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      </invstOrSec>
      <invstOrSec>
        <name>CAPRICOR THERAPEUTICS INC</name>
        <lei>5493002ZI5PDLXV4DX14</lei>
        <title>CAPRICOR THERAPEUTICS INC</title>
        <cusip>14070B309</cusip>
        <identifiers>
          <isin value="US14070B3096"/>
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        <balance>389900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10889907.00000000</valUSD>
        <pctVal>0.718422411452</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10887337.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CORCEPT THERAPEUTICS INC</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>CORCEPT THERAPEUTICS INC</title>
        <cusip>218352102</cusip>
        <identifiers>
          <isin value="US2183521028"/>
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        <balance>158100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5644170.00000000</valUSD>
        <pctVal>0.372353797149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
        </identifiers>
        <balance>4809384.32900000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4810346.21000000</valUSD>
        <pctVal>0.317345274308</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
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        <balance>64528910.92100000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64535363.81000000</valUSD>
        <pctVal>4.257488304754</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="64535363.81000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>FINANCIERE DE TUBIZE SA</name>
        <lei>549300I1MGC0OK6W8828</lei>
        <title>FINANCIERE DE TUBIZE SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003823409"/>
        </identifiers>
        <balance>91587.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84631009"/>
        <valUSD>24511648.56000000</valUSD>
        <pctVal>1.617067773596</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>472500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70378875.00000000</valUSD>
        <pctVal>4.642992919300</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GSK PLC</name>
        <lei>5493000HZTVUYLO1D793</lei>
        <title>GSK PLC SPONS ADR</title>
        <cusip>37733W204</cusip>
        <identifiers>
          <isin value="US37733W2044"/>
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        <balance>2581360.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>152635816.80000000</valUSD>
        <pctVal>10.06959853555</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JAZZ PHARMACEUTICALS PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
        <title>JAZZ PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B4Q5ZN47"/>
        </identifiers>
        <balance>227700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43267554.00000000</valUSD>
        <pctVal>2.854421115106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IONIS PHARMACEUTICALS INC</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
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        <balance>100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8115.00000000</valUSD>
        <pctVal>0.000535357911</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>JOHNSON and JOHNSON</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>JOHNSON and JOHNSON</title>
        <cusip>478160104</cusip>
        <identifiers>
          <isin value="US4781601046"/>
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        <balance>459700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>114203271.00000000</valUSD>
        <pctVal>7.534149680765</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ELI LILLY and CO</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
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        <balance>362801.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>381663023.99000000</valUSD>
        <pctVal>25.17884404864</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MEDAVAIL HOLDINGS INC</name>
        <lei>549300ZNQGSJ2V3ZB668</lei>
        <title>MEDAVAIL HOLDINGS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="554051920"/>
        </identifiers>
        <balance>66.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.01000000</valUSD>
        <pctVal>0.000000000659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MERCK and CO INC</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC NEW</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
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        <balance>561536.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69529387.52000000</valUSD>
        <pctVal>4.586951040900</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MERCK KGAA</name>
        <lei>529900OAREIS0MOPTW25</lei>
        <title>MERCK KGAA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DE0006599905"/>
        </identifiers>
        <balance>94700.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84631009"/>
        <valUSD>14348541.37000000</valUSD>
        <pctVal>0.946593363181</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>705578.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11028184.14000000</valUSD>
        <pctVal>0.727544747976</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
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        <balance>1331717.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11905549.98000000</valUSD>
        <pctVal>0.785425800817</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
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        <balance>155600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10610364.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PHIBRO ANIMAL HEALTH CORP</name>
        <lei>549300U24SP4AF2JUX52</lei>
        <title>PHIBRO ANIMAL HEALTH CORP CL A</title>
        <cusip>71742Q106</cusip>
        <identifiers>
          <isin value="US71742Q1067"/>
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        <balance>150755.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8229715.45000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ROCHE HOLDING AG</name>
        <lei>549300U41AUUVOAAOB37</lei>
        <title>ROCHE HOLDINGS AG (GENUSSCHEINE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
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        <balance>157090.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.76885000"/>
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        <pctVal>4.931979632574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
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        <balance>296800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4134424.00000000</valUSD>
        <pctVal>0.272753739774</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
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        <balance>384500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5298410.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
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        <balance>254500.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84631009"/>
        <valUSD>75870949.38000000</valUSD>
        <pctVal>5.005312755452</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
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        <balance>64300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2175912.00000000</valUSD>
        <pctVal>0.143547961075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
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        <balance>268600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11611578.00000000</valUSD>
        <pctVal>0.766032057714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
        <cusip>60770K107</cusip>
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          <isin value="US60770K1079"/>
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        <balance>688800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36899016.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>IDORSIA LTD</name>
        <lei>506700XOVZUB107S5720</lei>
        <title>IDORSIA LTD</title>
        <cusip>N/A</cusip>
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          <isin value="CH0363463438"/>
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        <balance>639660.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
