X0201 4 2004-02-03 0 0000318771 GENENTECH INC DNA 0001214127 LAVIGNE LOUIS J JR 1 DNA WAY SO SAN FRANCISCO CA 94080 0 1 0 0 EVP AND CFO Common Stock 2004-02-03 4 M 0 400 24.25 A 695 D Common Stock 2004-02-03 4 S 0 400 96.77 D 295 D Common Stock 2004-02-03 4 M 0 1200 24.25 A 1495 D Common Stock 2004-02-03 4 S 0 1200 96.8 D 295 D Common Stock 2004-02-03 4 M 0 5800 24.25 A 6095 D Common Stock 2004-02-03 4 S 0 5800 96.82 D 295 D Common Stock 2004-02-03 4 M 0 2200 24.25 A 2495 D Common Stock 2004-02-03 4 S 0 2200 96.83 D 295 D Common Stock 2004-02-03 4 M 0 800 24.25 A 1095 D Common Stock 2004-02-03 4 S 0 800 96.81 D 295 D Common Stock 2004-02-03 4 M 0 1000 24.25 A 1295 D Common Stock 2004-02-03 4 S 0 1000 96.75 D 295 D Common Stock 2004-02-03 4 M 0 100 24.25 A 395 D Common Stock 2004-02-03 4 S 0 100 96.66 D 295 D Common Stock 2004-02-03 4 M 0 100 24.25 A 395 D Common Stock 2004-02-03 4 S 0 100 96.71 D 295 D Common Stock 2004-02-03 4 M 0 100 24.25 A 395 D Common Stock 2004-02-03 4 S 0 100 96.78 D 295 D Common Stock 2004-02-03 4 M 0 200 24.25 A 495 D Common Stock 2004-02-03 4 S 0 200 96.74 D 295 D Common Stock 2004-02-03 4 M 0 200 24.25 A 495 D Common Stock 2004-02-03 4 S 0 200 96.76 D 295 D Common Stock 2004-02-03 4 M 0 200 24.25 A 495 D Common Stock 2004-02-03 4 S 0 200 96.84 D 295 D Common Stock 2765 I by Trust Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 4000 0 D 1999-07-16 2009-07-16 Common Stock 4000 246000 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 6100 0 D 1999-07-16 2009-07-16 Common Stock 6100 239900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1000 0 D 1999-07-16 2009-07-16 Common Stock 1000 238900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1400 0 D 1999-07-16 2009-07-16 Common Stock 1400 237500 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 2100 0 D 1999-07-16 2009-07-16 Common Stock 2100 235400 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1000 0 D 1999-07-16 2009-07-16 Common Stock 1000 234400 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 2600 0 D 1999-07-16 2009-07-16 Common Stock 2600 231800 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 300 0 D 1999-07-16 2009-07-16 Common Stock 300 231500 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 600 0 D 1999-07-16 2009-07-16 Common Stock 600 230900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 4800 0 D 1999-07-16 2009-07-16 Common Stock 4800 226100 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 800 0 D 1999-07-16 2009-07-16 Common Stock 800 225300 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 6100 0 D 1999-07-16 2009-07-16 Common Stock 6100 219200 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1000 0 D 1999-07-16 2009-07-16 Common Stock 1000 218200 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 2700 0 D 1999-07-16 2009-07-16 Common Stock 2700 215500 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 3200 0 D 1999-07-16 2009-07-16 Common Stock 3200 212300 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 400 0 D 1999-07-16 2009-07-16 Common Stock 400 211900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1200 0 D 1999-07-16 2009-07-16 Common Stock 1200 210700 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 5800 0 D 1999-07-16 2009-07-16 Common Stock 5800 204900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 2200 0 D 1999-07-16 2009-07-16 Common Stock 2200 202700 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 800 0 D 1999-07-16 2009-07-16 Common Stock 800 201900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 1000 0 D 1999-07-16 2009-07-16 Common Stock 1000 200900 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 100 0 D 1999-07-16 2009-07-16 Common Stock 100 200800 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 100 0 D 1999-07-16 2009-07-16 Common Stock 100 200700 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 100 0 D 1999-07-16 2009-07-16 Common Stock 100 200600 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 200 0 D 1999-07-16 2009-07-16 Common Stock 200 200400 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 200 0 D 1999-07-16 2009-07-16 Common Stock 200 200200 D Non-Qualified Stock Option (right to buy) 24.25 2004-02-03 4 M 0 200 0 D 1999-07-16 2009-07-16 Common Stock 200 200000 D This stock option vests over three years in equal monthly increments beginning one month from grant date. This option may be immediately exercisable with the consent of Genentech. /s/ Louis J. Lavigne Jr. 2004-02-04