X0306 4 2022-03-18 0000318154 AMGEN INC AMGN 0001642156 Gordon Murdo ONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320 1 EVP Global Commercial Ops Common Stock 2022-03-18 4 F 0 4995 235.86 D 44865 D These shares include the following Restricted Stock Units granted under the Company's equity plans: 3,023 RSUs which vest in installments of 1,489 on 5/3/2022 and 1,534 on 5/3/2023; 3,469 RSUs which vest in installments of 1,144 on 5/5/2022, 1,145 on 5/5/2023 and 1,180 on 5/5/2024; and 4,172 RSUs which vest in installments of 1,376 on 4/30/2023, 1,377 on 4/30/2024 and 1,419 on 4/30/2025. Vested RSUs will be paid in shares of the Company's common stock on a one-to-one basis. These shares include 632 Dividend Equivalents (DEs) granted pursuant to the Amgen Inc. Amended and Restated Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited on the reporting person's unvested RSUs and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount. /s/ Murdo Gordon 2022-03-21