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        <lei>549300MYI59DZW1WIX92</lei>
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          <isin value="US46185L1035"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALLAKOS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RELAY THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>GENERATION BIO</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
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          <isin value="US3621LQ1099"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AVROBIO</name>
        <lei>N/A</lei>
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          <isin value="US05455M1009"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIOMARIN PHARMACEUTICAL INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BLUEBIRD BIO INC</name>
        <lei>N/A</lei>
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          <isin value="US09609G1004"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>COHERUS BIOSCIENCES INC</name>
        <lei>5493007IL8W5MV932D26</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KALVISTA PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
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        <assetCat>STIV</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BICYCLE THERAPEUTICS LTD</name>
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        <title>BICYCLE THERAPEUTICS LTD ADR</title>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KALA PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ACCELERON PHARMA INC</name>
        <lei>529900TQRID2UY164805</lei>
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        <name>EVELO BIOSCIENCES INC</name>
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        <name>COMPUGEN LTD</name>
        <lei>N/A</lei>
        <title>COMPUGEN LTD (NASDAQ)</title>
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        <name>BLACK DIAMOND THERAPEUTICS INC</name>
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        <name>MOLECULAR TEMPLATES INC</name>
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        <name>ALLENA PHARMACEUTICALS INC</name>
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        <name>SANGAMO THERAPEUTICS INC</name>
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        <name>KODIAK SCIENCES INC</name>
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        <name>CHIMERIX INC</name>
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        <name>PREVAIL THERAPEUTICS INC</name>
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        <name>ATHENEX INC</name>
        <lei>5493001V4L0Q5EPPOH52</lei>
        <title>ATHENEX INC</title>
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        <invCountry>US</invCountry>
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      <invstOrSec>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
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          <isin value="US4131971040"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RETROPHIN INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ALECTOR INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BERKELEY LIGHTS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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        <name>INTELLIA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ZEALAND PHARMA A/S</name>
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        <fairValLevel>1</fairValLevel>
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        <name>NEKTAR THERAPEUTICS</name>
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        <title>NEKTAR THERAPEUTICS</title>
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        <name>INHIBRX INC</name>
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        <name>ZENTALIS PHARMACEUTICALS INC</name>
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        <name>MORPHOSYS AG</name>
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        <title>MORPHOSYS AG SPONSORED ADR</title>
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        <name>SYROS PHARMACEUTICALS INC</name>
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        <title>SYROS PHARMACEUTICALS INC WT 10/04/2022</title>
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        <name>UROVANT SCIENCES LTD</name>
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        <name>REPLIMUNE GROUP INC</name>
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        <name>CRINETICS PHARMACEUTICALS INC</name>
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        <name>MERSANA THERAPEUTICS INC</name>
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        <name>ORIC PHARMACEUTICALS INC</name>
        <lei>54930033FJRNEYBW0L25</lei>
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        <name>REGENXBIO INC</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE LTD</name>
        <lei>N/A</lei>
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        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="77R99Y239"/>
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        <balance>76348.00000000</balance>
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        <assetCat>EP</assetCat>
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        <invCountry>GB</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
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          <isin value="US23284F1057"/>
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        <balance>2100.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
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          <isin value="US76243J1051"/>
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        <balance>118978.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
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          <isin value="JE00BYSS4X48"/>
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        <balance>900.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MYOKARDIA INC</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
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          <isin value="US62857M1053"/>
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        <balance>840640.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="GDE967000"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>FATE THERAPEUTICS INC</title>
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          <isin value="US31189P1021"/>
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        <balance>1045687.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
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          <isin value="US24823R1059"/>
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        <balance>521086.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SERES THERAPEUTICS INC</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>SERES THERAPEUTICS INC</title>
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          <isin value="US81750R1023"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GW PHARMACEUTICALS PLC</name>
        <lei>213800ISBN5CNUZMHZ39</lei>
        <title>GW PHARMACEUTICALS PLC ADR</title>
        <cusip>36197T103</cusip>
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          <isin value="US36197T1034"/>
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        <balance>5050.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
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          <isin value="US03753U1060"/>
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        <balance>262134.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HOOKIPA PHARMA INC</name>
