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Collaborations - Kyowa Kirin (Details) - Kyowa Kirin Co. Ltd. - USD ($)
$ in Millions
3 Months Ended
Sep. 30, 2021
Dec. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Up-front payment $ 400  
Revenue Recognition, Milestone Method, Potential Future Milestone payments   $ 850