<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000320351</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000007486</seriesId>
        <classId>C000020460</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>FIDELITY SELECT PORTFOLIOS</regName>
      <regFileNumber>811-03114</regFileNumber>
      <regCik>0000320351</regCik>
      <regLei>Z57125JG1LHEQKDYS630</regLei>
      <regStreet1>245 Summer Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02210</regZipOrPostalCode>
      <regPhone>1-800-FIDELITY</regPhone>
      <seriesName>Select Biotechnology Portfolio</seriesName>
      <seriesId>S000007486</seriesId>
      <seriesLei>FQDPG178WXRZSXLIRG32</seriesLei>
      <repPdEnd>2021-02-28</repPdEnd>
      <repPdDate>2020-02-29</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>7358252988.22</totAssets>
      <totLiabs>707754773.59</totLiabs>
      <netAssets>6650498214.63</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>804780.75000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>69208.94000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="118526219.29000000" lei="MBNUM2BPBDO7JBLYG310" name="CITIGROUP GLOBAL MARKETS INC."/>
        <borrower aggrVal="66360.00000000" lei="549300F35UE0BOM1WJ55" name="SG AMERICAS SECURITIES LLC"/>
        <borrower aggrVal="1014220.00000000" lei="KBVRJ5K57JZ3E2AVWX40" name="ING FINANCIAL MARKETS LLC"/>
        <borrower aggrVal="62165584.30000000" lei="FOR8UP27PHTHYVLBNG30" name="GOLDMAN SACHS and CO LLC (GOV REPO)"/>
        <borrower aggrVal="8179632.00000000" lei="549300BLWPABP1VNME36" name="SCOTIA CAPITAL (USA) INC."/>
        <borrower aggrVal="2253238.00000000" lei="9J6MBOOO7BECTDTUZW19" name="DEUTSCHE BANK SECURITIES INC."/>
        <borrower aggrVal="2773452.60000000" lei="RCNB6OTYUAMMP879YW96" name="BNP PARIBAS SECURITIES CORP."/>
        <borrower aggrVal="1301025.00000000" lei="1V8Y6QCX6YMJ2OELII46" name="CREDIT SUISSE SECURITIES(USA)LLC"/>
        <borrower aggrVal="108675522.21000000" lei="ZBUT11V806EZRVTWT807" name="JPMORGAN SECURITIES LLC"/>
        <borrower aggrVal="3935633.00000000" lei="549300JRHF1MHHWUAW04" name="NATIONAL FINANCIAL SERVICES, LLC"/>
        <borrower aggrVal="172447915.50000000" lei="549300HN4UKV1E2R3U73" name="BOFA SECURITIES INC"/>
        <borrower aggrVal="1699765.00000000" lei="OXTKY6Q8X53C9ILVV871" name="NOMURA SECURITIES INTERNATIONAL INC"/>
        <borrower aggrVal="78877699.78000000" lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY and CO LLC"/>
        <borrower aggrVal="501768.00000000" lei="VYVVCKR63DVZZN70PB21" name="WELLS FARGO SECURITIES, LLC"/>
        <borrower aggrVal="31505866.24000000" lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL INC."/>
        <borrower aggrVal="403648.00000000" lei="RUC0QBLBRPRCU4W1NE59" name="BMO CAPITAL MARKETS CORP"/>
        <borrower aggrVal="2613720.00000000" lei="T6FIZBDPKLYJKFCRVK44" name="UBS SECURITIES LLC."/>
        <borrower aggrVal="7323832.00000000" lei="58PU97L1C0WSRCWADL48" name="JEFFERIES LLC"/>
      </borrowers>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000020460" rtn1="3.59000000" rtn2="-4.44000000" rtn3="-0.43000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <commodityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </commodityContracts>
          <creditContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </creditContracts>
          <equityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </equityContracts>
          <foreignExchgContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </foreignExchgContracts>
          <interestRtContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </interestRtContracts>
          <otherContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </otherContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="142647384.25000000" netUnrealizedAppr="111106061.17000000"/>
        <othMon2 netRealizedGain="54982622.71000000" netUnrealizedAppr="-377740721.92000000"/>
        <othMon3 netRealizedGain="92797617.39000000" netUnrealizedAppr="-111918233.40000000"/>
      </returnInfo>
      <mon1Flow redemption="148093089.91000000" reinvestment="352258326.33000000" sales="99857170.91000000"/>
      <mon2Flow redemption="220141274.17000000" reinvestment="1499.12000000" sales="65328053.65000000"/>
      <mon3Flow redemption="160625055.23000000" reinvestment="0.00000000" sales="45455866.08000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>512605.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13840335.00000000</valUSD>
        <pctVal>0.208109746869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10926900.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EGI379000"/>
        </identifiers>
        <balance>2086600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1609561.51000000</valUSD>
        <pctVal>0.024202119270</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HERON THERAPEUTICS INC</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>HERON THERAPEUTICS INC</title>
        <cusip>427746102</cusip>
        <identifiers>
          <isin value="US4277461020"/>
        </identifiers>
        <balance>1962225.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36595496.25000000</valUSD>
        <pctVal>0.550266988561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10113895.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
        </identifiers>
        <balance>51563.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>770866.85000000</valUSD>
        <pctVal>0.011591114306</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>391584.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78211072.32000000</valUSD>
        <pctVal>1.176018243985</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITY BIOTECHNOLOGY INC</name>
        <lei>549300WDOM0RU3CUO763</lei>
        <title>UNITY BIOTECHNOLOGY INC</title>
        <cusip>91381U101</cusip>
        <identifiers>
          <isin value="US91381U1016"/>
        </identifiers>
        <balance>51400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>308914.00000000</valUSD>
        <pctVal>0.004644975309</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC 8% SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="78Z99F247"/>
        </identifiers>
        <balance>2783187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12468677.76000000</valUSD>
        <pctVal>0.187484867412</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADAPTIVE BIOTECHNOLOGIES CORP</name>
        <lei>549300ZTF7OT1FW66Q96</lei>
        <title>ADAPTIVE BIOTECHNOLOGIES CORP</title>
        <cusip>00650F109</cusip>
        <identifiers>
          <isin value="US00650F1093"/>
        </identifiers>
        <balance>169780.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4770818.00000000</valUSD>
        <pctVal>0.071736249616</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="101160.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="038505921"/>
        </identifiers>
        <balance>148009.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14963.71000000</valUSD>
        <pctVal>0.000225001338</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SANGAMO THERAPEUTICS INC</name>
        <lei>2549006WMRKRC4G32Z67</lei>
        <title>SANGAMO THERAPEUTICS INC</title>
        <cusip>800677106</cusip>
        <identifiers>
          <isin value="US8006771062"/>
        </identifiers>
        <balance>915227.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7806886.31000000</valUSD>
        <pctVal>0.117387991967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6783201.01000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATYR PHARMA INC</name>
        <lei>529900ENQUXMC5EBKO36</lei>
        <title>ATYR PHARMA INC</title>
        <cusip>002120202</cusip>
        <identifiers>
          <isin value="US0021202025"/>
        </identifiers>
        <balance>407046.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1510140.66000000</valUSD>
        <pctVal>0.022707180894</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="403648.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
        </identifiers>
        <balance>223309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17418102.00000000</valUSD>
        <pctVal>0.261906723945</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10732800.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRUM PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>MIRUM PHARMACEUTICALS INC</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
        </identifiers>
        <balance>235000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3891600.00000000</valUSD>
        <pctVal>0.058515916769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2720808.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARUNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
        </identifiers>
        <balance>226008.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19721458.08000000</valUSD>
        <pctVal>0.296541062692</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TRANSLATE BIO INC</name>
        <lei>N/A</lei>
        <title>TRANSLATE BIO INC</title>
        <cusip>89374L104</cusip>
        <identifiers>
          <isin value="US89374L1044"/>
        </identifiers>
        <balance>1613497.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12230307.26000000</valUSD>
        <pctVal>0.183900617146</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4186145.96000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPERO THERAPEUTICS INC</name>
        <lei>54930074G13LHWJT2323</lei>
        <title>SPERO THERAPEUTICS INC</title>
        <cusip>84833T103</cusip>
        <identifiers>
          <isin value="US84833T1034"/>
        </identifiers>
        <balance>98952.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>944002.08000000</valUSD>
        <pctVal>0.014194456558</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AURINIA PHARMACEUTICALS INC</name>
        <lei>5299008YP2BW4570ML28</lei>
        <title>AURINIA PHARMACEUTICALS INC</title>
        <cusip>05156V102</cusip>
        <identifiers>
          <isin value="CA05156V1022"/>
        </identifiers>
        <balance>2288586.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40050255.00000000</valUSD>
        <pctVal>0.602214356089</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="311500.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
        </identifiers>
        <balance>161012.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1358941.28000000</valUSD>
        <pctVal>0.020433676337</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1018463.24000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IOVANCE BIOTHERAPEUTICS INC</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
        </identifiers>
        <balance>1556507.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51224645.37000000</valUSD>
        <pctVal>0.770237713278</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="575925.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EIDOS THERAPEUTICS INC</name>
        <lei>549300VGYGU07QRG6271</lei>
        <title>EIDOS THERAPEUTICS INC</title>
        <cusip>28249H104</cusip>
        <identifiers>
          <isin value="US28249H1041"/>
        </identifiers>
        <balance>118947.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6016339.26000000</valUSD>
        <pctVal>0.090464489513</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4623012.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PHARMING GROUP NV</name>
        <lei>724500DCJ9MPG74JEH91</lei>
        <title>PHARMING GROUP NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010391025"/>
        </identifiers>
        <balance>2612556.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.90583813"/>
        <valUSD>3249429.39000000</valUSD>
        <pctVal>0.048859939287</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACORDA THERAPEUTICS INC</name>
