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        <title>UPSTREAM BIO INC</title>
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          <isin value="US91678A1079"/>
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        <balance>234657.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IDEAYA BIOSCIENCES INC</name>
        <lei>549300ULW08F62IJML11</lei>
        <title>IDEAYA BIOSCIENCES</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
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        <balance>637957.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>18800592.79000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>NEURONA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NEURONA THERAPEUTICS INC SER F PC PERP PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LCW622000"/>
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        <balance>1618100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4741033.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ZYMEWORKS DELAWARE INC</name>
        <lei>894500AHOYAGYLYZJL67</lei>
        <title>ZYMEWORKS DELAWARE INC</title>
        <cusip>98985Y108</cusip>
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          <isin value="US98985Y1082"/>
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        <balance>47873.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1203048.49000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ABIVAX SA</name>
        <lei>969500D8TMNB184OJU95</lei>
        <title>ABIVAX SA</title>
        <cusip>00370M103</cusip>
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          <isin value="US00370M1036"/>
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        <balance>255300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33860439.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TWIST BIOSCIENCE CORP</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>TWIST BIOSCIENCE CORP</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
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        <balance>238825.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15970227.75000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DIANTHUS THERAPEUTICS INC</name>
        <lei>549300Z3N6ODPCOFC890</lei>
        <title>DIANTHUS THERAPEUTICS INC</title>
        <cusip>252828108</cusip>
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          <isin value="US2528281080"/>
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        <balance>420518.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>39112379.18000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG2545C1042"/>
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        <balance>113421.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIOCRYST PHARMACEUTICALS INC</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BIOCRYST PHARMACEUTICALS INC</title>
        <cusip>09058V103</cusip>
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          <isin value="US09058V1035"/>
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        <balance>37881.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>337519.71000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEUROGENE INC</name>
        <lei>529900A7VIY892SZVW73</lei>
        <title>NEUROGENE INC</title>
        <cusip>64135M105</cusip>
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          <isin value="US64135M1053"/>
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        <balance>51100.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UNITED THERAPEUTICS CORP DEL</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>UNITED THERAPEUTICS CORP DEL</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
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        <balance>82591.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
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          <isin value="US0311621009"/>
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        <balance>1020981.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PRAXIS PRECISION MEDICINES INC.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC</title>
        <cusip>74006W207</cusip>
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          <isin value="US74006W2070"/>
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        <balance>371429.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AXSOME THERAPEUTICS INC</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC</title>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
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        <balance>2230183.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC</title>
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        <balance>1428500.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIOXCEL THERAPEUTICS INC</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>BIOXCEL THERAPEUTICS INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MANNKIND CORP</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MANNKIND CORP</title>
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        <balance>4078401.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TRIVENI BIO INC</name>
        <lei>N/A</lei>
        <title>TRIVENI BIO INC SERIES B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KQD153000"/>
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        <balance>7167431.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 8) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA098000"/>
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        <balance>9200.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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        <name>GUBRA A/S</name>
        <lei>254900T17RRFZONO6W53</lei>
        <title>GUBRA A/S</title>
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        <assetCat>EC</assetCat>
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        <invCountry>DK</invCountry>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
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          <other otherDesc="Internal" value="74W995233"/>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 6) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
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        <balance>9200.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>LENZ THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>LENZ THERAPEUTICS INC</title>
        <cusip>52635N103</cusip>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC</title>
        <cusip>344174107</cusip>
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          <isin value="US3441741077"/>
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        <balance>351578.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1504753.84000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TREVI THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TREVI THERAPEUTICS INC</title>
        <cusip>89532M101</cusip>
        <identifiers>
          <isin value="US89532M1018"/>
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        <balance>2374785.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33579459.90000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="4435718.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>TG THERAPEUTICS INC</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG THERAPEUTICS INC</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
