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      </invstOrSec>
      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
        <cusip>09627Y109</cusip>
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          <isin value="US09627Y1091"/>
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        <balance>1098241.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC WT</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="AAJ520000"/>
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        <balance>382683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INTRA-CELLULAR THERAPIES INC</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>INTRA-CELLULAR THERAPIES INC</title>
        <cusip>46116X101</cusip>
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          <isin value="US46116X1019"/>
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        <balance>706344.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZAI LAB LTD</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>ZAI LAB LTD UNSPNRD ADR</title>
        <cusip>98887Q104</cusip>
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          <isin value="US98887Q1040"/>
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        <balance>38400.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SPECTRUM PHARMACEUTICALS INC</name>
        <lei>549300COU30WSP3O5I07</lei>
        <title>SPECTRUM PHARMACEUTICAL INC</title>
        <cusip>84763A108</cusip>
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          <isin value="US84763A1088"/>
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        <balance>55103.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>EQUILLIUM INC</name>
        <lei>549300OC7SSPSNNGHE64</lei>
        <title>EQUILLIUM INC</title>
        <cusip>29446K106</cusip>
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          <isin value="US29446K1060"/>
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        <balance>619843.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IMMUNOGEN INC</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>IMMUNOGEN INC</title>
        <cusip>45253H101</cusip>
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          <isin value="US45253H1014"/>
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        <balance>1573743.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
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          <isin value="US91307C1027"/>
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        <balance>305616.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEKTAR THERAPEUTICS</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>NEKTAR THERAPEUTICS</title>
        <cusip>640268108</cusip>
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          <isin value="US6402681083"/>
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        <balance>543851.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALEXION PHARMACEUTICALS INC</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>ALEXION PHARMACEUTICALS INC</title>
        <cusip>015351109</cusip>
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          <isin value="US0153511094"/>
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        <balance>802761.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KODIAK SCIENCES INC</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC</title>
        <cusip>50015M109</cusip>
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          <isin value="US50015M1099"/>
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        <balance>351813.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>EVOTEC SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>EVOTEC SE</title>
        <cusip>N/A</cusip>
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          <isin value="DE0005664809"/>
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        <balance>594300.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>HALOZYME THERAPEUTICS INC</name>
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        <title>HALOZYME THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>ESPERION THERAPEUTICS INC NEW</name>
        <lei>549300OFU56UKEWVUS92</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>CORTEXYME INC</name>
        <lei>N/A</lei>
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        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
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        <name>AGIOS PHARMACEUTICALS INC</name>
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        <name>AUTOLUS THERAPEUTICS LTD</name>
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        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ASSEMBLY BIOSCIENCES INC</name>
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        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
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        <fairValLevel>1</fairValLevel>
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        <name>IRONWOOD PHARMACEUTICALS INC</name>
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        <title>IRONWOOD PHARMA CL A (PEND)</title>
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        <fairValLevel>1</fairValLevel>
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        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 THERAPEUTICS INC</title>
        <cusip>3621LQ109</cusip>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ATRECA INC</name>
        <lei>549300B5CQV1OOXFLU71</lei>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CRISPR THERAPEUTICS AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR THERAPEUTICS AG</title>
        <cusip>N/A</cusip>
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          <isin value="CH0334081137"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Y-MABS THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MOLECULAR TEMPLATES INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AKEBIA THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARGENX SE</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CORBUS PHARMACEUTICALS HLDGS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ADC THERAPEUTICS SA</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VOYAGER THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ACORDA THERAPEUTICS INC</name>
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        <name>RADIUS HEALTH INC</name>
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        <name>EMERGENT BIOSOLUTIONS INC</name>
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        <name>NUVATION BIO INC</name>
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        <name>DENALI THERAPEUTICS INC</name>
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        <name>X4 PHARMACEUTICALS INC</name>
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        <name>REGENXBIO INC</name>
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        <name>GW PHARMACEUTICALS PLC</name>
        <lei>213800ISBN5CNUZMHZ39</lei>
        <title>GW PHARMACEUTICALS PLC ADR</title>
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        <name>SUTRO BIOPHARMA INC</name>
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        <name>VIELA BIO INC</name>
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        <name>VERTEX PHARMACEUTICALS INC</name>
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        <title>VERTEX PHARMACEUTICALS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TURNING POINT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC</title>
        <cusip>90041T108</cusip>
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          <isin value="US90041T1088"/>
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        <balance>936458.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>PREVAIL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PREVAIL THERAPEUTICS INC</title>
        <cusip>74140Y101</cusip>
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          <isin value="US74140Y1010"/>
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        <balance>742000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>12376560.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC</title>