        <lei>5493007NPB5YRM8QGL53</lei>
        <title>ACORDA THERAPEUTICS INC</title>
        <cusip>00484M106</cusip>
        <identifiers>
          <isin value="US00484M1062"/>
        </identifiers>
        <balance>2605026.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3751237.44000000</valUSD>
        <pctVal>0.056405359702</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="507312.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVOTEC SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>EVOTEC SE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE0005664809"/>
        </identifiers>
        <balance>540500.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.90583813"/>
        <valUSD>13159500.48000000</valUSD>
        <pctVal>0.197872400763</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9544716.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HOOKIPA PHARMA INC</name>
        <lei>N/A</lei>
        <title>HOOKIPA PHARMA INC</title>
        <cusip>43906K100</cusip>
        <identifiers>
          <isin value="US43906K1007"/>
        </identifiers>
        <balance>234603.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2327261.76000000</valUSD>
        <pctVal>0.034993795726</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="101184.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CODIAK BIOSCIENCES INC</name>
        <lei>549300QVVVW74Y10Q230</lei>
        <title>CODIAK BIOSCIENCES INC 8% SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="78Z99F239"/>
        </identifiers>
        <balance>856366.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3836519.68000000</valUSD>
        <pctVal>0.057687703329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCTURUS THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>ARCTURUS THERAPEUTICS HOLDINGS INC</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>400000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5540000.00000000</valUSD>
        <pctVal>0.083302029730</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENANTA PHARMACEUTICALS INC</name>
        <lei>529900SSN4DODDQSN594</lei>
        <title>ENANTA PHARMACEUTICALS INC</title>
        <cusip>29251M106</cusip>
        <identifiers>
          <isin value="US29251M1062"/>
        </identifiers>
        <balance>12167.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>619056.96000000</valUSD>
        <pctVal>0.009308429835</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UROVANT SCIENCES LTD</name>
        <lei>N/A</lei>
        <title>UROVANT SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG9381B1081"/>
        </identifiers>
        <balance>893536.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11178135.36000000</valUSD>
        <pctVal>0.168079668609</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1635057.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATRECA INC</name>
        <lei>549300B5CQV1OOXFLU71</lei>
        <title>ATRECA INC</title>
        <cusip>04965G109</cusip>
        <identifiers>
          <isin value="US04965G1094"/>
        </identifiers>
        <balance>117700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2782428.00000000</valUSD>
        <pctVal>0.041837888083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2070864.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APREA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APREA THERAPEUTICS INC</title>
        <cusip>03836J102</cusip>
        <identifiers>
          <isin value="US03836J1025"/>
        </identifiers>
        <balance>535700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18374510.00000000</valUSD>
        <pctVal>0.276287721716</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FATE THERAPEUTICS INC</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>FATE THERAPEUTICS INC</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>1045687.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30534060.40000000</valUSD>
        <pctVal>0.459124405639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARENA PHARMACEUTICALS INC</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>ARENA PHARMACEUTICALS INC</title>
        <cusip>040047607</cusip>
        <identifiers>
          <isin value="US0400476075"/>
        </identifiers>
        <balance>877773.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39148675.80000000</valUSD>
        <pctVal>0.588657789786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KEZAR LIFE SCIENCES INC</name>
        <lei>549300EV1V8GXBV18004</lei>
        <title>KEZAR LIFE SCIENCES INC</title>
        <cusip>49372L100</cusip>
        <identifiers>
          <isin value="US49372L1008"/>
        </identifiers>
        <balance>820472.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3593667.36000000</valUSD>
        <pctVal>0.054036062322</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOMEDICS INC</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>IMMUNOMEDICS INC</title>
        <cusip>452907108</cusip>
        <identifiers>
          <isin value="US4529071080"/>
        </identifiers>
        <balance>3409783.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54556528.00000000</valUSD>
        <pctVal>0.820337458026</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2912.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMA INC</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>1343737.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75356770.96000000</valUSD>
        <pctVal>1.133099634463</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3151696.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>276555.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28474102.80000000</valUSD>
        <pctVal>0.428149920217</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="BCI060000"/>
        </identifiers>
        <balance>303621.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1776182.85000000</valUSD>
        <pctVal>0.026707515627</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UROGEN PHARMA LTD</name>
        <lei>549300C0YCX7CG2G5D50</lei>
        <title>UROGEN PHARMA LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
        </identifiers>
        <balance>314603.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8576077.78000000</valUSD>
        <pctVal>0.128953914477</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6408826.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVELO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>EVELO BIOSCIENCES INC</title>
        <cusip>299734103</cusip>
        <identifiers>
          <isin value="US2997341035"/>
        </identifiers>
        <balance>26600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>134596.00000000</valUSD>
        <pctVal>0.002023848374</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="56166.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GLOBAL BLOOD THERAPEUTICS INC</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>GLOBAL BLOOD THERAPEUTICS INC</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
        </identifiers>
        <balance>943569.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>60350673.24000000</valUSD>
        <pctVal>0.907460934388</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FIBROGEN INC</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
        </identifiers>
        <balance>1834342.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76675495.60000000</valUSD>
        <pctVal>1.152928594602</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTAGONIST THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
        </identifiers>
        <balance>608963.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4749911.40000000</valUSD>
        <pctVal>0.071421888206</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SEATTLE GENETICS INC</name>
        <lei>N/A</lei>
        <title>SEATTLE GENETICS INC</title>
        <cusip>812578102</cusip>
        <identifiers>
          <isin value="US8125781026"/>
        </identifiers>
        <balance>1443928.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>164405642.08000000</valUSD>
        <pctVal>2.472080087448</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="74W995233"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82.75000000</valUSD>
        <pctVal>0.000001244267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
        </identifiers>
        <balance>13406450.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15417417.50000000</valUSD>
        <pctVal>0.231823496562</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11155230.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>926227.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>285639144.53000000</valUSD>
        <pctVal>4.295003702153</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
        <identifiers>
          <isin value="US23284F1057"/>
        </identifiers>
        <balance>4700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31443.00000000</valUSD>
        <pctVal>0.000472791646</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MYOVANT SCIENCES LTD</name>
        <lei>N/A</lei>
        <title>MYOVANT SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
        </identifiers>
        <balance>654006.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6736261.80000000</valUSD>
        <pctVal>0.101289581360</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="560320.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REVANCE THERAPEUTICS INC</name>
        <lei>549300N33TFDZHS81H11</lei>
        <title>REVANCE THERAPEUTICS INC</title>
        <cusip>761330109</cusip>
        <identifiers>
          <isin value="US7613301099"/>
        </identifiers>
        <balance>7600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>175712.00000000</valUSD>
        <pctVal>0.002642087770</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RIGEL PHARMACEUTICALS INC</name>
        <lei>529900KPTNUS5J8K9K66</lei>
        <title>RIGEL PHARMACEUTICALS INC</title>
        <cusip>766559603</cusip>
        <identifiers>
          <isin value="US7665596034"/>
        </identifiers>
        <balance>290839.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>616578.68000000</valUSD>
        <pctVal>0.009271165258</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>BIOHAVEN PHARMACEUTICAL HOLDING CO LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
        </identifiers>
        <balance>790293.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34899338.88000000</valUSD>
        <pctVal>0.524762773459</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARDELYX INC</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>ARDELYX INC</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
        </identifiers>
        <balance>563494.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3899378.48000000</valUSD>
        <pctVal>0.058632877630</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROCKET PHARMACEUTICALS INC</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>1149536.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22404456.64000000</valUSD>
        <pctVal>0.336883883236</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10318044.98000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KURA ONCOLOGY INC</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>KURA ONCOLOGY INC</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
        </identifiers>
        <balance>2096963.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25310343.41000000</valUSD>
        <pctVal>0.380578155097</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>1269378.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>149355015.48000000</valUSD>
        <pctVal>2.245771830318</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM BIOSCIENCES INC</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM BIOSCIENCES INC</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
