<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2023-08-14</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000318154</issuerCik>
        <issuerName>AMGEN INC</issuerName>
        <issuerTradingSymbol>AMGN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001987926</rptOwnerCik>
            <rptOwnerName>Busch Matthew C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE AMGEN CENTER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>THOUSAND OAKS</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91320</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>VP, Finance &amp; CAO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4596</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>177.46</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2020-04-27</value>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2028-04-27</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1257</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>177.31</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2021-05-03</value>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2029-05-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1476</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>236.36</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2022-05-05</value>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <value>2030-05-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1558</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>239.64</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2023-04-30</value>
                <footnoteId id="F6"/>
            </exerciseDate>
            <expirationDate>
                <value>2031-04-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1086</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>230.92</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2024-05-02</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2032-05-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1753</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Nqso (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>235.97</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2025-05-02</value>
                <footnoteId id="F8"/>
            </exerciseDate>
            <expirationDate>
                <value>2033-05-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2508</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These shares include the following Restricted Stock Units (RSUs) granted under the Company's equity plans: 64 RSUs which will vest on 5/5/2024; 84 RSUs which will vest in installments of 41 on 4/30/2024 and 43 on 4/30/2025; 175 RSUs which will vest on 11/5/2023; 1,496 RSUs which will vest in installments of 493 on 11/5/2023, 494 on 11/5/2024 and 509 on 11/5/2025; 214 RSUs which will vest in installments of 70 on 5/2/2024, 71 on 5/2/2025, and 73 on 5/2/2026; and 296 RSUs which will vest in installments of 97 on 5/2/2025, 98 on 5/2/2026 and 101 on 5/2/2027. Vested RSUs will be paid in shares of the Company's common stock on a one-to-one basis.</footnote>
        <footnote id="F2">These shares include 126 Dividend Equivalents (DEs) granted pursuant to the Amgen Inc. 2009 Amended and Restated Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited on the reporting person's unvested RSUs and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount.</footnote>
        <footnote id="F3">1,257 of these non-qualified stock options have vested and are exercisable.</footnote>
        <footnote id="F4">1,476 of these non-qualified stock options have vested and are exercisable.</footnote>
        <footnote id="F5">1,028 of these non-qualified stock options have vested and 530 will vest and become exercisable on 5/5/2024.</footnote>
        <footnote id="F6">358 of these non-qualified stock options have vested and the remaining options will vest and become exercisable in installments of 358 on 4/30/2024 and 370 on 4/30/2025.</footnote>
        <footnote id="F7">These non-qualified stock options will vest and become exercisable in two installments of 578 on 5/2/2024 and 5/2/2025 and one installment of 597 on 5/2/2026.</footnote>
        <footnote id="F8">These non-qualified stock options will vest and become exercisable in installments of 827 on 5/2/2025, 828 on 5/2/2026 and 853 on 5/2/2027.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matthew C. Busch</signatureName>
        <signatureDate>2023-08-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