        <cusip>23255M105</cusip>
        <identifiers>
          <isin value="US23255M1053"/>
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        <balance>837285.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S</title>
        <cusip>N/A</cusip>
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          <isin value="DK0060257814"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM BIOSCIENCES INC</title>
        <cusip>449585108</cusip>
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          <isin value="US4495851085"/>
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        <balance>12928.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
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          <isin value="US30063P1057"/>
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        <balance>849312.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
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          <isin value="US03969F1093"/>
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        <balance>509142.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PRECIPIO INC</name>
        <lei>54930079ULTBRXUQNR89</lei>
        <title>PRECIPIO INC PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="BIG915000"/>
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        <balance>525.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HOMOLOGY MEDICINES INC</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>HOMOLOGY MEDICINES INC</title>
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          <isin value="US4380831077"/>
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        <balance>426676.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MERSANA THERAPEUTICS INC</name>
        <lei>529900VWD5VDZ7PVOS22</lei>
        <title>MERSANA THERAPEUTICS INC</title>
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          <isin value="US59045L1061"/>
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        <balance>93306.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2112447.84000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KALVISTA PHARMACEUTICALS INC</name>
        <lei>529900Q7IDA3WUGRZA51</lei>
        <title>KALVISTA PHARMACEUTICALS INC</title>
        <cusip>483497103</cusip>
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          <isin value="US4834971032"/>
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        <balance>884861.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9954686.25000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
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        <balance>790293.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49369603.71000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
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          <isin value="US02043Q1076"/>
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        <curCd>USD</curCd>
        <valUSD>171708762.06000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
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          <isin value="US0197701065"/>
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        <balance>7560.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC 144A</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="BCI060000"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE N.V.</title>
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        <balance>574315.00000000</balance>
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        <curCd>USD</curCd>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
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          <isin value="US3755581036"/>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>INCYTE CORP</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP</title>
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          <isin value="US45337C1027"/>
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        <balance>18371.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SEATTLE GENETICS INC</name>
        <lei>N/A</lei>
        <title>SEATTLE GENETICS INC</title>
        <cusip>812578102</cusip>
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          <isin value="US8125781026"/>
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        <balance>2486760.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>390943539.60000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BRUKER CORP</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP</title>
        <cusip>116794108</cusip>
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          <isin value="US1167941087"/>
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        <balance>316600.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>13702448.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>GENMAB AS</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>GENMAB</title>
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          <ticker value="GMAB"/>
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        <balance>281690.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALKERMES PLC</name>
        <lei>N/A</lei>
        <title>ALKERMES PLC</title>
        <cusip>N/A</cusip>
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        <balance>60274.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>986082.64000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC 8% SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="78Z99F247"/>
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        <balance>2783187.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>11884208.49000000</valUSD>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
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          <isin value="US09062X1037"/>
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        <balance>14914.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4579940.26000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC</title>
        <cusip>299734103</cusip>
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          <isin value="US2997341035"/>
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        <balance>26600.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>KURA ONCOLOGY INC</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>KURA ONCOLOGY INC</title>
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          <isin value="US50127T1097"/>
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        <balance>2429963.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEXTCURE INC</name>
        <lei>549300Y5PR6RJR1STI24</lei>
        <title>NEXTCURE INC</title>
        <cusip>65343E108</cusip>
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          <isin value="US65343E1082"/>
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        <balance>148490.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
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          <isin value="US76243J1051"/>
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        <balance>226078.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LIGAND PHARMACEUTICALS INC</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>LIGAND PHARMACEUTICALS</title>
        <cusip>53220K504</cusip>
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          <isin value="US53220K5048"/>
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        <balance>4940.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <title>SCHOLAR ROCK HOLDING CORP</title>
        <cusip>80706P103</cusip>
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          <isin value="US80706P1030"/>
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        <balance>1528947.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
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          <isin value="US60770K1079"/>
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        <balance>311805.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ADVERUM BIOTECHNOLOGIES INC</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
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          <isin value="US00773U1088"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