        </identifiers>
        <balance>12928.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>664628.48000000</valUSD>
        <pctVal>0.009993664512</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="493536.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>1773977.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90082552.06000000</valUSD>
        <pctVal>1.354523362803</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA PHARMACEUTICALS INC</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA PHARMACEUTICALS INC</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>1734880.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74148771.20000000</valUSD>
        <pctVal>1.114935585380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
        </identifiers>
        <balance>226078.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4313568.24000000</valUSD>
        <pctVal>0.064860828479</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4312213.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
        <cusip>05454B105</cusip>
        <identifiers>
          <isin value="US05454B1052"/>
        </identifiers>
        <balance>511870.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1927190.55000000</valUSD>
        <pctVal>0.028978137995</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>THERAVANCE BIOPHARMA INC</name>
        <lei>5493007VTSXP4Z6MIW52</lei>
        <title>THERAVANCE BIOPHARMA INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG8807B1068"/>
        </identifiers>
        <balance>371300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9041155.00000000</valUSD>
        <pctVal>0.135947032962</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GENMAB AS</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>GENMAB</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="GMAB"/>
        </identifiers>
        <balance>281690.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6416898.20000000</valUSD>
        <pctVal>0.096487480981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BIOCRYST PHARMACEUTICALS INC</title>
        <cusip>09058V103</cusip>
        <identifiers>
          <isin value="US09058V1035"/>
        </identifiers>
        <balance>2556584.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7669752.00000000</valUSD>
        <pctVal>0.115325976377</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENXBIO INC</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
        </identifiers>
        <balance>412408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16496320.00000000</valUSD>
        <pctVal>0.248046378897</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAGENTA THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>MAGENTA THERAPEUTICS INC</title>
        <cusip>55910K108</cusip>
        <identifiers>
          <isin value="US55910K1088"/>
        </identifiers>
        <balance>40712.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>478773.12000000</valUSD>
        <pctVal>0.007199056439</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OBSEVA SA</name>
        <lei>549300PNZ0UEJVKN1618</lei>
        <title>OBSEVA SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0346177709"/>
        </identifiers>
        <balance>1222003.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3702669.09000000</valUSD>
        <pctVal>0.055675063288</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="625695.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
        </identifiers>
        <balance>277400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1642208.00000000</valUSD>
        <pctVal>0.024693007155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="162800.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
        </identifiers>
        <balance>1186356.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16537802.64000000</valUSD>
        <pctVal>0.248670131263</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4640626.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VANDA PHARMACEUTICALS INC</name>
        <lei>529900AY8VOOQBKJ0O70</lei>
        <title>VANDA PHARMACEUTICALS INC</title>
        <cusip>921659108</cusip>
        <identifiers>
          <isin value="US9216591084"/>
        </identifiers>
        <balance>232692.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2566592.76000000</valUSD>
        <pctVal>0.038592488519</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
        </identifiers>
        <balance>990700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20388606.00000000</valUSD>
        <pctVal>0.306572610682</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
        </identifiers>
        <balance>166453.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>783161.37000000</valUSD>
        <pctVal>0.011775980456</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="587184.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DK0060257814"/>
        </identifiers>
        <balance>162144.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.76935000"/>
        <valUSD>5868515.90000000</valUSD>
        <pctVal>0.088241748371</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AGIOS PHARMACEUTICALS INC</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>AGIOS PHARMACEUTICALS INC</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
        </identifiers>
        <balance>1827003.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>86746102.44000000</valUSD>
        <pctVal>1.304354946659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="23991644.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALBIREO PHARMA INC</name>
        <lei>549300835H8LC7O8VC29</lei>
        <title>ALBIREO PHARMA INC</title>
        <cusip>01345P106</cusip>
        <identifiers>
          <isin value="US01345P1066"/>
        </identifiers>
        <balance>275900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6450542.00000000</valUSD>
        <pctVal>0.096993364885</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MOLECULAR TEMPLATES INC</name>
        <lei>529900VZKP6N0B8U5F61</lei>
        <title>MOLECULAR TEMPLATES INC</title>
        <cusip>608550109</cusip>
        <identifiers>
          <isin value="US6085501095"/>
        </identifiers>
        <balance>387000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6226830.00000000</valUSD>
        <pctVal>0.093629526676</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARIX BIOSCIENCE PLC</name>
        <lei>213800OVT3AHQCXNIX43</lei>
        <title>ARIX BIOSCIENCE PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BD045071"/>
        </identifiers>
        <balance>2049700.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.77993994"/>
        <valUSD>2157620.18000000</valUSD>
        <pctVal>0.032442985628</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="40000.78000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RUBIUS THERAPEUTICS</name>
        <lei>549300ER84PB0QV6HZ76</lei>
        <title>RUBIUS THERAPEUTICS INC</title>
        <cusip>78116T103</cusip>
        <identifiers>
          <isin value="US78116T1034"/>
        </identifiers>
        <balance>595627.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4985397.99000000</valUSD>
        <pctVal>0.074962774653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17577.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQUILLIUM INC</name>
        <lei>549300OC7SSPSNNGHE64</lei>
        <title>EQUILLIUM INC</title>
        <cusip>29446K106</cusip>
        <identifiers>
          <isin value="US29446K1060"/>
        </identifiers>
        <balance>619843.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2981444.83000000</valUSD>
        <pctVal>0.044830398171</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AC IMMUNE SA</name>
        <lei>967600VLQ0ZC2HSOG765</lei>
        <title>AC IMMUNE SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0329023102"/>
        </identifiers>
        <balance>67232.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>461883.84000000</valUSD>
        <pctVal>0.006945101330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="333195.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MOMENTA PHARMACEUTICALS INC</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>MOMENTA PHARMACEUTICALS INC</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
        </identifiers>
        <balance>1392056.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39381264.24000000</valUSD>
        <pctVal>0.592155098295</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
        </identifiers>
        <balance>124798.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3902433.46000000</valUSD>
        <pctVal>0.058678813737</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC WT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AAJ520000"/>
        </identifiers>
        <balance>382683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325992.34000000</valUSD>
        <pctVal>0.004901773212</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BLUEBIRD BIO INC</name>
        <lei>N/A</lei>
        <title>BLUEBIRD BIO INC</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
        </identifiers>
        <balance>939007.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67918376.31000000</valUSD>
        <pctVal>1.021252455351</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
        </identifiers>
        <balance>214500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3093090.00000000</valUSD>
        <pctVal>0.046509147137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRATI THERAPEUTICS INC</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>854540.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76472784.60000000</valUSD>
        <pctVal>1.149880537247</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14935881.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRINCIPIA BIOPHARMA INC</name>
        <lei>549300WHPKRLU16IRE69</lei>
        <title>PRINCIPIA BIOPHARMA INC</title>
        <cusip>74257L108</cusip>
        <identifiers>
          <isin value="US74257L1089"/>
        </identifiers>
        <balance>1028008.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66368196.48000000</valUSD>
        <pctVal>0.997943226779</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARYOPHARM THERAPEUTICS INC</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>KARYOPHARM THERAPEUTICS INC</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
        </identifiers>
        <balance>631798.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10323579.32000000</valUSD>
        <pctVal>0.155230164520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRUKER CORP</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
        </identifiers>
        <balance>316600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13791096.00000000</valUSD>
        <pctVal>0.207369366247</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="ADJ381000"/>
        </identifiers>
        <balance>287485.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1923274.65000000</valUSD>
        <pctVal>0.028919256692</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LIGAND PHARMACEUTICALS INC</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>LIGAND PHARMACEUTICALS</title>
        <cusip>53220K504</cusip>
        <identifiers>
          <isin value="US53220K5048"/>
        </identifiers>
        <balance>11198.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1048132.80000000</valUSD>
        <pctVal>0.015760214741</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="776880.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MACROGENICS INC</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MACROGENICS INC</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
        </identifiers>
        <balance>46231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>405445.87000000</valUSD>