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        <balance>146231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5548004.14000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
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        <balance>886871.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31528264.05000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>KARDIGAN INC</name>
        <lei>N/A</lei>
        <title>KARDIGAN, INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LSE718000"/>
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        <balance>93611.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1996722.63000000</valUSD>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ABSCI CORP</name>
        <lei>N/A</lei>
        <title>ABSCI CORP</title>
        <cusip>00091E109</cusip>
        <identifiers>
          <isin value="US00091E1091"/>
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        <balance>1540796.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10400373.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="9436500.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>TRIVENI BIO INC</name>
        <lei>N/A</lei>
        <title>TRIVENI BIO INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MTS687000"/>
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        <balance>2388534.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2999998.70000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ODYSSEY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ODYSSEY THERAPEUTICS</title>
        <cusip>67613T104</cusip>
        <identifiers>
          <isin value="US67613T1043"/>
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        <balance>339500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5774895.00000000</valUSD>
        <pctVal>0.109663303535</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BICARA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC</title>
        <cusip>055477103</cusip>
        <identifiers>
          <isin value="US0554771032"/>
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        <balance>944900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20551575.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9600450.00000000"/>
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      <invstOrSec>
        <name>LB PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LB PHARMACEUTICALS INC</title>
        <cusip>50180M108</cusip>
        <identifiers>
          <isin value="US50180M1080"/>
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        <balance>187731.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5250836.07000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 5) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA095000"/>
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        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>85744.00000000</valUSD>
        <pctVal>0.001628249569</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CAMP4 THERAPEUTICS CORP</name>
        <lei>N/A</lei>
        <title>CAMP4 THERAPEUTICS CORP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LPK424000"/>
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        <balance>1226606.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5384800.34000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIO AB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>BIO AB2 HOLDINGS LLC ADI</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="71E99L226"/>
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        <balance>1954526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8736731.22000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IMMUNOCORE HOLDINGS PLC</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>IMMUNOCORE HOLDINGS LTD ADR</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
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        <balance>287200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8297208.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIOMEA FUSION INC</name>
        <lei>N/A</lei>
        <title>BIOMEA FUSION INC WT 12/20/2026</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LHP002000"/>
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        <balance>46134.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>856.81000000</valUSD>
        <pctVal>0.000016270532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>KORRO BIO INC</name>
        <lei>N/A</lei>
        <title>KORRO BIO INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JVX197000"/>
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        <balance>32866.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>440733.06000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
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        <balance>1914833.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26941700.31000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>REGENERON PHARMACEUTICALS INC</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC</title>
        <cusip>75886F107</cusip>
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          <isin value="US75886F1075"/>
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        <balance>1000.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 9) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA099000"/>
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        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42872.00000000</valUSD>
        <pctVal>0.000814124784</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEWAMSTERDAM PHARMA COMPANY NV</name>
        <lei>984500B6549TF6E14D36</lei>
        <title>NEWAMSTERDAM PHARMA COMPANY NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150012L7"/>
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        <balance>523700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17638216.00000000</valUSD>
        <pctVal>0.334943758289</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DAMORA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DAMORA THERAPEUTICS INC</title>
        <cusip>36322Q206</cusip>
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          <isin value="US36322Q2066"/>
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        <balance>454559.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11309427.92000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KORSANA BIOSCIENCES FWD CMMT PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MJJ384000"/>
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        <balance>246900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>629595.00000000</valUSD>
        <pctVal>0.011955796181</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Bloomberg" value="EQ0000000096770470"/>
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        <balance>149142.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3079782.30000000</valUSD>
        <pctVal>0.058484024590</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
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        <balance>454774.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31638627.18000000</valUSD>
        <pctVal>0.600806833003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HANSA BIOPHARMA AB</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PROTHENA CORP PLC</name>
