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      <invstOrSec>
        <name>INTELLIA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal" value="FEC032000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
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          <other otherDesc="Internal" value="JMF122000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>DISC MEDICINE INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MERCK and CO INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>LEAP THERAPEUTICS INC</name>
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        <title>LEAP THERAPEUTICS INC WT</title>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
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      <invstOrSec>
        <name>ROYALTY PHARMA PLC</name>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>EDGEWISE THERAPEUTICS INC</name>
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        <title>EDGEWISE THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
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      <invstOrSec>
        <name>ULTRAGENYX PHARMACEUTICAL INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
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        <name>MEDAVAIL HOLDINGS INC</name>
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        <title>MEDAVAIL HOLDINGS INC PIPE</title>
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        <name>UNIQURE N.V.</name>
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        <name>AVIDITY BIOSCIENCES INC</name>
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        <title>AVIDITY BIOSCIENCES</title>
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        <name>BIONTECH SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
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        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-3 PC PP</title>
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        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC SER B PC PP</title>
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        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>MODERNA INC</title>
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        <name>ASTRAZENECA PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC SPONS ADR</title>
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        <name>ELI LILLY and CO</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO</title>
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        <name>ELANCO ANIMAL HEALTH INC</name>
        <lei>549300SHPNDCE059M934</lei>
        <title>ELANCO ANIMAL HEALTH INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>SUMMIT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC</title>
        <cusip>86627T108</cusip>
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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CASTLE CREEK BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>CASTLE CREEK BIOSCIENCES INC SER D-2 PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JAC126000"/>
        </identifiers>
        <balance>85.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15776.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
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        <balance>36100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7013147.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LEGEND BIOTECH CORP</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>LEGEND BIOTECH CORP SPON ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
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        <balance>832700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28919671.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA SER D PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KRS502000"/>
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        <balance>7649.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>METSERA INC</name>
        <lei>N/A</lei>
        <title>METSERA INC</title>
        <cusip>59267L107</cusip>
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          <isin value="US59267L1070"/>
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        <balance>278676.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9834476.04000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>VIR BIOTECHNOLOGY INC</name>
        <lei>N/A</lei>
        <title>VIR BIOTECHNOLOGY INC</title>
        <cusip>92764N102</cusip>
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          <isin value="US92764N1028"/>
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        <balance>280800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PTC THERAPEUTICS INC</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>150800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7438964.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
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        <balance>234100.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ARRIVENT BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ARRIVENT BIOPHARMA INC</title>
        <cusip>04272N102</cusip>
        <identifiers>
          <isin value="US04272N1028"/>
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        <balance>107000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2045840.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GSK PLC</name>
        <lei>5493000HZTVUYLO1D793</lei>
        <title>GSK PLC SPONS ADR</title>
        <cusip>37733W204</cusip>
        <identifiers>
          <isin value="US37733W2044"/>
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        <balance>1342860.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53271256.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>HARMONY BIOSCIENCES HOLDINGS INC</name>
        <lei>N/A</lei>
        <title>HARMONY BIOSCIENCES HOLDINGS INC</title>
        <cusip>413197104</cusip>
        <identifiers>
          <isin value="US4131971040"/>
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        <balance>93877.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3463122.53000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>FINANCIERE DE TUBIZE SA</name>
        <lei>549300I1MGC0OK6W8828</lei>
        <title>FINANCIERE DE TUBIZE SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003823409"/>
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        <balance>141200.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
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          <isin value="US31635A3032"/>
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        <balance>12994526.18500000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <cashCollateralCondition cashCollateralVal="12995825.64000000" isCashCollateral="Y"/>
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      <invstOrSec>
        <name>EVOZYNE INC</name>
        <lei>N/A</lei>
        <title>EVOZYNE INC SER A PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="HED067000"/>
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        <balance>5900.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BEAM THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC</title>
        <cusip>07373V105</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AGOMAB THERAPEUTICS SA</name>
        <lei>894500APP6UE5N4PKJ68</lei>
        <title>AGOMAB THERAPEUTICS SA ANTI-DILUTION WT PP 10/10/2033</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="JYV555000"/>
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        <invCountry>BE</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>OCULAR THERAPEUTIX INC</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>OCULAR THERAPEUTIX INC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
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        <balance>416900.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>47097193.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PARAGON BIOSCIENCES EMALEX CAPITAL INC</name>
        <lei>N/A</lei>
        <title>PARAGON BIOSCIENCES EMALEX CAPITAL INC SER D-1 PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="JMF025000"/>
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        <balance>15977.00000000</balance>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
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        <balance>65000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1758250.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
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          <isin value="NL0011606264"/>
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        <balance>90400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5951936.00000000</valUSD>
        <pctVal>0.551255982785</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>JAZZ PHARMACEUTICALS PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
        <title>JAZZ PHARMA PLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B4Q5ZN47"/>
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        <balance>57100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7294525.00000000</valUSD>
        <pctVal>0.675603794769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCUS BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>853517.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9038745.03000000</valUSD>
        <pctVal>0.837149840767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2470647.00000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