        <pctVal>0.006096473631</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEKTAR THERAPEUTICS</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>NEKTAR THERAPEUTICS</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
        </identifiers>
        <balance>543851.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11317539.31000000</valUSD>
        <pctVal>0.170175811567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>PROTHENA CORP PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
        </identifiers>
        <balance>685651.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7309039.66000000</valUSD>
        <pctVal>0.109902137014</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
        <cusip>09075P105</cusip>
        <identifiers>
          <isin value="US09075P1057"/>
        </identifiers>
        <balance>605490.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22705875.00000000</valUSD>
        <pctVal>0.341416150598</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="983400.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORBUS PHARMACEUTICALS HLDGS INC</name>
        <lei>529900MX6XCNZC7MM155</lei>
        <title>CORBUS PHARMACEUTICALS HOLDINGS INC</title>
        <cusip>21833P103</cusip>
        <identifiers>
          <isin value="US21833P1030"/>
        </identifiers>
        <balance>1479867.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7014569.58000000</valUSD>
        <pctVal>0.105474347238</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5260452.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PUMA BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>PUMA BIOTECHNOLOGY INC</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
        </identifiers>
        <balance>122868.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1321445.34000000</valUSD>
        <pctVal>0.019869869855</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="990535.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HORIZON THERAPEUTICS PLC</name>
        <lei>N/A</lei>
        <title>HORIZON THERAPEUTICS PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>470319.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16094316.18000000</valUSD>
        <pctVal>0.242001661538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZOGENIX INC</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>ZOGENIX INC</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
        </identifiers>
        <balance>1018372.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25540769.76000000</valUSD>
        <pctVal>0.384042953410</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
        </identifiers>
        <balance>709416.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14025154.32000000</valUSD>
        <pctVal>0.210888776560</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14022861.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRECIPIO INC</name>
        <lei>54930079ULTBRXUQNR89</lei>
        <title>PRECIPIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="BIG915000"/>
        </identifiers>
        <balance>525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>803.25000000</valUSD>
        <pctVal>0.000012078042</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
        </identifiers>
        <balance>729786.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103177144.68000000</valUSD>
        <pctVal>1.551419778641</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARVINAS HOLDING CO LLC</name>
        <lei>N/A</lei>
        <title>ARVINAS HOLDING CO LLC</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
        </identifiers>
        <balance>519739.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24495299.07000000</valUSD>
        <pctVal>0.368322767399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>487093.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>216546935.01000000</valUSD>
        <pctVal>3.256100941935</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC</title>
        <cusip>87184Q107</cusip>
        <identifiers>
          <isin value="US87184Q1076"/>
        </identifiers>
        <balance>704361.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4120511.85000000</valUSD>
        <pctVal>0.061957942352</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HALOZYME THERAPEUTICS INC</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>HALOZYME THERAPEUTICS INC</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
        </identifiers>
        <balance>1992677.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38996688.89000000</valUSD>
        <pctVal>0.586372443559</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVROBIO</name>
        <lei>N/A</lei>
        <title>AVROBIO INC</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
        </identifiers>
        <balance>762751.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14721094.30000000</valUSD>
        <pctVal>0.221353255424</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADVERUM BIOTECHNOLOGIES INC</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
        <title>ADVERUM BIOTECHNOLOGIES INC</title>
        <cusip>00773U108</cusip>
        <identifiers>
          <isin value="US00773U1088"/>
        </identifiers>
        <balance>173108.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2130959.48000000</valUSD>
        <pctVal>0.032042102880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CABALETTA BIO INC</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC</title>
        <cusip>12674W109</cusip>
        <identifiers>
          <isin value="US12674W1099"/>
        </identifiers>
        <balance>30550.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>456417.00000000</valUSD>
        <pctVal>0.006862899368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2988.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUTIS BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
        </identifiers>
        <balance>605515.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16091561.13000000</valUSD>
        <pctVal>0.241960235318</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10X GENOMICS INC</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X GENOMICS INC</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
        </identifiers>
        <balance>45719.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3643804.30000000</valUSD>
        <pctVal>0.054789944789</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STEMLINE THERAPEUTICS INC</name>
        <lei>529900EFNCIRC8Q7V234</lei>
        <title>STEMLINE THERAPEUTICS INC</title>
        <cusip>85858C107</cusip>
        <identifiers>
          <isin value="US85858C1071"/>
        </identifiers>
        <balance>884698.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5325881.96000000</valUSD>
        <pctVal>0.080082450789</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2845654.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
        <lei>549300749HO5QS40BX97</lei>
        <title>ALLENA PHARMACEUTICALS INC 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="DBD780000"/>
        </identifiers>
        <balance>1447443.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2851462.71000000</valUSD>
        <pctVal>0.042875926253</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>8738317.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>748961150.07000000</valUSD>
        <pctVal>11.26172996216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHOSYS AG</name>
        <lei>529900493806K77LRE72</lei>
        <title>MORPHOSYS AG SPONSORED ADR</title>
        <cusip>617760202</cusip>
        <identifiers>
          <isin value="US6177602025"/>
        </identifiers>
        <balance>567212.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15138888.28000000</valUSD>
        <pctVal>0.227635401009</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2733056.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARADIGM CORP</name>
        <lei>549300I46MRQ1CGCIY65</lei>
        <title>ARADIGM CORP</title>
        <cusip>038505400</cusip>
        <identifiers>
          <isin value="US0385054004"/>
        </identifiers>
        <balance>11945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1207.64000000</valUSD>
        <pctVal>0.000018158639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC CL A WT 04/16/2024</title>
        <cusip>98420X111</cusip>
        <identifiers>
          <isin value="US98420X1110"/>
        </identifiers>
        <balance>450000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1618174.25000000</valUSD>
        <pctVal>0.024331624455</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC</title>
        <cusip>23255M105</cusip>
        <identifiers>
          <isin value="US23255M1053"/>
        </identifiers>
        <balance>837285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3583579.80000000</valUSD>
        <pctVal>0.053884381054</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="651844.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RETROPHIN INC</name>
        <lei>N/A</lei>
        <title>RETROPHIN INC</title>
        <cusip>761299106</cusip>
        <identifiers>
          <isin value="US7612991064"/>
        </identifiers>
        <balance>856699.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13274551.01000000</valUSD>
        <pctVal>0.199602354313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC PP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EDE963000"/>
        </identifiers>
        <balance>94809.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>405782.52000000</valUSD>
        <pctVal>0.006101535657</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GW PHARMACEUTICALS PLC</name>
        <lei>213800ISBN5CNUZMHZ39</lei>
        <title>GW PHARMACEUTICALS PLC ADR</title>
        <cusip>36197T103</cusip>
        <identifiers>
          <isin value="US36197T1034"/>
        </identifiers>
        <balance>86800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8880508.00000000</valUSD>
        <pctVal>0.133531469574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6650150.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FULCRUM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FULCRUM THERAPEUTICS INC</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>81267.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1537571.64000000</valUSD>
        <pctVal>0.023119645932</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD 144A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="ADG927000"/>
        </identifiers>
        <balance>336313.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24466770.75000000</valUSD>
        <pctVal>0.367893802244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOGEN INC</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>IMMUNOGEN INC</title>
        <cusip>45253H101</cusip>
        <identifiers>
          <isin value="US45253H1014"/>
        </identifiers>
        <balance>1573743.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7003156.35000000</valUSD>
        <pctVal>0.105302732577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KALEIDO BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>KALEIDO BIOSCIENCES INC</title>
        <cusip>483347100</cusip>
        <identifiers>
          <isin value="US4833471000"/>
        </identifiers>
        <balance>66633.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>397799.01000000</valUSD>
        <pctVal>0.005981491869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="388348.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MILESTONE PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>MILESTONE PHARMACEUTICALS INC</title>
        <cusip>59935V107</cusip>
        <identifiers>
          <isin value="CA59935V1076"/>
        </identifiers>
        <balance>169500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3220500.00000000</valUSD>