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        <invCountry>IE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BIOGEN INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARROWHEAD PHARMACEUTICALS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KRYSTAL BIOTECH INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BELITE BIO INC</name>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>MIRUM PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>GH RESEARCH PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CARDURION PHARMACEUTICALS INC</name>
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        <fairValLevel>3</fairValLevel>
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        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CELLCENTRIC LTD</name>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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        <name>ORUKA THERAPEUTICS INC</name>
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        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <name>SANA BIOTECHNOLOGY INC</name>
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        <name>ARS PHARMACEUTICALS INC</name>
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        <name>MBX BIOSCIENCES INC</name>
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        <name>KEROS THERAPEUTICS INC</name>
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        <name>TUBULIS GMBH</name>
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        <name>ALUMIS INC</name>
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        <name>BIO AB HOLDINGS LLC</name>
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        <title>BIO AB2 HOLDINGS LLC ARC</title>
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        <name>SOLID BIOSCIENCES INC</name>
        <lei>N/A</lei>
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        <name>ARGENX SE</name>
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        <title>ARGENX SE SPONSORED ADR</title>
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        <valUSD>118245769.56000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AVALYN PHARMA INC</name>
        <lei>N/A</lei>
        <title>AVALYN PHARMA INC</title>
        <cusip>05348Y105</cusip>
        <identifiers>
          <isin value="US05348Y1055"/>
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        <balance>15000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>431700.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CAMP4 THERAPEUTICS CORP</name>
        <lei>N/A</lei>
        <title>CAMP4 THERAPEUTICS CORP</title>
        <cusip>13463J101</cusip>
        <identifiers>
          <isin value="US13463J1016"/>
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        <balance>1326208.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5822053.12000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PARABILIS MEDICINES INC</name>
        <lei>N/A</lei>
        <title>PARABILIS MEDICINES INC SER F PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MBT390000"/>
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        <balance>491600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3382208.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>REPLIMUNE GROUP INC</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>REPLIMUNE GROUP INC</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
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        <balance>1514745.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13163134.05000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="8304233.52000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS INTERNATIONAL PLC</name>
        <lei>N/A</lei>
        <title>KINIKSA PHARMACEUTICALS INTERNATIONAL PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BRXB0C07"/>
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        <balance>637600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30847088.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYCLERION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CYCLERION THERAPEUTICS INC PP PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="EDE963000"/>
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        <balance>4740.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14931.00000000</valUSD>
        <pctVal>0.000283534641</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
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        <balance>699425.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23892358.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="116144.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>DESIGN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DESIGN THERAPEUTICS INC</title>
        <cusip>25056L103</cusip>
        <identifiers>
          <isin value="US25056L1035"/>
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        <balance>534931.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5606076.88000000</valUSD>
        <pctVal>0.106457504514</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 11) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA101000"/>
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        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19320.00000000</valUSD>
        <pctVal>0.000366880267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>ULTRAGENYX PHARMA INC</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
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        <balance>3489.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>83526.66000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SEPTERNA INC</name>
        <lei>N/A</lei>
        <title>SEPTERNA INC</title>
        <cusip>81734D104</cusip>
        <identifiers>
          <isin value="US81734D1046"/>
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        <balance>19400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>585880.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SENSORION SA</name>
        <lei>969500P0W8XJ9CGZDP97</lei>
        <title>SENSORION SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
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        <balance>17132230.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.85733882"/>
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        <pctVal>0.152167887684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="403068.03000000"/>
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      <invstOrSec>
        <name>CARTESIAN THERAPEUTICS INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>CARTESIAN THERAPEUTICS INC</title>
        <cusip>816212302</cusip>
        <identifiers>
          <isin value="US8162123025"/>
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        <balance>366554.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2763817.16000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <loanByFundCondition isLoanByFund="Y" loanVal="369460.00000000"/>
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      <invstOrSec>
        <name>VTV THERAPEUTICS INC</name>
        <lei>549300WQE5EI9R35SE66</lei>
        <title>VTV THERAPEUTICS INC CL A</title>
        <cusip>918385204</cusip>
        <identifiers>
          <isin value="US9183852048"/>