        <lei>N/A</lei>
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        <cusip>43906K100</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP PIPE</title>
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        <balance>148009.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARENA PHARMACEUTICALS INC</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>ARENA PHARMACEUTICALS INC</title>
        <cusip>040047607</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>N/A</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VIELA BIO INC</name>
        <lei>N/A</lei>
        <title>VIELA BIO INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
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        <fairValLevel>1</fairValLevel>
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        <name>EDITAS MEDICINE INC</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>EDITAS MEDICINE INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ZOGENIX INC</name>
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        <title>ZOGENIX INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
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        <title>TAYSHA GENE THERAPIES INC SER B PC PP</title>
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        <fairValLevel>3</fairValLevel>
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        <name>FUSION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>FUSION PHARMACEUTICALS INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>RPI INTERNATIONAL HOLDINGS LP P/P</title>
        <cusip>N/A</cusip>
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        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
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      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
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      <invstOrSec>
        <name>GERON CORP</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ACADIA PHARMACEUTICALS INC</name>
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      <invstOrSec>
        <name>DECIPHERA PHARMACEUTICALS INC</name>
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        <name>ALLENA PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AMARIN CORPORATION PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>INTRA-CELLULAR THERAPIES INC</name>
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        <name>SEATTLE GENETICS INC</name>
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        <name>POSEIDA THERAPEUTICS INC</name>
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        <name>23ANDME INC</name>
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        <name>CORTEXYME INC</name>
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        <name>AVIDITY BIOSCIENCES</name>
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        <name>ZAI LAB LTD</name>
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        <title>ZAI LAB LTD UNSPNRD ADR</title>
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        <name>UROGEN PHARMA LTD</name>
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        <name>XENCOR INC</name>
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        <title>XENCOR INC</title>
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        <name>ALEXION PHARMACEUTICALS INC</name>
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        <name>ALLOGENE THERAPEUTICS INC</name>
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        <title>ALLOGENE THERAPEUTICS INC</title>
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        <name>SURFACE ONCOLOGY INC</name>
        <lei>549300FCSG6MNIMFH738</lei>
        <title>SURFACE ONCOLOGY INC</title>
        <cusip>86877M209</cusip>
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          <isin value="US86877M2098"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>LA JOLLA PHARMACEUTICAL CO</name>
        <lei>529900H2JU56H90RYN44</lei>
        <title>LA JOLLA PHARMACEUTICAL CO</title>
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          <isin value="US5034596040"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>AURINIA PHARMACEUTICALS INC</name>
        <lei>5299008YP2BW4570ML28</lei>
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        <cusip>05156V102</cusip>
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          <isin value="CA05156V1022"/>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CONSTELLATION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
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          <isin value="US2103731061"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <cusip>359616109</cusip>
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          <isin value="US3596161097"/>
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        <balance>171222.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OVID THERAPEUTICS INC</name>
        <lei>549300H36NUI4L6U8F17</lei>
        <title>OVID THERAPEUTICS INC</title>
        <cusip>690469101</cusip>
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          <isin value="US6904691010"/>
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        <balance>1822543.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
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          <isin value="US5011471027"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEXTCURE INC</name>
        <lei>549300Y5PR6RJR1STI24</lei>
        <title>NEXTCURE INC</title>
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          <isin value="US65343E1082"/>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>N/A</lei>
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          <isin value="US92243G1085"/>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MORPHOSYS AG</name>
        <lei>529900493806K77LRE72</lei>
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        <cusip>N/A</cusip>
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          <isin value="DE0006632003"/>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INTERCEPT PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>INTERCEPT PHARMACEUTICALS INC</title>
        <cusip>45845P108</cusip>
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          <isin value="US45845P1084"/>
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        <balance>484825.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>10X GENOMICS INC</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X GENOMICS INC</title>
        <cusip>88025U109</cusip>
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          <isin value="US88025U1097"/>
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        <balance>90619.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ADURO BIOTECH INC</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>ADURO BIOTECH INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
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        <balance>1049754.00000000</balance>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HALOZYME THERAPEUTICS INC</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>HALOZYME THERAPEUTICS INC</title>
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        <balance>494277.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>BRUKER CORP</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>AKOUOS INC</name>
        <lei>N/A</lei>
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        <name>PANDION THERAPEUTICS INC</name>