        <pctVal>0.048424943456</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>4943162.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6277815.74000000</valUSD>
        <pctVal>0.094396172097</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4708328.15000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EDITAS MEDICINE INC</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>EDITAS MEDICINE INC</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
        </identifiers>
        <balance>140589.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3118264.02000000</valUSD>
        <pctVal>0.046887675469</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2337772.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MEDICINOVA INC</name>
        <lei>N/A</lei>
        <title>MEDICINOVA INC</title>
        <cusip>58468P206</cusip>
        <identifiers>
          <isin value="US58468P2065"/>
        </identifiers>
        <balance>96484.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>405232.80000000</valUSD>
        <pctVal>0.006093269811</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="280140.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EPIZYME INC</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>EPIZYME INC</title>
        <cusip>29428V104</cusip>
        <identifiers>
          <isin value="US29428V1044"/>
        </identifiers>
        <balance>1992046.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42689545.78000000</valUSD>
        <pctVal>0.641899966021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PORTOLA PHARMACEUTICALS INC</name>
        <lei>549300BM3O4O0CNBGJ64</lei>
        <title>PORTOLA PHARMACEUTICALS INC</title>
        <cusip>737010108</cusip>
        <identifiers>
          <isin value="US7370101088"/>
        </identifiers>
        <balance>510932.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5165522.52000000</valUSD>
        <pctVal>0.077671211288</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3394654.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REATA PHARMACEUTICALS INC</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>REATA PHARMACEUTICALS INC CL A</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
        </identifiers>
        <balance>212303.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41346009.25000000</valUSD>
        <pctVal>0.621697922706</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BLUEPRINT MEDICINES CORP</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>BLUEPRINT MEDICINES CORP</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
        </identifiers>
        <balance>941306.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50952893.78000000</valUSD>
        <pctVal>0.766151529338</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHRODINGER INC</name>
        <lei>N/A</lei>
        <title>SCHRODINGER INC</title>
        <cusip>80810D103</cusip>
        <identifiers>
          <isin value="US80810D1037"/>
        </identifiers>
        <balance>134600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6242748.00000000</valUSD>
        <pctVal>0.093868877165</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
        </identifiers>
        <balance>217400.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.90583813"/>
        <valUSD>20128187.86000000</valUSD>
        <pctVal>0.302656841794</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAGE THERAPEUTICS INC</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>836193.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39301071.00000000</valUSD>
        <pctVal>0.590949275251</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PREVAIL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>PREVAIL THERAPEUTICS INC</title>
        <cusip>74140Y101</cusip>
        <identifiers>
          <isin value="US74140Y1010"/>
        </identifiers>
        <balance>788600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10078308.00000000</valUSD>
        <pctVal>0.151542150298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BLACK DIAMOND THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BLACK DIAMOND THERAPEUTICS INC</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
        </identifiers>
        <balance>341300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9211687.00000000</valUSD>
        <pctVal>0.138511231831</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIRAGEN THERAPEUTICS</name>
        <lei>549300C775BNYF550E70</lei>
        <title>MIRAGEN THERAPEUTICS INC</title>
        <cusip>60463E103</cusip>
        <identifiers>
          <isin value="US60463E1038"/>
        </identifiers>
        <balance>3888656.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2887327.08000000</valUSD>
        <pctVal>0.043415199686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="55836.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLENA PHARMACEUTICALS INC</name>
        <lei>549300749HO5QS40BX97</lei>
        <title>ALLENA PHARMACEUTICALS INC</title>
        <cusip>018119107</cusip>
        <identifiers>
          <isin value="US0181191075"/>
        </identifiers>
        <balance>28440.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56026.80000000</valUSD>
        <pctVal>0.000842445155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SYROS PHARMACEUTICALS INC</name>
        <lei>549300512PURS7IGVT96</lei>
        <title>SYROS PHARMACEUTICALS INC WT 10/04/2022</title>
        <cusip>87184Q115</cusip>
        <identifiers>
          <isin value="US87184Q1159"/>
        </identifiers>
        <balance>21625.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25237.29000000</valUSD>
        <pctVal>0.000379479689</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SERES THERAPEUTICS INC</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>SERES THERAPEUTICS INC</title>
        <cusip>81750R102</cusip>
        <identifiers>
          <isin value="US81750R1023"/>
        </identifiers>
        <balance>491475.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1543231.50000000</valUSD>
        <pctVal>0.023204750233</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="810120.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXELIXIS INC</name>
        <lei>N/A</lei>
        <title>EXELIXIS INC</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>2345650.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43605633.50000000</valUSD>
        <pctVal>0.655674689214</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EMERGENT BIOSOLUTIONS INC</name>
        <lei>549300YW6TUOX8BE5103</lei>
        <title>EMERGENT BIOSOL</title>
        <cusip>29089Q105</cusip>
        <identifiers>
          <isin value="US29089Q1058"/>
        </identifiers>
        <balance>290222.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17030226.96000000</valUSD>
        <pctVal>0.256074453527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AUTOLUS THERAPEUTICS LTD</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>AUTOLUS THERAPEUTICS LTD ADR</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
        </identifiers>
        <balance>212108.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1735043.44000000</valUSD>
        <pctVal>0.026088924228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1298984.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROQR THERAPEUTICS NV</name>
        <lei>549300NGS2FJGGDBGS06</lei>
        <title>PROQR THERAPEUTICS NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010872495"/>
        </identifiers>
        <balance>890216.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6311631.44000000</valUSD>
        <pctVal>0.094904640769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FORTY SEVEN INC</name>
        <lei>549300J6U8QUO8OJJ167</lei>
        <title>FORTY SEVEN INC</title>
        <cusip>34983P104</cusip>
        <identifiers>
          <isin value="US34983P1049"/>
        </identifiers>
        <balance>1076670.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62446860.00000000</valUSD>
        <pctVal>0.938980178396</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALDEYRA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALDEYRA THERAPEUTICS INC</title>
        <cusip>01438T106</cusip>
        <identifiers>
          <isin value="US01438T1060"/>
        </identifiers>
        <balance>1206333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4584065.40000000</valUSD>
        <pctVal>0.068928150223</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>THERAPEUTICSMD INC</name>
        <lei>5299004JS7RE49QHRW30</lei>
        <title>THERAPEUTICS MD INC</title>
        <cusip>88338N107</cusip>
        <identifiers>
          <isin value="US88338N1072"/>
        </identifiers>
        <balance>2529642.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4275094.98000000</valUSD>
        <pctVal>0.064282326557</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4275024.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TREVI THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TREVI THERAPEUTICS INC</title>
        <cusip>89532M101</cusip>
        <identifiers>
          <isin value="US89532M1018"/>
        </identifiers>
        <balance>792700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4114113.00000000</valUSD>
        <pctVal>0.061861726253</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="519.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FREQUENCY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FREQUENCY THERAPEUTICS INC</title>
        <cusip>35803L108</cusip>
        <identifiers>
          <isin value="US35803L1089"/>
        </identifiers>
        <balance>88256.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1911624.96000000</valUSD>
        <pctVal>0.028744086507</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1080834.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTERCEPT PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>INTERCEPT PHARMACEUTICALS INC</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
        </identifiers>
        <balance>578525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53189588.50000000</valUSD>
        <pctVal>0.799783516714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2537544.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DYNAVAX TECHNOLOGIES CORP</name>
        <lei>549300T5URIXWDILX594</lei>
        <title>DYNAVAX TECHNOLOGIES CORP</title>
        <cusip>268158201</cusip>
        <identifiers>
          <isin value="US2681582019"/>
        </identifiers>
        <balance>162598.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>641449.11000000</valUSD>
        <pctVal>0.009645128670</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="88368.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ODONATE THERAPEUTICS INC</name>
        <lei>549300D50X5LSJ208C14</lei>
        <title>ODONATE THERAPEUTICS INC</title>
        <cusip>676079106</cusip>
        <identifiers>
          <isin value="US6760791060"/>
        </identifiers>
        <balance>154594.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4574436.46000000</valUSD>
        <pctVal>0.068783364980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>529408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27243335.68000000</valUSD>
        <pctVal>0.409643530466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4862970.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
        </identifiers>
        <balance>29800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1045980.00000000</valUSD>
        <pctVal>0.015727844234</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APELLIS PHARMACEUTICALS INC</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>APELLIS PHARMACEUTICALS INC</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>539434.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18675205.08000000</valUSD>
