Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Disaggregation of Revenue [Line Items]
Total revenues	$ 33,424	$ 28,190	$ 26,323
U.S.
Disaggregation of Revenue [Line Items]
Total revenues	23,863	19,806	18,595
ROW
Disaggregation of Revenue [Line Items]
Total revenues	9,561	8,384	7,728
Prolia
Disaggregation of Revenue [Line Items]
Total revenues	4,374	4,048	3,628
Prolia | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	2,885	2,733	2,465
Prolia | ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,489	1,315	1,163
ENBREL
Disaggregation of Revenue [Line Items]
Total revenues	3,316	3,697	4,117
ENBREL | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	3,288	3,650	4,044
ENBREL | ROW
Disaggregation of Revenue [Line Items]
Total revenues	28	47	73
XGEVA
Disaggregation of Revenue [Line Items]
Total revenues	2,225	2,112	2,014
XGEVA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,507	1,527	1,480
XGEVA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	718	585	534
Repatha
Disaggregation of Revenue [Line Items]
Total revenues	2,222	1,635	1,296
Repatha | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,139	793	608
Repatha | ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,083	842	688
Otezla
Disaggregation of Revenue [Line Items]
Total revenues	2,126	2,188	2,288
Otezla | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,699	1,777	1,886
Otezla | ROW
Disaggregation of Revenue [Line Items]
Total revenues	427	411	402
TEPEZZA
Disaggregation of Revenue [Line Items]
Total revenues	1,851	448	0
TEPEZZA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,835	441	0
TEPEZZA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	16	7	0
EVENITY
Disaggregation of Revenue [Line Items]
Total revenues	1,563	1,160	787
EVENITY | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,131	809	533
EVENITY | ROW
Disaggregation of Revenue [Line Items]
Total revenues	432	351	254
KYPROLIS
Disaggregation of Revenue [Line Items]
Total revenues	1,503	1,403	1,247
KYPROLIS | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	948	921	850
KYPROLIS | ROW
Disaggregation of Revenue [Line Items]
Total revenues	555	482	397
Nplate
Disaggregation of Revenue [Line Items]
Total revenues	1,456	1,477	1,307
Nplate | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	970	996	848
Nplate | ROW
Disaggregation of Revenue [Line Items]
Total revenues	486	481	459
Aranesp
Disaggregation of Revenue [Line Items]
Total revenues	1,342	1,362	1,421
Aranesp | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	386	452	521
Aranesp | ROW
Disaggregation of Revenue [Line Items]
Total revenues	956	910	900
BLINCYTO
Disaggregation of Revenue [Line Items]
Total revenues	1,216	861	583
BLINCYTO | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	800	566	336
BLINCYTO | ROW
Disaggregation of Revenue [Line Items]
Total revenues	416	295	247
KRYSTEXXA
Disaggregation of Revenue [Line Items]
Total revenues	1,185	272	0
KRYSTEXXA | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,185	272	0
KRYSTEXXA | ROW
Disaggregation of Revenue [Line Items]
Total revenues	0	0	0
Vectibix
Disaggregation of Revenue [Line Items]
Total revenues	1,045	984	893
Vectibix | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	519	461	396
Vectibix | ROW
Disaggregation of Revenue [Line Items]
Total revenues	526	523	497
TEZSPIRE
Disaggregation of Revenue [Line Items]
Total revenues	972	567	170
TEZSPIRE | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	972	567	170
TEZSPIRE | ROW
Disaggregation of Revenue [Line Items]
Total revenues	0	0	0
Other products
Disaggregation of Revenue [Line Items]
Total revenues	5,630	4,696	5,050
Other products | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	4,037	3,307	3,606
Other products | ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,593	1,389	1,444
Product sales
Disaggregation of Revenue [Line Items]
Total revenues	32,026	26,910	24,801
Product sales | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	23,301	19,272	17,743
Product sales | ROW
Disaggregation of Revenue [Line Items]
Total revenues	8,725	7,638	7,058
Other revenues
Disaggregation of Revenue [Line Items]
Total revenues	1,398	1,280	1,522
Other revenues | U.S.
Disaggregation of Revenue [Line Items]
Total revenues	562	534	852
Other revenues | ROW
Disaggregation of Revenue [Line Items]
Total revenues	$ 836	$ 746	$ 670