X0306 4 2020-11-02 0 0000318306 ABEONA THERAPEUTICS INC. ABEO 0001744816 Mann Paul Elliot 1330 AVENUE OF THE AMERICAS, 33RD FLOOR NEW YORK NY 10019 1 0 0 0 Common Stock 2020-11-02 4 S 0 30488 1.0361 D 820474 D The sales reported in this Form 4 were to cover tax obligations associated with vested restricted stock awards and were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 19, 2020. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $1.03 to $1.055, inclusive. The reporting person undertakes to provide to the Issuer, any security holder, or the Staff of the SEC, upon request, full information regarding the number of shares disposed at each separate price within the ranges set forth in this footnote. /s/ Brendan M. O'Malley, as Attorney-in-fact 2020-11-06