        <pctVal>0.280809113502</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TURNING POINT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
        </identifiers>
        <balance>798119.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39562758.83000000</valUSD>
        <pctVal>0.594884135792</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EAGLE PHARMACEUTICALS INC</name>
        <lei>549300TN20OLYTJVP152</lei>
        <title>EAGLE PHARMACEUTICALS INC</title>
        <cusip>269796108</cusip>
        <identifiers>
          <isin value="US2697961082"/>
        </identifiers>
        <balance>48108.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2208157.20000000</valUSD>
        <pctVal>0.033202883885</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HOMOLOGY MEDICINES INC</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>HOMOLOGY MEDICINES INC</title>
        <cusip>438083107</cusip>
        <identifiers>
          <isin value="US4380831077"/>
        </identifiers>
        <balance>327367.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5237872.00000000</valUSD>
        <pctVal>0.078759091889</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALECTOR INC</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>ALECTOR INC</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
        </identifiers>
        <balance>693918.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19068866.64000000</valUSD>
        <pctVal>0.286728392739</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16713336.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNOCORE LTD</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE LIMITED SERIES A STOCK PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="77R99Y239"/>
        </identifiers>
        <balance>73318.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.77993994"/>
        <valUSD>9042309.62000000</valUSD>
        <pctVal>0.135964394368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JOUNCE THERAPEUTICS INC</name>
        <lei>5493004MZJQIV2K8ZT61</lei>
        <title>JOUNCE THERAPEUTICS INC</title>
        <cusip>481116101</cusip>
        <identifiers>
          <isin value="US4811161011"/>
        </identifiers>
        <balance>563774.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2548258.48000000</valUSD>
        <pctVal>0.038316805715</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="196168.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHEMOCENTRYX INC</name>
        <lei>529900YTTXUSFQTAKY40</lei>
        <title>CHEMOCENTRYX INC</title>
        <cusip>16383L106</cusip>
        <identifiers>
          <isin value="US16383L1061"/>
        </identifiers>
        <balance>2018222.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90315434.50000000</valUSD>
        <pctVal>1.358025092034</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VOYAGER THERAPEUTICS INC</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>VOYAGER THERAPEUTICS INC</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
        </identifiers>
        <balance>229729.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2504046.10000000</valUSD>
        <pctVal>0.037652007702</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZAI LAB LTD</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>ZAI LAB LTD UNSPNRD ADR</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
        </identifiers>
        <balance>38400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2110848.00000000</valUSD>
        <pctVal>0.031739697265</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MYOKARDIA INC</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MYOKARDIA INC</title>
        <cusip>62857M105</cusip>
        <identifiers>
          <isin value="US62857M1053"/>
        </identifiers>
        <balance>729501.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46243068.39000000</valUSD>
        <pctVal>0.695332393117</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FIDELITY REVERE STREET TRUST</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
        </identifiers>
        <balance>638604047.74200000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>638667908.15000000</valUSD>
        <pctVal>9.603309218924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="638667908.15000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRITSTONE ONCOLOGY INC</name>
        <lei>5493003TER6KY3MUVY84</lei>
        <title>GRITSTONE ONCOLOGY INC</title>
        <cusip>39868T105</cusip>
        <identifiers>
          <isin value="US39868T1051"/>
        </identifiers>
        <balance>1248800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10489920.00000000</valUSD>
        <pctVal>0.157731340742</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AKEBIA THERAPEUTICS INC</name>
        <lei>549300CBQEHMKEEGNX42</lei>
        <title>AKEBIA THERAPEUTICS INC</title>
        <cusip>00972D105</cusip>
        <identifiers>
          <isin value="US00972D1054"/>
        </identifiers>
        <balance>1016067.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9012514.29000000</valUSD>
        <pctVal>0.135516377858</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IRONWOOD PHARMACEUTICALS INC</name>
        <lei>549300PC8MR6QHH6P296</lei>
        <title>IRONWOOD PHARMA CL A (PEND)</title>
        <cusip>46333X108</cusip>
        <identifiers>
          <isin value="US46333X1081"/>
        </identifiers>
        <balance>2167620.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26098144.80000000</valUSD>
        <pctVal>0.392423905063</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12015920.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
        </identifiers>
        <balance>830456.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11086587.60000000</valUSD>
        <pctVal>0.166703113694</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8314353.30000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
        </identifiers>
        <balance>654831.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20050925.22000000</valUSD>
        <pctVal>0.301495084622</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SAREPTA THERAPEUTICS INC</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>SAREPTA THERAPEUTICS INC</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>958204.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109685611.88000000</valUSD>
        <pctVal>1.649284133912</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>228505.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5925134.65000000</valUSD>
        <pctVal>0.089093094363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHIC HOLDING INC</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>MORPHIC HOLDING INC</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
        </identifiers>
        <balance>758437.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11983304.60000000</valUSD>
        <pctVal>0.180186569686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1418840.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERRICA PHARMACEUTICALS INC</name>
        <lei>5493002L68H6THU5GW50</lei>
        <title>VERRICA PHARMACEUTICALS INC</title>
        <cusip>92511W108</cusip>
        <identifiers>
          <isin value="US92511W1080"/>
        </identifiers>
        <balance>635680.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7545521.60000000</valUSD>
        <pctVal>0.113457990010</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2111043.89000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
        </identifiers>
        <balance>651431.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24692492.06000000</valUSD>
        <pctVal>0.371287853377</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
        </identifiers>
        <balance>147700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10745175.00000000</valUSD>
        <pctVal>0.161569474244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
        </identifiers>
        <balance>2431403.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30514107.65000000</valUSD>
        <pctVal>0.458824386763</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="22517210.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHIMERIX INC</name>
        <lei>5299002IR2GXUBEPKS66</lei>
        <title>CHIMERIX INC</title>
        <cusip>16934W106</cusip>
        <identifiers>
          <isin value="US16934W1062"/>
        </identifiers>
        <balance>1443267.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2554582.59000000</valUSD>
        <pctVal>0.038411897989</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LEXICON PHARMACEUTICALS INC</title>
        <cusip>528872302</cusip>
        <identifiers>
          <isin value="US5288723027"/>
        </identifiers>
        <balance>390904.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1084758.60000000</valUSD>
        <pctVal>0.016310937391</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="132090.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MORPHOSYS AG</name>
        <lei>529900493806K77LRE72</lei>
        <title>MORPHOSYS AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE0006632003"/>
        </identifiers>
        <balance>96475.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.90583813"/>
        <valUSD>10398849.79000000</valUSD>
        <pctVal>0.156361966493</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC</title>
        <cusip>68404V100</cusip>
        <identifiers>
          <isin value="US68404V1008"/>
        </identifiers>
        <balance>190615.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1153220.75000000</valUSD>
        <pctVal>0.017340366282</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>STOKE THERAPEUTICS INC</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
        </identifiers>
        <balance>521347.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12903338.25000000</valUSD>
        <pctVal>0.194020625727</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1289475.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALEXION PHARMACEUTICALS INC</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>ALEXION PHARMACEUTICALS INC</title>
        <cusip>015351109</cusip>
        <identifiers>
          <isin value="US0153511094"/>
        </identifiers>
        <balance>276866.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26033709.98000000</valUSD>
        <pctVal>0.391455032988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REDHILL BIOPHARMA LTD</name>
        <lei>52990034U7FZBKRAOE32</lei>
        <title>REDHILL BIOPHARMA LTD SP ADR</title>
        <cusip>757468103</cusip>
        <identifiers>
          <isin value="US7574681034"/>
        </identifiers>
        <balance>93300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>385329.00000000</valUSD>
        <pctVal>0.005793986970</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="288274.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MINERVA NEUROSCIENCES INC</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC</title>
        <cusip>603380106</cusip>
        <identifiers>
          <isin value="US6033801068"/>
        </identifiers>
        <balance>1946914.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14173533.92000000</valUSD>
        <pctVal>0.213119881587</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Y-MABS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>Y-MABS THERAPEUTICS INC</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
        </identifiers>
        <balance>1390842.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40918571.64000000</valUSD>
        <pctVal>0.615270770992</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPRINGWORKS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>901412.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28809127.52000000</valUSD>