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        <name>IMMUNOMEDICS INC</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>IMMUNOMEDICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
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        <title>ULTRAGENYX PHARMA INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>IMARA INC</name>
        <lei>N/A</lei>
        <title>IMARA INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
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          <isin value="US67576A1007"/>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      </invstOrSec>
      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
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        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="EGI379000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>FORMA THERAPEUTICS HOLDINGS</name>
        <lei>N/A</lei>
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          <isin value="US34633R1041"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
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          <isin value="US00287Y1091"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LIGAND PHARMACEUTICALS INC</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>LIGAND PHARMACEUTICALS</title>
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          <isin value="US53220K5048"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>REPARE THERAPEUTICS INC</name>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MYOS RENS TECHNOLOGY INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MYOS CORP PIPE</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
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          <isin value="US88322Q1085"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KRONOS BIO INC</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal" value="GEH523000"/>
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        <balance>8000000.00000000</balance>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
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        <title>ALNYLAM PHARMACEUTICALS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALLOVIR INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>PLIANT THERAPEUTICS INC</name>
        <lei>5493002Q5LITR7VHZH02</lei>
        <title>PLIANT THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>CLOVIS ONCOLOGY INC</name>
        <lei>529900WCUY9ZAHMRV489</lei>
        <title>CLOVIS ONCOLOGY INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>FREQUENCY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FREQUENCY THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>DYNAVAX TECHNOLOGIES CORP</name>
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        <name>ADVERUM BIOTECHNOLOGIES INC</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
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        <name>TCR2 THERAPEUTICS INC</name>
        <lei>5493007TR1ORJAZ8YK34</lei>
        <title>TCR2 THERAPEUTICS INC</title>
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        <name>YUMANITY HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>YUMANITY HOLDINGS LLC CLASS A PREF UNITS PP</title>
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        <fairValLevel>3</fairValLevel>
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        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>ROYALTY PHARMA PLC (180 DAY LOCKUP)</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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        <name>PRELUDE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC SER C PC PP</title>
        <cusip>N/A</cusip>
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        <fairValLevel>3</fairValLevel>
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        <name>MIRAGEN THERAPEUTICS</name>
        <lei>549300C775BNYF550E70</lei>
        <title>MIRAGEN THERAPEUTICS INC</title>
        <cusip>60463E103</cusip>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IRONWOOD PHARMACEUTICALS INC</name>
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        <title>IRONWOOD PHARMA CL A (PEND)</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RADIUS HEALTH INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
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        <title>BLUEPRINT MEDICINES CORP</title>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IOVANCE BIOTHERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CALITHERA BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>INSMED INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IDORSIA LTD</name>
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        <title>IDORSIA LTD</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TRANSLATE BIO INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>GERON CORP</name>
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        <fairValLevel>2</fairValLevel>
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        <name>CORBUS PHARMACEUTICALS HLDGS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>EIDOS THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>KINNATE BIOPHARMA INC</name>
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        <name>X4 PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>KARUNA THERAPEUTICS INC</name>
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        <name>CODIAK BIOSCIENCES INC</name>
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        <title>CODIAK BIOSCIENCES INC 8% SER A PC PP</title>
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        <name>GALAPAGOS GENOMICS NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS GENOMICS NV SPON AR</title>
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        <name>APPLIED MOLECULAR TRANSPORT INC</name>
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        <name>UNIQURE N.V.</name>
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        <title>UNIQURE N.V.</title>
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        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>HERON THERAPEUTICS INC</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>HERON THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
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        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ARDELYX INC</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>ARDELYX INC</title>
        <cusip>039697107</cusip>
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          <isin value="US0396971071"/>
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        <balance>244494.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KEZAR LIFE SCIENCES INC</name>
        <lei>549300EV1V8GXBV18004</lei>
        <title>KEZAR LIFE SCIENCES INC</title>
        <cusip>49372L100</cusip>
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          <isin value="US49372L1008"/>
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        <balance>1013094.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4923636.84000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="ADG927000"/>
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        <balance>336313.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27829900.75000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KALEIDO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>KALEIDO BIOSCIENCES INC</title>
        <cusip>483347100</cusip>
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          <isin value="US4833471000"/>
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        <balance>70133.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AC IMMUNE SA</name>
