.247213450438</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRATI THERAPEUTICS INC</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>681222.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>93170732.94000000</valUSD>
        <pctVal>1.340071371556</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
        </identifiers>
        <balance>827869.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22104102.30000000</valUSD>
        <pctVal>0.317922525148</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TRAVERE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TRAVERE THERAPEUTICS INC</title>
        <cusip>89422G107</cusip>
        <identifiers>
          <isin value="US89422G1076"/>
        </identifiers>
        <balance>372928.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10647094.40000000</valUSD>
        <pctVal>0.153136783896</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>C4 THERAPEUTICS INC</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
        </identifiers>
        <balance>579281.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21502910.72000000</valUSD>
        <pctVal>0.309275607819</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR THERAPEUTICS AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR THERAPEUTICS AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>260522.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20815707.80000000</valUSD>
        <pctVal>0.299391592415</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="19279870.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>COGENT BIOSCIENCES INC</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
        </identifiers>
        <balance>366678.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2904089.76000000</valUSD>
        <pctVal>0.041769420771</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CONNECT BIOPHARMA HOLDINGS LTD</name>
        <lei>N/A</lei>
        <title>CONNECT BIOPHARMA HOLDINGS LTD ADR</title>
        <cusip>207523101</cusip>
        <identifiers>
          <isin value="US2075231017"/>
        </identifiers>
        <balance>1010500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4395675.00000000</valUSD>
        <pctVal>0.063222838763</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQRX INC</name>
        <lei>N/A</lei>
        <title>EQRX INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="GIF522000"/>
        </identifiers>
        <balance>1823553.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9262919.82000000</valUSD>
        <pctVal>0.133228249645</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
        </identifiers>
        <balance>714051.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33031999.26000000</valUSD>
        <pctVal>0.475098082378</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC</title>
        <cusip>23255M105</cusip>
        <identifiers>
          <isin value="US23255M1053"/>
        </identifiers>
        <balance>837285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1825281.30000000</valUSD>
        <pctVal>0.026252956674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="963342.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRITSTONE BIO INC</name>
        <lei>5493003TER6KY3MUVY84</lei>
        <title>GRITSTONE BIO INC</title>
        <cusip>39868T105</cusip>
        <identifiers>
          <isin value="US39868T1051"/>
        </identifiers>
        <balance>285880.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3773616.00000000</valUSD>
        <pctVal>0.054275786067</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
        </identifiers>
        <balance>87053.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>595442.52000000</valUSD>
        <pctVal>0.008564228801</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>574220.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15802534.40000000</valUSD>
        <pctVal>0.227287295905</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3155333.12000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOATLA INC</name>
        <lei>N/A</lei>
        <title>BIOATLA INC</title>
        <cusip>09077B104</cusip>
        <identifiers>
          <isin value="US09077B1044"/>
        </identifiers>
        <balance>1019190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25734547.50000000</valUSD>
        <pctVal>0.370139090640</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5451475.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BOLT BIOTHERAPEUTICS INC</name>
        <lei>254900W0P77PQ6B8OY50</lei>
        <title>BOLT BIOTHERAPEUTICS INC</title>
        <cusip>097702104</cusip>
        <identifiers>
          <isin value="US0977021049"/>
        </identifiers>
        <balance>177700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1647279.00000000</valUSD>
        <pctVal>0.023692755860</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>4984161.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>343558217.73000000</valUSD>
        <pctVal>4.941385749743</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TALARIS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TALARIS THERAPEUTICS INC</title>
        <cusip>87410C104</cusip>
        <identifiers>
          <isin value="US87410C1045"/>
        </identifiers>
        <balance>4900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>63504.00000000</valUSD>
        <pctVal>0.000913375796</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="51840.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALX ONCOLOGY HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ALX ONCOLOGY HOLDINGS INC</title>
        <cusip>00166B105</cusip>
        <identifiers>
          <isin value="US00166B1052"/>
        </identifiers>
        <balance>201765.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6488762.40000000</valUSD>
        <pctVal>0.093327641145</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
        </identifiers>
        <balance>882847.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11459354.06000000</valUSD>
        <pctVal>0.164819485988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2872474.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
        <lei>549300749HO5QS40BX97</lei>
        <title>ALLENA PHARMACEUTICALS INC</title>
        <cusip>018119107</cusip>
        <identifiers>
          <isin value="US0181191075"/>
        </identifiers>
        <balance>1923287.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1308989.13000000</valUSD>
        <pctVal>0.018827144570</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1122445.52000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZYMEWORKS INC</name>
        <lei>894500AHOYAGYLYZJL67</lei>
        <title>ZYMEWORKS INC</title>
        <cusip>98985W102</cusip>
        <identifiers>
          <isin value="CA98985W1023"/>
        </identifiers>
        <balance>709195.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14261911.45000000</valUSD>
        <pctVal>0.205128570257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STEMCENTRX INC</name>
        <lei>N/A</lei>
        <title>STEMCENTRX INC (CVR) 12/31/21</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AIC419000"/>
        </identifiers>
        <balance>876163.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8.76000000</valUSD>
        <pctVal>0.000000125994</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INVITAE CORP</name>
        <lei>549300MYI59DZW1WIX92</lei>
        <title>INVITAE CORP</title>
        <cusip>46185L103</cusip>
        <identifiers>
          <isin value="US46185L1035"/>
        </identifiers>
        <balance>217217.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3692689.00000000</valUSD>
        <pctVal>0.053111815876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="664700.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHOSYS AG</name>
        <lei>529900493806K77LRE72</lei>
