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        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>MASIMO CORP</title>
        <cusip>574795100</cusip>
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          <isin value="US5747951003"/>
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        <balance>650000.00000000</balance>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GENERATION BIO</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="CII824000"/>
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        <balance>130800.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>HARMONY BIOSCIENCES II INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES II INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EIJ810000"/>
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        <balance>1845926.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALEXION PHARMACEUTICALS INC</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>ALEXION PHARMACEUTICALS INC</title>
        <cusip>015351109</cusip>
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          <isin value="US0153511094"/>
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        <balance>700000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>BLACK DIAMOND THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BLACK DIAMOND THERAPEUTICS INC</title>
        <cusip>09203E105</cusip>
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          <isin value="US09203E1055"/>
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        <balance>230000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>GENMARK DIAGNOSTICS INC</name>
        <lei>N/A</lei>
        <title>GENMARK DIAGNOSTICS INC</title>
        <cusip>372309104</cusip>
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          <isin value="US3723091043"/>
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        <balance>2470000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CASTLIGHT HEALTH INC</name>
        <lei>549300K52FAO83JL0L06</lei>
        <title>CASTLIGHT HEALTH INC</title>
        <cusip>14862Q100</cusip>
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          <isin value="US14862Q1004"/>
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        <balance>3850000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SHOCKWAVE MEDICAL INC</name>
        <lei>549300LDXO56IC5Y1538</lei>
        <title>SHOCKWAVE MEDICAL INC</title>
        <cusip>82489T104</cusip>
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          <isin value="US82489T1043"/>
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        <balance>610000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GRITSTONE ONCOLOGY INC</name>
        <lei>5493003TER6KY3MUVY84</lei>
        <title>GRITSTONE ONCOLOGY INC</title>
        <cusip>39868T105</cusip>
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          <isin value="US39868T1051"/>
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        <balance>584900.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CLARIVATE ANALYTICS PLC</name>
        <lei>549300WDHIIODXFO0R55</lei>
        <title>CLARIVATE ANALYTICS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BJJN4441"/>
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        <balance>1000000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZOGENIX INC</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>ZOGENIX INC</title>
        <cusip>98978L204</cusip>
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          <isin value="US98978L2043"/>
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        <balance>600000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
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          <isin value="US0311621009"/>
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        <balance>550000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>10X GENOMICS INC</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X GENOMICS INC CL B (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="FAE924000"/>
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        <balance>3018778.00000000</balance>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BECTON DICKINSON and CO</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LILLY (ELI) and CO</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>LILLY (ELI) and CO</title>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES II INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES II INC SER A PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="CCF830000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>BRISTOL-MYERS SQUIBB CO</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>BRISTOL-MYERS SQUIBB CO</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MYOKARDIA INC</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MYOKARDIA INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PRINCIPIA BIOPHARMA INC</name>
        <lei>549300WHPKRLU16IRE69</lei>
        <title>PRINCIPIA BIOPHARMA INC</title>
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      <invstOrSec>
        <name>HEAL OSH HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>HEAL OSH HOLDINGS LLC</title>
        <cusip>N/A</cusip>
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      <invstOrSec>
        <name>OUTSET MEDICAL INC</name>
        <lei>N/A</lei>
        <title>OUTSET MEDICAL INC SER E PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="FFI728000"/>
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        <fairValLevel>3</fairValLevel>
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        <name>STRYKER CORP</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP</title>
        <cusip>863667101</cusip>
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        <balance>700000.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BLUEBIRD BIO INC</name>
        <lei>N/A</lei>
        <title>BLUEBIRD BIO INC</title>
        <cusip>09609G100</cusip>
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        <balance>351960.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>PENUMBRA INC</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC</title>
        <cusip>70975L107</cusip>
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        <balance>747507.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
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          <isin value="US78667J1088"/>
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        <balance>88979.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4182013.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
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          <isin value="US02043Q1076"/>
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        <balance>730000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>85891800.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HCA HEALTHCARE INC</name>
        <lei>529900PH4ZGUH2MNEU89</lei>
        <title>HCA HEALTHCARE INC</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
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        <balance>1180000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>149871800.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INSULET CORP</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP</title>