        <pctVal>0.433187508518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9383456.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>1528947.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21573442.17000000</valUSD>
        <pctVal>0.324388361198</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="313242.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CONSTELLATION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CONSTELLATION PHARMACEUTICALS INC</title>
        <cusip>210373106</cusip>
        <identifiers>
          <isin value="US2103731061"/>
        </identifiers>
        <balance>152100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5375214.00000000</valUSD>
        <pctVal>0.080824230403</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="42408.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KODIAK SCIENCES INC</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
        </identifiers>
        <balance>351813.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22505477.61000000</valUSD>
        <pctVal>0.338402881764</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16875286.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC</title>
        <cusip>98420X103</cusip>
        <identifiers>
          <isin value="US98420X1037"/>
        </identifiers>
        <balance>824800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8808864.00000000</valUSD>
        <pctVal>0.132454196899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INNOVENT BIOLGICS INC</name>
        <lei>25490058ONL9SCIE1R22</lei>
        <title>INNOVENT BIOLOGICS INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG4818G1010"/>
        </identifiers>
        <balance>1268500.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.79500000"/>
        <valUSD>5793277.74000000</valUSD>
        <pctVal>0.087110432226</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATHENEX INC</name>
        <lei>5493001V4L0Q5EPPOH52</lei>
        <title>ATHENEX INC</title>
        <cusip>04685N103</cusip>
        <identifiers>
          <isin value="US04685N1037"/>
        </identifiers>
        <balance>717400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8766628.00000000</valUSD>
        <pctVal>0.131819116659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2208154.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPECTRUM PHARMACEUTICALS INC</name>
        <lei>549300COU30WSP3O5I07</lei>
        <title>SPECTRUM PHARMACEUTICAL INC</title>
        <cusip>84763A108</cusip>
        <identifiers>
          <isin value="US84763A1088"/>
        </identifiers>
        <balance>55103.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>157594.58000000</valUSD>
        <pctVal>0.002369665774</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIELA BIO INC</name>
        <lei>N/A</lei>
        <title>VIELA BIO INC</title>
        <cusip>926613100</cusip>
        <identifiers>
          <isin value="US9266131005"/>
        </identifiers>
        <balance>1676392.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73157746.88000000</valUSD>
        <pctVal>1.100034080440</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13087636.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>CORCEPT THERAPEUTICS INC</title>
        <cusip>218352102</cusip>
        <identifiers>
          <isin value="US2183521028"/>
        </identifiers>
        <balance>499959.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6309482.58000000</valUSD>
        <pctVal>0.094872329506</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DECIPHERA PHARMACEUTICALS INC</name>
        <lei>529900QR4WAPYY0CBF25</lei>
        <title>DECIPHERA PHARMACEUTICALS INC</title>
        <cusip>24344T101</cusip>
        <identifiers>
          <isin value="US24344T1016"/>
        </identifiers>
        <balance>324000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17249760.00000000</valUSD>
        <pctVal>0.259375454940</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ATARA BIOTHERAPEUTICS INC</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>ATARA BIOTHERAPEUTICS INC</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
        </identifiers>
        <balance>673043.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8177472.45000000</valUSD>
        <pctVal>0.122960298403</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="481140.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SUTRO BIOPHARMA INC</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>SUTRO BIOPHARMA INC</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
        </identifiers>
        <balance>96300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>936999.00000000</valUSD>
        <pctVal>0.014089154973</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RPI INTERNATIONAL HOLDINGS LP</name>
        <lei>N/A</lei>
        <title>RPI INTERNATIONAL HOLDINGS LP P/P</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="FCG412000"/>
        </identifiers>
        <balance>54958.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11266390.00000000</valUSD>
        <pctVal>0.169406706631</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GALAPAGOS GENOMICS NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS GENOMICS NV SPON AR</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
        </identifiers>
        <balance>453279.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>95805049.44000000</valUSD>
        <pctVal>1.440569508450</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="95788352.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACCELERON PHARMA INC</name>
        <lei>529900TQRID2UY164805</lei>
        <title>ACCELERON PHARMA INC</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
        </identifiers>
        <balance>1703258.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146360959.94000000</valUSD>
        <pctVal>2.200751811616</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>1880151.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66482139.36000000</valUSD>
        <pctVal>0.999656525187</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1142128.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>23ANDME INC</name>
        <lei>N/A</lei>
        <title>23ANDME SER E PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="75P99S238"/>
        </identifiers>
        <balance>1505457.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20338724.07000000</valUSD>
        <pctVal>0.305822562665</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COHERUS BIOSCIENCES INC</name>
        <lei>5493007IL8W5MV932D26</lei>
        <title>COHERUS BIOSCIENCES INC</title>
        <cusip>19249H103</cusip>
        <identifiers>
          <isin value="US19249H1032"/>
        </identifiers>
        <balance>100387.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1942488.45000000</valUSD>
        <pctVal>0.029208164370</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARAVIVE INC</name>
        <lei>5493002Z0KHRW71RNC19</lei>
        <title>ARAVIVE INC</title>
        <cusip>03890D108</cusip>
        <identifiers>
          <isin value="US03890D1081"/>
        </identifiers>
        <balance>699083.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5970168.82000000</valUSD>
        <pctVal>0.089770249195</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AIA874000"/>
        </identifiers>
        <balance>8274568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13404800.16000000</valUSD>
        <pctVal>0.201560841419</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ESPERION THERAPEUTICS INC NEW</name>
        <lei>549300OFU56UKEWVUS92</lei>
        <title>ESPERION THERAPEUTICS INC NEW</title>
        <cusip>29664W105</cusip>
        <identifiers>
          <isin value="US29664W1053"/>
        </identifiers>
        <balance>207432.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10473241.68000000</valUSD>
        <pctVal>0.157480557726</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7851043.53000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>1659927.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>91030396.68000000</valUSD>
        <pctVal>1.368775597589</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AERIE PHARMACEUTICALS INC</name>
        <lei>529900SFXHDHUO324R09</lei>
        <title>AERIE PHARMACEUTICALS INC</title>
        <cusip>00771V108</cusip>
        <identifiers>
          <isin value="US00771V1089"/>
        </identifiers>
        <balance>440504.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7708820.00000000</valUSD>
        <pctVal>0.115913421088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5327000.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZYMEWORKS INC</name>
        <lei>894500AHOYAGYLYZJL67</lei>
        <title>ZYMEWORKS INC</title>
        <cusip>98985W102</cusip>
        <identifiers>
          <isin value="CA98985W1023"/>
        </identifiers>
        <balance>709195.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29027351.35000000</valUSD>
        <pctVal>0.436468824037</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
        </identifiers>
        <balance>784161.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24999052.68000000</valUSD>
        <pctVal>0.375897442164</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16195040.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SPERO THERAPEUTICS INC</name>
        <lei>54930074G13LHWJT2323</lei>
        <title>SPERO THERAPEUTICS INC RT 03/02/20</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="1783681D"/>
        </identifiers>
        <balance>15040.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8121.60000000</valUSD>
        <pctVal>0.000122120174</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR THERAPEUTICS AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR THERAPEUTICS AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>537942.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28752999.90000000</valUSD>
        <pctVal>0.432343547386</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21128785.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
        </identifiers>
        <balance>649309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84656907.42000000</valUSD>
        <pctVal>1.272940833722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>1275820.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31767918.00000000</valUSD>
        <pctVal>0.477677265292</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MYOS RENS TECHNOLOGY INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MYOS CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
        </identifiers>
        <balance>33334.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39000.78000000</valUSD>
        <pctVal>0.000586433959</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
        <lei>549300YONUY68210OE41</lei>
        <title>KRYSTAL BIOTECH INC</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
        </identifiers>
        <balance>1148286.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61375886.70000000</valUSD>
        <pctVal>0.922876523220</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12603510.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMARIN CORPORATION PLC</name>
        <lei>5493009JFIGUFEVPK217</lei>
        <title>AMARIN CORP PLC ADR</title>
        <cusip>023111206</cusip>
        <identifiers>
          <isin value="US0231112063"/>
        </identifiers>
        <balance>556831.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8168710.77000000</valUSD>
        <pctVal>0.122828553686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7131087.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CHIASMA INC</name>
        <lei>549300PP2WZZEZZ6XS69</lei>
        <title>CHIASMA INC</title>
        <cusip>16706W102</cusip>
        <identifiers>
          <isin value="US16706W1027"/>