        <title>MORPHOSYS AG SPONSORED ADR</title>
        <cusip>617760202</cusip>
        <identifiers>
          <isin value="US6177602025"/>
        </identifiers>
        <balance>31236.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>315795.96000000</valUSD>
        <pctVal>0.004542082174</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOMEA FUSION INC</name>
        <lei>N/A</lei>
        <title>BIOMEA FUSION INC</title>
        <cusip>09077A106</cusip>
        <identifiers>
          <isin value="US09077A1060"/>
        </identifiers>
        <balance>335863.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4053866.41000000</valUSD>
        <pctVal>0.058306617848</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2175014.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
        </identifiers>
        <balance>675686.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17574592.86000000</valUSD>
        <pctVal>0.252774750345</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9259560.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ERASCA INC</name>
        <lei>N/A</lei>
        <title>ERASCA INC</title>
        <cusip>29479A108</cusip>
        <identifiers>
          <isin value="US29479A1088"/>
        </identifiers>
        <balance>746088.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10572066.96000000</valUSD>
        <pctVal>0.152057666868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XILIO THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>XILIO THERAPEUTICS INC</title>
        <cusip>98422T100</cusip>
        <identifiers>
          <isin value="US98422T1007"/>
        </identifiers>
        <balance>698942.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11071241.28000000</valUSD>
        <pctVal>0.159237273538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AURINIA PHARMACEUTICALS INC</name>
        <lei>5299008YP2BW4570ML28</lei>
        <title>AURINIA PHARMACEUTICALS INC</title>
        <cusip>05156V102</cusip>
        <identifiers>
          <isin value="CA05156V1022"/>
        </identifiers>
        <balance>589486.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11105916.24000000</valUSD>
        <pctVal>0.159736002267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11104296.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
        </identifiers>
        <balance>849200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32354520.00000000</valUSD>
        <pctVal>0.465353922034</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELEVATEBIO, LLC</name>
        <lei>N/A</lei>
        <title>ELEVATEBIO LLC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HCJ459000"/>
        </identifiers>
        <balance>216600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>809650.80000000</valUSD>
        <pctVal>0.011645178950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHEMOCENTRYX INC</name>
        <lei>529900YTTXUSFQTAKY40</lei>
        <title>CHEMOCENTRYX INC</title>
        <cusip>16383L106</cusip>
        <identifiers>
          <isin value="US16383L1061"/>
        </identifiers>
        <balance>1819622.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66015886.16000000</valUSD>
        <pctVal>0.949504166377</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6151999.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENXBIO INC</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
        </identifiers>
        <balance>6852.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>219264.00000000</valUSD>
        <pctVal>0.003153666392</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>1246677.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33036940.50000000</valUSD>
        <pctVal>0.475169152059</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AUTOLUS THERAPEUTICS PLC</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
        </identifiers>
        <balance>646285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4155612.55000000</valUSD>
        <pctVal>0.059770028997</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1781753.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZAI LAB LTD</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>ZAI LAB LTD UNSPNRD ADR</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
        </identifiers>
        <balance>173549.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12018268.25000000</valUSD>
        <pctVal>0.172858329105</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>204174.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4355031.42000000</valUSD>
        <pctVal>0.062638263583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MONTE ROSA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
        </identifiers>
        <balance>260200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5045278.00000000</valUSD>
        <pctVal>0.072566055841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTURY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CENTURY THERAPEUTICS INC (180 DAY LOCK UP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHC002000"/>
        </identifiers>
        <balance>767618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13935720.98000000</valUSD>
        <pctVal>0.200436984211</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NGM BIOPHARMACEUTICALS INC</name>
        <lei>5493008V5DSDZIGQOP17</lei>
        <title>NGM BIOPHARMACEUTICALS INC</title>
        <cusip>62921N105</cusip>
        <identifiers>
          <isin value="US62921N1054"/>
        </identifiers>
        <balance>327000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5892540.00000000</valUSD>
        <pctVal>0.084752195357</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>3091165.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>135393027.00000000</valUSD>
        <pctVal>1.947353140474</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="38676319.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>1110324.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44135379.00000000</valUSD>
        <pctVal>0.634797602255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8371350.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SEER INC</name>
        <lei>N/A</lei>
        <title>SEER INC</title>
        <cusip>81578P106</cusip>
        <identifiers>
          <isin value="US81578P1066"/>
        </identifiers>
        <balance>40900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>912479.00000000</valUSD>
        <pctVal>0.013124153330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC WT 10/04/2022</title>
        <cusip>87184Q115</cusip>
        <identifiers>
          <isin value="US87184Q1159"/>
        </identifiers>
        <balance>21625.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1121.92000000</valUSD>
        <pctVal>0.000016136535</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MYOVANT SCIENCES LTD</name>
        <lei>N/A</lei>
        <title>MYOVANT SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
        </identifiers>
        <balance>21966.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>369248.46000000</valUSD>
        <pctVal>0.005310887599</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="186591.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT THERAPEUTICS INC</name>
        <lei>549300MB473BIU78ES48</lei>
        <title>RAPT THERAPEUTICS INC</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
        </identifiers>
        <balance>1065921.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34802320.65000000</valUSD>
        <pctVal>0.500560552602</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FULCRUM THERAPEUTICS INC</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>1144976.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16602152.00000000</valUSD>
        <pctVal>0.238788167693</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2021-12-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
