Collaborations - BeiGene (Details) - USD ($)		12 Months Ended
	Jan. 02, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from Contract with Customer, Including Assessed Tax		$ 25,979,000,000	$ 25,424,000,000	$ 23,362,000,000
BeiGene
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Ownership percentage	20.50%	18.40%	20.50%
Equity Method Investment, Aggregate Cost	$ 2,800,000,000
BeiGene
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross	$ 1,250,000,000
BeiGene | Other current assets [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related Party Transaction, Due from (to) Related Party		$ 61,000,000	$ 99,000,000
BeiGene | Trade Accounts Receivable
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related Party Transaction, Due from (to) Related Party		21,000,000	22,000,000
BeiGene | Research and Development Expense [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cost recoveries		220,000,000	$ 225,000,000
BeiGene | Selling, general and administrative [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Profit and loss share of expenses		64,000,000
BeiGene | BeiGene
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from Contract with Customer, Including Assessed Tax		$ 72,000,000