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        <balance>260391.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8684039.85000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TECTONIC THERAPEUTIC INC</name>
        <lei>N/A</lei>
        <title>TECTONIC THERAPEUTIC INC</title>
        <cusip>878972108</cusip>
        <identifiers>
          <isin value="US8789721086"/>
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        <balance>405389.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>12633948.19000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH SHAREHOLDER REPRESENTATIVE ESCROW LINE PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA090000"/>
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        <balance>9200.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>184.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MEDAVAIL HOLDINGS INC PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="554051920"/>
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        <balance>55.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TYRA BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC</title>
        <cusip>90240B106</cusip>
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          <isin value="US90240B1061"/>
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        <balance>337000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>11259170.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PERSPECTIVE THERAPEUTICS INC</name>
        <lei>5493005LRKM6BCABC605</lei>
        <title>PERSPECTIVE THERAPEUTICS INC</title>
        <cusip>46489V302</cusip>
        <identifiers>
          <isin value="US46489V3024"/>
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        <balance>258600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1018884.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IMMUNOME INC</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
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        <balance>2131664.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46534225.12000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NOVOCURE LTD</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>NOVOCURE LTD</title>
        <cusip>N/A</cusip>
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          <isin value="JE00BYSS4X48"/>
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        <balance>11113.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>189365.52000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 10) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA100000"/>
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        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20332.00000000</valUSD>
        <pctVal>0.000386097805</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>473082.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13497029.46000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SHATTUCK LABS INC</name>
        <lei>N/A</lei>
        <title>SHATTUCK LABS INC</title>
        <cusip>82024L103</cusip>
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          <isin value="US82024L1035"/>
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        <balance>391662.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2330388.90000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>INMED PHARMACEUTICALS INC</name>
        <lei>549300VA5DNHEJGHG397</lei>
        <title>MENTARI THERAPEUTICS FWD CMMT PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MQW790000"/>
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        <balance>191200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>441672.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
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        <balance>64900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6227155.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
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          <isin value="US47103J1051"/>
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        <balance>206670.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3015315.30000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ALLOGENE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
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        <balance>9546893.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20716757.81000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BRIDGEBIO ONCOLOGY THERAPEUTIC</name>
        <lei>N/A</lei>
        <title>BRIDGEBIO ONCOLOGY THERAPEUTIC</title>
        <cusip>107924102</cusip>
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          <isin value="US1079241022"/>
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        <balance>240300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2155491.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>HEMAB THERAPEUTICS HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HEMAB THERAPEUTICS HOLDINGS INC</title>
        <cusip>423494103</cusip>
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          <isin value="US4234941031"/>
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        <balance>379476.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC</title>
        <cusip>29337E102</cusip>
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          <isin value="US29337E1029"/>
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        <balance>340067.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>RELAY THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC</title>
        <cusip>75943R102</cusip>
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          <isin value="US75943R1023"/>
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        <balance>1010467.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ANTARES THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ANTARES THERAPEUTICS INC</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Bloomberg" value="EQ0000000097509153"/>
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        <balance>325500.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CARTESIAN THERAPEUTICS INC</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>CARTESIAN THERAPEUTICS INC CVR RT</title>
        <cusip>816212112</cusip>
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          <isin value="US8162121128"/>
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        <balance>5385728.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>REVOLUTION MEDICINES INC</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION MEDICINES INC</title>
        <cusip>76155X100</cusip>
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          <isin value="US76155X1000"/>
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        <balance>675072.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>BRIDGEBIO PHARMA INC</title>
        <cusip>10806X102</cusip>
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          <isin value="US10806X1028"/>
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        <balance>707304.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NUVATION BIO INC</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC</title>
        <cusip>67080N101</cusip>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VAXCYTE INC</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>VAXCYTE INC</title>
        <cusip>92243G108</cusip>