        <cusip>45784P101</cusip>
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          <isin value="US45784P1012"/>
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        <balance>1019100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
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        <balance>853108.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>111228221.04000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>APREA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APREA THERAPEUTICS INC</title>
        <cusip>03836J102</cusip>
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          <isin value="US03836J1025"/>
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        <balance>408557.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>14013505.10000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TURNING POINT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC</title>
        <cusip>90041T108</cusip>
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          <isin value="US90041T1088"/>
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        <balance>215000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>10657550.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ROCHE HOLDING LTD</name>
        <lei>549300U41AUUVOAAOB37</lei>
        <title>ROCHE HOLDINGS AG (GENUSSCHEINE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
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        <balance>1400000.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RECORDATI SPA</name>
        <lei>815600FBF92FD3531704</lei>
        <title>RECORDATI SPA</title>
        <cusip>N/A</cusip>
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          <isin value="IT0003828271"/>
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        <balance>600000.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IT</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CARRIAGE SERVICES INC</name>
        <lei>N/A</lei>
        <title>CARRIAGE SERVICES INC</title>
        <cusip>143905107</cusip>
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          <isin value="US1439051079"/>
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        <balance>243598.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HEALTHEQUITY INC</name>
        <lei>529900LRJU1RAFQHM467</lei>
        <title>HEALTHEQUITY INC</title>
        <cusip>42226A107</cusip>
        <identifiers>
          <isin value="US42226A1079"/>
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        <balance>630000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>44723700.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
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        <balance>600000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56820000.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIONTECH AG</name>
        <lei>N/A</lei>
        <title>BIONTECH SE (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="FBF821000"/>
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        <balance>1638432.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>54633515.04000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ATRICURE INC</name>
        <lei>N/A</lei>
        <title>ATRICURE INC</title>
        <cusip>04963C209</cusip>
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          <isin value="US04963C2098"/>
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        <balance>1000000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>38420000.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CIGNA CORP</name>
        <lei>549300VIWYMSIGT1U456</lei>
        <title>CIGNA CORP</title>
        <cusip>125523100</cusip>
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        <balance>1800000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NOTRE DAME INTERMEDICA PARTICIPACOES SA</name>
        <lei>N/A</lei>
        <title>NOTRE DAME INTERMEDICA PARTICIPACOES SA</title>
        <cusip>N/A</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>BR</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>FIDELITY REVERE STREET TRUST</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
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          <isin value="US31635A3032"/>
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        <balance>79946994.84400000</balance>
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        <curCd>USD</curCd>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HEALTH CATALYST INC</name>
        <lei>N/A</lei>
        <title>HEALTH CATALYST INC</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>SANOFI</name>
        <lei>549300E9PC51EN656011</lei>
        <title>SANOFI</title>
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        <invCountry>FR</invCountry>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>FIBROGEN INC</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC</title>
        <cusip>31572Q808</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
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        <balance>600000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>84828000.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
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        <curCd>USD</curCd>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ZYMEWORKS INC</name>
        <lei>894500AHOYAGYLYZJL67</lei>
        <title>ZYMEWORKS INC</title>
        <cusip>98985W102</cusip>
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        <balance>856925.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GENERATION BIO</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO SER C PC PP</title>
        <cusip>N/A</cusip>
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        <balance>124500.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>696129.30000000</valUSD>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INNOVENT BIOLGICS INC</name>
        <lei>25490058ONL9SCIE1R22</lei>
        <title>INNOVENT BIOLOGICS INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG4818G1010"/>
        </identifiers>
        <balance>6644500.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.79500000"/>
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        <pctVal>0.418784396627</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CELLECTIS SA</name>
        <lei>5493000KKX5VQ37Q2W83</lei>
        <title>CELLECTIS SA SPON ADR</title>
        <cusip>15117K103</cusip>
        <identifiers>
          <isin value="US15117K1034"/>
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        <balance>690000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10777800.00000000</valUSD>
        <pctVal>0.148738852983</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTERCEPT PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>INTERCEPT PHARMACEUTICALS INC</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
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        <balance>340600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31314764.00000000</valUSD>
        <pctVal>0.432158889459</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
