0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONSOLIDATED STATEMENTS OF INCOME link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Segment and other information link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Acquisitions link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Stock-based compensation link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Defined contribution plan link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Collaborations link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Property, plant and equipment link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Goodwill and other intangible assets link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Other current assets and accrued liabilities link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Financing arrangements link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Stockholders' equity link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Fair value measurement link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Derivative instruments link:presentationLink link:calculationLink link:definitionLink 9952177 - Disclosure - Contingencies and commitments link:presentationLink link:calculationLink link:definitionLink 9952178 - Disclosure - SCHEDULE II - VALUATION AND QUALIFYING ACCOUNTS link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Segment and other information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Acquisitions (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Stock-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Property, plant and equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Goodwill and other intangible assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Other current assets and accrued liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Financing arrangements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Fair value measurement (Tables) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Derivative instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of significant accounting policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Segment and other information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Segment and other information - Schedule of Reconciliation of Segment Net Income to Consolidated Net Income (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Revenues - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Revenues - Schedule of Revenues Earned from Major Customers (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Acquisitions - Acquisition of Horizon Therapeutics plc (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Acquisitions - Schedule of Business Acquisitions, by Acquisition (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Acquisitions - Schedule of Supplemental Pro Forma Financial Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Stock-based compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stock-based compensation - Schedule of Components of Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Stock-based compensation - Schedule of RSUs (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-based compensation - Schedule of Stock Option Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-based compensation - Schedule of Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-based compensation - Schedule of Weighted-Average Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Defined contribution plan - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Income taxes - Schedule of Income before Income Tax, Domestic and Foreign (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Income taxes - Schedule of Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Income taxes - Schedule of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Income taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Income taxes - Schedule of Reconciliation of Total Gross Amounts of UTBs (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Income taxes - Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Income taxes - Schedule of Reconciliation of Federal Statutory Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Income taxes - Schedule of Income Taxes Paid (Net of Refunds Received (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Earnings per share - Schedule of Computation for Basic and Diluted Earnings per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Collaborations - AstraZeneca PLC (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Collaborations - UCB (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Collaborations - BeOne (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Collaborations - Kyowa Kirin (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Investments - Schedule of Available-For-Sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Investments - Schedule of Fair Values by Classification (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Investments - Available-For-Sale (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Investments - BeOne (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Investments - Other Equity Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Investments - Neumora Therapeutics, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Investments - Limited Partnership Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Property, plant and equipment - Schedule of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Property, plant and equipment - Schedule of Property, Plant and Equipment by Geographic Area (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Goodwill and other intangible assets - Schedule of Goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Goodwill and other intangible assets - Schedule of Other Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Goodwill and other intangible assets - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Leases - Schedule of Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Leases - Schedule of Components of Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Leases - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Leases - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Leases - Schedule of Weighted Average Remaining Lease Terms & Discount Rates (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - Leases - Schedule of Cash and Noncash Information of Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955576 - Disclosure - Other current assets and accrued liabilities - Schedule of Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Other current assets and accrued liabilities - Schedule of Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955578 - Disclosure - Financing arrangements - Schedule of Borrowings (Details) link:presentationLink link:calculationLink link:definitionLink 9955579 - Disclosure - Financing arrangements - Miscellaneous (Details) link:presentationLink link:calculationLink link:definitionLink 9955580 - Disclosure - Financing arrangements - Schedule of Debt Issuances (Details) link:presentationLink link:calculationLink link:definitionLink 9955581 - Disclosure - Financing arrangements - Debt Issuances and Acquisition-Related Financing (Details) link:presentationLink link:calculationLink link:definitionLink 9955582 - Disclosure - Financing arrangements - Debt Extinguishment (Details) link:presentationLink link:calculationLink link:definitionLink 9955583 - Disclosure - Financing arrangements - Debt Repayments (Details) link:presentationLink link:calculationLink link:definitionLink 9955584 - Disclosure - Financing arrangements - Cross-Currency Swaps (Details) link:presentationLink link:calculationLink link:definitionLink 9955585 - Disclosure - Financing arrangements - Shelf Registration Statement and Other Facilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955586 - Disclosure - Financing arrangements - Schedule of Contractual Maturities of Long-term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955587 - Disclosure - Financing arrangements - Interest Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955588 - Disclosure - Stockholders' equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955589 - Disclosure - Stockholders' equity - Schedule of Components of AOCI (Details) link:presentationLink link:calculationLink link:definitionLink 9955590 - Disclosure - Stockholders' equity - Schedule of Reclassifications Out of AOCI (Details) link:presentationLink link:calculationLink link:definitionLink 9955591 - Disclosure - Fair value measurement - Fair Value of Financial Assets and Liabilities on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955592 - Disclosure - Fair value measurement - Schedule of Contingent Consideration Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955593 - Disclosure - Fair value measurement - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955594 - Disclosure - Derivative instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955595 - Disclosure - Derivative instruments - Schedule of Cross-Currency Swaps (Details) link:presentationLink link:calculationLink link:definitionLink 9955596 - Disclosure - Derivative instruments - Schedule of Effective Portion of Unrealized Gain (Loss) Recognized in AOCI (Details) link:presentationLink link:calculationLink link:definitionLink 9955597 - Disclosure - Derivative instruments - Schedule of Interest Rate Derivatives (Details) link:presentationLink link:calculationLink link:definitionLink 9955598 - Disclosure - Derivative instruments - Schedule of Hedged Liabilities and Cumulative Amount (Details) link:presentationLink link:calculationLink link:definitionLink 9955599 - Disclosure - Derivative instruments - Schedule of Income and Expense Line Items (Details) link:presentationLink link:calculationLink link:definitionLink 9955600 - Disclosure - Derivative instruments - Schedule of Fair Value of Derivatives (Details) link:presentationLink link:calculationLink link:definitionLink 9955601 - Disclosure - Contingencies and commitments (Details) link:presentationLink link:calculationLink link:definitionLink 9955602 - Disclosure - SCHEDULE II - VALUATION AND QUALIFYING ACCOUNTS (Details) link:presentationLink link:calculationLink link:definitionLink