        <lei>967600VLQ0ZC2HSOG765</lei>
        <title>AC IMMUNE SA</title>
        <cusip>N/A</cusip>
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          <isin value="CH0329023102"/>
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        <balance>35332.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="221160.00000000"/>
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      <invstOrSec>
        <name>JOUNCE THERAPEUTICS INC</name>
        <lei>5493004MZJQIV2K8ZT61</lei>
        <title>JOUNCE THERAPEUTICS INC</title>
        <cusip>481116101</cusip>
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          <isin value="US4811161011"/>
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        <balance>296774.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="141328.00000000"/>
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      <invstOrSec>
        <name>REVANCE THERAPEUTICS INC</name>
        <lei>549300N33TFDZHS81H11</lei>
        <title>REVANCE THERAPEUTICS INC</title>
        <cusip>761330109</cusip>
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          <isin value="US7613301099"/>
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        <balance>4000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116920.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GAMIDA CELL LTD</name>
        <lei>N/A</lei>
        <title>GAMIDA CELL LTD</title>
        <cusip>N/A</cusip>
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          <isin value="IL0011552663"/>
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        <balance>1465111.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6387883.96000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TREVI THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TREVI THERAPEUTICS INC</title>
        <cusip>89532M101</cusip>
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          <isin value="US89532M1018"/>
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        <balance>792700.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>2307744.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>114060247.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CATABASIS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CATABASIS PHARMACEUTICALS INC</title>
        <cusip>14875P206</cusip>
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          <isin value="US14875P2065"/>
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        <balance>369200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2436720.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC WT</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="AAJ520000"/>
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        <balance>382683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
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        <balance>412463.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>9239171.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AERIE PHARMACEUTICALS INC</name>
        <lei>529900SFXHDHUO324R09</lei>
        <title>AERIE PHARMACEUTICALS INC</title>
        <cusip>00771V108</cusip>
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          <isin value="US00771V1089"/>
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        <balance>213043.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2343473.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC</title>
        <cusip>68404V100</cusip>
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          <isin value="US68404V1008"/>
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        <balance>229115.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
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          <isin value="US09075V1026"/>
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        <balance>183828.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>APREA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APREA THERAPEUTICS INC</title>
        <cusip>03836J102</cusip>
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          <isin value="US03836J1025"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC 144A</title>
        <cusip>N/A</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>AUTOLUS THERAPEUTICS LTD</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
        <cusip>05280R100</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>AMICUS THERAPEUTICS INC</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC</title>
        <cusip>03152W109</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <name>MIRUM PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>MIRUM PHARMACEUTICALS INC</title>
        <cusip>604749101</cusip>
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        <fairValLevel>1</fairValLevel>
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        <name>HOMOLOGY MEDICINES INC</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>HOMOLOGY MEDICINES INC</title>
        <cusip>438083107</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>PROQR THERAPEUTICS NV</name>
        <lei>549300NGS2FJGGDBGS06</lei>
        <title>PROQR THERAPEUTICS NV</title>
        <cusip>N/A</cusip>
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        <balance>253116.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>VOR BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>VOR BIOPHARMA INC SER B PC PP</title>
        <cusip>N/A</cusip>
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        <balance>5769231.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3000000.12000000</valUSD>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ITEOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ITEOS THERAPEUTICS INC</title>
        <cusip>46565G104</cusip>
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          <isin value="US46565G1040"/>
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        <balance>115900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3361100.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRATI THERAPEUTICS INC</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
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        <balance>854540.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>127642639.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Y-MABS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>Y-MABS THERAPEUTICS INC</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
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        <balance>1114642.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47963045.26000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC</title>
        <cusip>603380106</cusip>
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          <isin value="US6033801068"/>
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        <balance>782914.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2489666.52000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1765536.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>AGIOS PHARMACEUTICALS INC</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>AGIOS PHARMACEUTICALS INC</title>
        <cusip>00847X104</cusip>
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          <isin value="US00847X1046"/>
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        <balance>997715.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40916292.15000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>THERAPEUTICSMD INC</name>
        <lei>5299004JS7RE49QHRW30</lei>
        <title>THERAPEUTICS MD INC</title>
        <cusip>88338N107</cusip>