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        <balance>474755.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>VIRIDIAN THERAPEUTICS INC</name>
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        <title>VIRIDIAN THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SIONNA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>KAILERA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CITY THERAPEUTICS INC</name>
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        <title>CITY THERAPEUTICS INC SER B PC PP</title>
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        <name>VIATRIS INC</name>
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        <name>TANGO THERAPEUTICS INC</name>
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        <name>SPYRE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CANDEL THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>CANDEL THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MINERALYS THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US92337R1014"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
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        <cusip>N/A</cusip>
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          <isin value="CH0363463438"/>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>STRUCTURE THERAPEUTICS INC</name>
        <lei>N/A</lei>
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          <isin value="US86366E1064"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>INHIBIKASE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
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          <isin value="US86627T1088"/>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BLUE MARLIN THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>GENERATE BIOMEDICINE INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ANNEXON INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
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      <invstOrSec>
        <name>AKTIS ONCOLOGY INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ROIVANT SCIENCES LTD</name>
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        <fairValLevel>1</fairValLevel>
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        <name>JADE BIOSCIENCES INC</name>
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        <name>PROTAGONIST THERAPEUTICS INC</name>
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        <name>TUBULIS GMBH</name>
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        <name>CYTOKINETICS INC</name>
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        <name>ATYR PHARMA INC</name>
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        <name>EIKON THERAPEUTICS INC</name>
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        <name>GALDERMA GROUP AG</name>
        <lei>89450001OK6O8ELQ4584</lei>
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        <name>Fidelity Revere Street Trust</name>
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        <title>Fidelity Cash Central Fund</title>
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      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
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        <balance>344940.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2269705.20000000</valUSD>
        <pctVal>0.043100934351</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DK0060615755"/>
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        <balance>480401.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>107662668.11000000</valUSD>
        <pctVal>2.044477666236</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
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        <balance>32710.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>888403.60000000</valUSD>
        <pctVal>0.016870483991</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CAPRICOR THERAPEUTICS INC</name>
        <lei>5493002ZI5PDLXV4DX14</lei>
        <title>CAPRICOR THERAPEUTICS INC</title>
        <cusip>14070B309</cusip>
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          <isin value="US14070B3096"/>
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        <balance>334200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10012632.00000000</valUSD>
        <pctVal>0.190136496369</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GERON CORP</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>GERON CORP</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
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        <balance>5452212.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6815265.00000000</valUSD>
        <pctVal>0.129419578082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VOR BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>VOR BIOPHARMA INC</title>
        <cusip>929033207</cusip>
        <identifiers>
          <isin value="US9290332074"/>
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        <balance>1185725.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17750303.25000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12690069.00000000"/>
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      <invstOrSec>
        <name>VERTEX PHARMACEUTICALS INC</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
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        <balance>5106.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2285139.24000000</valUSD>
        <pctVal>0.043394021553</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BIOHAVEN LTD</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
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        <balance>1448896.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15952344.96000000</valUSD>
        <pctVal>0.302929637239</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AXCELLA HEALTH INC</name>
        <lei>N/A</lei>
        <title>AXCELLA HEALTH INC</title>
        <cusip>05454B204</cusip>
        <identifiers>
          <isin value="US05454B2043"/>
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        <balance>66454.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.66000000</valUSD>
        <pctVal>0.000000012533</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NATERA INC</name>
        <lei>529900CQ3OZ0A0VYVU59</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
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        <balance>331532.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74054302.84000000</valUSD>
        <pctVal>1.406266172880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>OPTINOSE INC</name>
        <lei>549300CPBME7Z3CYMN16</lei>
        <title>OPTINOSE INC WT 11/23/27</title>
        <cusip>68404V118</cusip>
        <identifiers>
          <isin value="US68404V1180"/>
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        <balance>91712.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.92000000</valUSD>
        <pctVal>0.000000017470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
        <identifiers>
          <isin value="US23284F1057"/>
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        <balance>2774340.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9987624.00000000</valUSD>
        <pctVal>0.189661602905</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PHARVARIS BV</name>
        <lei>9845003BE146D3B75D32</lei>
        <title>PHARVARIS BV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