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          <isin value="US76155X1000"/>
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        <balance>451167.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US74366E1029"/>
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        <balance>652063.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DICERNA PHARMACEUTICALS INC</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>DICERNA PHARMACEUTICALS INC</title>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC 144A</title>
        <cusip>N/A</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KEZAR LIFE SCIENCES INC</name>
        <lei>549300EV1V8GXBV18004</lei>
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        <balance>820472.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>FREQUENCY THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>AMARIN CORPORATION PLC</name>
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        <title>AMARIN CORP PLC ADR</title>
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        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>MORPHOSYS AG</name>
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        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
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        <name>LEXICON PHARMACEUTICALS INC</name>
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        <name>ACADIA PHARMACEUTICALS INC</name>
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        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
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        <invCountry>CH</invCountry>
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        <name>MIRUM PHARMACEUTICALS INC</name>
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        <title>MIRUM PHARMACEUTICALS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BLUEBIRD BIO INC</name>
        <lei>N/A</lei>
        <title>BLUEBIRD BIO INC</title>
        <cusip>09609G100</cusip>
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        <balance>499084.00000000</balance>
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        <name>CYTOMX THERAPEUTICS INC</name>
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      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
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      <invstOrSec>
        <name>GALAPAGOS GENOMICS NV</name>
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      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
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      <invstOrSec>
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        <fairValLevel>1</fairValLevel>
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        <name>INSMED INC</name>
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        <name>LA JOLLA PHARMACEUTICAL CO</name>
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        <name>STEMCENTRX INC</name>
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        <name>CYCLERION THERAPEUTICS INC</name>
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        <name>UROVANT SCIENCES LTD</name>
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        <fairValLevel>1</fairValLevel>
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        <name>PROTHENA CORP PLC</name>
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        <name>MACROGENICS INC</name>
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        <name>ORIC PHARMACEUTICALS INC</name>
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        <name>SYROS PHARMACEUTICALS INC</name>
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        <name>GLOBAL BLOOD THERAPEUTICS INC</name>
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        <name>KARYOPHARM THERAPEUTICS INC</name>
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        <name>ATARA BIOTHERAPEUTICS INC</name>
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        <name>BLACK DIAMOND THERAPEUTICS INC</name>
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        <name>NATERA INC</name>
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        <title>NATERA INC</title>
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        <name>ENANTA PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>OVID THERAPEUTICS INC</name>
        <lei>549300H36NUI4L6U8F17</lei>
        <title>OVID THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARIX BIOSCIENCE PLC</name>
        <lei>213800OVT3AHQCXNIX43</lei>
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        <cusip>N/A</cusip>
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          <isin value="GB00BD045071"/>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
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        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>MIRATI THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>BIOCRYST PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>RIGEL PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARDELYX INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ALDEYRA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HOOKIPA PHARMA INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ANAPTYSBIO INC</name>
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        <name>ARVINAS INC</name>
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        <name>MYOS RENS TECHNOLOGY INC</name>
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        <name>TRANSLATE BIO INC</name>
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        <name>CHEMOCENTRYX INC</name>
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        <name>CYTOKINETICS INC</name>
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        <name>GAMIDA CELL LTD</name>
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        <name>MORPHOSYS AG</name>
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        <name>ARROWHEAD PHARMACEUTICALS INC</name>
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        <name>GERON CORP</name>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>APPLIED THERAPEUTICS INC</title>
        <cusip>03828A101</cusip>
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          <isin value="US03828A1016"/>
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        <balance>973740.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44324644.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVROBIO</name>
        <lei>N/A</lei>
        <title>AVROBIO INC</title>
        <cusip>05455M100</cusip>
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          <isin value="US05455M1009"/>
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        <balance>776654.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15703943.88000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ODONATE THERAPEUTICS INC</name>
        <lei>549300D50X5LSJ208C14</lei>
        <title>ODONATE THERAPEUTICS INC</title>
        <cusip>676079106</cusip>
        <identifiers>
          <isin value="US6760791060"/>
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        <balance>154594.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5050585.98000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ALECTOR INC</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>ALECTOR INC</title>
        <cusip>014442107</cusip>
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          <isin value="US0144421072"/>
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        <balance>608182.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19887551.40000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7227877.20000000"/>
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      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC 8% SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="78Z99F239"/>
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        <balance>856366.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3656682.82000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RETROPHIN INC</name>
        <lei>N/A</lei>
        <title>RETROPHIN INC</title>
        <cusip>761299106</cusip>
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          <isin value="US7612991064"/>