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          <isin value="US88338N1072"/>
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        <balance>385742.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="563122.00000000"/>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
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          <isin value="US75886F1075"/>
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        <balance>724970.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>449430652.10000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MESOBLAST LTD</name>
        <lei>529900J5ALF3JG921927</lei>
        <title>MESOBLAST LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="AU000000MSB8"/>
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        <balance>442900.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="AUD" exchangeRt="1.35584028"/>
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        <pctVal>0.023112380276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>AU</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KEROS THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>KEROS THERAPEUTICS</title>
        <cusip>492327101</cusip>
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          <isin value="US4923271013"/>
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        <balance>271167.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14518281.18000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC</title>
        <cusip>23255M105</cusip>
        <identifiers>
          <isin value="US23255M1053"/>
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        <balance>837285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5710283.70000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ANNEXON INC</name>
        <lei>N/A</lei>
        <title>ANNEXON INC</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
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        <balance>461300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11380271.00000000</valUSD>
        <pctVal>0.152603694868</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ADAPTIMMUNE THERAPEUTICS PLC</name>
        <lei>549300UUNWK8TRT5EW12</lei>
        <title>ADAPTIMMUNE THERAPEUTICS PLC SPN ADR</title>
        <cusip>00653A107</cusip>
        <identifiers>
          <isin value="US00653A1079"/>
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        <balance>945000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8221500.00000000</valUSD>
        <pctVal>0.110246168773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PASSAGE BIO INC</name>
        <lei>N/A</lei>
        <title>PASSAGE BIO INC</title>
        <cusip>702712100</cusip>
        <identifiers>
          <isin value="US7027121000"/>
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        <balance>630262.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10437138.72000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ASSEMBLY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ASSEMBLY BIOSCIENCES INC</title>
        <cusip>045396108</cusip>
        <identifiers>
          <isin value="US0453961080"/>
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        <balance>195733.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4280680.71000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SELECTA BIOSCIENCES INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>SELECTA BIOSCIENCES INC</title>
        <cusip>816212104</cusip>
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          <isin value="US8162121045"/>
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        <balance>2515686.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6540783.60000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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        <name>ADAPTIVE BIOTECHNOLOGIES CORP</name>
        <lei>549300ZTF7OT1FW66Q96</lei>
        <title>ADAPTIVE BIOTECHNOLOGIES CORP</title>
        <cusip>00650F109</cusip>
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          <isin value="US00650F1093"/>
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        <balance>36780.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC 8% SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="78Z99F247"/>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC</title>
        <cusip>501575104</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
        <cusip>09075P105</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>PRECIPIO INC</name>
        <lei>54930079ULTBRXUQNR89</lei>
        <title>PRECIPIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="BIG915000"/>
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        <balance>525.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1144.50000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>GENMAB AS</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>GENMAB</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="GMAB"/>
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        <balance>281690.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10636614.40000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>STEMCENTRX INC</name>
        <lei>N/A</lei>
        <title>STEMCENTRX INC (CVR) 12/31/21</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="AIC419000"/>
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        <balance>876163.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8.76000000</valUSD>
        <pctVal>0.000000117467</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>RUBIUS THERAPEUTICS</name>
        <lei>549300ER84PB0QV6HZ76</lei>
        <title>RUBIUS THERAPEUTICS INC</title>
        <cusip>78116T103</cusip>
        <identifiers>
          <isin value="US78116T1034"/>
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        <balance>82842.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>398884.23000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
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        <balance>375061.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11199321.46000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11197500.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>APPLIED THERAPEUTICS INC</title>
        <cusip>03828A101</cusip>
        <identifiers>
          <isin value="US03828A1016"/>
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        <balance>973740.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23467134.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
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        <balance>690811.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>192819166.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARIX BIOSCIENCE PLC</name>
        <lei>213800OVT3AHQCXNIX43</lei>
        <title>ARIX BIOSCIENCE PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BD045071"/>
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        <balance>1515373.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.74808304"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>HORIZON THERAPEUTICS PLC</name>
        <lei>N/A</lei>
        <title>HORIZON THERAPEUTICS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
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        <balance>470319.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>35330363.28000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LEXICON PHARMACEUTICALS INC</title>
        <cusip>528872302</cusip>
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          <isin value="US5288723027"/>