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        <balance>147914.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4461086.24000000</valUSD>
        <pctVal>0.084714519386</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CANDID THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>CANDID THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KPC029000"/>
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        <balance>1666667.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6183334.57000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MADRIGAL PHARMACEUTICALS INC</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>MADRIGAL PHARMACEUTICALS INC</title>
        <cusip>558868105</cusip>
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          <isin value="US5588681057"/>
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        <balance>98095.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>48779700.65000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>160411.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FIRST TRACKS BIOTHERAPEUTICS INC</name>
        <lei>529900CGIGKN4R5RO925</lei>
        <title>FIRST TRACKS BIOTHERAPEUTICS INC</title>
        <cusip>337185102</cusip>
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          <isin value="US3371851029"/>
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        <balance>23300.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ZENAS BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="LSC975000"/>
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        <balance>263137.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IMMUNEERING CORP</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP</title>
        <cusip>45254E107</cusip>
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        <balance>1095798.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VERADERMICS INC</name>
        <lei>N/A</lei>
        <title>VERADERMICS INC</title>
        <cusip>922967104</cusip>
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          <isin value="US9229671048"/>
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        <balance>20800.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>STOKE THERAPEUTICS INC</title>
        <cusip>86150R107</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
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          <isin value="BE0003739530"/>
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        <balance>357874.00000000</balance>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BEONE MEDICINES LTD</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD ADR</title>
        <cusip>07725L102</cusip>
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        <balance>29698.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8550648.16000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
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          <isin value="US76243J1051"/>
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        <balance>99803.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8814600.96000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DYNE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC</title>
        <cusip>26818M108</cusip>
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          <isin value="US26818M1080"/>
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        <balance>1883544.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>36408905.52000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ARRIVENT BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ARRIVENT BIOPHARMA INC</title>
        <cusip>04272N102</cusip>
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          <isin value="US04272N1028"/>
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        <balance>1439803.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43582836.81000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>RAPPORT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RAPPORT THERAPEUTICS INC</title>
        <cusip>75383L102</cusip>
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          <isin value="US75383L1026"/>
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        <balance>428273.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16916783.50000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH ADJUSTMENT ESCROW LINE PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA089000"/>
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        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31832.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CELCUITY INC</name>
        <lei>25490070W7UU7W2SEY87</lei>
        <title>CELCUITY INC</title>
        <cusip>15102K100</cusip>
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          <isin value="US15102K1007"/>
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        <balance>375600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49909728.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>ALNYLAM PHARMACEUTICALS INC</title>
        <cusip>02043Q107</cusip>
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          <isin value="US02043Q1076"/>
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        <balance>511683.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ZENAS BIOPHARMA INC</title>
        <cusip>98937L105</cusip>
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          <isin value="US98937L1052"/>
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        <balance>380400.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
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          <isin value="US4131971040"/>
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        <balance>17525.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC WT 12/31/2030</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MCK855000"/>
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        <balance>372579.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ZEALAND PHARMA A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S</title>
        <cusip>N/A</cusip>
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          <isin value="DK0060257814"/>
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        <currencyConditional curCd="DKK" exchangeRt="6.40775000"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TARSUS PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC</title>
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          <isin value="US87650L1035"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FOGHORN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>FOGHORN THERAPEUTICS INC WT 06/30/2027</title>
        <cusip>N/A</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LEXICON PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>LEXICON PHARMACEUTICALS INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>CORCEPT THERAPEUTICS INC</name>
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        <title>CORCEPT THERAPEUTICS INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
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        <assetCat>STIV</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>IMMUNOVANT INC</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 2) 05/21/2036 PP</title>