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        <balance>700000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59997000.00000000</valUSD>
        <pctVal>0.827987619223</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BELLUS HEALTH INC NEW</name>
        <lei>549300QZYQDSMOXCP667</lei>
        <title>BELLUS HEALTH INC</title>
        <cusip>07987C204</cusip>
        <identifiers>
          <isin value="CA07987C2040"/>
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        <balance>1200000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10524000.00000000</valUSD>
        <pctVal>0.145236290226</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
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          <isin value="US92532F1003"/>
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        <balance>1200000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>268836000.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>EBOS GROUP LTD</name>
        <lei>N/A</lei>
        <title>EBOS GROUP LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NZEBOE0001S6"/>
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        <balance>2280000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="NZD" exchangeRt="1.59987201"/>
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        <pctVal>0.458050543535</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NZ</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MOMENTA PHARMACEUTICALS INC</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>MOMENTA PHARMACEUTICALS INC</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
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        <balance>500000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14145000.00000000</valUSD>
        <pctVal>0.195207841623</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VIELA BIO INC</name>
        <lei>N/A</lei>
        <title>VIELA BIO INC</title>
        <cusip>926613100</cusip>
        <identifiers>
          <isin value="US9266131005"/>
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        <balance>700000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30548000.00000000</valUSD>
        <pctVal>0.421577175392</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BOSTON SCIENTIFIC CORP</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
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        <balance>12200000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>456158000.00000000</valUSD>
        <pctVal>6.295201033545</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TANDEM DIABETES CARE INC</name>
        <lei>549300JEPFOD0K4D3I05</lei>
        <title>TANDEM DIABETES CARE INC</title>
        <cusip>875372203</cusip>
        <identifiers>
          <isin value="US8753722037"/>
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        <balance>248557.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18557265.62000000</valUSD>
        <pctVal>0.256099241295</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BENEFITFOCUS INC</name>
        <lei>254900W89KP1OS3RXO89</lei>
        <title>BENEFITFOCUS INC</title>
        <cusip>08180D106</cusip>
        <identifiers>
          <isin value="US08180D1063"/>
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        <balance>344526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4299684.48000000</valUSD>
        <pctVal>0.059337725486</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="556608.00000000"/>
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      <invstOrSec>
        <name>RPI INTERNATIONAL HOLDINGS LP</name>
        <lei>N/A</lei>
        <title>RPI INTERNATIONAL HOLDINGS LP P/P</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="FCG412000"/>
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        <balance>199753.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40949365.00000000</valUSD>
        <pctVal>0.565121043303</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DECHRA PHARMACEUTICALS PLC</name>
        <lei>213800J4UVB5OWG8VX82</lei>
        <title>DECHRA PHARMACEUTICALS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB0009633180"/>
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        <balance>1280000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.77993994"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ACCELERON PHARMA INC</name>
        <lei>529900TQRID2UY164805</lei>
        <title>ACCELERON PHARMA INC</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
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        <balance>888101.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76314518.93000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
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        <balance>1280000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16064000.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
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          <isin value="US75886F1075"/>
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        <balance>100000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>44457000.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
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          <isin value="US24823R1059"/>
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        <balance>360000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7117200.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
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          <isin value="US92686J1060"/>
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        <balance>1160000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6867200.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DANAHER CORP</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
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        <balance>620000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89639600.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>1LIFE HEALTHCARE INC</name>
        <lei>N/A</lei>
        <title>1LIFE HEALTHCARE INC (180 DAY LOCKUP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="FGA879000"/>
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        <balance>1639892.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>31909018.54000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MOLINA HEALTHCARE INC</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC</title>
        <cusip>60855R100</cusip>
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          <isin value="US60855R1005"/>
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        <balance>670000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82108500.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNITEDHEALTH GROUP INC</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC</title>
        <cusip>91324P102</cusip>
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          <isin value="US91324P1021"/>
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        <balance>2000000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>509920000.00000000</valUSD>
        <pctVal>7.037142637036</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CENTENE CORP DEL</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
