Revenues (Details) $ in Millions	3 Months Ended
	Mar. 31, 2022 USD ($) segment	Mar. 31, 2021 USD ($)
Revenue from Contract with Customer [Abstract]
Number of operating segments | segment	1
Revenue from External Customer [Line Items]
Total revenues	$ 6,238	$ 5,901
Product sales [Member]
Revenue from External Customer [Line Items]
Total revenues	5,731	5,592
Product sales [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	4,037	3,903
Product sales [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	1,694	1,689
Enbrel® (etanercept) [Member]
Revenue from External Customer [Line Items]
Total revenues	862	924
Enbrel® (etanercept) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	843	894
Enbrel® (etanercept) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	19	30
Prolia® (denosumab) [Member]
Revenue from External Customer [Line Items]
Total revenues	852	758
Prolia® (denosumab) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	582	501
Prolia® (denosumab) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	270	257
XGEVA® (denosumab) [Member]
Revenue from External Customer [Line Items]
Total revenues	502	468
XGEVA® (denosumab) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	368	334
XGEVA® (denosumab) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	134	134
Otezla (apremilast) [Member]
Revenue from External Customer [Line Items]
Total revenues	451	476
Otezla (apremilast) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	350	366
Otezla (apremilast) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	101	110
Aranesp® (darbepoetin alfa) [Member]
Revenue from External Customer [Line Items]
Total revenues	358	355
Aranesp® (darbepoetin alfa) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	137	125
Aranesp® (darbepoetin alfa) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	221	230
Neulasta® (pegfilgrastim) [Member]
Revenue from External Customer [Line Items]
Total revenues	348	482
Neulasta® (pegfilgrastim) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	304	421
Neulasta® (pegfilgrastim) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	44	61
Repatha (evolocumab) [Member]
Revenue from External Customer [Line Items]
Total revenues	329	286
Repatha (evolocumab) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	165	139
Repatha (evolocumab) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	164	147
KYPROLIS® (carfilzomib) [Member]
Revenue from External Customer [Line Items]
Total revenues	287	251
KYPROLIS® (carfilzomib) [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	196	159
KYPROLIS® (carfilzomib) [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	91	92
Nplate [Member]
Revenue from External Customer [Line Items]
Total revenues	266	227
Nplate [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	156	112
Nplate [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	110	115
Other products [Member]
Revenue from External Customer [Line Items]
Total revenues	1,476	1,365
Other products [Member] | US [Member]
Revenue from External Customer [Line Items]
Total revenues	936	852
Other products [Member] | ROW [Member]
Revenue from External Customer [Line Items]
Total revenues	540	513
Other revenues [Member]
Revenue from External Customer [Line Items]
Total revenues	$ 507	$ 309