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          <isin value="US22663K1079"/>
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        <balance>122800.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ELANCO ANIMAL HEALTH INC</name>
        <lei>549300SHPNDCE059M934</lei>
        <title>ELANCO ANIMAL HEALTH INC</title>
        <cusip>28414H103</cusip>
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          <isin value="US28414H1032"/>
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        <balance>2536200.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
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          <isin value="US09075V1026"/>
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        <balance>132653.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
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        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="FEC032000"/>
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        <balance>200.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
        <cusip>07373V105</cusip>
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          <isin value="US07373V1052"/>
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        <balance>415400.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DEFINIUM THERAPEUTICS INC</name>
        <lei>529900UG3DGE202N5D44</lei>
        <title>DEFINIUM THERAPEUTICS INC</title>
        <cusip>24477V105</cusip>
        <identifiers>
          <isin value="CA24477V1058"/>
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        <balance>188000.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
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        <balance>2598400.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ROYALTY PHARMA PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>ROYALTY PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
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        <balance>750500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34680605.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ANNEXON INC</name>
        <lei>N/A</lei>
        <title>ANNEXON INC</title>
        <cusip>03589W102</cusip>
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          <isin value="US03589W1027"/>
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        <balance>1264100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7078960.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
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        <balance>158577.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC</title>
        <cusip>254604101</cusip>
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          <isin value="US2546041011"/>
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        <balance>53800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3584156.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC</title>
        <cusip>501575104</cusip>
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          <isin value="US5015751044"/>
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        <balance>102000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>9317700.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SUMMIT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC</title>
        <cusip>86627T108</cusip>
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          <isin value="US86627T1088"/>
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        <balance>169304.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2808753.36000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC</title>
        <cusip>92337R101</cusip>
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          <isin value="US92337R1014"/>
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        <balance>100700.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VIATRIS INC</name>
        <lei>254900ZZTSW7NL773X71</lei>
        <title>VIATRIS INC</title>
        <cusip>92556V106</cusip>
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          <isin value="US92556V1061"/>
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        <balance>1729600.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER C PC PP</title>
        <cusip>N/A</cusip>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>EDGEWISE THERAPEUTICS INC</title>
        <cusip>28036F105</cusip>
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          <isin value="US28036F1057"/>
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        <balance>83600.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>EVOZYNE INC</name>
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        <title>EVOZYNE INC SER A PC PP</title>
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        <balance>5900.00000000</balance>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
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        <cusip>03237H101</cusip>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK BIOSCIENCES INC SER D-1 PC PP</title>
        <cusip>N/A</cusip>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK BIOSCIENCES INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
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        <balance>85.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-1 PC PP</title>
        <cusip>N/A</cusip>
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        <curCd>USD</curCd>
        <valUSD>149544.72000000</valUSD>
        <pctVal>0.009865674551</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JMF122000"/>
        </identifiers>
        <balance>22477.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>196898.52000000</valUSD>
        <pctVal>0.012989671036</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC CPIK 6% 09/13/2028 P/P</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JYB817000"/>
        </identifiers>
        <balance>1009195.86000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>1194383.30000000</valUSD>
        <pctVal>0.078795138524</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2028-09-13</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>0.06000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>Y</isPaidKind>
          <isMandatoryConvrtbl>N</isMandatoryConvrtbl>
          <isContngtConvrtbl>Y</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>EVOZYNE INC</name>
              <title>EVOZYNE INC</title>
              <curCd>USD</curCd>
              <identifiers>
                <other otherDesc="Internal" value="HED066000"/>
              </identifiers>
            </dbtSecRefInstrument>
          </dbtSecRefInstruments>
          <currencyInfos>
            <currencyInfo convRatio="1000.00000000" curCd="USD"/>
          </currencyInfos>
          <delta>XXXX</delta>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JYB818000"/>
        </identifiers>
        <balance>56643.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>960098.85000000</valUSD>
        <pctVal>0.063339065342</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARRIVENT BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ARRIVENT BIOPHARMA INC</title>
        <cusip>04272N102</cusip>
        <identifiers>
          <isin value="US04272N1028"/>
        </identifiers>
        <balance>107000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2457790.00000000</valUSD>
        <pctVal>0.162143847384</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-3 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LEV772000"/>
        </identifiers>
        <balance>4581.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47092.68000000</valUSD>
        <pctVal>0.003106770032</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA ADR</title>
        <cusip>00860C102</cusip>
        <identifiers>
          <isin value="US00860C1027"/>
        </identifiers>
        <balance>9100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>145782.00000000</valUSD>
        <pctVal>0.009617442645</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA (180 DAY LOCK-UP)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MER014000"/>
        </identifiers>
        <balance>332858.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84631009"/>
        <valUSD>5332386.09000000</valUSD>
        <pctVal>0.351784976086</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-03-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