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        <balance>205504.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>359632.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="59500.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>ESPERION THERAPEUTICS INC NEW</name>
        <lei>549300OFU56UKEWVUS92</lei>
        <title>ESPERION THERAPEUTICS INC NEW</title>
        <cusip>29664W105</cusip>
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          <isin value="US29664W1053"/>
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        <balance>123732.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4466725.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="4462501.50000000"/>
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      <invstOrSec>
        <name>EPIZYME INC</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>EPIZYME INC</title>
        <cusip>29428V104</cusip>
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          <isin value="US29428V1044"/>
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        <balance>1992046.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="4002700.00000000"/>
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      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
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          <isin value="US8036071004"/>
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        <balance>733004.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
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          <isin value="US6323071042"/>
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        <balance>343115.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
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          <isin value="US5588681057"/>
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        <balance>34241.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NOVAVAX INC</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>NOVAVAX INC</title>
        <cusip>670002401</cusip>
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          <isin value="US6700024010"/>
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        <balance>21230.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>EXELIXIS INC</name>
        <lei>N/A</lei>
        <title>EXELIXIS INC</title>
        <cusip>30161Q104</cusip>
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          <isin value="US30161Q1040"/>
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        <balance>4112350.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>APPLIED GENETIC TECHNOLOGIES CORP</name>
        <lei>549300I3X9WJZYN79L35</lei>
        <title>APPLIED GENETIC TECHNOLOGIES CORP</title>
        <cusip>03820J100</cusip>
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          <isin value="US03820J1007"/>
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        <balance>129100.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>663574.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TURNING POINT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC</title>
        <cusip>90041T108</cusip>
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        <balance>890858.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>CORCEPT THERAPEUTICS INC</title>
        <cusip>218352102</cusip>
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        <balance>131759.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INCYTE CORP</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP</title>
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        <balance>413105.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>SPERO THERAPEUTICS INC</name>
        <lei>54930074G13LHWJT2323</lei>
        <title>SPERO THERAPEUTICS INC</title>
        <cusip>84833T103</cusip>
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        <balance>21752.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>MARINUS PHARMACEUTICALS INC</name>
        <lei>549300NCT4OJF7JV1084</lei>
        <title>MARINUS PHARMACEUTICALS INC</title>
        <cusip>56854Q101</cusip>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
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        <balance>534212.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ATARA BIOTHERAPEUTICS INC</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>ATARA BIOTHERAPEUTICS INC</title>
        <cusip>046513107</cusip>
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          <isin value="US0465131078"/>
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        <balance>1128895.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INOVIO PHARMACEUTICALS INC</name>
        <lei>529900B9W875XDZXTM97</lei>
        <title>INOVIO PHARMACEUTICALS INC</title>
        <cusip>45773H201</cusip>
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        <balance>229400.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALDEYRA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALDEYRA THERAPEUTICS INC</title>
        <cusip>01438T106</cusip>
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        <balance>322333.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CABALETTA BIO INC</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC</title>
        <cusip>12674W109</cusip>
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        <balance>89850.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS LTD</name>
        <lei>N/A</lei>
        <title>KINIKSA PHARMACEUTICALS LTD</title>
        <cusip>N/A</cusip>
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        <balance>507140.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ZYMEWORKS INC</name>
        <lei>894500AHOYAGYLYZJL67</lei>
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        <cusip>98985W102</cusip>
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          <isin value="CA98985W1023"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ADC THERAPEUTICS SA</name>
        <lei>N/A</lei>
        <title>ADC THERAPEUTICS SA</title>
        <cusip>N/A</cusip>
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          <isin value="CH0499880968"/>
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        <balance>742345.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>THERAVANCE BIOPHARMA INC</name>
        <lei>5493007VTSXP4Z6MIW52</lei>
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        <cusip>N/A</cusip>
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          <isin value="KYG8807B1068"/>
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        <balance>371300.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US03969K1088"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FIBROGEN INC</name>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MACROGENICS INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IMMUNOGEN INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>CRISPR THERAPEUTICS AG</name>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>MANNKIND CORP</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SUTRO BIOPHARMA INC</name>
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        <name>GLOBAL BLOOD THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ARGENX SE</name>
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        <title>ARGENX SE SPONSORED ADR</title>
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        <name>GRITSTONE ONCOLOGY INC</name>
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        <name>CELLECTIS SA</name>
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        <name>IMMUNIC INC</name>
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        <name>INOZYME PHARMA INC</name>
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        <name>VERRICA PHARMACEUTICALS INC</name>