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        <balance>781199.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12253106.32000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MESOBLAST LTD</name>
        <lei>529900J5ALF3JG921927</lei>
        <title>MESOBLAST LTD</title>
        <cusip>N/A</cusip>
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          <isin value="AU000000MSB8"/>
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        <balance>2182670.00000000</balance>
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        <currencyConditional curCd="AUD" exchangeRt="1.50026255"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>AU</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>FIBROGEN INC</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC</title>
        <cusip>31572Q808</cusip>
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          <isin value="US31572Q8087"/>
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        <balance>1409365.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47129165.60000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MIRAGEN THERAPEUTICS</name>
        <lei>549300C775BNYF550E70</lei>
        <title>MIRAGEN THERAPEUTICS INC</title>
        <cusip>60463E103</cusip>
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          <isin value="US60463E1038"/>
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        <balance>3888656.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3838103.47000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ARAVIVE INC</name>
        <lei>5493002Z0KHRW71RNC19</lei>
        <title>ARAVIVE INC</title>
        <cusip>03890D108</cusip>
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          <isin value="US03890D1081"/>
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        <balance>774799.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9925175.19000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>APREA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APREA THERAPEUTICS INC</title>
        <cusip>03836J102</cusip>
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          <isin value="US03836J1025"/>
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        <balance>535700.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>14388902.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CONSTELLATION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CONSTELLATION PHARMACEUTICALS INC</title>
        <cusip>210373106</cusip>
        <identifiers>
          <isin value="US2103731061"/>
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        <balance>152100.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5404113.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
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        <balance>54800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3695164.00000000</valUSD>
        <pctVal>0.049720294378</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>KALEIDO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>KALEIDO BIOSCIENCES INC</title>
        <cusip>483347100</cusip>
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          <isin value="US4833471000"/>
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        <balance>66633.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>481090.26000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HORIZON THERAPEUTICS PLC</name>
        <lei>N/A</lei>
        <title>HORIZON THERAPEUTICS PLC</title>
        <cusip>N/A</cusip>
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          <isin value="IE00BQPVQZ61"/>
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        <balance>470319.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
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          <other otherDesc="Internal" value="AIA874000"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>INNOVENT BIOLGICS INC</name>
        <lei>25490058ONL9SCIE1R22</lei>
        <title>INNOVENT BIOLOGICS INC</title>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>PRINCIPIA BIOPHARMA INC</name>
        <lei>549300WHPKRLU16IRE69</lei>
        <title>PRINCIPIA BIOPHARMA INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>EIDOS THERAPEUTICS INC</name>
        <lei>549300VGYGU07QRG6271</lei>
        <title>EIDOS THERAPEUTICS INC</title>
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        <balance>118947.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ROCKET PHARMACEUTICALS INC</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
        <cusip>75615P103</cusip>
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        <balance>226552.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>KARUNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC</title>
        <cusip>48576A100</cusip>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        <name>ORAGENICS INC</name>
        <lei>549300639MGD19K4ZW90</lei>
        <title>ORAGENICS INC PIPE</title>
        <cusip>N/A</cusip>
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        <balance>155806.00000000</balance>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>AC IMMUNE SA</name>
        <lei>967600VLQ0ZC2HSOG765</lei>
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        <cusip>N/A</cusip>
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          <isin value="CH0329023102"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>MOMENTA PHARMACEUTICALS INC</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>MOMENTA PHARMACEUTICALS INC</title>
        <cusip>60877T100</cusip>
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          <isin value="US60877T1007"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
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          <isin value="US67576A1007"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>COHERUS BIOSCIENCES INC</name>
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          <isin value="US19249H1032"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
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          <isin value="US05464T1043"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>XERIS PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IMARA INC</name>
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          <isin value="US45249V1070"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PASSAGE BIO INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>YUMANITY HOLDINGS LLC</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal" value="ABI743000"/>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
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        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALBIREO PHARMA INC</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>10X GENOMICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>EPIZYME INC</name>
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        <name>SERES THERAPEUTICS INC</name>
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        <name>ZOGENIX INC</name>
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        <name>THERAPEUTICSMD INC</name>
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        <name>ASCENDIS PHARMA A/S</name>
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        <name>IONIS PHARMACEUTICALS INC</name>
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        <name>CHIMERIX INC</name>
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        <name>INTELLIA THERAPEUTICS INC</name>
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        <name>AXCELLA HEALTH INC</name>
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        <name>GRITSTONE ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>EAGLE PHARMACEUTICALS INC</name>
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      <invstOrSec>
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        <name>BIONTECH SE</name>
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      </invstOrSec>
      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>MORPHIC HOLDING INC</title>
        <cusip>61775R105</cusip>
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          <isin value="US61775R1059"/>