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        <isRestrictedSec>Y</isRestrictedSec>

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        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
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      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
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        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TRAVERE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TRAVERE THERAPEUTICS INC</title>
        <cusip>89422G107</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>OLEMA PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>OLEMA PHARMACEUTICALS INC</title>
        <cusip>68062P106</cusip>
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        <balance>628100.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
        <cusip>032724106</cusip>
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          <isin value="US0327241065"/>
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        <balance>23300.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1297111.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>COGENT BIOSCIENCES INC</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
        </identifiers>
        <balance>1604794.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56103598.24000000</valUSD>
        <pctVal>1.065388361730</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
        </identifiers>
        <balance>128728.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8018467.12000000</valUSD>
        <pctVal>0.152267979533</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DENALI THERAPEUTICS INC</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>DENALI THERAPEUTICS INC</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
        </identifiers>
        <balance>205263.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4318733.52000000</valUSD>
        <pctVal>0.082011289363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
        </identifiers>
        <balance>784000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7063840.00000000</valUSD>
        <pctVal>0.134139933287</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>1109201.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>118584678.91000000</valUSD>
        <pctVal>2.251882958554</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAZE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MAZE THERAPEUTICS INC</title>
        <cusip>578784100</cusip>
        <identifiers>
          <isin value="US5787841007"/>
        </identifiers>
        <balance>739660.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19571403.60000000</valUSD>
        <pctVal>0.371654337195</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13230.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>1886298.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>253575040.14000000</valUSD>
        <pctVal>4.815304277539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TAYSHA GENE THERAPIES INC</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
        </identifiers>
        <balance>940476.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5520594.12000000</valUSD>
        <pctVal>0.104834215804</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
        </identifiers>
        <balance>404257.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13235374.18000000</valUSD>
        <pctVal>0.251335280746</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TUBULIS GMBH</name>
        <lei>391200YI45XXSZ9Z2J67</lei>
        <title>TUBULIS GMBH CVR (MILESTONE 4) 05/21/2036 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MRA092000"/>
        </identifiers>
        <balance>9200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>512348.00000000</valUSD>
        <pctVal>0.009729315293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
        </identifiers>
        <balance>398657.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32745685.98000000</valUSD>
        <pctVal>0.621829505314</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZURA BIO LTD</name>
        <lei>549300LQXD6M2MIQFN24</lei>
        <title>ZURA BIO LTD A</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG9TY5A1016"/>
        </identifiers>
        <balance>509657.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2191525.10000000</valUSD>
        <pctVal>0.041616320685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BIOMEA FUSION INC</name>
        <lei>N/A</lei>
        <title>BIOMEA FUSION INC</title>
        <cusip>09077A106</cusip>
        <identifiers>
          <isin value="US09077A1060"/>
        </identifiers>
        <balance>452663.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>624674.94000000</valUSD>
        <pctVal>0.011862365905</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="464784.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ERASCA INC</name>
        <lei>N/A</lei>
        <title>ERASCA INC</title>
        <cusip>29479A108</cusip>
        <identifiers>
          <isin value="US29479A1088"/>
        </identifiers>
        <balance>2533680.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32532451.20000000</valUSD>
        <pctVal>0.617780248938</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SCORPION THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SCORPION THERAPEUTICS INC CVR 03/05/2040 PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LBN633000"/>
        </identifiers>
        <balance>5166448.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4288151.84000000</valUSD>
        <pctVal>0.081430553600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELEVATEBIO, LLC</name>
        <lei>N/A</lei>
        <title>ELEVATEBIO LLC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HCJ459000"/>
        </identifiers>
        <balance>216600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>398544.00000000</valUSD>
        <pctVal>0.007568215810</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JAZZ PHARMACEUTICALS PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
        <title>JAZZ PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B4Q5ZN47"/>
        </identifiers>
        <balance>410452.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>97067793.48000000</valUSD>
        <pctVal>1.843284579182</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>476377.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36442840.50000000</valUSD>
        <pctVal>0.692037219627</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>529900RZ62O2T6LNQS60</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>273399.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30180515.61000000</valUSD>
        <pctVal>0.573117787282</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>852700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21607418.00000000</valUSD>
        <pctVal>0.410317562266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FORTE BIOSCIENCES INC</name>
        <lei>529900Z84WFDHPS3JP76</lei>
        <title>FORTE BIOSCIENCES INC</title>
        <cusip>34962G208</cusip>
        <identifiers>
          <isin value="US34962G2084"/>
        </identifiers>
        <balance>563591.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10747680.37000000</valUSD>
        <pctVal>0.204094816393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-06-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