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        <balance>4380000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>232227600.00000000</valUSD>
        <pctVal>3.204853203358</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HUMANA INC</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>HUMANA INC</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
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        <balance>700000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>223776000.00000000</valUSD>
        <pctVal>3.088217035506</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHOSYS AG</name>
        <lei>529900493806K77LRE72</lei>
        <title>MORPHOSYS AG SPONSORED ADR</title>
        <cusip>617760202</cusip>
        <identifiers>
          <isin value="US6177602025"/>
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        <balance>99.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2642.31000000</valUSD>
        <pctVal>0.000036465156</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>LONZA GROUP AG</name>
        <lei>549300EFW4H2TCZ71055</lei>
        <title>LONZA GROUP AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0013841017"/>
        </identifiers>
        <balance>170000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.96480000"/>
        <valUSD>67836420.73000000</valUSD>
        <pctVal>0.936175417051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
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        <balance>600000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32478000.00000000</valUSD>
        <pctVal>0.448212108890</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>OUTSET MEDICAL INC</name>
        <lei>N/A</lei>
        <title>OUTSET MEDICAL INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="75M99T239"/>
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        <balance>8159125.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16155067.50000000</valUSD>
        <pctVal>0.222947745349</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
        <cusip>76155X100</cusip>
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          <isin value="US76155X1000"/>
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        <balance>207458.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6487211.66000000</valUSD>
        <pctVal>0.089526658628</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASTRAZENECA PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
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        <balance>3860000.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.77993994"/>
        <valUSD>338772646.39000000</valUSD>
        <pctVal>4.675226377025</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
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        <balance>596829.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15860730.68000000</valUSD>
        <pctVal>0.218885754868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>KURA ONCOLOGY INC</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>KURA ONCOLOGY INC</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
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        <balance>1000000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>12070000.00000000</valUSD>
        <pctVal>0.166571837992</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CASTLIGHT HEALTH INC</name>
        <lei>549300K52FAO83JL0L06</lei>
        <title>CASTLIGHT HEALTH INC A (UNLISTED)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Bloomberg" value="EQ0000000034547942"/>
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        <balance>1845550.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1672621.97000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
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          <isin value="US0197701065"/>
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        <balance>280000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7560000.00000000</valUSD>
        <pctVal>0.104331656604</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6002100.00000000"/>
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      <invstOrSec>
        <name>FIDELITY REVERE STREET TRUST</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
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          <isin value="US31635A1051"/>
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        <balance>36520440.46400000</balance>
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        <curCd>USD</curCd>
        <valUSD>36527744.55000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>MORPHIC HOLDING INC</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
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        <balance>258259.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4080492.20000000</valUSD>
        <pctVal>0.056312766003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>OUTSET MEDICAL INC</name>
        <lei>N/A</lei>
        <title>OUTSET MEDICAL INC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="75M99T221"/>
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        <balance>3279404.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7214688.80000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BRUKER CORP</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
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        <balance>1800000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78408000.00000000</valUSD>
        <pctVal>1.082068324217</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>INTUITIVE SURGICAL INC</name>
        <lei>N/A</lei>
        <title>INTUITIVE SURGICAL INC</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
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        <balance>420000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>224263200.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>BEIGENE LTD</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD SP ADR</title>
        <cusip>07725L102</cusip>
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          <isin value="US07725L1026"/>
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        <balance>260000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>41171000.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
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          <isin value="US98401F1057"/>
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        <balance>1200000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38988000.00000000</valUSD>
        <pctVal>0.538053257634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 THERAPEUTICS INC</title>
        <cusip>3621LQ109</cusip>
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        <curCd>USD</curCd>
        <valUSD>16520999.82000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
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        <balance>1000000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>114470000.00000000</valUSD>
        <pctVal>1.579741366609</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5425878.00000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2020-03-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