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        <name>CYCLERION THERAPEUTICS INC</name>
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        <name>ROCKET PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CHEMOCENTRYX INC</name>
        <lei>529900YTTXUSFQTAKY40</lei>
        <title>CHEMOCENTRYX INC</title>
        <cusip>16383L106</cusip>
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          <isin value="US16383L1061"/>
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        <balance>2062222.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>110328877.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>KURA ONCOLOGY INC</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>KURA ONCOLOGY INC</title>
        <cusip>50127T109</cusip>
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          <isin value="US50127T1097"/>
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        <balance>1865963.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB HOLDINGS LLC</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="71E99L226"/>
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        <balance>1954526.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
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          <isin value="US04351P1012"/>
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        <balance>659409.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ARVINAS INC</name>
        <lei>N/A</lei>
        <title>ARVINAS INC</title>
        <cusip>04335A105</cusip>
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          <isin value="US04335A1051"/>
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        <balance>968821.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
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          <isin value="US91307C1027"/>
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        <balance>218716.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AKEBIA THERAPEUTICS INC</name>
        <lei>549300CBQEHMKEEGNX42</lei>
        <title>AKEBIA THERAPEUTICS INC</title>
        <cusip>00972D105</cusip>
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          <isin value="US00972D1054"/>
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        <balance>1525367.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AIMMUNE THERAPEUTICS INC</name>
        <lei>549300WDF7T2EVBC1877</lei>
        <title>AIMMUNE THERAPEUTICS INC</title>
        <cusip>00900T107</cusip>
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          <isin value="US00900T1079"/>
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        <balance>69560.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PUMA BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>PUMA BIOTECHNOLOGY INC</title>
        <cusip>74587V107</cusip>
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          <isin value="US74587V1070"/>
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        <balance>25768.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC</title>
        <cusip>16706W102</cusip>
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          <isin value="US16706W1027"/>
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        <balance>1658899.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OBSEVA SA</name>
        <lei>549300PNZ0UEJVKN1618</lei>
        <title>OBSEVA SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0346177709"/>
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        <balance>1355036.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARAVIVE INC</name>
        <lei>5493002Z0KHRW71RNC19</lei>
        <title>ARAVIVE INC</title>
        <cusip>03890D108</cusip>
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          <isin value="US03890D1081"/>
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        <balance>575269.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
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          <isin value="BE0003739530"/>
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        <balance>744327.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
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          <isin value="US60770K1079"/>
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        <balance>751105.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC</title>
        <cusip>87184Q107</cusip>
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          <isin value="US87184Q1076"/>
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        <balance>758619.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>POSEIDA THERAPEUTICS INC</name>
        <lei>549300USKSDMNGMN8V04</lei>
        <title>POSEIDA THERAPEUTICS INC</title>
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        <balance>101700.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC 144A</title>
        <cusip>N/A</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ATYR PHARMA INC</name>
        <lei>529900ENQUXMC5EBKO36</lei>
        <title>ATYR PHARMA INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>DICERNA PHARMACEUTICALS INC</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>DICERNA PHARMACEUTICALS INC</title>
        <cusip>253031108</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALX ONCOLOGY HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ALX ONCOLOGY HOLDINGS INC</title>
        <cusip>00166B105</cusip>
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        <balance>92330.00000000</balance>
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        <assetCat>EC</assetCat>
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        <name>EVOTEC SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>EVOTEC SE</title>
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        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SPRINGWORKS THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
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        <balance>449149.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</title>
        <cusip>N/A</cusip>
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        <balance>1018184.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>1335442.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31783519.60000000</valUSD>
        <pctVal>0.426200968928</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EMERGENT BIOSOLUTIONS INC</name>
        <lei>549300YW6TUOX8BE5103</lei>
        <title>EMERGENT BIOSOL</title>
        <cusip>29089Q105</cusip>
        <identifiers>
          <isin value="US29089Q1058"/>
        </identifiers>
        <balance>96306.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10983699.30000000</valUSD>
        <pctVal>0.147285868368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQUILLIUM INC</name>
        <lei>549300OC7SSPSNNGHE64</lei>
        <title>EQUILLIUM INC</title>
        <cusip>29446K106</cusip>
        <identifiers>
          <isin value="US29446K1060"/>
        </identifiers>
        <balance>209800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1235722.00000000</valUSD>
        <pctVal>0.016570408826</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MYOVANT SCIENCES LTD</name>
        <lei>N/A</lei>
        <title>MYOVANT SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
        </identifiers>
        <balance>502466.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10240257.08000000</valUSD>
        <pctVal>0.137316683127</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2020-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
