Property, plant and equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 16,931	$ 15,749
Less accumulated depreciation and amortization	(10,388)	(9,808)
Property, plant and equipment, net	6,543	5,941
Depreciation and amortization charges associated with property, plant and equipment	694	685	$ 661
Land
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	346	339
Buildings and improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 4,803	4,507
Buildings and improvements | Minimum
Property, Plant and Equipment [Line Items]
Useful life (in years)	10 years
Buildings and improvements | Maximum
Property, Plant and Equipment [Line Items]
Useful life (in years)	40 years
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 3,291	3,220
Manufacturing equipment | Minimum
Property, Plant and Equipment [Line Items]
Useful life (in years)	8 years
Manufacturing equipment | Maximum
Property, Plant and Equipment [Line Items]
Useful life (in years)	12 years
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 1,345	1,346
Laboratory equipment | Minimum
Property, Plant and Equipment [Line Items]
Useful life (in years)	8 years
Laboratory equipment | Maximum
Property, Plant and Equipment [Line Items]
Useful life (in years)	12 years
Fixed equipment
Property, Plant and Equipment [Line Items]
Useful life (in years)	12 years
Property, plant and equipment, gross	$ 2,592	2,526
Capitalized software
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 1,442	1,320
Capitalized software | Minimum
Property, Plant and Equipment [Line Items]
Useful life (in years)	3 years
Capitalized software | Maximum
Property, Plant and Equipment [Line Items]
Useful life (in years)	5 years
Other
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 1,059	941
Other | Minimum
Property, Plant and Equipment [Line Items]
Useful life (in years)	5 years
Other | Maximum
Property, Plant and Equipment [Line Items]
Useful life (in years)	10 years
Construction in progress
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 2,053	$ 1,550