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        <balance>758437.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
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          <isin value="US5011471027"/>
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        <balance>1329286.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>68338593.26000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7906858.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOVANT INC</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC</title>
        <cusip>45258J102</cusip>
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          <isin value="US45258J1025"/>
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        <balance>500000.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC</title>
        <cusip>87184Q107</cusip>
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          <isin value="US87184Q1076"/>
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        <balance>758619.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PHARMING GROUP NV</name>
        <lei>724500DCJ9MPG74JEH91</lei>
        <title>PHARMING GROUP NV</title>
        <cusip>N/A</cusip>
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          <isin value="NL0010391025"/>
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        <balance>792029.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>AMICUS THERAPEUTICS INC</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC</title>
        <cusip>03152W109</cusip>
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          <isin value="US03152W1099"/>
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        <balance>4114481.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
        <cusip>03753U106</cusip>
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          <isin value="US03753U1060"/>
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        <balance>498134.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
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          <isin value="CA98420N1050"/>
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        <balance>214500.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2938650.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RPI INTERNATIONAL HOLDINGS LP</name>
        <lei>N/A</lei>
        <title>RPI INTERNATIONAL HOLDINGS LP P/P</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="FCG412000"/>
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        <balance>54958.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
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          <isin value="US98401F1057"/>
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        <balance>1014543.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>VERASTEM INC</name>
        <lei>549300IY0EFBIU8NQC81</lei>
        <title>VERASTEM INC</title>
        <cusip>92337C104</cusip>
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          <isin value="US92337C1045"/>
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        <balance>475000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MEDICINOVA INC</name>
        <lei>N/A</lei>
        <title>MEDICINOVA INC</title>
        <cusip>58468P206</cusip>
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          <isin value="US58468P2065"/>
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        <balance>96484.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB HOLDINGS LLC</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="71E99L226"/>
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        <balance>1954526.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RUBIUS THERAPEUTICS</name>
        <lei>549300ER84PB0QV6HZ76</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IOVANCE BIOTHERAPEUTICS INC</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC</title>
        <cusip>462260100</cusip>
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        <balance>1518407.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CABALETTA BIO INC</name>
        <lei>N/A</lei>
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        <cusip>12674W109</cusip>
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        <balance>170550.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC</title>
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        <balance>299014.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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        <name>DYNAVAX TECHNOLOGIES CORP</name>
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        <fairValLevel>1</fairValLevel>
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        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>MAGENTA THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>MAGENTA THERAPEUTICS INC</title>
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        <balance>40712.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ATHENEX INC</name>
        <lei>5493001V4L0Q5EPPOH52</lei>
        <title>ATHENEX INC</title>
        <cusip>04685N103</cusip>
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        <balance>717400.00000000</balance>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>OBSEVA SA</name>
        <lei>549300PNZ0UEJVKN1618</lei>
        <title>OBSEVA SA</title>
        <cusip>N/A</cusip>
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        <balance>1355036.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>THERAVANCE BIOPHARMA INC</name>
        <lei>5493007VTSXP4Z6MIW52</lei>
        <title>THERAVANCE BIOPHARMA INC</title>
        <cusip>N/A</cusip>
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        <balance>371300.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>VANDA PHARMACEUTICALS INC</name>
        <lei>529900AY8VOOQBKJ0O70</lei>
        <title>VANDA PHARMACEUTICALS INC</title>
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        <balance>232692.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARENA PHARMACEUTICALS INC</name>
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      <invstOrSec>
        <name>DECIPHERA PHARMACEUTICALS INC</name>
        <lei>529900QR4WAPYY0CBF25</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS LTD</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AIMMUNE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARADIGM CORP</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HERON THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CLOVIS ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>EDITAS MEDICINE INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SAGE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>BIOMARIN PHARMACEUTICAL INC</name>
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        <name>ADAPTIVE BIOTECHNOLOGIES CORP</name>
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        <name>PROQR THERAPEUTICS NV</name>
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        <name>MYOVANT SCIENCES LTD</name>
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        <name>VIKING THERAPEUTICS INC</name>
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        <name>23ANDME INC</name>
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        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
        <cusip>09075P105</cusip>
        <identifiers>
          <isin value="US09075P1057"/>
        </identifiers>
        <balance>280190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13045646.40000000</valUSD>
        <pctVal>0.175535748716</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>736328.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>451229161.68000000</valUSD>
        <pctVal>6.071515838291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PUMA BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>PUMA BIOTECHNOLOGY INC</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
        </identifiers>
        <balance>122868.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1254482.28000000</valUSD>
        <pctVal>0.016879691470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="940341.00000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2020-06-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