        </identifiers>
        <balance>1625699.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7234360.55000000</valUSD>
        <pctVal>0.108779227007</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INCYTE CORP</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>893771.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67399271.11000000</valUSD>
        <pctVal>1.013446946902</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CLOVIS ONCOLOGY INC</name>
        <lei>529900WCUY9ZAHMRV489</lei>
        <title>CLOVIS ONCOLOGY INC</title>
        <cusip>189464100</cusip>
        <identifiers>
          <isin value="US1894641000"/>
        </identifiers>
        <balance>590070.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4443227.10000000</valUSD>
        <pctVal>0.066810439708</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2395293.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BELLUS HEALTH INC NEW</name>
        <lei>549300QZYQDSMOXCP667</lei>
        <title>BELLUS HEALTH INC</title>
        <cusip>07987C204</cusip>
        <identifiers>
          <isin value="CA07987C2040"/>
        </identifiers>
        <balance>464300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4071911.00000000</valUSD>
        <pctVal>0.061227157253</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>STEMCENTRX INC</name>
        <lei>N/A</lei>
        <title>STEMCENTRX INC (CVR) 12/31/21</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="AIC419000"/>
        </identifiers>
        <balance>876163.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8.76000000</valUSD>
        <pctVal>0.000000131719</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OVID THERAPEUTICS INC</name>
        <lei>549300H36NUI4L6U8F17</lei>
        <title>OVID THERAPEUTICS INC</title>
        <cusip>690469101</cusip>
        <identifiers>
          <isin value="US6904691010"/>
        </identifiers>
        <balance>2084900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6838472.00000000</valUSD>
        <pctVal>0.102826461707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="98400.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALKERMES PLC</name>
        <lei>N/A</lei>
        <title>ALKERMES PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>99974.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2083458.16000000</valUSD>
        <pctVal>0.031327850828</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DICERNA PHARMACEUTICALS INC</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>DICERNA PHARMACEUTICALS INC</title>
        <cusip>253031108</cusip>
        <identifiers>
          <isin value="US2530311081"/>
        </identifiers>
        <balance>722512.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14262386.88000000</valUSD>
        <pctVal>0.214455916229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALLAKOS INC</name>
        <lei>549300S6ZD1W6BPMDY37</lei>
        <title>ALLAKOS INC</title>
        <cusip>01671P100</cusip>
        <identifiers>
          <isin value="US01671P1003"/>
        </identifiers>
        <balance>604425.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37673810.25000000</valUSD>
        <pctVal>0.566481021934</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31059039.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LA JOLLA PHARMACEUTICAL CO</name>
        <lei>529900H2JU56H90RYN44</lei>
        <title>LA JOLLA PHARMACEUTICAL CO</title>
        <cusip>503459604</cusip>
        <identifiers>
          <isin value="US5034596040"/>
        </identifiers>
        <balance>1254989.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8533925.20000000</valUSD>
        <pctVal>0.128320088579</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5959520.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FIDELITY REVERE STREET TRUST</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
        </identifiers>
        <balance>53592745.30700000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53603463.86000000</valUSD>
        <pctVal>0.806006740097</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
        </identifiers>
        <balance>1090151.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103237299.70000000</valUSD>
        <pctVal>1.552324297642</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEXTCURE INC</name>
        <lei>549300Y5PR6RJR1STI24</lei>
        <title>NEXTCURE INC</title>
        <cusip>65343E108</cusip>
        <identifiers>
          <isin value="US65343E1082"/>
        </identifiers>
        <balance>148490.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6200942.40000000</valUSD>
        <pctVal>0.093240268621</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="471888.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORTEXYME INC</name>
        <lei>N/A</lei>
        <title>CORTEXYME INC</title>
        <cusip>22053A107</cusip>
        <identifiers>
          <isin value="US22053A1079"/>
        </identifiers>
        <balance>8847.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>444561.75000000</valUSD>
        <pctVal>0.006684638288</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="331650.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>XENCOR INC</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>1034543.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33612302.07000000</valUSD>
        <pctVal>0.505410286346</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GOSSAMER BIO INC</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>GOSSAMER BIO INC</title>
        <cusip>38341P102</cusip>
        <identifiers>
          <isin value="US38341P1021"/>
        </identifiers>
        <balance>153014.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2009073.82000000</valUSD>
        <pctVal>0.030209373120</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>G1 THERAPEUTICS INC</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 THERAPEUTICS INC</title>
        <cusip>3621LQ109</cusip>
        <identifiers>
          <isin value="US3621LQ1099"/>
        </identifiers>
        <balance>789800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14169012.00000000</valUSD>
        <pctVal>0.213051887884</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>1342693.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>300803512.79000000</valUSD>
        <pctVal>4.523022232052</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB HOLDINGS LLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="71E99L226"/>
        </identifiers>
        <balance>1954526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89966831.78000000</valUSD>
        <pctVal>1.352783338578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>868512.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70306046.40000000</valUSD>
        <pctVal>1.057154578965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="69568430.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0363463438"/>
        </identifiers>
        <balance>432921.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.96480000"/>
        <valUSD>11627220.20000000</valUSD>
        <pctVal>0.174832318192</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>YUMANITY HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>YUMANITY HOLDINGS LLC CLASS A PREF UNITS PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="ABI743000"/>
        </identifiers>
        <balance>588700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4792018.00000000</valUSD>
        <pctVal>0.072055022726</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTRA-CELLULAR THERAPIES INC</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>INTRA-CELLULAR THERAPIES INC</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
        </identifiers>
        <balance>804084.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16966172.40000000</valUSD>
        <pctVal>0.255111299220</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KALVISTA PHARMACEUTICALS INC</name>
        <lei>529900Q7IDA3WUGRZA51</lei>
        <title>KALVISTA PHARMACEUTICALS INC</title>
        <cusip>483497103</cusip>
        <identifiers>
          <isin value="US4834971032"/>
        </identifiers>
        <balance>884861.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11901380.45000000</valUSD>
        <pctVal>0.178954719870</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOMARIN PHARMACEUTICAL INC</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
        </identifiers>
        <balance>962958.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87022514.46000000</valUSD>
        <pctVal>1.308511207003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REPLIMUNE GROUP INC</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>REPLIMUNE GROUP INC</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
        </identifiers>
        <balance>868010.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12039298.70000000</valUSD>
        <pctVal>0.181028523149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>34241.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2950546.97000000</valUSD>
        <pctVal>0.044365803504</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2205952.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GAMIDA CELL LTD</name>
        <lei>N/A</lei>
        <title>GAMIDA CELL LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0011552663"/>
        </identifiers>
        <balance>694871.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3015740.14000000</valUSD>
        <pctVal>0.045346078484</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AIMMUNE THERAPEUTICS INC</name>
        <lei>549300WDF7T2EVBC1877</lei>
        <title>AIMMUNE THERAPEUTICS INC</title>
        <cusip>00900T107</cusip>
        <identifiers>
          <isin value="US00900T1079"/>
        </identifiers>
        <balance>354260.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8434930.60000000</valUSD>
        <pctVal>0.126831559497</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8432549.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ASSEMBLY BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ASSEMBLY BIOSCIENCES INC</title>
        <cusip>045396108</cusip>
        <identifiers>
          <isin value="US0453961080"/>
        </identifiers>
        <balance>578333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10479393.96000000</valUSD>
        <pctVal>0.157573066284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RADIUS HEALTH INC</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>RADIUS HEALTH INC</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
        </identifiers>
        <balance>483221.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10176634.26000000</valUSD>
        <pctVal>0.153020629907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMICUS THERAPEUTICS INC</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>3855481.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36800566.15000000</valUSD>
        <pctVal>0.553350515440</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APPLIED THERAPEUTICS INC</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>APPLIED THERAPEUTICS INC</title>
        <cusip>03828A101</cusip>
        <identifiers>
          <isin value="US03828A1016"/>
        </identifiers>
        <balance>973740.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40458897.00000000</valUSD>
        <pctVal>0.608358888225</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORAGENICS INC</name>
        <lei>549300639MGD19K4ZW90</lei>
        <title>ORAGENICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="684023922"/>
        </identifiers>
        <balance>155806.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116418.24000000</valUSD>
        <pctVal>0.001750519077</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2020-03-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
